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TR-530: Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB... 8.2MB
https://ntp.niehs.nih.gov/go/tr530
2',4,4',5,5'- HEXACHLOROBIPHENYL (PCB 153) (CAS NO. 35065-27-1) IN FEMALE HARLAN ... OF 3,3N,4,4N,5-PENTACHLOROBIPHENYL (PCB 126) (CAS NO. 57465-28-8) AND ...
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RoC Profile: Polychlorinated Biphenyls; 15th RoC 2021 176KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/polychlorinatedbiphenyls.pdf
Also known as PCBs or chlorodiphenyls (Cl) x (Cl) y Polychlorinated biphenyls (number of chlorine atoms [x + y] = 1-10) Carcinogenicity Polychlorinated biphenyls (PCBs) are ...
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TR-529: 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) (CASRN 35065... 4.0MB
https://ntp.niehs.nih.gov/go/tr529
OF 2,2',4,4',5,5' -HEXACHLOROBIPHENYL (PCB 153) (CAS NO. 35065-27-1) IN FEMALE HARLAN ... OF 2,2N,4,4N,5,5N-HEXACHLOROBIPHENYL (PCB 153) (CAS NO. 35065-27-1) IN FEMALE HARLAN ...
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TR-531: Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB... 7.2MB
https://ntp.niehs.nih.gov/go/tr531
3',4,4',5- PENTACHLOROBIPHENYL (PCB 118) (CAS NO. 31508-00-6) IN FEMALE HARLAN ... OF 3,3N,4,4N,5-PENTACHLOROBIPHENYL (PCB 126) (CAS NO. 57465-28-8) AND ...
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TR-559: 2,3',4,4',5-Pentachlorobiphenyl (PCB 118) (CASRN 31508... 5.4MB
https://ntp.niehs.nih.gov/go/tr559
2,3',4,4',5- PENTACHLOROBIPHENYL (PCB 118) (CAS NO. 31508-00-6) IN FEMALE HARLAN ... STUDIES OF 2,3´,4,4´,5-PENTACHLOROBIPHENYL (PCB 118) (CAS NO. 31508-00-6) IN FEMALE ...
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Minutes: BSC TRRS; Feb. 17, 2004 661KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2004/feb/trrs17feb2004mins_508.pdf
2 3,3',4,4',5-Pentachlrobiphenyl (PCB 126) ......4 Dioxin Mixture (TCDD, PeCDF, PCB 126)......
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Abstract for TR-530 78KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr530
Toxicology and Carcinogenesis Studies of a Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) and 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) in Female Harlan ...
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TR-520: 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465... 12.8MB
https://ntp.niehs.nih.gov/go/tr520
OF 3,3',4,4',5- PENTACHLOROBIPHENYL (PCB 126) (CAS NO. 57465-28-8) IN FEMALE HARLAN ... OF 3,3N,4,4N,5-PENTACHLOROBIPHENYL (PCB 126) (CAS NO. 57465-28-8) IN FEMALE HARLAN ...
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TR-526: Mixture of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD... 6.6MB
https://ntp.niehs.nih.gov/go/tr526
AND 3,3',4,4',5-PENTACHLOROBIPHENYL (PCB 126) (CAS NO. 57465-28-8) IN FEMALE HARLAN ... AND 3,3N,4,4N,5-PENTACHLOROBIPHENYL (PCB 126) (CAS NO. 57465-28-8) IN FEMALE HARLAN ...
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Abstract for TR-531 78KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr531
Toxicology and Carcinogenesis Studies of a Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) and 2,3',4,4',5-Pentachlorobiphenyl (PCB 118) in Female Harlan Sprague-Dawley ...
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TR-525: 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CASRN 57117... 4.3MB
https://ntp.niehs.nih.gov/go/tr525
... structurally related poly- chlorinated biphenyls (PCBs) and mixtures of these compounds. ... polychlorinated dibenzodioxins (PCDDs), polychlori- nated dibenzofurans (PCDFs), and PCBs. ...
