Background Document for 1-Chloro-4-(trifluoromethyl)benzene;... 395KB

https://ntp.niehs.nih.gov/ntp/noms/support_docs/pcbtf060409.pdf

... Aqueous photolysis of the primary atmospheric oxidation product, o-CTFP, produces 3,4-dihydroxybenzoic acid (protocatechuic acid, CAS RN: 99-50-3; PubChem CID:72) which is an ...

TR-538: Methyl Isobutyl Ketone (CASRN 108-10-1) in F344/N Rats... 13.7MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr538.pdf

... 97 50 2 159 50 157 99 50 158 100 50 157 99 50 3 187 50 187 100 50 190 102 50 191 102 50 4 ... 50 2 25.7 50 25.2 98 50 25.3 98 50 25.4 99 50 3 27.1 50 26.7 99 50 26.4 97 50 26.8 99 50 ...

TR-346: Chloroethane (Ethyl Chloride) (CASRN 75-00-3) in F344... 8.7MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr346.pdf

... 101 50 1 202 50 202 100 50 2 223 50 220 99 50 3 242 50 240 99 50 4 259 50 254 98 50 5 274 ... 377 50 361 96 50 25 394 50 379 96 50 29 399 50 391 1 8 50 33 417 50 400 96 50 38 422 50 ...

TR-406: g-Butyrolactone (CASRN 96-48-0) in F344/N Rats and B6C3F1Mice... 11.0MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr406.pdf

... 278 98 50 6 298 50 295 99 50 293 98 50 7 308 50 305 99 50 3 0 1 98 50 8 316 50 3 1 5 100 50 310 98 50 9 330 50 327 99 50 323 98 50 10 339 50 337 99 50 3 3 1 98 5 0 11 343 50 340 ...

TR-472: Isobutyraldehyde (CASRN 78-84-2) in F344/N Rats and B6C3F1Mice... 11.3MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr472.pdf

... 99 50 2 170 50 171 101 50 170 100 50 168 99 50 3 203 50 206 101 50 205 101 50 202 100 50 4 ... 99 50 2 124 50 124 100 50 123 99 50 122 99 50 3 138 50 138 100 50 137 99 50 138 99 50 4 ...

TR-378: Benzaldehyde (CASRN 100-52-7) in F344/N Rats and B6C3F1Mice... 14.1MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr378.pdf

... 50 161 101 50 2 210 50 209 100 50 208 99 50 3 235 50 233 99 50 235 100 50 4 253 50 255 ... 50 317 100 50 319 101 50 9 328 50 325 99 50 329 100 50 10 337 50 334 99 50 339 101 50 ...

TR-379: 2-Chloroacetophenone (CASRN 532-27-4) in F344/N Rats... 24.3MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr379.pdf

... 101 50 5 287 50 293 102 50 290 101 50 6 299 50 311 104 50 306 102 50 7 312 50 322 103 50 ... 49 303 101 50 300 100 49 56 310 49 307 99 50 306 99 49 61 316 49 314 99 50 316 100 49 65 ...

TR-541: Formamide (CASRN 75-12-7) in F344/N rats and B6C3F1 Mice... 2.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr541.pdf

... 50 2 153 50 153 100 50 154 101 50 151 99 50 3 189 50 189 100 50 190 101 50 185 98 50 4 ... 50 329 96 50 17 379 50 378 100 50 376 99 50 359 95 50 21 400 50 401 100 50 400 100 50 ...

TR-306: Dichloromethane (Methylene Chloride) (CASRN 75-09-2)... 13.6MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr306.pdf

... 50 2 226 50 232 103 50 229 101 50 223 99 50 3 246 50 246 101 50 244 99 50 242 9!1 50 4 ... 50 327 100 50 322 98 50 10 344 50 342 99 50 336 98 50 331 941 50 11 350 50 351 100 50 ...

TR-376: Allyl Glycidyl Ether (CASRN 106-92-3) in Osborne-Mendel... 14.3MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr376.pdf

... Wt. (grams) Wt. (percent of ch. controls) NO. of Survivors MALE 1 177 50 187 106 50 182 103 50 2 256 50 257 100 50 254 99 50 3 293 50 290 99 50 291 99 50 4 324 50 320 99 50 315 97 ...

TR-440: Ozone (CASRN 10028-15-6) and Ozone/NNK (CASRN 10028-15... 16.7MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr440.pdf

... Survivors 1 126 50 125 99 50 125 99 50 3 215 50 21 9 102 50 207 97 50 7 302 50 305 ... 30.8 98 50 8 32.2 50 32.3 1 0 0 50 32.0 99 50 31.4 98 50 9 32.5 50 32.8 101 50 32.4 100 ...

