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Search suggestions for "91-64-5".

  1. CEBS Data Related to Coumarin (91-64-5) https://cebs.niehs.nih.gov/cebs/test_article/91-64-5


79 results found for "91-64-5".

  1. TR-422: Coumarin (CASRN 91-64-5) in F344/N Rats and B6C3F1Mice... 18.8MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr422.pdf

    ... Park, NC 27709 (919-541-1371). 2 Coumarin, NTP TR 422 CONTRIBUTORS National ... . . . .. . .... . . . . . 335 5 CAS No. 91-64-5 Chemical Formula: C & 0 2 Molecular ...

  2. Abstract for TR-422 75KB

    https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr422

    Abstract for TR-422 Toxicology and Carcinogenesis Studies of Coumarin in F344/N Rats and B6C3F1 Mice (Gavage Studies) CASRN: 91-64-5 Chemical Formula: C9H6O26 Molecular Weight: ...

  3. Target Organs and Levels of Evidence for TR-422 61KB

    https://ntp.niehs.nih.gov/data/tr/400s/tr422levels

    Target Organs and Levels of Evidence for TR-422 Toxicology and Carcinogenesis Studies of Coumarin (CASRN 91-64-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies) Chemical (Study ...

  4. Minutes: BSC TRRS; June 23, 1992 1.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1992/june/trrs23june1992mins_508.pdf

    Hart, 919/541-3971. CONTENTS Technical Report Coumarin 2,3-Dibromo-1 -Propano1 ... (Curcumin) CAS No. Lonn-Term Studies 91-64-5 96-13-9 119-84-6 57-41-0 10034-96-5 ...

  5. TR-423: 3,4-Dihydrocoumarin (CASRN 119-84-6) in F344/N Rats and... 24.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr423.pdf

    ... because of interest in the structure-activity relationships of the coumarin derivatives. ... There was no evidence of carcinogenic activity of 3,4-dihydro- coumarin in male B6C3F1 ...

  6. Studies on Historical Control Reports for NIH-07 Feed 312KB

    https://ntp.niehs.nih.gov/ntp/historical_controls/nih-07_1999/histcont_1999_by_list_of_studies_508.pdf

    Rats Fischer344 Gavage Corn Oil Coumarin Rats Fischer344 Gavage Corn Oil ... Mice B6C3F1 Gavage Corn Oil Coumarin Mice B6C3F1 Gavage Corn Oil ...

  7. Target Organs and Levels of Evidence for TR-550 58KB

    https://ntp.niehs.nih.gov/data/tr/500s/tr550levels

    photographic developers, explosives, organic intermediate in production of coumarin, salicylaldehyde, synthetic resins, degreasing compounds, obtained from coal tar (HSDB 1990). ...

  8. Abstract for TR-423 72KB

    https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr423

    candy, and other food items; as a fragrance in perfumes, creams, and cosmetics; and because of interest in the structure-activity relationships of the coumarin derivatives. ...

  9. Skin - Atrophy - Nonneoplastic Lesion Atlas 290KB

    https://ntp.niehs.nih.gov/atlas/nnl/integumentary-system/skin/Atrophy

    Other compounds are known to affect hair follicles in the telogen phase, such as thallium, triparanol, and coumarin. Some compounds, such as phenyl glycidyl ether and dixyrazine, ...

  10. Skin - Atrophy 492KB

    https://ntp.niehs.nih.gov/sites/default/files/nnl/integumentary/skin/atrophy/skin-atrophy_508.pdf

    Other compounds are known to affect hair follicles in the telogen phase, such as thallium, triparanol, and coumarin. Some compounds, such as phenyl glycidyl ether and dixyrazine, ...

  11. NIST Update: ICCVAM Public Forum 2017 908KB

    https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2017/03o-petersen-nist-508.pdf

    ... Different manufacturers' relative intensity beads NIST SRM 1934 Fluorescein Nile red Allophycocyanin (APC) Coumarin 30 Calibrated fluorometer Calibrated fluorometer Emission of RF ...

  12. Nomination Background: p-Synephrine (CASRN: 94-07-5) 1.3MB

    https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/bitterorange_508.pdf

    ... Constituents of C. aurantium include flavonone glycosides and flavone aglycones, coumarins... chromatographic determination of some coumarins and psoralens found in citrus peel oils. ...

  13. Presentation: Setting the Stage: Purpose, Definitions, Scope... 2.1MB

    https://ntp.niehs.nih.gov/iccvam/meetings/ivive-wksp-2016/webinar-slides/1-wetmore-07oct2015-fd-508.pdf

    ... Acetaminophen 1.1 0.52 0.57 2-Chloro-2'-deoxyadenosine 0.28 1.36 0.58 Coumarin 0.01-0.02 ... Acetaminophen 1.1 0.52 0.57 2-Chloro-2'-deoxyadenosine 0.28 1.36 0.58 Coumarin 0.01-0.02 ...