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TR-521: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (CASRN 1746... 12.8MB
https://ntp.niehs.nih.gov/go/tr521
... structurally related poly- chlorinated biphenyls (PCBs) and mixtures of these compounds. ... polychlorinated dibenzodioxins (PCDDs), polychlori- nated dibenzofurans (PCDFs), and PCBs. ...
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Abstract for TR-38 58KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr038
Aroclor® is the registered trademark of the Monsanto Chemical Company for their polychlorinated biphenyls (PCBs). PCBs were developed in 1929 primarily for use as heat transfer ...
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Abstract for TR-529 67KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr529
Toxicology and Carcinogenesis Studies of 2,2',4,4',5,5',-Hexachlorobiphenyl (PCB 153) in ... related polychlorinated biphenyls (PCBs) and mixtures of these compounds. ...
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Abstract for TR-520 72KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr520
Toxicology and Carcinogenesis Studies of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) in ... polychlorinated biphenyls (PCBs) and mixtures of these compounds. ...
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NTP Monograph on Health Effects of Low-Level Lead Appendix E... 2.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/lead/final/leadappendixe_final_508.pdf
BMI, and other pollutants (p,p'-DDE, HCB, PCBs, mirex, mercury) Binary Logistic ... µg/dL 12.7 years (12.2-13.1) Increasing PCB levels were associated with a greater ...
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Abstract for TR-526 73KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr526
and 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) in Female Harlan Sprague-Dawley Rats ... 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) Report Date: ...
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Target Organs and Levels of Evidence for TR-531 56KB
https://ntp.niehs.nih.gov/data/tr/500s/tr531levels
Toxicology and Carcinogenesis Studies of a Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) and 2,3',4,4',5-Pentachlorobiphenyl (PCB 118) (CASRN ...
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Abstract for TR-559 67KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr559
Toxicology and Carcinogenesis Studies of 2,3',4,4',5-Pentachlorobiphenyl (PCB 118) in ... and structurally related polychlorinated biphenyls (PCBs) and mixtures of these compounds. ...
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Historical Controls: Pathology Tables for All Routes/Vehicles... 81KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/historical_controls/ntp2000_2009/2008_hc_report_sd_rats_byroute.pdf
Battelle Columbus Laboratory 059602001 N/A N/A 0 (0) 0(0) N/A TEF evaluation (Binary mixture; PCB 126/PCB 153) Battelle Columbus Laboratory 059600704 N/A N/A 0 (0) 0(0) N/A TEF ...
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Target Organs and Levels of Evidence for TR-530 55KB
https://ntp.niehs.nih.gov/data/tr/500s/tr530levels
Toxicology and Carcinogenesis Studies of a Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) and 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) (CASRN ...
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NTP at the SOT; March 6, 2005 308KB
https://ntp.niehs.nih.gov/ntp/meetings/2005/ntpsot2_508.pdf
PCBs. 116 Xie, Yaxiong Arsenic and Uranium Toxicology 138 Symposium/Presentation 220-222 Walker, Nigel Testing the Toxic Equivalency Factor (TEF) Hypothesis: The NTP Dioxin/PCB ...
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Target Organs and Levels of Evidence for TR-529 54KB
https://ntp.niehs.nih.gov/data/tr/500s/tr529levels
Toxicology and Carcinogenesis Studies of 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) ... Toxic equivalency factor evaluation (PCB 153- 2,2'-4,4',5,5'-hexachlorobiphenyl) ...
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Target Organs and Levels of Evidence for TR-520 55KB
https://ntp.niehs.nih.gov/data/tr/500s/tr520levels
Toxicology and Carcinogenesis Studies of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN ... Toxic equivalency factor evaluation ((PCB 126) 3,3',4,4',5-pentachlorobiphenyl) ...
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RoC Background Document: 2,3,7,8-Tetrachlorodibenzo-p-dioxin... 7.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/other_background/tetrachl_tcdd_4apps_508.pdf
... of action ofTCDD and other chlorinated dibenzodioxins, dibenzofurans, and planar PCBs. ... hospital wastes; PCB-filled electrical transformer fires; and smelters (Schecter, 1994). ...