TR-275: 2-Chloroethanol (Ethylene Chlorohydrin) (CASRN 107-07... 14.0MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr275.pdf

... 100 50 196 98 50 2 209 50 212 101 50 207 99 50 3 243 50 236 97 50 217 89 50 4 241 50 236 ... 50 324 105 50 302 98 50 10 316 50 313 99 50 310 98 50 11 326 50 323 99 50 319 98 50 12 ...

TR-332: 2-Mercaptobenzothiazole (CASRN 149-30-4) in F344/N Rats... 10.3MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr332.pdf

... 0 112 50 112 100 50 112 100 50 1 131 50 131 100 50 129 96 50 2 148 50 148 100 50 141 99 50 3 159 50 160 101 50 159 100 50 4 168 50 169 101 50 168 100 50 5 119 50 181 101 50 119 ...

TR-339: 2-Amino-4-Nitrophenol (CASRN 99-57-0) in F344/N Rats... 11.1MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr339.pdf

... 98 50 117 100 50 2 132 50 133 101 50 131 99 50 3 141 50 141 100 49 137 97 50 4 149 50 154 ... 50 31.5 101 50 31.0 99 50 6 31.8 50 31.6 99 50 31.8 100 50 7 32.6 50 31.8 98 50 32.8 101 ...

TR-364: Rhodamine 6G (C.I. Basic Red 1) (CASRN 989-38-8) in F344... 11.2MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr364.pdf

... 101 50 157 99 50 2 197 50 198 in1 50 195 99 50 3 226 so 225 100 50 225 100 50 4 252 50 252 ... 50 224 99 50 29 239 50 244 102 50 236 99 50 34 243 so 252 104 50 244 100 50 39 251 50 ...

TR-400: 2,3-Dibromo-1-Propanol (CASRN 96-13-9) in F344/N Rats... 11.3MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr400.pdf

... 50 324 100 5 0 318 98 50 8 333 50 334 100 50 327 98 50 9 345 50 342 99 50 335 97 50 10 354 50 352 99 50 343 97 50 11 355 50 355 100 50 348 98 50 12 362 50 365 101 50 356 98 50 ...

TR-479: Coconut Oil Acid Diethanolamine Condensate (CASRN 68603... 7.5MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr479.pdf

... 100 50 129 100 50 2 167 50 165 99 50 165 99 50 3 200 50 197 99 50 196 98 50 4 229 50 226 ... 35.6 101 50 35.5 101 49 21 37.9 50 37.5 99 50 37.2 98 49 25 40.4 50 40.7 101 50 40.6 101 ...

TR-321: Bromodichloromethane (CASRN 75-27-4) in F344/N Rats and... 10.6MB

https://ntp.niehs.nih.gov/go/tr321

... 50 305 100 50 295 96 50 10 313 50 310 99 50 304 97 50 11 338 50 322 95 50 314 93 50 12 ... 98 50 121 98 50 2 137 50 132 96 50 135 99 50 3 148 50 143 97 50 141 95 50 4 160 50 154 ...

TR-322: Phenylephrine Hydrochloride (CASRN 61-76-7) in F344/N... 10.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr322.pdf

... 95 38 33.3 90 43 FEMALE 1 19.1 50 18.9 99 50 19.0 99 50 2 19.4 50 19.4 100 50 19.2 99 50 3 19.8 50 19.8 99 50 19.2 97 50 4 20.7 50 20.5 99 50 20.4 99 50 5 21.5 50 21.3 99 50 ...

TR-330: 4-Hexylresorcinol (CASRN 136-77-6) in F344/N Rats and... 9.4MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr330.pdf

... 50 25.5 97 SO 2 28.0 50 2'7.6 99 50 27.8 99 50 3 29.3 50 28.0 98 50 29.7 101 50 4 30.2 50 29.7 98 50 30.3 100 50 5 31.1 50 30.7 99 50 31.3 101 50 0 31.9 50 31.8 100 50 32.4 102 50 ...

TR-331: Malonaldehyde, Sodium Salt (3-Hydroxy-2-propenal, Sodium... 7.0MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr331.pdf

... 50 310 100 50 302 98 50 12 318 50 317 100 50 307 97 50 13 324 50 321 99 50 313 97 50 16 342 50 340 99 50 328 96 50 20 359 50 358 100 50 344 96 50 25 391 50 388 99 50 367 94 50 29 ...

TR-312: n-Butyl Chloride (CASRN 109-69-3) in F344/N Rats and... 15.1MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr312.pdf

... No. ot Survivon MALE 0 24.8 50 24.2 98 50 1 25.7 50 25.4 99 50 2 27.0 50 26.6 99 50 3 28.3 50 27.8 98 50 4 5 28.5 29.8 50 50 28.8 29.1 100 98 50 50 8 30.2 50 30.1 100 50 7 ...

