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RoC Background Document for Nitrobenzene; Sept. 19, 2002 1.3MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/nbpub_no_appendices_508.pdf
FINAL Report on Carcinogens Background Document for Nitrobenzene September 19, 2002 ... 09/19/02 RoC Background Document for Nitrobenzene FOREWORD The Report on Carcinogens ...
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RoC Profile: Nitrobenzene; 15th RoC 2021 133KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nitrobenzene.pdf
Nitrobenzene CAS No. 98-95-3 Reasonably anticipated to be a human carcinogen First listed in the Eleventh Report on Carcinogens (2004) NO 2 Carcinogenicity Nitrobenzene is ...
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Abstract for TR-109 61KB
https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr109
Full Report PDF Abstract 4-Nitroanthranilic acid, a nitrobenzene derivative formerly used as a dye intermediate, was selected for bioassay by the National Cancer Institute along ...
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Minutes: BSC RoC; Nov. 11, 2008 624KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/twelfth/draftbackgrounddocs/roc_minutes20021120.pdf
......... 16 Nitrobenzene ......Nitrobenzene Dr. Jameson presented the nomination and said that nitrobenzene is a nitro ...
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Abstract for TR-127 62KB
https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr127
CASRN: 99-59-2 Chemical Formula: C7H8N2O3 Molecular Weight: 168.1512 Synonyms/Common Names: 2-methoxy-5-nitro-benzeneamine; 3-amino-4-methoxy-nitrobenzene; 2-methoxy-5-nitroaniline...
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Abstract for TR-498 72KB
https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr498
CASRN: 99-99-0 Chemical Formula: C7H7NO2 Molecular Weight: 137.14 Synonyms/Common Names: Methyl nitrobenzene; 1-methyl-4-nitrobenzene; 4-methylnitrobenzene; p-methylnitrobenzene; ...
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Abstract for TR-180 62KB
https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr180
4-nitro-phenylenediamine; 4-nitro-1,2-diaminobenzene; 1,2-diamino-4-nitrobenzene; 2-amino-4-nitroaniline; 4-NO; 4-NOP; 4-NOPD; 4-N-o-PDA; C.I. 76020 Report Date: ...
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Abstract for TR-169 63KB
https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr169
o-Nitro-p-phenylenediamine; 2-Nitro-1,4-diaminobenzene; 1,4-Diamino-2-nitrobenzene; 2-NP; 2-NPPD; 2-N-p-PDA; Ursol Brown RR; Zoba Brown RR; Fourrine Brown 2R; ...
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TR-325: Pentachloronitrobenzene (CASRN 82-68-8) in B6C3F1Mice... 6.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr325.pdf
... Pentachloro- nitrobenzene was not mutagenic at the TK+'- locus of L5178Y mouse lymphoma ... draft Technical Report on pentachloro- nitrobenzene on March 26, 1986, are listed below. ...
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TOX-33: 2-Chloronitrobenzene (CASRN 88-73-3) and 4-Chloronitrobenzene... 10.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox33.pdf
... 2-chloro- I -nitrobenzene ONCI3 0 Molecular Formula Molecular Weight 0 4-Chloronitrobenzen e N02 C 1 100-00-5 p-chloronitrobenzene 4-chloro- I -nitrobenzene PNC13 C,H4CINO, ...
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TR-498: p-Nitrotoluene (CASRN 99-99-0) in F344/N Rats and B6C3F1Mice... 10.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr498.pdf
... CH 3 NO 2 5 ABSTRACT p-NITROTOLUENE CAS No. 99-99-0 Chemical Formula: C 7 H 7 NO 2 Molecular Weight: 137.14 Synonyms: Methyl nitrobenzene; 1-methyl-4-nitrobenzene; ...
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Agenda: BSC RoC; Nov. 19-20, 2002 50KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/meetings/2002/nov2002rocagenda.pdf
Listing in the 11th Report 4,4'-Thiodianiline/ (139-65-1) Listing in the 11th Report Nitrobenzene (98-95-3) Listing in the 11th Report Note: Public comments are welcomed. ...
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Captafol/o-Nitrotoluene Expert Panel Report Part A - Peer Review... 138KB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2007/expertpanelmtgs/o_nitrotolouene_reportparta_508.pdf
... 88-72-2 Molecular formula C 7 H 7 NO 2 Synonyms 1-methyl-2-nitrobenzene 2-methylnitrobenzene 2-methyl-1-nitrobenzene 2-nitrotoluene 2-nitrotoluol benzene, 1-methyl-2-nitro ...
