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CERHR Monograph: Potential Human Reproductive and Developmental... 6.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/bisphenol/bisphenol.pdf
MoNogRaPH oN THE PoTENTial HuMaN REPRoduCTivE aNd dEvEloPMENTal EffECTs of BisPHENol a ... at current human expo- sures to bisphenol A. The NTP has minimal concern for ...
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RR-09: The CLARITY-BPA Core Study: A Perinatal and Chronic Extended... 5.1MB
https://ntp.niehs.nih.gov/go/rr09
The cLaRITY-BPa coRe sTudY: a PeRINaTaL aNd chRoNIc exTeNded-dose- RaNge sTudY of BIsPheNoL a IN RaTs NTP RR 9 SEPTEMBER 2018 NTP Research Report on the CLARITY-BPA Core Study: A ...
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RR-04: Biological Activity of Bisphenol A (BPA) Structural Analogues... 7.7MB
https://ntp.niehs.nih.gov/go/rr04
oN Biological acTiviTy of BisPheNol a (BPa) sTRucTuRal aNalogues aNd fuNcTioNal alTeRNaTives NTP RR 4 OCTOBER 2017 NTP Research Report on Biological Activity of Bisphenol A (BPA) ...
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TR-215: Bisphenol A (CASRN 80-05-7) in F344 Rats and B6C3F1Mice... 4.3MB
https://ntp.niehs.nih.gov/go/tr215
OFFICIAL NTP FILE COPY THIS OFFICE J I B 0 U W I & ^FMI I W « No. 215 . CARCINOGENESIS BIOASSAY OF BISPHENOL A (CAS NO. 80-05-7) IN F344 RATS AND B6C3F 1 MICE (FEED STUDY) U.S. ...
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CLARITY-BPA Program 71KB
https://ntp.niehs.nih.gov/research/topics/bpa
bpa CLARITY-BPA Program The CLARITY-BPA Core Study Research Report, CLARITY-BPA Grantee Studies data, and CLARITY-BPA Compendium Report are now available. Various sizes of metal ...
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Abstract for RR-09 130KB
https://ntp.niehs.nih.gov/publications/reports/rr/rr09
9abs Abstract for RR-09 The CLARITY-BPA Core Study: A Perinatal and Chronic Extended-Dose-Range Study of Bisphenol A in Rats CASRN: 80-05-7 Chemical Formula: C15-H16-O2 Synonyms/...
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Bisphenol A: Target Organs and Levels of Evidence for TR-215 51KB
https://ntp.niehs.nih.gov/data/tr/200s/tr215levels
2 Bisphenol A: Target Organs and Levels of Evidence for TR-215 Carcinogenesis Bioassay of Bisphenol A (CASRN 80-05-7) in F344 Rats and B6C3F1 Mice (Feed Study) Chemical (Study ...
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RR-09: Lay Summary; Bisphenol A (CASRN 80-05-7) 221KB
https://ntp.niehs.nih.gov/sites/default/files/2024-08/rr09_summary_508.pdf
CLARITY-BPA Core Study: A Perinatal and Chronic Extended-Dose-Range Study of Bisphenol A in Rats RR-09 Full report: https://ntp.niehs.nih.gov/go/rr09abs SUMMARY Background: ...
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Abstract for RACB82081 54KB
https://ntp.niehs.nih.gov/publications/abstracts/repro/racb82081
Abstract for RACB82081 Bisphenol A: Reproduction and Fertility Assessment in CD-1 Mice When Administered Via Subcutaneous Silastic® Implants CASRN: 80-05-7 Chemical Formula: ...
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Abstract for TER85052 55KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter85052
Abstract for TER85052 Teratologic Evaluation of Bisphenol A Administered to CD-1 Mice on Gestational Days 6 Through 15 CASRN: 80-05-7 Chemical Formula: C15H16O2 Molecular Weight: ...
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Abstract for TER85051 54KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter85051
Abstract for TER85051 Teratologic Evaluation of Bisphenol A Administered to CD Rats on Gestational Days 6 Through 15 CASRN: 80-05-7 Chemical Formula: C15H16O2 Molecular Weight: ...
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Abstract for RACB84080 56KB
https://ntp.niehs.nih.gov/publications/abstracts/repro/racb84080
80abs Abstract for RACB84080 Bisphenol A: Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Feed CASRN: 80-05-7 Chemical Formula: C15H16O2 Molecular ...