TR-411: C.I. Pigment Red 23 (CASRN 6471-49-4) in F344 Rats and... 15.0MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr411.pdf

... 52 3 5 . 9 25 3 6 . 8 58 3 5 . 8 97 51 3 6 . 6 28 37.2 58 3 6 . 7 99 50 3 7 . 3 32 3 8 . 1 58 3 7 . 7 99 50 3 8 . 5 36 39.3 58 3 8 . 2 97 50 3 9 . 2 40 38.8 58 3 7 . 7 97 49 38.0 ...

TR-419: HC Yellow 4 (CASRN 59820-43-8) in F344 Rats and B6C3F1Mice... 10.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr419.pdf

... 23.1 101 50 2 23.9 50 23.9 100 50 23.7 99 50 3 24.0 50 24.7 103 50 24.2 101 50 4 26.7 50 ... 50 30.2 99 50 28.3 93 50 9 31.7 49 31.4 99 50 30.4 96 50 10 326 48 323 99 50 31.1 95 50 ...

TR-476: Primidone (CASRN 125-33-7) in F344/N Rats and B6C3F1Mice... 13.4MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr476.pdf

... 99 50 2 191 50 192 100 50 191 100 50 190 99 50 3 222 50 227 102 50 223 100 50 227 102 50 4 ... 50 296 101 50 7 308 50 309 100 50 306 99 50 305 99 50 8 327 50 330 101 50 329 101 50 ...

TR-523: Diisopropylcarbodiimide (CASRN 693-13-0) in F344/N Rats... 10.1MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr523.pdf

... Survivors 1 101 50 100 99 50 101 100 50 102 101 50 2 126 50 123 98 50 125 99 50 124 99 50 3 155 50 151 97 50 153 99 50 153 99 50 4 182 50 177 97 50 179 98 50 179 98 50 5 208 50 ...

TR-351: para-Chloroaniline Hydrochloride (CASRN 20265-96-7) in... 12.2MB

https://ntp.niehs.nih.gov/go/tr351

... 50 307 101 50 307 101 50 9 316 49 315 100 50 313 99 50 315 100 50 10 330 49 325 98 50 319 97 50 324 98 50 11 337 48 334 99 50 326 97 50 331 98 50 12 346 48 344 99 50 338 98 50 341 ...

TR-250: Benzyl Acetate (CASRN 140-11-4) in F344/N Rats and B6C3F1Mice... 8.5MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr250.pdf

... 50 19.7 101 50 19.4 99 50 1 18.7 50 19.9 106 50 20.8 111 50 2 21.7 50 21.4 99 50 21.4 99 50 3 22.2 50 22.2 100 50 22.1 100 50 4 22.4 50 22.1 99 50 22.7 101 50 5 22.7 50 22.8 100 48 ...

TR-323: Dimethyl Methylphosphonate (CASRN 756-79-6) in F344/N... 9.8MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr323.pdf

... MALE 0 22.4 50 23.0 103 50 22.0 98 50 I 21.9 49 23.8 109 50 23.1 105 50 2 24.6 49 25.0 102 49 24.4 99 50 3 26.4 49 26.1 99 49 25.3 96 50 4 26.8 49 27.0 101 49 26.1 97 49 5 27.4 49 ...

TR-334: 2-Amino-5-Nitrophenol (CASRN 121-88-0) in F344/N Rats... 9.0MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr334.pdf

... 24.4 100 50 23.1 98 50 1 25.2 50 25.3 100 49 25.5 101 50 2 27.0 49 27.2 101 49 20.8 99 50 3 28.4 49 27.8 98 49 27 5 97 50 4 2 8 . 4 49 28.5 100 49 27.8 98 50 5 30.4 49 30.4 100 ...

TR-338: Erythromycin Stearate (CASRN 643-22-1) in F344/N Rats... 10.0MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr338.pdf

... 95 369 50 369 100 50 350 95 396 50 393 99 50 375 95 407 50 406 100 50 390 96 432 50 426 ... 50 19.7 99 50 2 20.7 50 20.5 99 50 20.5 99 50 3 21.7 50 21.1 97 50 21.0 97 50 4 21.9 50 ...

TR-393: Sodium Fluoride (CASRN 7681-49-4)in F344/N Rats and B6C3F1Mice... 21.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr393.pdf

... 3 5 1 0 1 51 329 100 50 331 100 80 1 2 342 79 3 4 1 100 51 340 99 50 3 4 1 100 80 1 3 346 7 9 342 99 51 343 99 50 341 98 80 17 367 7 9 368 1 0 0 51 365 100 50 367 100 80 2 1 392 79 ...

TR-477: 1-Chloro-2-Propanol (Technical Grade) (CASRN 127-00-4... 9.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr477.pdf

... 99 50 2 128 50 128 100 50 128 100 50 127 99 50 3 144 50 143 99 50 143 100 50 143 100 50 4 ... 50 301 102 50 61 305 50 305 100 49 302 99 50 309 101 50 65 305 50 307 101 49 303 99 50 ...

