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FDA Activities (ICCVAM Public Forum 2019) 1.5MB
https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2019/05-fitzpatrick-fda_update_508.pdf
Public Hearing on the Roadmap Federal Register Notice: https://www.federalregister.gov/documents/2018/06/29/2018-14052/the-food-and-drug- administration-predictive-toxicology-roadm...
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Submission of the CertiChem Cell Proliferation Test Method for... 3.1MB
https://ntp.niehs.nih.gov/iccvam/methods/endocrine/endodocs/submdoc.pdf
... dexamethasone, 2,4,5-trichloro-phenoxyacetic acid, and clomiphene citrate. ... ICCVAM (2003a) anticipated that. clomiphene citrate should be EA positive, but this ...
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Advancing Regulatory Science Through Innovation: In Vitro Microphysiol... 2.1MB
https://ntp.niehs.nih.gov/ntp/about_ntp/sacatm/2019/september/presentations/3-3-fitzpatrick-508.pdf
... Public Hearing on the Roadmap Federal Register Notice: https://www.federalregister.gov/documents/2018/06/29/2018-14052/the-food-and- drug-administration-predictive-toxicology-roadm...
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ICCVAM Test Method Evaluation Report on the BG1Luc ER TA Test... 17.5MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/bg1lucer-ta-tmer-combined.pdf
... Clomiphene citrate . p,p'-DDE . 5∝-Dihydrotestosterone . Flutamide . Procymidone . ... not possible. These seven substances (clomiphene citrate, p,p'-DDE, ...
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NICEATM Validation Study Report on the MCF-7 Cell Proliferation... 1.8MB
https://ntp.niehs.nih.gov/iccvam/methods/endocrine/mcf7/mcf7-valstudyreport-19jun12-wcv2-draft.pdf
... NEG (3/3) NEG (3/3) NT NT NEG NEG 3 Clomiphene citrate POS (3/3) NEG (1/1) POS (1/1) ... POS 3 Actinomycin D NEG (1/1) NT NEG 3 Clomiphene citrate POS (2/2) POS (1/1) POS 3 ...
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Addendum to ICCVAM Evaluation of In Vitro Test Methods for Detecting... 2.9MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edaddendfinal.pdf
... inhibitor; being tested in vivo by OECD Clomiphene citrate 50-41-9 Amine, Carboxylic Acid, ... Flame Retardant, Fungicide Clomiphene citrate 50-41-9 598.1 Y ++ slightly ...
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ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential... 10.6MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edfinalrpt0503/edfinrpt.pdf
... Nitrile; Imidazole Metabolic inhibitor Clomiphene citrate 50-41-9 Chlorinated ... Chemical Class <1 to 0.1 (Positive) Clomiphene citrate e,g 50-41-9 0.72 1/1 1 ...
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Peer Review Panel Report on Evaluation of the LUMI-CELL ER Test... 287KB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edprprept2011.pdf
... Section 4.4.1 According to table 4-14 substance clomiphene citrate was not "negative" but ... dicofol, fluoranthene, butylphenol, androstenedione, clomiphene citrat, resveratrol. ...
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TR-425: Promethazine Hydrochloride (CASRN 58-33-3) in F344/N... 22.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr425.pdf
... Res., Chandigarh13, 236- 239. Koch, Y., Dikstein, S., Superstine, E., and Sulman, F.G. (1971). The effect of promethazine and clomiphene on gonadotrophin secretion in the rat. J. ...
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Monograph on Potential Human Reproductive and Developmental Effects... 2.4MB
https://ntp.niehs.nih.gov/ntp/ohat/fluoxetine/fluoxetine_monograph.pdf
... case, but neither woman had responded to clomiphene, suggesting a hypothalamic cause. ... Strain, S. L. Fluoxetine-initiated ovulatory cycles in two clomiphene-resistant women. ...
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NTP Monograph on Health Effects of Low-Level Lead Appendix E... 2.5MB
https://ntp.niehs.nih.gov/ntp/ohat/lead/final/leadappendixe_final_508.pdf
... Authors state GnRH-stimulated LH, clomiphene- stimulated E 2 , and hCG-stimulated T were reduced in the Pb-poisoned men. Occupational Pb exposure was associated with reduced T and ...
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NTP Monograph on Health Effects of Low-Level Lead Appendices... 6.8MB
https://ntp.niehs.nih.gov/ntp/ohat/lead/final/appendicesathrue_final_508.pdf
... Authors state GnRH-stimulated LH, clomiphene- stimulated E 2 , and hCG-stimulated T were reduced in the Pb-poisoned men. Occupational Pb exposure was associated with reduced T and ...