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Abstract for RR-18 55KB
https://ntp.niehs.nih.gov/publications/reports/rr/rr18
Abstract for RR-18 Consortium Linking Academic and Regulatory Insights on Bisphenol A Toxicity (CLARITY-BPA): A Compendium of Published Findings CASRN: 80-05-7 Chemical Formula: ...
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Abstract for RR-04 53KB
https://ntp.niehs.nih.gov/publications/reports/rr/rr04
4abs Abstract for RR-04 Biological Activity of Bisphenol A (BPA) Structural Analogues and Functional Alternatives Report Date: October 2017 Full Report PDF Abstract Background ...
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Abstract for TR-215 56KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr215
5abs Abstract for TR-215 Carcinogenesis Bioassay of Bisphenol A in F344 Rats and B6C3F1 Mice (Feed Study) CASRN: 80-05-7 Chemical Formula: C15H16O2 Molecular Weight: 228.289 ...
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Using APROBA for Integrated TDI Derivation and Uncertainty Analysis... 1.5MB
https://ntp.niehs.nih.gov/sites/default/files/2025-01/1_2_Herzler_EPAWksp2024_508.pdf
Using APROBA for integrated TDI derivation and uncertainty analysis - the case of BPA ... This presentation is not about the correct TDI for BPA, only about how we derived one ...
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Research Reports 94KB
https://ntp.niehs.nih.gov/publications/reports/rr
PDF (2.96 MB) Consortium Linking Academic and Regulatory Insights on Bisphenol A Toxicity (CLARITY-BPA): A Compendium of Published Findings 2021 Research Report RR-17 PDF (960.56 ...
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Public Health Impact 1.9MB
https://ntp.niehs.nih.gov/media/impact
... A, Holmgren S, Hsieh J-H, Svoboda D, Auerbach S et al. 2017. NTP research report on biological activity of bisphenol A (BPA) structural analogues and functional alternatives. ...
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BG1Luc ER TA Protocol Standardization Study Report (Annex C of... 2.9MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/appxc/annexc/c0-prot-stand.pdf
... C-58 10.2.2 N0002 - Bisphenol A ......C-58 Table 10-5 Concentrations of N0002 - Bisphenol A Used in Comprehensive Testing ...
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Abstract for TR-203 55KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr203
Approximately 90% of the phenol produced is used in the manufacture of phenolic (phenol formaldehyde) resins, caprolactam, bisphenol A, alkyl phenol, and adipic acid. The remainder ...
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Update on Alternatives Research at EPA (ICCVAM Public Forum 2021... 1.8MB
https://ntp.niehs.nih.gov/sites/default/files/iccvam/meetings/iccvam-forum-2021/present/11_thomas-508.pdf
over Prioritization Mode Desc Summary Log 80-05-7 80-05-1 80-05-2 80-05-3 80-05-5 CHEMICAL SUMMARY CASRN Chemical Name 80-05-7 Bisphenol A 80-05-1 Bisphenol B 80-05-2 ...
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EPA Office of Resarch and Development: Update on Alternatives... 1.4MB
https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2022/present/05_harrill_508.pdf
over Prioritization Mode Desc Summary Log 80-05-7 80-05-1 80-05-2 80-05-3 80-05-5 CHEMICAL SUMMARY CASRN Chemical Name 80-05-7 Bisphenol A 80-05-1 Bisphenol B 80-05-2 ...
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Minutes: BSC; Dec. 11, 2012 248KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2012/december/bscminutes20121211_508.pdf
......... 22 VIII. NTP Update: BPA Studies and a Cooperative (U01) BPA Research Consortium ...... 23 IX. Adjournment ...
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Minutes: BSC; June 15-16, 2016 457KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2016/june/minutes201606_508.pdf
... Abbreviations and Acronyms ADME absorption, distribution, metabolism, excretion BPA bisphenol A BSB Biomolecular Screening Branch BSC Board of Scientific Counselors CDMA Code ...
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NICEATM Update 7.0MB
https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2022/present/17-kleinstreuer-508.pdf
... ACC - - AC 50 - - Top of Curve Concentration Response Curve Overlay: Scaled Response ~ ATG_chERa_XSPl_up: Bisphenol A ATG_hERb_XSP2_up: Bisphenol A ATG_frERl_XSPl_up: Bisphenol A ...
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Completed Evaluations 71KB
https://ntp.niehs.nih.gov/research/assessments/noncancer/completed
Go » photo of inside of can and paper receipt Bisphenol A Structural Analogues Scoping review of the biological activity of BPA analogues. Go » Pregnant woman with Cancer ...