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Appendix G; 15th RoC 2021 73KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_g.pdf
... 97-56-3 see o-Aminoazotoluene 98-07-7 see Benzotrichloride 98-82-8 see Cumene 98-95-3 see Nitrobenzene 100-42-5 see Styrene 100-75-4 (N-nitrosopiperidine) see N-Nitrosamines: 15 ...
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RoC Profile: Benzene; 15th RoC 2021 110KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/benzene.pdf
... As a raw material, it is used in the synthesis of ethylbenzene (used to produce styrene) (53%), cumene (used to produce phenol and acetone) (22%), cyclohexane (12%), nitrobenzene ...
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RoC Profile: Coal Tars and Coal-Tar Pitches; 15th RoC 2021 134KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/coaltars.pdf
... water, partially soluble in acetone, carbon disulfide, chloroform, diethyl ether, ethanol, methanol, petroleum ether, and sodium hydroxide, and soluble in benzene and nitrobenzene. ...
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RoC Profile: Hydrazobenzene; 15th RoC 2021 129KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/hydrazobenzene.pdf
... in the production of benzidine, which is formed by the reduction of nitrobenzene to hydrazobenzene followed by the rear- rangement of hydrazobenzene to benzidine (NCI 1978). ...
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TR-417: p-Nitrophenol (CASRN 100-02-7) in Swiss Webster Mice... 7.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr417.pdf
... as nitrobenzene with an estimated annual production o f 900 million pounds, or through microbial metabolites. In studies with Sprague-Dawley rats and B6C3Fl mice, nitrobenzene was ...
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Public Comment: 2-Butoxyethanol (Attachment); Seth Barna; RoC... 758KB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2013/publiccomm/barna_attachmentacc_508be.pdf
... 3. Anonymous (2003). "Nitrobenzene." Environmental Health Criteria 230(2003). Effects on laboratory mammals and in vitro test systems Nitrobenzene causes toxicity in multiple ...
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TR-180: 4-Nitro-o-phenylenediamine (CASRN 99-56-9) 2.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr180.pdf
...itro-l,2-diaminobenzene; 1,2~diamino-4-nitrobenzene; 2-amino-4-nitroaniline; 4-NO; 4-NOP; ... "o-Phenylenediamine and 1:2- Diamino-4-nitrobenzene as Reagents for o-Keto Acids." ...
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RoC Background Document: o-Nitroanisole; Nov. 18-19, 1996 2.3MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/nitroanisole-o_508.pdf
... (SCI) Anisole, 2-nitro- 1-Methoxy-2-nitrobenzene 2-Methoxynitrobenzene NCI-C60388 ... Carcinog. 14:37-45. Shimizu, M., and E. Yano. 1986. Mutagenicity of Mono-Nitrobenzene ...
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Listed Substances; 15th RoC 2021 76KB
https://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf
... (see Nickel Compounds and Metallic Nickel) Nitrilotriacetic Acid o-Nitroanisole Nitrobenzene 6-Nitrochrysene (see Nitroarenes [Selected]) Nitrofen Nitrogen Mustard ...
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Background Document: RoC: o-Nitrotoluene ; 2010 1.5MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/o-nt-final_508.pdf
... 88-72-2 Molecular formula C 7 H 7 NO 2 Synonyms 1-methyl-2-nitrobenzene 2-methylnitrobenzene 2-methyl-1-nitrobenzene 2-nitrotoluene 2-nitrotoluol benzene, 1-methyl-2-nitro ...
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TOX-43: o-,m-, and p-Chloroanilines (CASRNs 95-51-2; 108-42-9... 5.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox043.pdf
... USE, AND EXPOSURE o-Chloroaniline and m-chloroaniline are synthesized by the reduction of 1-chloro-2-nitrobenzene and 1-chloro-3-nitrobenzene, respectively (Merck Index, 1983). ...
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RoC Profile: Nitromethane; 15th RoC 2021 136KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nitromethane.pdf
... Technical Report Series no. 461. Research Triangle Park, NC: National Toxicology Program. 284 pp. NTP. 2002. Report on Carcinogens Background Document for Nitrobenzene. National ...
