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CERHR Monograph: Potential Human Reproductive and Developmental... 6.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/bisphenol/bisphenol.pdf
MoNogRaPH oN THE PoTENTial HuMaN REPRoduCTivE aNd dEvEloPMENTal EffECTs of BisPHENol a ... NTP.Brief.on.Bisphenol.A......
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DART-08: Modified One-Generation Study of Bisphenol AF (CASRN... 5.8MB
https://ntp.niehs.nih.gov/go/dart08
moDifieD oNe-GeNeRaT ioN STuDy of BiSPheNol af (caSRN 1478-61-1) aDmiNiSTeReD iN feeD To ... on the Modified One-Generation Study of Bisphenol AF (CASRN 1478-61-1) Administered in ...
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TR-215: Bisphenol A (CASRN 80-05-7) in F344 Rats and B6C3F1Mice... 4.3MB
https://ntp.niehs.nih.gov/go/tr215
« No. 215 . CARCINOGENESIS BIOASSAY OF BISPHENOL A (CAS NO. 80-05-7) IN F344 RATS AND ... on the CARCINOGENESIS BIOASSAY of BISPHENOL A (CAS NO. 80-05-7) IN F344 RATS AND ...
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RR-04: Biological Activity of Bisphenol A (BPA) Structural Analogues... 7.7MB
https://ntp.niehs.nih.gov/go/rr04
Biological acTiviTy of BisPheNol a (BPa) sTRucTuRal aNalogues aNd fuNcTioNal alTeRNaTives NTP RR 4 OCTOBER 2017 NTP Research Report on Biological Activity of Bisphenol A (BPA) ...
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Bisphenol A: Target Organs and Levels of Evidence for TR-215 51KB
https://ntp.niehs.nih.gov/data/tr/200s/tr215levels
2 Bisphenol A: Target Organs and Levels of Evidence for TR-215 Carcinogenesis Bioassay of Bisphenol A (CASRN 80-05-7) in F344 Rats and B6C3F1 Mice (Feed Study) Chemical (Study ...
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RR-09: The CLARITY-BPA Core Study: A Perinatal and Chronic Extended... 5.1MB
https://ntp.niehs.nih.gov/go/rr09
sTudY of BIsPheNoL a IN RaTs NTP RR 9 SEPTEMBER 2018 NTP Research Report on the CLARITY-BPA Core Study: A Perinatal and Chronic Extended-Dose-Range Study of Bisphenol A in Rats ...
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Abstract for RACB84080 56KB
https://ntp.niehs.nih.gov/publications/abstracts/repro/racb84080
80abs Abstract for RACB84080 Bisphenol A: Reproduction and Fertility Assessment in CD-1 ... Bisphenol A (BPA), used in the manufacture of epoxy resins and polycarbonates, was tested ...
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Abstract for DART-08 119KB
https://ntp.niehs.nih.gov/publications/reports/dart/dart08
Abstract for DART-08 Modified One-Generation Study of Bisphenol AF Administered in Feed to ... Full Report PDF Lay Summary Abstract Bisphenol AF (BPAF) is used as a curing or ...
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Abstract for RR-09 129KB
https://ntp.niehs.nih.gov/publications/reports/rr/rr09
Study of Bisphenol A in Rats CASRN: 80-05-7 Chemical Formula: C15-H16-O2 Synonyms/Common Names: BPA; 4,4'-(1-Methylethylidene)bisphenol Report Date: September ...
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DART-08: Lay Summary; Bisphenol AF (CASRN 1478-61-1) 193KB
https://ntp.niehs.nih.gov/sites/default/files/2025-03/dart08_summary_508.pdf
the Modified One- Generation Study of Bisphenol AF (CASRN 1478-61-1) Administered in .../go/dart08abs SUMMARY Background: Bisphenol AF (BPAF) is a chemical used in the ...
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Abstract for TER85051 54KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter85051
Abstract for TER85051 Teratologic Evaluation of Bisphenol A Administered to CD Rats on ... Bisphenol A, a widely distributed industrial chemical used in making epoxy resins and ...
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Abstract for TER85052 54KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter85052
Abstract for TER85052 Teratologic Evaluation of Bisphenol A Administered to CD-1 Mice on ... Bisphenol A, a widely distributed industrial chemical used in making epoxy resins and ...
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Abstract for RACB82081 54KB
https://ntp.niehs.nih.gov/publications/abstracts/repro/racb82081
1abs Abstract for RACB82081 Bisphenol A: Reproduction and Fertility Assessment in CD-1 ... Bisphenol A (BPA) was examined in the Reproductive Assessment by Continuous Breeding ...