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Agency Response to ICCVAM Recommendations on In Vitro Cytotoxicity... 271KB
https://ntp.niehs.nih.gov/iccvam/methods/acutetox/agencyresp/epa_resp.pdf
Specifically, ICCVAM seeks to know ifthe . Envi.Ionmentat Protection AgenCy (BPA) wlll ... BPA was iDstriuncntal in ha'Ving ICCVAM review the revised UDP and this review was ...
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Expanding PBPK Modeling to Predict Chemical Distribution in Brain... 1.8MB
https://ntp.niehs.nih.gov/sites/default/files/2023-09/Unnikrishnan-WC12-poster-FD.pdf
... We chose bisphenol A as the test chemical for the adipose compartment. Bisphenol A is a lipophilic chemical that accumulates in human tissues, which can contribute to development ...
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All Past Events 212KB
https://ntp.niehs.nih.gov/events/past
For example, type "BPA" in the search box and click "Apply" to see all events related to BPA. Sort by clicking the underlined text in a column header. Click again to reverse the ...
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Site Map 56KB
https://ntp.niehs.nih.gov/support/sitemap
Artificial Butter Flavorings (ABF) Components Botanical Dietary Supplements Cell Phones CLARITY-BPA Glyphosate & Glyphosate Formulations Hexavalent Chromium Mold Polyfluorinated ...
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Peer Review Panel Report on Evaluation of the LUMI-CELL ER Test... 287KB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edprprept2011.pdf
... Abbreviations and Acronyms BG1Luc ER TA LUMI-CELL ® BG-1Luc4E2 ER TA test method BPA Bisphenol A BRD Background review document CERI Chemicals Evaluation and Research Institute ...
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Applying In vitro Approaches to Understand Complex Mixtures in... 5.3MB
https://ntp.niehs.nih.gov/iccvam/meetings/commprac-2021/20210126-iccvam-cop-rider-508.pdf
EPA (2000) Supplementary Guidance for Problem formulation Adapted from U.S Conducting Health Risk Assessment of Chemical Mixtures Bisphenol A & Analogues Botanical Dietary ...
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Abstract for DART-08 119KB
https://ntp.niehs.nih.gov/publications/reports/dart/dart08
BPAF was selected for evaluation based on a review of compounds that are potentially endocrine-active after concerns were raised about possible effects of bisphenol A (BPA) on the ...
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Agenda: Workshop on Probabilistic Methods for Health Assessments... 33KB
https://ntp.niehs.nih.gov/sites/default/files/2024-10/AbridgedAgenda_ProbWorkshop_FINAL_rev_508.pdf
AM Using APROBA for integrated TDI derivation and uncertainty analysis - the case of BPA Matthias Herzler (BfR) 9:50 - 10:10 AM APROBA case study application in EPA human health ...
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Minutes: BSC; June 29, 2017 285KB
https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2017/june/minutes20170629_508.pdf
Toxic Substances and Disease Registry AUC area under the curve BMD benchmark dose BPA bisphenol A BSC Board of Scientific Counselors CDC Centers for Disease Control and ...
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DART-08: Lay Summary; Bisphenol AF (CASRN 1478-61-1) 193KB
https://ntp.niehs.nih.gov/sites/default/files/2025-03/dart08_summary_508.pdf
BPAF was selected for evaluation due to concerns about the potential health effects of a related chemical, bisphenol A (BPA), in fetuses, infants, and children. The effects of BPAF ...
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Reproductive Abstracts 197KB
https://ntp.niehs.nih.gov/publications/abstracts/repro
... CD-1 Mice When Administered in the Drinking Water 1984 Reproductive RACB82081 Bisphenol A Bisphenol A: (CASRN: 80-05-7) Reproduction and Fertility Assessment in CD-1 Mice When ...
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Comment: National Toxicology Program Board of Scientific Counselors... 328KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may/publiccomm/kall20230428_bsc_508.pdf
We have especially focused on three commonly used toxic materials in dentistry: 1. mercury, a neurotoxin, used in amalgam fillings 2. bisphenol A, an endocrine disrupter, used in ...
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XDS Submission of the LUMI-CELL ER Test Method 3.2MB
https://ntp.niehs.nih.gov/iccvam/methods/endocrine/endodocs/iccvamsubmission28jan05.pdf
... 45. pg - pico grams 46. ug or mg - micro grams 47. DES - Diethylstilbestrol 48. BPA - Bisphenol A 11 Submission of XDS's LUMI-CELL ER High-Throughput System for Screening ...