  14. ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential... 10.6MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edfinalrpt0503/edfinrpt.pdf

    ... triphenylethylene 1 Phenoxazone 1 Coumarin 1 Phorbol ester 1 Coumestan 1 Phthalate ... Coumestan; Ketone Benzopyranone; Coumarin Natural product 4-Cumylphenol 599-64-4 ...

  15. Report: International Workshop on In Vitro Methods for Assessing... 25.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf

    ... (acetonitrile, p-aminophenol, caffeine, coumarin, dimethyl-formamide, mercury (II) ... 1.7 887.1 5.83 NA NA 152.16 5.83 260 Coumarin 91-64-5 249.92 1.71 292.3 2 195.8 1.34 ...

  16. NTP Technical Reports Index 1.5MB

    https://ntp.niehs.nih.gov/data/tr

    ... SE Some Evidence NE No Evidence NE No Evidence SE Some Evidence TR-422 06/23/92 Coumarin 91-64-5 SE Some Evidence EE Equivocal Evidence SE Some Evidence P Clear Evidence TR-421 ...

  17. Usefulness and Limitations of the LLNA for Potency Categorization... 25.3MB

    https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-pot/tmer.pdf

    ... 2 + + Citral 8.48 2 4.94 2 2.75 2 + + Coumarin NC 29.58 3 NA + delta-Damascone 2.12 2 ... Scholes 1992; Basketter et al. 1999b) Coumarin AOO 5.0 10.0 25.0 2.7 2.9 2.3 NC NC N NA ...

  18. TR-096: Coumaphos (CASRN 56-72-4) 2.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr096.pdf

    ... Coumaphos contains the moiety coumarin, a carcinogen shown to induce carcinomas of the bile duct in rats (IARC, 1976). Aflatoxins also contain the moiety coumarin and are known to ...

  19. Peer Review Evaluation Report: Oral Up-and-down Procedure (NIH... 2.1MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/udpproc/udpfin01/vol_2.pdf

    ... Test Substance Chemical/Product Class CAS Number Barium acetate Metal salt 543-80-6 Barbital CNS depressant 57-44-3 Coumarin anticoagulant drug 91-64-5 Allyl heptanoate alkyl ester ...

  20. TR-359: 8-Methoxypsoralen (CASRN 298-81-7) in F344/N Rats (Gavage... 7.8MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr359.pdf

    ... 8-MP; 8-MOP; 8-methoxy-(furano-3',2':6,7-coumarin); 8-methoxy-4',5':6,7- furocoumarin; ... 8-MOP; 8-methoxy-(furano-3' ,2':6,7-coumarin); 8-methoxy-4',5':6,7- futocoumarin; ...

  21. TR-475: Tetrahydrofuran (CASRN 109-99-9) in F344/N Rats and B6C3F1Mice... 9.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr475.pdf

    ... preparations from week 2. Tetrahydrofuran inhibited O-dealkylation of 7-ethoxy- coumarin by liver microsomal cytochrome P 450 from Sprague-Dawley rats pretreated with ethanol ...

  22. Technical Reports 903KB

    https://ntp.niehs.nih.gov/publications/reports/tr

    ... Report TR-422 PDF (18.83 MB) Toxicology and Carcinogenesis Studies of Coumarin (CASRN 91-64-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1993 Technical Report TR-421 ...

  23. Study Reports 1.1MB

    https://ntp.niehs.nih.gov/publications/reports

    ... Report TR-422 PDF (18.83 MB) Toxicology and Carcinogenesis Studies of Coumarin (CASRN 91-64-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1993 Technical Report TR-421 ...

  24. Toxicology/Carcinogenicity 1.1MB

    https://ntp.niehs.nih.gov/whatwestudy/testpgm/cartox

    ... TR-422 PDF (18.83 MB) Toxicology and Carcinogenesis Studies of Coumarin (CASRN 91-64-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1993 Long-Term ...

  25. TOX-99: A Gum Guggul Extract Formulation Administered by Gavage... 1.1MB

    https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox99_508.pdf

    ... (50 μM) CYP2A6 b Coumarin-7-hydroxylation Potassium phosphate buffer (100 mM), EDTA (1 mM), NADPH (10 mM), microsomal protein (0.01 mg), coumarin (5 μM) CYP2C8 c ...

  26. TOX-99: A Gum Guggul Extract Formulation Administered by Gavage... 1.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox99_508.pdf

    ... (50 μM) CYP2A6 b Coumarin-7-hydroxylation Potassium phosphate buffer (100 mM), EDTA (1 mM), NADPH (10 mM), microsomal protein (0.01 mg), coumarin (5 μM) CYP2C8 c ...