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RR-09: Lay Summary; Bisphenol A (CASRN 80-05-7) 221KB
https://ntp.niehs.nih.gov/sites/default/files/2024-08/rr09_summary_508.pdf
Chronic Extended-Dose-Range Study of Bisphenol A in Rats RR-09 Full report: https://ntp.niehs.nih.gov/go/rr09abs SUMMARY Background: Bisphenol A (BPA) is an industrial chemical ...
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Abstract for TR-215 55KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr215
Abstract for TR-215 Carcinogenesis Bioassay of Bisphenol A in F344 Rats and B6C3F1 Mice ... Full Report PDF Abstract A carcinogenesis bioassay of bisphenol A, an intermediate used in ...
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Abstract for RR-18 55KB
https://ntp.niehs.nih.gov/publications/reports/rr/rr18
Bisphenol A Toxicity (CLARITY-BPA): A Compendium of Published Findings CASRN: 80-05-7 Chemical Formula: C15-H16-O2 Synonyms/Common Names: BPA; 4,4'-(1-methylethylidene)bisphenol ...
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BG1Luc ER TA Protocol Standardization Study Report (Annex C of... 2.9MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/appxc/annexc/c0-prot-stand.pdf
... N0002 - Bisphenol A ...... C-61 ICCVAM BG1Luc ER TA Evaluation Report C-4 10.2.3 N0003 - Bisphenol B ...
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Abstract for TR-40 54KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr040
Full Report PDF Abstract Hexachlorophene is a chlorinated bisphenol which was widely used as an antiseptic prior to 1972. It is highly effective against gram-positive bacteria and ...
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Abstract for RR-04 53KB
https://ntp.niehs.nih.gov/publications/reports/rr/rr04
Abstract for RR-04 Biological Activity of Bisphenol A (BPA) Structural Analogues and ... functional similarity to bisphenol A (BPA), referred to as BPA analogues or derivatives. ...
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CLARITY-BPA Program 71KB
https://ntp.niehs.nih.gov/research/topics/bpa
Various sizes of metal food container cans Research Overview Status: Completed Substances: Bisphenol A Background Information Bisphenol A (BPA) is a chemical produced in large ...
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Update on Alternatives Research at EPA (ICCVAM Public Forum 2021... 1.8MB
https://ntp.niehs.nih.gov/sites/default/files/iccvam/meetings/iccvam-forum-2021/present/11_thomas-508.pdf
Desc Summary Log 80-05-7 80-05-1 80-05-2 80-05-3 80-05-5 CHEMICAL SUMMARY CASRN Chemical Name 80-05-7 Bisphenol A 80-05-1 Bisphenol B 80-05-2 Bisphenol C 80-05-3 Bisphenol D ...
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Research Reports 94KB
https://ntp.niehs.nih.gov/publications/reports/rr
Academic and Regulatory Insights on Bisphenol A Toxicity (CLARITY-BPA): A Compendium ... Chronic Extended-Dose-Range Study of Bisphenol A in Rats 2018 Research Report RR-08 PDF ...
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Abstract for TR-203 55KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr203
Approximately 90% of the phenol produced is used in the manufacture of phenolic (phenol formaldehyde) resins, caprolactam, bisphenol A, alkyl phenol, and adipic acid. The remainder ...
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RoC Protocol: Organohalogen Flame Retardants; Jan. 31, 2025 662KB
https://ntp.niehs.nih.gov/sites/default/files/2025-03/organohalogen_flame_retardants_508.pdf
... IARC Classification Polyhalogenated bisphenol aliphatics and functionalized (PBAFs) ... RoC, we identified the following NAS- defined OFR subclasses: 1. Polyhalogenated bisphenol ...
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Public Health Impact 1.9MB
https://ntp.niehs.nih.gov/media/impact
... At this meeting the DARTIC will consider the possible listing of bisphenol S (BPS) based ... identification document entitled "Evidence on the Developmental Toxicity of Bisphenol S". ...
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Expanding PBPK Modeling to Predict Chemical Distribution in Brain... 1.8MB
https://ntp.niehs.nih.gov/sites/default/files/2023-09/Unnikrishnan-WC12-poster-FD.pdf
... We chose bisphenol A as the test chemical for the adipose compartment. Bisphenol A is a lipophilic chemical that accumulates in human tissues, which can contribute to development ...