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NTP Monograph on Health Effects of Low-Level Lead Appendix B... 873KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/lead/final/leadappendixb_final_508.pdf
... (conA) response, NK function, plasma PCBs, chlorin- ated pesticides, metals ... Correlation for serum IgG and cord blood: Pb level - IgG r=0.31; p=0.002 Sum PCBs - IgG ...
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Minutes; BSC; Dec. 15, 2011 258KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2011/december/minutesbsc20111215.pdf
... Administration PBZT phenolic benzotriazole PCB polychlorinated biphenyl PCPC Personal Care ... and dioxin, and dioxin-like chemicals, including polychlorinated biphenyls (PCBs). ...
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Minutes: BSC; Oct. 26, 2004 769KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2004/october/bscmins2004oct26_508.pdf
... administered transplacentally, three studies of polychlorinated biphenyls (PCB 153, a mixture of PCB 126 and PCB 153 and a mixture of PCB 118 and PCB 153), two water disinfection ...
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Agenda: BSC TRRS; Feb. 25, 2009 125KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2009/feb/trrs25feb2009agenda_508.pdf
2,3',4,4',5- Pentachlorobiphenyl (PCB 118) [31508-00-6] TR 559 Insulating fluid for electronics; a representative mono-ortho substituted PCB evaluated as part of a series of ...
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Presentation: Adverse Outcome Pathway (AOP) for Sustained Aryl... 822KB
https://ntp.niehs.nih.gov/iccvam/meetings/aop-wksp-2014/presentations/simon-508.pdf
variety of exogenous chemicals ¤ Dioxins, PCBs, Dibenzofurans ¤ Other planar ... was similar at 14, 31 and 53 weeks in three NTP bioassays for TCDD, 4-PeCDF and PCB126. . ...
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TR-038: Aroclor (CASRN 27323-18-8) 1.9MB
https://ntp.niehs.nih.gov/go/tr038
... Aroclor® (CAS 27323-18-8; NCI C02664) is the registered trademark of the Monsanto Chemical Company for their polychlorinated biphenyls (PCBs). PCBs were developed in 1929 ...
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Department of the Interior: Potential Metrics to Track and Encourage... 220KB
https://ntp.niehs.nih.gov/ntp/about_ntp/sacatm/2022/ppt/06_rattner_508.pdf
Habitat affected by mining, smelting and manufacturing, oil spills Water, soil, plants, SPMDs, inverts, F&W: metals, PAHs, PCBs in vivo (trend toward sublethal and minimally ...
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Abstract for TR-525 71KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr525
related polychlorinated biphenyls (PCBs) and mixtures of these compounds. ... polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and PCBs. ...
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Presentation: Using Adverse Outcome Pathway Analysis to Identify... 2.2MB
https://ntp.niehs.nih.gov/iccvam/meetings/aop-wksp-2014/presentations/paul-508.pdf
... Perchlorate, bromate, some small organics PCBs, PTU, FD&C Red No3 dye, etc. ? Figure ... Similar AOP for PCBs or other chemicals also have data gaps despite some human ...
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Minutes: BSC TRRS; Feb. 25, 2009 76KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2009/feb/minutes_final0209.pdf
3 2,3',4,4',5-Pentachlorobiphenyl (PCB 118) ......8 yes votes, 0 no votes, and 0 abstentions. 2,3',4,4',5-Pentachlorobiphenyl (PCB 118) Dr. ...
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Abstract for TR-521 73KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr521
and structurally related polychlorinated biphenyls (PCBs) and mixtures of these compounds. ... polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and PCBs. ...
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Emerging Contaminants and Issues of Concern Program; Esra Mutlu... 3.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2021/april/presentations/ecic_bsc_presentation_508.pdf
... TCPMe: Tris(4-chlorophenyl)methanol PCB 11: 3,3'-dicholorobiphenyl *Multiple ... Microcystin LR Pyriproxyfen* PCB 11 Sulfolane TCPMe Vanadium 22 ECIC Program Strategic ...
