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Final RoC Background Document for Formaldehyde 5.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/twelfth/2009/november/formaldehyde_bd_final.pdf
FINAL Report on Carcinogens Background Document for Formaldehyde January 22, 2010 U.S. ... This Page Intentionally Left Blank Formaldehyde: RoC Background Document 1/22/10 i ...
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RoC Profile: Formaldehyde; 15th RoC 2021 298KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/formaldehyde.pdf
Formaldehyde CAS No. 50-00-0 Known to be a human carcinogen First listed in the Second Annual Report on Carcinogens (1981) H 2 C=O Carcinogenicity Formaldehyde is known to be a ...
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RR-03: Absence of Formaldehyde-Induced Neoplasia in TRP53 Haploinsuffi... 1.0MB
https://ntp.niehs.nih.gov/go/rr03
foRmaldehyde-INduced NeoPlasIa IN TRP53 haPloINsuffIcIeNT mIce exPosed by INhalaTIoN NTP RR 3 AUGUST 2017 NTP Research Report on Absence of Formaldehyde-Induced Neoplasia in ...
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Abstract for RR-03 52KB
https://ntp.niehs.nih.gov/publications/reports/rr/rr03
Abstract for RR-03 Absence of Formaldehyde-Induced Neoplasia in Trp53 Haploinsufficient Mice Exposed by Inhalation Report Date: August 2017 Full Report PDF Abstract Formaldehyde ...
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NTP Response to BSC Peer Review Comments on the Draft Substances... 324KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/twelfth/2011/response062110bsc2011.pdf
and Technical Issues 4 References 4 Formaldehyde 5 BSC Comments and NTP Responses: ... cobalt-tungsten carbide: powders and hard metals, formaldehyde, and glass wool fibers. ...
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RoC Background Document: Methyl tertiary-Butyl Ether; Dec. 2... 1.2MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/mtbe1_508.pdf
... Carcinogenicity and Genotoxicity Studies of Formaldehyde ......32 6.4.1 Carcinogenicity of Formaldehyde (IARC 1995) ......
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Abstract for TR-552 70KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr552
It is also a by-product in the industrial synthesis of butynediol from acetylene and formaldehyde with copper acetylide as catalyst. Propargyl alcohol is used as a reactant/...
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Abstract for TOX-78 64KB
https://ntp.niehs.nih.gov/publications/reports/tox/tox078
Triethylamine is used primarily as a catalyst to cure the resin systems incorporated into sand cores for foundry molds. It is also used as a curing catalyst in phenol-formaldehyde ...
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Response to Expert Panels' Peer-Review Comments on Background... 354KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/twelfth/2011/responseexpertpanelreport2011.pdf
Peer-Review Comments 9 References 10 Formaldehyde 11 Expert Panel Meeting 11 NTP ... Expert Panels' Peer-Review Comments Formaldehyde 11 Formaldehyde Expert Panel Meeting ...
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RoC Background Document: Wood Dust; Dec. 13-14, 2000 1.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/roc10/wd_no_appendices_508.pdf
... dust rather than other concurrent exposure(s) such as formaldehyde or wood preservatives. ... the incidence of tumors induced by formaldehyde in female Sprague-Dawley rats, ...
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TR-490: Glutaraldehyde (CASRN 111-30-8) in F344/N Rats and B6C3F1Mice... 10.7MB
https://ntp.niehs.nih.gov/go/tr490
... Bus commented that the section comparing delivered doses of glutaraldehyde to formaldehyde ... anterior portion of the nose, whereas formaldehyde is deposited deeper in the respiratory ...
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NIEHS/DTT Toxicity Specifications: Chapter 3. Health and Safety... 334KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/test_info/toxspecs/chapter3_health_safety_508.pdf
Occupational Exposure to Blood-borne Pathogens, 29 CFR 1910.1030 . Formaldehyde, 29 CFR 1910.1048 (applicable to the use of formaldehyde in histology, pathology, and anatomy ...
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CERHR Monograph: Potential Human Reproductive and Developmental... 5.0MB
https://ntp.niehs.nih.gov/go/methanol_monograph
... in the production of chemicals such as formaldehyde, methyl tertiary butyl ether (MTBE), ... In primates, including humans, methanol is converted to formaldehyde by the enzyme alco - ...
