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Final RoC Background Document for Formaldehyde 5.8MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2009/november/formaldehyde_bd_final.pdf
Formaldehyde January 22, 2010 U.S. Department of Health and Human Services Public Health ... This Page Intentionally Left Blank Formaldehyde: RoC Background Document 1/22/10 i ...
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Formaldehyde Expert Panel Report Part B - Recommendation for... 406KB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2009/november/fa_partb.pdf
B Formaldehyde Expert Panel Report Part B - Recommendation for Listing Status for Formaldehyde and Scientific Justification for the Recommendation The Report on Carcinogens (RoC) ...
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RoC Profile: Formaldehyde 496KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/formaldehyde.pdf
Formaldehyde CAS No. 50-00-0 Known to be a human carcinogen First listed in the Second Annual Report on Carcinogens (1981) H 2 C=O Carcinogenicity Formaldehyde is known to be a ...
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Formaldehyde Expert Panel Report Part A - Peer Review of the... 567KB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2009/november/fa_parta.pdf
A Formaldehyde Expert Panel Report Part A - Peer Review of the Draft Background Document on Formaldehyde The Report on Carcinogens (RoC) expert panel for formaldehyde exposures met ...
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RR-03: Absence of Formaldehyde-Induced Neoplasia in TRP53 Haploinsuffi... 1.0MB
https://ntp.niehs.nih.gov/ntp/results/pubs/rr/reports/rr03_508.pdf
foRmaldehyde-INduced NeoPlasIa IN TRP53 haPloINsuffIcIeNT mIce exPosed by INhalaTIoN NTP RR 3 AUGUST 2017 NTP Research Report on Absence of Formaldehyde-Induced Neoplasia in ...
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Formaldehyde 10002-S 28KB
https://ntp.niehs.nih.gov/go/ts-10002-s
Formaldehyde 10002-S CASRN: 50-00-0 Formula: C-H2-O Synonyms/Common Names Formalin Short-Term Toxicity 2 weeks (Inhalation) (C02799) Completed Mice: B6C3F1 2 weeks (Inhalation) ...
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Agenda: Formaldehyde Expert Panel Meeting; RoC; Nov. 2-4, 2009 163KB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2009/november/agenda_formaldehyde.pdf
Report on Carcinogens (RoC) Formaldehyde Expert Panel Meeting November 2 - 4, 2009 ... James Swenberg (UNC) / Independent Scientist . Dr. Robert Golden / Formaldehyde Council, ...
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Nomination Summary for Formaldehyde (N79334) 19KB
https://ntp.niehs.nih.gov/go/nm-n79334
Formaldehyde (N79334) Nominated Substances: Formaldehyde Nomination Date: 01/00/1979 Nominator: CPSC, NCI, NIOSH, OSHA Rationale: High production, worker & consumer exposure, ...
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Roster: Formaldehyde Expert Panel; RoC; Nov. 2-4, 2009 144KB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2009/november/eproster_formaldehyde.pdf
Report on Carcinogens (RoC) Formaldehyde Expert Panel Roster November 2-4, 2009 Kenneth E. McMartin, Ph.D., Chair Department of Pharmacology Toxicology & Neuroscience Louisiana ...
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Minutes: BSC; June 21-22, 2010 364KB
https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2010/june/minutes20100622.pdf
for the 12 th Report on Carcinogens: Formaldehyde ......FDA Food and Drug Administration FDH formaldehyde dehydrogenase FEMA Federal Emergency ...
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Nomination Background: Methylolurea (CASRN: 1000-82-4) 497KB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/methylolurea_508.pdf
The nomination is based on high production volumes (including urea- formaldehyde [UF] ... Nontoxicological Information Methylolurea, as a solution, is a mixture of formaldehyde gas ...
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NTP Response to BSC Peer Review Comments on the Draft Substances... 324KB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2011/Response062110BSC2011.pdf
and Technical Issues 4 References 4 Formaldehyde 5 BSC Comments and NTP Responses: ... cobalt-tungsten carbide: powders and hard metals, formaldehyde, and glass wool fibers. ...