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Completed RoC Evaluations 119KB
https://ntp.niehs.nih.gov/whatwestudy/assessments/cancer/completed/roc
... Request Archived Materials o-Nitroanisole Reasonably anticipated to be a human carcinogen Background Document Request Archived Materials Nitrobenzene Reasonably anticipated to be a ...
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RoC Background Document: 6-Nitrochrysene; Nov. 18-19, 1996 2.9MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/nitrochrysene-6_508.pdf
... and carbon disulfide; Somewhat soluble in benzene and acetic acid; Soluble in hot nitrobenzene Prager and Jacobson (1922); Boit (1965); both cited by IARC, (1989) Prager and ...
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RoC Concept: ortho-Toluidine 318KB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/concepts/otolconcdocroc8-30-12_508.pdf
... ortho-aminoazotoluene, aniline, 4-chloro-ortho-toluidine, nitrobenzene, hydroquinone, N-phenyl-2-naphthylamine (phenyl-β-naphthylamine), and 2-mercaptobenzothiazole. ...
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RoC Profile: o-Nitrotoluene; 15th RoC 2021 162KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nitrotoluene.pdf
... Cancer Res 43(6): 2836-2842. Dunlap KL. 1998. Nitrobenzene and nitrotoluenes. In ... EPA. 2016. Chemical Data Reporting Summary: 1-Methyl-2-nitrobenzene. U.S. Environmental ...
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TR-109: 4-Nitroanthranilic Acid (CASRN 619-17-0) 4.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr109.pdf
... C01945), a nitrobenzene deriva- tive formerly used as a dye intermediate, was selected for bioassay by the National Cancer Institute along with other dye intermediates in an ...
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TR-127: 5-Nitro-o-anisidine (CASRN 99-59-2) 5.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr127.pdf
... The Chemical Abstracts Service (CAS) Ninth Collective Index (1977) * name for this compound is 2-methoxy-5-nitro-benzenamine. It is also known as 3-amino-4-methoxy-nitrobenzene; ...
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RoC Background Document for 1-Amino-2,4-dibromoanthraquinone... 941KB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/adbaqpub_no_appendices_508.pdf
... in ether and benzene; soluble in hot nitrobenzene, chloroform, acetic acid, pyridine, ... aniline, substituted aniline, benzene, nitrobenzene, chlorobenzenes, chlorotoluenes, ...
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ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential... 10.6MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edfinalrpt0503/edfinrpt.pdf
... 1 Nitrile 5 Benzopyranone 1 Nitrobenzene 2 Benzylidene 3 Norpregnene 1 ... Flutamide 13311-84-7 Amide; Anilide; Nitrobenzene Pharmaceutical Genistein 446-72-0 ...
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Guidance Document on Using In Vitro Data to Estimate In Vivo... 6.5MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/guidance0801/iv_guide.pdf
... 3.96 Salicylic acid 69-72-7 1.63 2.04 Tin(II) chloride 7772-99-9 1.55 2.35 Nitrobenzene 98-95-3 1.39 1.33 Tetrachlorethene 127-18-4 1.08 2.35 Aniline 62-53-3 1.07 1.25 EDTA-Na ...
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RoC Monograph: ortho-Toluidine; July 2014 2.4MB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/monographs_final/otoluidine_508.pdf
... Nitrobenzene levels were mostly non-detectable (Hanley et al. 2012). The U.K. rubber ... U.S. dye workers cohort Ott and Langner (1983) Potential exposure: [Nitrobenzene]; ...
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Public Health Impact 1.5MB
https://ntp.niehs.nih.gov/media/impact
... bromide (bromomethane), metolachlor, nitrobenzene, and RDX. The Safe Drinking Water Act ... via gavage of nitrobenzene (C60082) in Fischer 344 rats and B6C3F1 mice [unpublished]. ...
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Draft RoC Monograph for ortho-Toluidine: Literature Search Strategy... 1.1MB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/litsearchstrategy/otol_literaturesearch20130815_508.pdf
... Aniline 4-Chloro-ortho-toluidine Nitrobenzene Hydroquinone N-Phenyl-2-naphthylamine ... General sources checklist for: Nitrobenzene Source Name of document 1) NTP technical ...
