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Independent Peer Review Evaluation of the Murine Local Lymph... 13.1MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna/llnarep.pdf
... Benzocaine yielded equivocal LLNA results among six separate studies and was excluded from ... of four tests, while benzocaine was identified as a non-sensitizer in five of six tests. ...
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Presentation: The Murine Local Lymph Node Assay: DA 1010KB
https://ntp.niehs.nih.gov/iccvam/meetings/implement-2011/acd-present/7-salicru.pdf
... Abbreviations: n = number of substances. Bold type = LLNA performance standards reference substance. Benzocaine and toluene 2,4-diisocyanate have also been tested in the LLNA: DA ...
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ICCVAM Test Method Evaluation Report on the LLNA: DA 30.4MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-da/tmer.pdf
... (benzocaine) was classified as equivocal due to highly variable results (Basketter et al. 1995; ICCVAM 1999) and was not included in the performance analyses. Similar to benzocaine...
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Usefulness and Limitations of the LLNA for Potency Categorization... 25.3MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-pot/tmer.pdf
... according to Table C-1. For example, there were six GPMTs and one BT for benzocaine. ... versus the three not classified tests, benzocaine was classified as GHS Subcategory 1B ...
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ICCVAM Test Method Evaluation Report on the Applicability Domain... 16.1MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ad/tmer-revmay2012.pdf
... DMSO 2 1 1 0 1 1 0 11.6 5.2 Benzocaine AOO 5 4 1 3 1 0 1 NC NC Cobalt chloride ... NY) s n, + Klink & Meade (2003) Benzocaine 94-09-7 AOO 2.5, 5, 10, 25, 50 2.1, ...
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ICCVAM Test Method Evaluation Report: LLNA BrdU-ELISA 35.6MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-elisa/tmer.pdf
... that included six results each for benzocaine and hexyl cinnamic aldehyde, five ... results for each substance were 100% concordant with the exception of benzocaine. ...
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ICCVAM Test Method Evaluation Report on the Reduced LLNA 21.6MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ld/tmer.pdf
... 50-32-8 252.31 5.39 Solid Hydrocarbons, Cyclic; Polycyclic Compounds Gerberick Benzocaine - 94-09-7 165.19 1.52 Solid Carboxylic Acids Gerberick Benzoquinone p-Quinone; 1,4- ...
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Peer Review Panel Report: Validation Status of the LLNA (2008... 6.2MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llnaprprept2008.pdf
... without data comparison (i.e., benzocaine produced divergent results in both tests). ... Table 6-3: Benzocaine was missing and it seems that salicylic acid was the same in both ...
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Comment: Antimony Trioxide (Attachment); Caroline Braibant, Geert... 9.7MB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2016/publiccomm/braibant_attach2.pdf
... dose: 5 % (w/v) benzocaine in 40 % ethanolic 0.9 % NaCl solution 2nd reading: 20 out of 20 (positive control); 72 h after chall.; dose: 5 % (w/v) benzocaine in 40 % ethanolic ...