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Nomination Summary for Synthetic polymer process emissions 1999... 20KB
https://ntp.niehs.nih.gov/go/nm-n20022
Synthetic polymer process emissions 1999 (N20022) Nominated Substances: 2-Ethylhexanol, Formaldehyde, Methyl ethyl ketone peroxide, Phenol-formaldehyde resin dust, ...
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Nomination Summary for Synthetic polymer process emissions (N94012... 21KB
https://ntp.niehs.nih.gov/go/nm-n94012
catalysts, Formaldehyde, 1,6-Hexanediamine dihydrochloride, Methyl ethyl ketone peroxide, Paint dust, Paint mist solids, Phenol-formaldehyde resin dust, ...
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Nomination Summary for Synthetic polymer process emissions 1998... 22KB
https://ntp.niehs.nih.gov/go/nm-n98031
Nominated Substances: Dimethylethylamine, 2-Ethylhexanol, Formaldehyde, 1,6-Hexanediamine dihydrochloride, Methyl ethyl ketone peroxide, Paint mist solids, Phenol-formaldehyde ...
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Nomination Background: 1,2,3,4-Butanetetracarboxylic acid (CASRN... 604KB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/btca_508.pdf
because of the increased potential for its use as a substitute for formaldehyde in the permanent press treatment of cotton resulting from the lowering of the TLV for formaldehyde. ...
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Nomination Background: Imidazolidinyl urea (CASRN: 39236-46-9... 157KB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/imidazolidinylurea_508.pdf
Division of Cancer Biology (DCB) as the result of a class study on formaldehyde releasers. ... of possible break- down products, especially diazolidinyl urea and formaldehyde. ...
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Nomination Background: 1,3,5-Triazine-1,3,5(2H,4H,6H)-triethanol... 103KB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/triazinetriethanol_508.pdf
is the possibility of the release of formaldehyde from TZT-like biocides, and that ... No structural counterpart among formaldehyde-releasing biocides Dermal absorption ...
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RoC Background Document: Methyl tertiary-Butyl Ether; Dec. 2... 1.2MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/mtbe1_508.pdf
... Carcinogenicity and Genotoxicity Studies of Formaldehyde ......32 6.4.1 Carcinogenicity of Formaldehyde (IARC 1995) ......
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Japanese Minimum Requirements for Biological Products 2.0MB
https://ntp.niehs.nih.gov/iccvam/methods/biologics/vaccine/japan-minreqs.pdf
.........306 Test for Formaldehyde Content......Virus shall then be inactivated by the addition of formalin or other suitable methods. The ...
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Response to Expert Panels' Peer-Review Comments on Background... 354KB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2011/ResponseExpertPanelReport2011.pdf
Peer-Review Comments 9 References 10 Formaldehyde 11 Expert Panel Meeting 11 NTP ... Expert Panels' Peer-Review Comments Formaldehyde 11 Formaldehyde Expert Panel Meeting ...
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Nose - Polyp, Inflammatory - Gallery - Nonneoplastic Lesion Atlas 175KB
https://ntp.niehs.nih.gov/nnl/respiratory/nose/polyp/gallery/index.htm
Polyp, Inflammatory - Gallery Image of polyp, inflammatory in the nose from a male B6C3F1/N mouse in a chronic study Nose - Polyp, Inflammatory in a male B6C3F1/N mouse from a ...
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Hydroxyacetonitrile 11505-R 21KB
https://ntp.niehs.nih.gov/go/ts-11505-r
Hydroxyacetonitrile 11505-R CASRN: 107-16-4 Formula: C2-H3-N-O Synonyms/Common Names Formaldehyde cyanohydrin Genetic Toxicology Salmonella (735832) Completed Citation: Zeiger, E., ...
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Methylal M980016 21KB
https://ntp.niehs.nih.gov/go/ts-m980016
CASRN: 109-87-5 Formula: C3-H8-O2 Synonyms/Common Names Dimethoxymethane (9CI) DMM Formal Formaldehyde dimethylacetal Methylene dimethyl ether Methyl formal Genetic Toxicology ...
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Nomination Background: N-(3-Chloroallyl)hexaminium chloride ... 3.2MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/chloroallylhexaminium_508.pdf
... chloride may also cause cross sensitization reactions in formaldehyde-sensitive patients. ... (hexamethylene-tetramine), a drug which is metabolized to formaldehyde and ammonia. ...