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TR-472: Isobutyraldehyde (CASRN 78-84-2) in F344/N Rats and B6C3F1Mice... 11.3MB
https://ntp.niehs.nih.gov/go/tr472
... its structural relationship to formaldehyde (a nasal carcinogen in rats), and the ... Formaldehyde (a structurally related chemical) was administered by inhalation 6 hours per ...
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NIEHS/DTT Toxicity Specifications: Chapter 8. Anatomic Pathology... 2.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/test_info/toxspecs/chapter8_anatomic_pathology_508.pdf
and fixed in 10% neutral buffered formalin (NBF) immediately after examination and/... The boxes shall be marked on one end to show: o Per the OSHA Formaldehyde Standard and the ...
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Abstract for TR-536 65KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr536
ethane; ethane, 1,1-[methylenebis(oxy)]bis(2-chloro)-; formaldehyde bis(2-chloroethyl) acetal; formaldehyde bis(beta;-chloroethyl) acetal; methane, bis(2-chloroethoxy)-; ...
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Appendix G; 15th RoC 2021 69KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/appendix_g.pdf
number of the major chemicals or metals that are highlighted in the profile. 50-00-0 see Formaldehyde 50-18-0 see Cyclophosphamide 50-28-2 (estradiol-17β) see Estrogens, ...
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TOX-59: Chloral Hydrate (CASRN 302-17-0) 10.8MB
https://ntp.niehs.nih.gov/go/tox059
... forming malondialdehyde, formaldehyde, acetaldehyde, acetone, and propionaldehyde. ... were fixed in 10% neutral buffered formalin, trimmed, embedded in paraffin, ...
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Background Document: RoC: Glass Wool Fibers; 2010 3.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/twelfth/2010/finalbds/glasswoolbd20100408_508.pdf
... exposures, including asbestos, formaldehyde, and silica, in the nested case- ... (95% CI = 0.55 to 3.42, P = 0.50). (Formaldehyde exposure was also independently ...
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TOX-19: Formic Acid (CASRN 64-18-6) 1.4MB
https://ntp.niehs.nih.gov/go/tox019
... of its structural relationship with formaldehyde and because inhalation is an important ... and as a by-product in the manufacture of acetaldehyde and formaldehyde (Wagner, 1980). ...
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Lung - Pigment - Nonneoplastic Lesion Atlas 280KB
https://ntp.niehs.nih.gov/atlas/nnl/respiratory-system/lung/Pigment
Acid hematin, an artifact of fixation in formalin with a low pH, appears as black to brown ... Elsevier Saunders, Philadelphia, 39-40. Pizzolato P. 1976. Formalin pigment (acid hematin) ...
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TOX-25: Glutaraldehyde (CASRN 111-30-8) 3.0MB
https://ntp.niehs.nih.gov/go/tox025
... the toxic effects of glutaraldehyde and formaldehyde be included in the discussion. Dr. ... glutaraldehyde and formaldehyde, a known nasal carcinogen in rats (Kerns et al., 1983). ...
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Abstract for TR-430 68KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr430
C.I. Direct Blue 218 is a copper chelated dye used for cellulose, acetate, nylon, silk, wool, tissue, papers, and textile goods with a urea-formaldehyde finish. C.I. Direct Blue ...
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Lung - Pigment 290KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/respiratory/lung/pigment/lung-pigment-508.pdf
Acid hematin, an artifact of fixation in formalin with a low pH, appears as black to brown ... Elsevier Saunders, Philadelphia, 39-40. Pizzolato P. 1976. Formalin pigment (acid hematin) ...
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Spinal cord - Demyelination - Nonneoplastic Lesion Atlas 280KB
https://ntp.niehs.nih.gov/atlas/nnl/nervous-system/spinal-cord/Demyelination
A common error in diagnosis of demyelination relates to use of the term to describe artifactual neuropil vacuolation commonly seen in immersion formalin-fixed neural tissue, or ...