  27. Guidance Document on Using In Vitro Data to Estimate In Vivo... 6.5MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/guidance0801/iv_guide.pdf

    ... 259 Methyl salicylate 1.7 5.83 887.1 260 Coumarin 1.71 2 292.3 103 18 Nicotine 1.79 0.31 ... 21 6-Mercaptopurine 0.008 1.84 280.0 260 Coumarin 1.71 2 292.3 228 2,4,5-Trichlorophenoxya...

  28. Background Review Document: Frog Embryo Teratogenesis Assay ... 2.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/fetax2000/brd/fetax-brd-all.pdf

    ... Chlorambucil** Not Tested Not Tested Coumarin* Tested Not Tested Cyclophosphamide** ... Results 4-Hydroxycoumarin + - + Coumarin + - + Isoniazid + - + *If tested with ...

  29. ICCVAM Test Method Evaluation Report on the Reduced LLNA 21.6MB

    https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ld/tmer.pdf

    ... Lipids Lalko & Api Clove stem oil - 8015-98-3 - - Liquid Lipids Lalko & Api Coumarin - 91-64-5 146.15 1.91 Solid Heterocyclic Compounds Gerberick Cyclamen aldehyde - 103-95-7 ...

  30. Public Health Impact 1.5MB

    https://ntp.niehs.nih.gov/media/impact

    ... of Hazard Identification Materials for Coumarin The California Environmental Protection ... Toxicology and carcinogenesis studies of coumarin (CAS No. 91-64-5) in F344/N rats and ...

  31. TR-476: Primidone (CASRN 125-33-7) in F344/N Rats and B6C3F1Mice... 13.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr476.pdf

    ... This has been observed in other NTP studies (e.g., coumarin; NTP, 1993a). The NTP has ... (NTP, 1996), methylphenidate hydrochloride (NTP, 1995), and coumarin (NTP, 1993a)]. ...

  32. TR-465: Phenolphthalein (CASRN 77-09-8) in F344 Rats and B6C3F1Mice... 18.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr465.pdf

    ... quer- cetin (NTP, 1992), coumarin (NTP, 1993b), and 3,4-dihydrocoumarin (NTP, 1993~). ... Toxicology and Carcinogenesis Studies of Coumarin (CAS No. 91-64-5) in F344/N Rats and ...

  33. Submission of the CertiChem Cell Proliferation Test Method for... 3.1MB

    https://ntp.niehs.nih.gov/iccvam/methods/endocrine/endodocs/submdoc.pdf

    ... 479-13-0 Coumestan; Benzopyranone; Coumarin; Ketone 1E-4 - 1E-16 97.5% Fluka ... 479-13-0 Coumestan; Benzopyranone; Coumarin; Ketone 4.4E-09 + 1.5E-08 + ER agonist ...

  34. TR-562: Goldenseal Root Powder (GOLDENSEALRT) in F344/N Rats... 6.4MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr562.pdf

    ... ethylene thiourea, o-nitroanisole, coumarin, oxazepam, methylphenidate ... Toxicology and Carcinogenesis Studies of Coumarin (CAS No. 91-64-5) in F344/N Rats and ...

  35. TR-442: p-Nitrobenzoic Acid (CASRN 62-23-7) in F344/N Rats and... 15.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr442.pdf

    ... 2/50 3/50 4/50 0/50 0150 0150 4/50 0150 Coumarin Quercetin 2/49 2/50 0149 1/50 0/49 0150 ... Mercuric Chloride Quercetin Coumarin 3,4-Dihydrocoumarin ...

  36. CERHR Monograph: Methylphenidate 11.6MB

    https://ntp.niehs.nih.gov/ntp/ohat/stimulants/methylphenidate/methylphenidatemonograph.pdf

    ... II-28 appendix II coumarin.anticoagulants,.anticonvulsants.(e.g.,.phenobarbital,.diphenylhydantoin,.and.primidone),. phenylbutazone,. and. tricyclic. drugs. (e.g.,. imipramine,. ...

  37. TR-470: Pyridine (CASRN 110-86-1) in F344/N Rats, Wistar Rats... 16.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr470.pdf

    ... (NTP, 1996), methylphenidate hydrochloride (NTP, 1995), and coumarin (NTP, 1993c). ... Toxicology and Carcinogenesis Studies of Coumarin (CAS No. 91-64-5) in F344/N Rats and ...

  38. TR-587: Tetrabromobisphenol A (CASRN 79-94-7) in F344/NTac Rats... 3.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr587_508.pdf

    ... ethylene thiourea, o-nitroanisole, coumarin, oxazepam, methyl-phenidate ... Toxicology and carcinogenesis studies of coumarin (CAS No. 91-64-5) in F344/N rats and ...