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Nomination Background: s-Trioxane (CASRN: 110-88-3) 72KB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/trioxane_508.pdf
O 3 ; mol. wt. = 90.08) is also called formaldehyde, trimer; metaformaldehyde; ... s-Trioxane is converted to formaldehyde in the presence of a strong acid in ...
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bis(2-Chloroethoxy)methane M980065 26KB
https://ntp.niehs.nih.gov/go/ts-m980065
Synonyms/Common Names CEM Dichloroethyl formal Ethane, 1,1'-(methylenebis(oxy))bis(2-chloro- Formaldehyde bis(2-chloroethyl) acetal Short-Term Toxicity 2 weeks (Topical ...
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RoC Background Document: Wood Dust; Dec. 13-14, 2000 1.2MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/wd_no_appendices_508.pdf
... dust rather than other concurrent exposure(s) such as formaldehyde or wood preservatives. ... the incidence of tumors induced by formaldehyde in female Sprague-Dawley rats, ...
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RoC Appendix G 201KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_g.pdf
G: List of Substances by CAS Number 50-00-0 see Formaldehyde 50-18-0 see Cyclophosphamide 50-29-3 see Dichlorodiphenyltrichloroethane 50-32-8 (benzo[a]pyrene) see Polycyclic ...
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Nomination Summary for Formic acid (N82307) 19KB
https://ntp.niehs.nih.gov/go/nm-n82307
Nomination Date: 12/00/1981 Nominator: NCI Rationale: Potential for human exposure, structural relationship to formaldehyde, a known nasal carcinogen in rats NTP Principles: Pre ...
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Nomination Background: bis(2-Chloroethoxy)methane (CASRN: 111... 531KB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/bis(2-chloroethoxy)methane_508.pdf
of ethylene chlorohydrin (a possible impurity) and formaldehyde under acid catalysis. ... Bis(β-chloroethyl)formal Formaldehyde bis(β-chloroethyl) acetal ...
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Presentation: Characteristics of Enzymatic and Binding Activities... 971KB
https://ntp.niehs.nih.gov/iccvam/meetings/histwksp-2012/present/oh-508.pdf
I) according to formaldehyde (at final concentration 0.26%), glutaraldehyde (at final concentration 0.05%), mixture of glutaraldehyde (0.05%) and formaldehyde (0.26%) § Methods ...
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Nomination Summary for Dimethyloldihydroxyethyleneurea (N79448... 19KB
https://ntp.niehs.nih.gov/go/nm-n79448
Nominator: NCI Rationale: Widely used in textiles with 0.5-1.5% of finished product as free formaldehyde NTP Principles: Pre 1993 - 3, 8 Agents and Status The following information ...
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Nomination Summary for N-(3-Chloroallyl)hexaminium chloride ... 19KB
https://ntp.niehs.nih.gov/go/nm-n80101
Nominated Substances: N-(3-Chloroallyl)hexaminium chloride Nomination Date: 01/00/1980 Nominator: NCI Rationale: Potential to metabolize to formaldehyde. Consumer exposure from ...
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Nomination Summary for Glutaraldehyde (N85003) 19KB
https://ntp.niehs.nih.gov/go/nm-n85003
Rationale: Increased incidence of leukemia in anatomists, embalmers, and pathologists exposed to glutaraldehyde and formaldehyde. NTP Principles: not specified Agents and Status ...
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Nomination Background: Methylal (CASRN: 109-87-5) 151KB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/methylal_508.pdf
on potential for metabolic release of formaldehyde and positive mutagenicity data . lack ... methylal; formal; methyl formal; formaldehyde dimethylacetal; methylene dimethyl ...
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Public Comment: General Issues; Richard Becker; RoC; Jan. 19... 85KB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2012/publiccomm/becker20120228.pdf
of Sciences (NAS) of the 12 th ROC's evaluation of formaldehyde and styrene is completed. ... peer review of the 12 th RoC determinations related to formaldehyde and styrene. ...
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Nomination Summary for 1,2,3,4-Butanetetracarboxylic acid (N89104... 19KB
https://ntp.niehs.nih.gov/go/nm-n89104
Nomination Date: 09/12/1989 Nominator: NCI Rationale: Potential exposure based on use as substitute for formaldehyde in permanent press treatment of cotton; limited toxicity ...