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TR-442: p-Nitrobenzoic Acid (CASRN 62-23-7) in F344/N Rats and... 15.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr442.pdf
... such as nitrobenzene and 0 - ,m -,andp-nitrotoluene (Rickert, 1987;NTP, 1 9 9 2 ) . ... The requirement of the gut flora in nitrobenzene- induced methemoglobinemia in rats. ...
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RoC Profile: o-Toluidine; 15th RoC 2021 192KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/toluidine.pdf
... exposed to o-toluidine, aniline and nitrobenzene at a rubber chemical manufacturing plant. ... Exposure to o-toluidine, aniline, and nitrobenzene in a rubber chemical manufacturing ...
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RoC Background Document: Dyes Metabolized to Benzidine (Benzidine... 8.5MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/dyesmetabenzidine_508.pdf
... Although several methods for the reduction of nitrobenzene can be used, the key reaction ... A sample from a rafter above the reactors in which nitrobenzene was reduced was found to ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
... Evidence TR-325 03/26/86 Pentachloro-Nitrobenzene 82-68-8 NT Chemical Not Tested in ... Evidence TR-061 01/18/78 Pentachloro-nitrobenzene 82-68-8 N No Evidence N No Evidence N ...
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Appendices A-G; 15th RoC 2021 448KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendices_508.pdf
... see p-Cresidine 1-methoxy-2-nitrobenzene see o-Nitroanisole ... see Benzotrichloride 98-82-8 see Cumene 98-95-3 see Nitrobenzene 100-42-5 see Styrene ...
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15th RoC: Appendix F 174KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_f.pdf
... Ultraviolet A Therapy 2-methoxy-5-methylbenzenamine see p-Cresidine 1-methoxy-2-nitrobenzene see o-Nitroanisole 4-methoxy-m-phenylenediamine sulfate see 2,4-Diaminoanisole ...
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RR-11: The Chemical and Physical Characterization of Recycled... 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/results/pubs/rr/reports/rr11_508.pdf
... 88-74-4 138.12 3-Nitroaniline 99-09-2 138.12 4-Nitroaniline 100-01-6 138.12 Nitrobenzene 98-95-3 123.11 Nitromethane 75-52-5 61.04 2-Nitrophenol 88-75-5 139.11 4-Nitrophenol ...
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RoC Profile: Nitroarenes (Selected); 15th RoC 2021 233KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nitroarenes.pdf
... slightly solu- ble in cold ethanol, diethyl ether, and carbon disulfide; slightly more soluble in benzene and acetic acid; and soluble in hot nitrobenzene (IARC 1989, WHO 2003). ...
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Minutes: BSC; June 29, 2004 883KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2004/june/20040629_508.pdf
... RoC. . Neutrons - the recommendation is to list as a known human carcinogen. . Nitrobenzene - the recommendation is to list as reasonably anticipated to be a human carcinogen. . ...
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TR-131: Bioassays of DDT, TDE, and p,p'-DDE (CASRN 50-29-3, CASRN... 7.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr131.pdf
... mexacarbate (315-18-4); methoxychlor (72-43-5); dicofol (115-32-2); pentachloro- nitrobenzene (82-68-8); clonitralid (1420-04-8); nitrofen (1836-75-5); endosulfan (115-29-7); ...
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National Toxicology Program, Board of Scientific Counselors 106KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2001/may/2001052501bscsummmins_508.pdf
... and GAMMA-Radiation, Neutrons, Occupational Exposure to Lead or Lead Compounds, Naphthalene, Nitrobenzene, Nitromethane, Phenylimidazopyridine (PhIP), and 4,4'-Thiodianiline. Dr. ...
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Minutes: BSC; Sept. 17, 2002 762KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2002/september/20020917bscsummmins_508.pdf
... 1-amino-2,4-dibromoanthraquinone, cobalt sulfate, diethanoamine, naphthalene, nitrobenzene, nitromethane, 4,4'-thiodianiline, and three selected heterocyclic amines - MeIQ ...
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Report: International Workshop on In Vitro Methods for Assessing... 25.4MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf
... 9.56 301 17 Xylene 1330-20-7 1274.16 12 4300.3 40.5 NA NA 106.18 40.5 302 Nitrobenzene 98-95-3 1502.06 12.2 640.2 5.2 NA NA 123.12 5.2 304 Calcium II chloride 10043-52-4 ...