  39. Background Document for Selected Heterocyclic Amines: PhIP, MeIQ... 3.3MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/hcaspub_508.pdf

    ... The bioantimutagens (e.g., vanillin, caffeine, coumarin) are agents that act on repair and ... Lack of effect of coumarin on unscheduled DNA synthesis in precision-cut human liver ...

  40. RoC Monograph: Cumene; September 2013 2.3MB

    https://ntp.niehs.nih.gov/ntp/roc/thirteenth/monographs_final/cumene_508.pdf

    ... Cruzan et al. based this proposed mode of action on collective data from studies with styrene, ethylbenzene, coumarin, naphthalene, divinylbenzene, benzofuran, cumene and its ...

  41. TR-579: N,N-Dimethyl-P-Toluidine (CASRN 99-97-8) in F344/N Rats... 11.5MB

    https://ntp.niehs.nih.gov/go/tr579

    ... ethylene thio- urea, o-nitroanisole, coumarin, methylphenidate hydro- chloride, ... Toxicol- ogy and Carcinogenesis Studies of Coumarin (CAS No. 91-64-5) in F344/N Rats and ...

  42. XDS Submission of the LUMI-CELL ER Test Method 3.2MB

    https://ntp.niehs.nih.gov/iccvam/methods/endocrine/endodocs/iccvamsubmission28jan05.pdf

    ... - 3.13E-07 98% Sigma liquid Coumesterol 479-13-0 Coumestan; Ketone Benzopyranone; Coumarin Natural Product 4.00E+06 - 1.22E+02 1.00E+01 - 3.05E-04 3.73E-05 - 1.14E-09 > 98% ...

  43. TR-451: Nickel Oxide (CASRN 1313-99-1) in F344 Rats and B6C3F1... 27.7MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr451.pdf

    ... chemicals (e.g., coumarin, NTP, 1993b; benzene, NTP, 1986; glycidol, NTP, 1990a). ... Toxicology and Carcinogenesis Studies of Coumarin (CAS No. 91-64-5) in F344/N Rats and ...

  44. TR-431: Benzyl Acetate (CASRN 140-11-4) in F344/N Rats and B6C3F1Mice... 15.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr431.pdf

    ... IARC Monographs on the Evaluation of the Carcino- genic Risk o f Chemicals to Humans. Some Naturally OccurringandSynthetic Food Components,Furo- coumarins and Ultraviolet ...

  45. TR-503: Chloral Hydrate (Ad Libitum and Dietary Controlled) ... 5.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr503.pdf

    ... Triamterene Feed 421 Talc Inhalation 422 Coumarin Gavage 423 3,4-Dihydrocoumarin Gavage ... Toxicology and Carcinogenesis Studies of Coumarin (CAS No. 91-64-5) in F344/N Rats and ...

  46. Submission of XDS's LUMI-CELL ER High-Throughput System for Screening... 2.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/appxc/annexa/xds-sub.pdf

    ... - 3.13E-07 98% Sigma liquid Coumesterol 479-13-0 Coumestan; Ketone Benzopyranone; Coumarin Natural Product 4.00E+06 - 1.22E+02 1.00E+01 - 3.05E-04 3.73E-05 - 1.14E-09 > 98% ...

  47. RoC Background Document: Diesel Exhaust Particulates; Dec. 2... 5.5MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/dieselexhaust_508.pdf

    ... anhydrides (ARB 1989; Jensen 1983) PAH carboxaldehydes (ARB 1989; Jensen 1983) PAH coumarin (Volkswagen 1989) PAH epoxides (Choudhury 1982) PAH esters (ARB 1989) PAH ketones ...

  48. TR-444: Initiation/Promotion Study of o-Benzyl-p-Chlorophenol... 6.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr444.pdf

    ... Acid Ethylene Glycol Pentachloroanisole Polysorbate 80 o-Nitroanisole p-Nitrophenol p-Nitroaniline HC Yellow 4 Triamterene Talc Coumarin Dihydrocoumarin o-Benzyl-p-chlorophenol ...

  49. TR-518: Triethanolamine (CASRN 102-71-6) in B6C3F1Mice (Dermal... 5.0MB

    https://ntp.niehs.nih.gov/go/tr518

    .../Promotion Studies (Mouse Skin) 441 Corn Oil, Safflower Oil, and Tricaprylin 426 Coumarin 422 CS2 377 Cytembena 207 D&C Red No. 9 225 D&C Yellow No. 11 463 Decabromodiphenyl ...

  50. TR-400: 2,3-Dibromo-1-Propanol (CASRN 96-13-9) in F344/N Rats... 11.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr400.pdf

    ... Dihydrochloride 419 HC Hellow 4 373 Succinic Anhydride 421 Talc 374 Glycidol 422 Coumarin 315 Vinyl Toluene 423 Dihydrocoumarin 376 AllylGlycidyl Ether 427 Turmeric Oleoresin ...

 
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