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Completed Evaluations 71KB
https://ntp.niehs.nih.gov/research/assessments/noncancer/completed
Go » photo of inside of can and paper receipt Bisphenol A Structural Analogues Scoping review of the biological activity of BPA analogues. Go » Pregnant woman with Cancer ...
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Applying In vitro Approaches to Understand Complex Mixtures in... 5.3MB
https://ntp.niehs.nih.gov/iccvam/meetings/commprac-2021/20210126-iccvam-cop-rider-508.pdf
EPA (2000) Supplementary Guidance for Problem formulation Adapted from U.S Conducting Health Risk Assessment of Chemical Mixtures Bisphenol A & Analogues Botanical Dietary ...
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Reproductive Abstracts 197KB
https://ntp.niehs.nih.gov/publications/abstracts/repro
... CD-1 Mice When Administered in the Drinking Water 1984 Reproductive RACB82081 Bisphenol A Bisphenol A: (CASRN: 80-05-7) Reproduction and Fertility Assessment in CD-1 Mice When ...
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Comment: National Toxicology Program Board of Scientific Counselors... 328KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may/publiccomm/kall20230428_bsc_508.pdf
We have especially focused on three commonly used toxic materials in dentistry: 1. mercury, a neurotoxin, used in amalgam fillings 2. bisphenol A, an endocrine disrupter, used in ...
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Minutes: BSC; June 29, 2017 285KB
https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2017/june/minutes20170629_508.pdf
Substances and Disease Registry AUC area under the curve BMD benchmark dose BPA bisphenol A BSC Board of Scientific Counselors CDC Centers for Disease Control and Prevention ...
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Peer Review Panel Report on Evaluation of the LUMI-CELL ER Test... 287KB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edprprept2011.pdf
... ® BG-1Luc4E2 ER TA test method BPA Bisphenol A BRD Background review document CERI ... Peer Review Panel Report 24 and bisphenol-A may deserve to be an ED by many ...
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ICE Tools to Facilitate PBPK Modeling and IVIVE for Various Exposure... 1016KB
https://ntp.niehs.nih.gov/iccvam/meetings/ascct-2022/unnikrishnan_ascct-2022-poster_fd.pdf
... Bisphenol A The box-and-whisker plots show distribution of Cmax values for all query ... Oral route of exposure 17-Methyltestosterone Bisphenol A 17-beta-Estradiol ...
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Using APROBA for Integrated TDI Derivation and Uncertainty Analysis... 1.5MB
https://ntp.niehs.nih.gov/sites/default/files/2025-01/1_2_Herzler_EPAWksp2024_508.pdf
Disclaimers Background - recent work on Bisphenol A (BPA) 12/21: EFSA draft opinion on ... Bisphenol A Methodology used to develop BfR opinion Dr. Matthias Herzler | Advancing ...
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Minutes: BSC; June 15-16, 2016 457KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2016/june/minutes201606_508.pdf
... distribution, metabolism, excretion BPA bisphenol A BSB Biomolecular Screening Branch BSC ... Birnbaum noted recent Congressional briefings on endometriosis awareness and bisphenol A ...
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Developmental Neurotoxicity Screening Assay Chemical List | National... 418KB
https://www.niehs.nih.gov/research/atniehs/dtt/strategic-plan/health/developmental/chemical-list
... Mixture* 107534-96-3 DTXSID9032113 Tebuconazole Mixture* 80-05-7 DTXSID7020182 Bisphenol A ... Mixture* NOCAS_ 1354862 DTXSID801354862 Bisphenol A + Acrylamide (1:10 molarity (Bisphenol ...
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PBPK Modeling to Predict Chemical Distribution in Brain and Adipose... 1.4MB
https://ntp.niehs.nih.gov/sites/default/files/2024-03/SOT2024-Unnikrishnan-poster.pdf
... Adipose Acetaminophen 6.1 4.2 1 2.5 Bisphenol A 7.4 2.7 1.5 12 Cmax* - Maximum ... diazepam, trichloroethylene, deltamethrin, acetaminophen, bisphenol A and dieldrin. . ...
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FAQs & Fact Sheets 62KB
https://ntp.niehs.nih.gov/media/faqs
to Animal Testing FAQ Dec 2025 Arsenic FAQ Dec 2025 Autoimmune Diseases FAQ Dec 2025 Bisphenol A (BPA) FAQ Dec 2025 Breast Cancer FAQ Dec 2025 Cell Phone Radiofrequency Radiation ...