TR-483: Pentachlorophenol (CASRN 87-86-5) in F344/N Rats (Feed... 7.7MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr483.pdf

... 310 50 311 100 50 297 96 50 9 327 50 325 99 50 313 96 50 10 337 50 335 100 50 325 97 50 11 344 50 342 100 50 334 97 50 12 358 50 353 99 50 342 96 50 13 366 50 361 99 50 349 95 50 17 ...

TR-296: Tetrakis(hydroxymethyl)phosphonium sulfate (THPS) (CASRN... 16.4MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr296.pdf

... 313 99 45 12 320 50 319 98 50 324 99 45 13 332 50 329 99 50 335 101 45 10 355 50 355 100 50 357 101 45 21 384 50 381 99 50 385 100 45 25 405 50 401 99 50 399 99 45 29 425 50 420 99 ...

TR-319: 1,4-Dichlorobenzene (CASRN 106-46-7) in F344/N Rats and... 17.6MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr319.pdf

... 50 328 100 50 329 100 49 10 332 50 331 100 50 330 99 49 11 341 50 336 99 50 337 99 49 12 345 50 341 99 50 340 99 49 16 376 50 368 98 50 362 96 49 20 397 50 388 98 50 398 100 49 25 ...

TR-345: Roxarsone (CASRN 121-19-7) in F344/N Rats and B6C3F1... 25.2MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr345.pdf

... 311 50 304 98 50 296 95 50 11 320 50 315 98 50 306 96 50 12 329 50 325 99 50 316 96 50 17 368 50 365 99 50 356 97 50 21 392 50 393 100 50 378 96 50 26 411 50 412 100 50 396 96 50 ...

TR-355: Diphenhydramine Hydrochloride (CASRN 147-24-0) in F344... 10.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr355.pdf

... 5 279 50 274 98 50 272 97 50 6 294 50 290 99 50 287 98 50 7 309 50 305 99 50 301 97 50 B 322 50 318 99 50 314 98 50 9 330 50 328 99 50 323 98 50 10 340 50 336 99 50 330 97 50 11 ...

TR-402: Furan (CASRN 110-00-9) in F344 Rats and B6C3F1 Mice(Gavage... 31.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr402.pdf

... 50 20.1 99 50 2 21.5 50 21.3 99 50 21.2 99 50 3 22.6 50 22.2 98 50 21.5 95 50 4 23.0 50 ... 34.1 100 50 32.2 94 50 40 35.8 50 35.5 99 50 33.5 94 50 44 36.1 50 36.6 101 50 34.0 94 ...

TR-465: Phenolphthalein (CASRN 77-09-8) in F344 Rats and B6C3F1Mice... 18.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr465.pdf

... 50 29.2 99 5 0 29.4 100 50 28.8 98 48 10 30.7 50 30.4 99 50 30.6 100 50 30.8 100 48 11 31.5 50 31.5 100 50 31.1 99 50 30.7 98 48 12 32.5 5 0 32.4 100 50 32.5 100 50 32.4 100 48 ...

TR-470: Pyridine (CASRN 110-86-1) in F344/N Rats, Wistar Rats... 16.2MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr470.pdf

... 50 282 94 50 9 314 50 309 98 50 306 97 50 291 93 50 10 331 50 326 99 50 323 98 50 309 93 50 11 333 50 329 99 50 328 99 50 311 94 50 12 342 50 339 99 50 340 100 50 323 95 50 13 351 ...

TR-519: Stoddard Solvent IIC (CASRN 64742-88-7) in F344/N Rats... 8.1MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr519.pdf

... 50 311 103 49 314 104 49 65 313 50 308 99 50 319 102 48 322 103 48 69 322 50 315 98 50 ... 50 28.3 102 50 9 32.5 50 31.9 98 50 32.1 99 50 31.8 98 50 13 36.4 50 35.9 99 50 35.7 98 49 ...

TR-398: Polybrominated Biphenyls (CASRN 67774-32-7)(Firemaster... 14.8MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr398.pdf

... 101 50 11 327 50 322 98 50 326 100 50 326 100 50 12 332 50 328 99 50 332 100 50 332 100 50 17 360 50 355 99 50 354 98 50 355 99 50 22 375 50 373 99 50 374 100 50 374 100 50 26 ...

TR-460: Effect of Dietary Restriction on Toxicology and Carcinogenesis... 30.2MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr460.pdf

... 100 50 2 140 61 140 1130 60 143 49 141 99 50 3 167 61 167 1130 60 171 49 168 98 50 4 183 ... 99 50 2 24.6 60 24.3 99 60 24.1 50 23.8 99 50 3 23.9 60 23.7 99 60 24.5 50 23.9 98 50 4 ...