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Submission of XDS's LUMI-CELL ER High-Throughput System for Screening... 2.4MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/appxc/annexa/xds-sub.pdf
... 45. pg - pico grams 46. ug or mg - micro grams 47. DES - Diethylstilbestrol 48. BPA - Bisphenol A 11 Submission of XDS's LUMI-CELL ER High-Throughput System for Screening ...
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Highlighted Research Topics 65KB
https://ntp.niehs.nih.gov/research/topics
Learn about NTP research on this topic. Go » Various sizes of metal food container cans CLARITY-BPA CLARITY-BPA is studying a range of potential health effects from exposure to ...
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DART-08: Modified One-Generation Study of Bisphenol AF (CASRN... 5.8MB
https://ntp.niehs.nih.gov/go/dart08
... BPAF was selected for evaluation based on a review of compounds that are potentially endocrine-active after concerns were raised about possible effects of bisphenol A (BPA) on the ...
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ICE Tools to Facilitate PBPK Modeling and IVIVE for Various Exposure... 1016KB
https://ntp.niehs.nih.gov/iccvam/meetings/ascct-2022/unnikrishnan_ascct-2022-poster_fd.pdf
... Bisphenol A The box-and-whisker plots show distribution of Cmax values for all query ... Oral route of exposure 17-Methyltestosterone Bisphenol A 17-beta-Estradiol ...
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Acronyms & Abbreviations 76KB
https://ntp.niehs.nih.gov/support/acronyms
CIN Cervical intraepithelial neoplasia CLARITY-BPA Consortium Linking Academic and Regulatory Insights on Bisphenol A Toxicity CoCrMo Cobalt-chromium-molybdenum COX ...
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Developmental Neurotoxicity Screening Assay Chemical List | National... 421KB
https://www.niehs.nih.gov/research/atniehs/dtt/strategic-plan/health/developmental/chemical-list
... ether (BDE-47) Mixture* 107534-96-3 DTXSID9032113 Tebuconazole Mixture* 80-05-7 DTXSID7020182 Bisphenol A (BPA) Mixture* 2921-88-2 DTXSID4020458 Chlorpyrifos Mixture* 70-30-4 ...
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RoC Protocol: Organohalogen Flame Retardants; Jan. 31, 2025 662KB
https://ntp.niehs.nih.gov/sites/default/files/2025-03/organohalogen_flame_retardants_508.pdf
... A (TBBPA), a widely used brominated bisphenol A flame retardant, and, to a lesser ... OR "Ethoxylated Tetrabromo Bisphenol A Diacrylate" OR "TBBPA-BHEEBA") OR ...
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FAQs & Fact Sheets 62KB
https://ntp.niehs.nih.gov/media/faqs
Testing FAQ Aug 2025 Arsenic FAQ Aug 2025 Autoimmune Diseases FAQ Aug 2025 Bisphenol A (BPA) FAQ Sep 2024 Breast Cancer FAQ Mar 2025 Cell Phone Radiofrequency Radiation Studies ...
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Study Abstracts 370KB
https://ntp.niehs.nih.gov/publications/abstracts
... CD-1 Mice When Administered in the Drinking Water 1984 Reproductive RACB82081 Bisphenol A Bisphenol A: (CASRN: 80-05-7) Reproduction and Fertility Assessment in CD-1 Mice When ...
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ICCVAM Test Method Evaluation Report on the BG1Luc ER TA Test... 17.5MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/bg1lucer-ta-tmer-combined.pdf
... NEG (3/3) POS (3/3) NEG (3/3) Bicalutamide 90357-06-5 NEG NEG NEG (1/1) NT NT Bisphenol A 80-05-7 POS POS POS (3/3) POS (3/3) POS (3/3) Bisphenol B 77-40-7 POS POS POS (3/3) POS ...
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Submission of the CertiChem Cell Proliferation Test Method for... 3.1MB
https://ntp.niehs.nih.gov/iccvam/methods/endocrine/endodocs/submdoc.pdf
... 2.29E-09 7.62E-10 2.54E-10 8.47E-11 BPA 5.00E-06 1.67E-06 5.56E-07 1.85E-07 ... 0.589 0.495 0.177 0.163 0.139 0.095 0.071 BPA 0.572 0.639 0.610 0.697 0.563 0.216 0.119 ...