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Study Abstracts 370KB
https://ntp.niehs.nih.gov/publications/abstracts
... CD-1 Mice When Administered in the Drinking Water 1984 Reproductive RACB82081 Bisphenol A Bisphenol A: (CASRN: 80-05-7) Reproduction and Fertility Assessment in CD-1 Mice When ...
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Synthetic Turf/Recycled Tire Crumb Rubber 62KB
https://ntp.niehs.nih.gov/research/topics/syntheticturf
although they did confirm that it contains many substances, such as polycyclic aromatic hydrocarbons (PAHs), metals, plasticizers, such as phthalates, and bisphenol A (BPA). ...
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ICCVAM Test Method Evaluation Report on the BG1Luc ER TA Test... 17.5MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/bg1lucer-ta-tmer-combined.pdf
... (3/3) Bicalutamide 90357-06-5 NEG NEG NEG (1/1) NT NT Bisphenol A 80-05-7 POS POS POS (3/3) POS (3/3) POS (3/3) Bisphenol B 77-40-7 POS POS POS (3/3) POS (3/3) POS (3/3) ...
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Minutes: BSC; Dec. 11, 2012 248KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2012/december/bscminutes20121211_508.pdf
... and Acronyms ADME absorption, distribution, metabolism and elimination BPA bisphenol A BSC Board of Scientific Counselors DNTP Division of the NTP EPA U.S. Environmental ...
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Acronyms & Abbreviations 76KB
https://ntp.niehs.nih.gov/support/acronyms
neoplasia CLARITY-BPA Consortium Linking Academic and Regulatory Insights on Bisphenol A Toxicity CoCrMo Cobalt-chromium-molybdenum COX Cyclooxygenase CPSC Consumer Product ...
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Highlighted Research Topics 65KB
https://ntp.niehs.nih.gov/research/topics
CLARITY-BPA CLARITY-BPA is studying a range of potential health effects from exposure to bisphenol A. The program unites standard regulatory research practices with innovative ...
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Join the Expert Directory 124KB
https://ntp.niehs.nih.gov/getinvolved/expert_directory_form
... - Asbestos/Mineral fibers Exposure - Bisphenol A Exposure - Botanicals/herbals Exposure ... - Asbestos/Mineral fibers Exposure - Bisphenol A Exposure - Botanicals/herbals Exposure ...
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RoC Profile: 4-Vinyl-1-cyclohexene Diepoxide; 15th RoC 2021 127KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/vinylcyclohexenediepoxide.pdf
Use 4-Vinyl-1-cyclohexene diepoxide is used as a reactive diluent for other diepoxides and for certain epoxy resins derived from bisphenol A and epichlorohydrin (NTP 1989). The ...
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XDS Submission of the LUMI-CELL ER Test Method 3.2MB
https://ntp.niehs.nih.gov/iccvam/methods/endocrine/endodocs/iccvamsubmission28jan05.pdf
... 47. DES - Diethylstilbestrol 48. BPA - Bisphenol A 11 Submission of XDS's LUMI-CELL ER ... (DES) (1.23 x 10 -5 mg/ml); Bisphenol A (7.81 x 10 -2 25 mg/ml); Estrone (7.81 ...
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NICEATM Validation Study Report on the MCF-7 Cell Proliferation... 1.8MB
https://ntp.niehs.nih.gov/iccvam/methods/endocrine/mcf7/mcf7-valstudyreport-19jun12-wcv2-draft.pdf
... 2 Atrazine POS (3/3) NEG (3/3) POS (1/1) NT POS NEG 2 Bisphenol A POS (3/3) POS (3/3) POS (1/1) POS (1/1) POS POS 2 Bisphenol B POS (3/3) POS (3/3) POS (1/1) POS (1/1) POS POS 2 ...
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Submission of XDS's LUMI-CELL ER High-Throughput System for Screening... 2.4MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/appxc/annexa/xds-sub.pdf
... 47. DES - Diethylstilbestrol 48. BPA - Bisphenol A 11 Submission of XDS's LUMI-CELL ER ... (DES) (1.23 x 10 -5 mg/ml); Bisphenol A (7.81 x 10 -2 25 mg/ml); Estrone (7.81 ...
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Monographs 65KB
https://ntp.niehs.nih.gov/publications/monographs
... All NTP-CERHR Monographs Substance/Topic Year Acrylamide 2005 Amphetamines 2005 Bisphenol A 2008 1-Bromopropane 2003 2-Bromopropane 2003 Ethylene Glycol 2004 Fluoxetine 2004 ...