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Immunotoxicity: Allergic Contact Dermatitis 30KB
https://ntp.niehs.nih.gov/iccvamreport/2015/actvities/immunotox/index.html
Allergic contact dermatitis (ACD) may develop in workers and consumers exposed to skin-sensitizing chemicals and products, which include chemicals such as formaldehyde, ...
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Skin Sensitizer Testing 31KB
https://ntp.niehs.nih.gov/iccvamreport/2017/activities/skinsens/index.html
Allergic contact dermatitis (ACD) may develop in workers and consumers exposed to skin-sensitizing chemicals and products, which include chemicals such as formaldehyde, ...
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Public Health Impact 765KB
https://ntp.niehs.nih.gov/media/impact/index.html
... Type: Legislation September 30, 2020 84-74-2 117-81-7 50-00-0 30525-89-4 463-57-0 ... Type: Legislation September 30, 2020 84-74-2 117-81-7 50-00-0 30525-89-4 463-57-0 ...
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TR-490: Glutaraldehyde (CASRN 111-30-8) in F344/N Rats and B6C3F1Mice... 10.7MB
https://ntp.niehs.nih.gov/go/tr490
... Bus commented that the section comparing delivered doses of glutaraldehyde to formaldehyde ... anterior portion of the nose, whereas formaldehyde is deposited deeper in the respiratory ...
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Nomination Summary for 1,3,5-Triazine-1,3,5(2H,4H,6H)-triethanol... 20KB
https://ntp.niehs.nih.gov/go/nm-n21002
Grotan was considered for study by NTP with moderate priority in the past. The mode of antimicrobial action of Grotan is release of formaldehyde. Formaldehyde is known to be ...
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Abstract for TR-536 35KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr536/index.html
ethane; ethane, 1,1-[methylenebis(oxy)]bis(2-chloro)-; formaldehyde bis(2-chloroethyl) acetal; formaldehyde bis(β;-chloroethyl) acetal; methane, bis(2-chloroethoxy)-; ...
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TR-472: Isobutyraldehyde (CASRN 78-84-2) in F344/N Rats and B6C3F1Mice... 11.3MB
https://ntp.niehs.nih.gov/go/tr472
... its structural relationship to formaldehyde (a nasal carcinogen in rats), and the ... Formaldehyde (a structurally related chemical) was administered by inhalation 6 hours per ...
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CERHR Monograph: Potential Human Reproductive and Developmental... 5.0MB
https://ntp.niehs.nih.gov/ntp/ohat/methanol/methanol_monograph.pdf
... in the production of chemicals such as formaldehyde, methyl tertiary butyl ether (MTBE), ... In primates, including humans, methanol is converted to formaldehyde by the enzyme alco - ...
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Nomination Background: Methylamine (CASRN: 74-89-5) 385KB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/methylamine_508.pdf
... to carcinogenic products, e.g., formaldehyde, a known rodent carcinogen - Positive ... Methylamine can also be synthesized by heating ammonium chloride and formaldehyde ...
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Phase 1 Validation of the Electrophilic Allergen Screening Assay... 622KB
https://ntp.niehs.nih.gov/iccvam/meetings/ascct-2018/strickland-poster-text-508.pdf
... Incubation Time (min) Negative Control Positive Control Formaldehyde Positive Criterion ... 4-Phenylenediamine 10-<30% <10% <10% Formaldehyde <10% <10% <10% Glutaraldehyde <10% ...
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Nomination Background: Chloramine-T (CASRN: 127-65-1) and Metabolite... 930KB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/chloraminet_508.pdf
... the formulation of toluenesulfonamide/formaldehyde resin (TSFR), which is used in ... Telechemische, Inc. produces Ultralac N (a toluenesulfonamide formaldehyde resin) in ...
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Public Comment: Draft OHAT Approach; Dr. Lorenz Rhomberg and... 609KB
https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/publiccomm/rhomberg20130611_508.pdf
The NRC Committee that reviewed US EPA's formaldehyde risk assessment made important ... The formaldehyde review Committee set out a so-called "roadmap" for reform that called for ...