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Abstract for TR-472 68KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr472
variety of aldehydes, its structural relationship to formaldehyde (a nasal carcinogen in rats), and the lack of toxicity and carcinogenicity studies on isobutyraldehyde in animals. ...
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Immunotoxicity Study Pathology Specifications; Oct. 7, 2016 678KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/levels/finalntpitoxspecs_508.pdf
... The tissues shall be stored in formalin and sent to the pathology contract laboratory with ... shall be weighed and transferred to a container filled with 10% neutral buffered formalin. ...
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Public Health Impact 1.9MB
https://ntp.niehs.nih.gov/media/impact
... website 78-79-5 2025 EPA Risk Evaluation for Formaldehyde In December 2024, EPA released the final risk evaluation under the Toxic Substances Control Act (TSCA) for formaldehyde. ...
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Listed Substances; 15th RoC 2021 76KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/listed_substances_508.pdf
Virus (see Viruses: Eight Listings) Erionite Estrogens, Steroidal Ethylene Oxide Formaldehyde Helicobacter pylori (Chronic Infection) Hepatitis B Virus (see Viruses: Eight ...
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RoC Profile: Wood Dust; 15th RoC 2021 313KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/wooddust.pdf
to other substances, such as formaldehyde or wood preservatives (IARC 1995, NTP 2000). ... or experimental animals), including formaldehyde or sidestream cigarette smoke in rats ...
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Urinary Bladder - Dilation 231KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/urinary/urinary_bladder/dilation/urinary_bladder-dilation_508.pdf
Formalin inflation of the urinary bladder is usually recommended, but overinflation and other inflation-related artifacts may occur. 1 Urinary bladder - Dilation Recommendation: ...
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ALTBIB - Alternatives to Animal Testing 58KB
https://ntp.niehs.nih.gov/whatwestudy/niceatm/altbib
Examples of search terms: acetone vinyl chloride 50-00-0 brain dna adducts skin tumors biomarkers aflatoxin b1 The term(s) entered will be searched for in all ALTBIB fields. You ...
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Urinary bladder - Dilation - Nonneoplastic Lesion Atlas 279KB
https://ntp.niehs.nih.gov/atlas/nnl/urinary-system/urinary-bladder/Dilation
Formalin inflation of the urinary bladder is usually recommended, but overinflation and other inflation-related artifacts may occur. Recommendations: Dilation of the urinary ...
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Spinal Cord - Demyelination 325KB
https://ntp.niehs.nih.gov/sites/default/files/2025-03/spinal_cord-demyelination_508.pdf
A common error in diagnosis of demyelination relates to use of the term to describe artifactual neuropil vacuolation commonly seen in immersion formalin-fixed neural tissue, or ...
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Usefulness and Limitations of the LLNA for Potency Categorization... 25.3MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-pot/tmer.pdf
... molecular weight less than 200; (4) formaldehyde and products containing ≥1%; and (5) ... pig data are 4-phenylenediamine and formaldehyde, two of the five substances that meet ...
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TR-552: Toxicology and Carcinogenesis Studies of Propargyl Alcohol... 1.4MB
https://ntp.niehs.nih.gov/go/tr552
... synthesis of butynediol from acetylene and formaldehyde with copper acetylide as catalyst. ... synthesis of butynediol from acetylene and formaldehyde with copper acetylide as catalyst. ...
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ICCVAM Test Method Evaluation Report: LLNA BrdU-ELISA 35.6MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-elisa/tmer.pdf
... Amines 0.11 (26.4) 0.285 (14.7) Formaldehyde Disinfectant; Manufacturing Aldehydes ... 2.60, 4.10, 5.10, 5.10, 5.40, 8.90 Formaldehyde (3, 1) ACE 1.97, 4.40, 16.60 4.00 ...
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RoC Background Document: Tobacco Smoking; Dec. 2-3, 1998 3.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/other_background/environmentalts_noapps_508.pdf
... Ethene Propene 1,3-Butadiene Isoprene Formaldehyde 1.2 mg 1.3 mg 0.4 mg 3.1 mg 1500 µg ... Prominent among them are the respiratory irritants: ammonia, formaldehyde, and sulfur ...
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RoC Background Document for Nitromethane; March 25, 2002 1.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/roc11/nmpub_no_appendices_508.pdf
... Although nitromethane may be metabolized to formaldehyde by rat liver microsomes in vitro, ...hydroxymethyl)nitromethane reaction of formaldehyde and nitromethane (3:1 molar ratio) via ...
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TR-536: Toxicology and Carcinogenesis Studies of bis(2-Chloroethoxy... 5.4MB
https://ntp.niehs.nih.gov/go/tr536
... ethane; ethane, 1,1-[methylenebis(oxy)]bis(2-chloro)-; formaldehyde bis(2-chloroethyl) acetal; formaldehyde bis(β-chloroethyl) acetal; methane, bis(2-chloroethoxy)-; ...
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ICCVAM Test Method Evaluation Report on the LLNA: DA 30.4MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-da/tmer.pdf
... Acids 0.360 (26.0) 0.030 (6.9) Formaldehyde 5, 6 Disinfectant; Manufacturing ... 2.60, 4.10, 5.10, 5.10, 5.40, 8.90 Formaldehyde (4, 1) ACE 2.69, 3.18, 4.84, 5.10 4.00 ...
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Protocol for a Systematic Review of Traffic-Related Air Pollution... 1.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/airpollchildhealth/protocol_20160616_508.pdf
... toxics as key: benzene, 1,3-butadiene, formaldehyde, acetaldehyde, acrolein, polycyclic ... Formaldehyde or other volatile organic compounds relevant to vehicle exhaust Comparators . ...
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FAQs & Fact Sheets 62KB
https://ntp.niehs.nih.gov/media/faqs
Fields FAQ Mar 2024 Endocrine Disruptors FAQ Jul 2024 Flame Retardants FAQ Jan 2025 Formaldehyde FAQ Mar 2025 Hexavalent Chromium FAQ Aug 2025 Lead FAQ Jun 2025 Lung Diseases FAQ ...
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Research Reports 95KB
https://ntp.niehs.nih.gov/publications/reports/rr
and Functional Alternatives 2017 Research Report RR-03 PDF (1 MB) Absence of Formaldehyde-Induced Neoplasia in Trp53 Haploinsufficient Mice Exposed by Inhalation 2017 ...
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RoC Profile: Nitromethane; 15th RoC 2021 136KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/nitromethane.pdf
Metabolism of nitro- methane by rat liver microsomes resulted in formation of only trace amounts of formaldehyde (IARC 2000). Properties Nitromethane is a nitroalkane compound that ...
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Stomach - Pigment - Nonneoplastic Lesion Atlas 284KB
https://ntp.niehs.nih.gov/atlas/nnl/alimentary-system/stomach-glandular-stomach/Pigment
NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/7698 Pizzolato P. 1976. Formalin pigment (acid hematin) and related pigments. Am J Med Technol 42:436-440. ...
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TOX-79: Reproductive Dose Range-Finding Toxicity Study of Genistein... 1.4MB
https://ntp.niehs.nih.gov/go/tox079
... and preputial glands were weighed and fixed in 10% neutral buffered formalin (NBF). ... and then perfused transcardially with 0.9% saline followed by 10% buffered formalin. ...
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TR-467: Chloroprene (CASRN 126-99-8) in F344/N Rats and B6C3F1Mice... 14.5MB
https://ntp.niehs.nih.gov/go/tr467
... Reaction of chloroprene with hydroxyl radicals or ozone may form formaldehyde, ... and preserved in 10% neutral buffered formalin, processed and trimmed, embedded in ...
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NTP Archives - 2014 1.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/pressctr/brochures/ntparchives2014_508.pdf
... of histologic slides, paraffin blocks, formalin fixed wet tissues, frozen tissues, and ... tissue blocks . 242,000 bags of formalin preserved tissues . 74,000 frozen specimens . ...
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RoC Profile: Coke-Oven Emissions; 15th RoC 2021 119KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/cokeovenemissions.pdf
... These emissions are complex mixtures of dusts, vapors, and gases that typ- ically include PAHs, formaldehyde, acrolein, aliphatic aldehydes, am- monia, carbon monoxide, nitrogen ...