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NTP Monograph on Health Effects of Low-Level Lead Appendices... 6.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/lead/final/appendicesathrue_final_508.pdf
... Maternal non-verbal intelligence, breastfeeding status, Hg levels, hemoglobin, PCB-153 ... = 0.8 - 27.1) *sig. correlation with PCB153 Venous blood at testing = 5.4 (5.0) ...
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Minutes: BSC; Aug. 18, 2005 1.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2005/august/bscmins2005aug18_508.pdf
... benzophenone, bromodichloromethane, 2,2',4,4',5,5'-hexachloro-biphenyl (PCB 153), a PCB mixture of 3,3',4,4',5 pentachlorobiphenyl (PCB 126) and 2,2',4,4',5,5'-hexachloro...
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Protocol: Systematic Review of Inflammation-based Atherosclerosis... 1001KB
https://ntp.niehs.nih.gov/sites/default/files/2023-07/protocol_atherosclerosisjuly2023_508.pdf
... Development OECD Polychlorinated biphenyl PCB Polycyclic aromatic hydrocarbon PAH ... including smoking, air pollution, metals, PAHs, and polychlorinated biphenyls (PCBs). ...
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RoC Profile: 2,3,7,8-Tetrachlorodibenzo-p-dioxin; 15th RoC 2021 154KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/tetrachlorodibenzodioxin.pdf
chlorinated dibenzodioxins, dibenzofurans, and planar polychlorinated biphenyls (PCBs). ... municipal, toxic, and hospital wastes, in PCB-filled electrical transformer fires, in ...
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TR-558: 3,3',4,4'-Tetrachloroazobenzene (TCAB) (CASRN 14047-09... 18.9MB
https://ntp.niehs.nih.gov/go/tr558
... greater than those observed following administration of TCDD or PCB 126 (NTP, 2006a,b). ... and B6C3F1 Mice a TCAB b TCDD c,d PeCDF e PCB 126 f Adrenal Gland Adenoma +FR - - +/- FR ...
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TR-584: Indole-3-Carbinol (CASRN 700-06-1) in F344/N Rats and... 4.1MB
https://ntp.niehs.nih.gov/go/tr584
... the current study of indole-3-carbinol and PCB 118. Because both studies were corn oil ... aryl hydrocarbon receptor ligands such as PCB 126 and TCDD induced moderate to marked ...
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RoC Profile: Mirex; 15th RoC 2021 138KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/mirex.pdf
... Kostyniak PJ, Vena JE. 1999. Comparison of PCB congeners and pesticide levels between ... Cole DC, Ferron LA, Weber JP. 1999. Blood PCB, p,p'-DDE, and mirex levels in Great Lakes ...
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TR-244: Polybrominated Biphenyl Mixture (Firemaster FF-1) in... 8.6MB
https://ntp.niehs.nih.gov/go/tr244
... toxicity of PBB was quite similar to that induced by PCB in rats (Kasza et al., 1978). ... aromatic hydrocarbons such as the PCB (Allen and Abrahamson, 1973), the diben- ...
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TR-305: Chlorinated Paraffins (C23, 43Chlorine) (CASRN 108171... 13.3MB
https://ntp.niehs.nih.gov/go/tr305
... of polychlorinated bi- phenyls (PCB's) and chlorinated naphthalenes (Howard et al., 1975). ... For many applications, chlorinated paraffins are being used in place of PCB's (Svanberg ...
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Addendum to ICCVAM Evaluation of In Vitro Test Methods for Detecting... 2.9MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edaddendfinal.pdf
... for Economic Co-operation and Development PAH Polycyclic aromatic hydrocarbon PCB Polychlorinated biphenyl P.L. Public Law pM Picomolar pmol Picomole RBA Relative binding ...
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Monograph: Perfluorooctanoic Acid or Perfluorooctane Sulfonate... 7.8MB
https://ntp.niehs.nih.gov/go/mgraph04
... the Faroe Island study corrected for PCBs because the known exposure and ... known or suspected immunotoxicants (e.g., PCBs and other potentially immunomodulatory ...
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The DNT In Vitro Battery (SACATM 2024 Presentation) 5.0MB
https://ntp.niehs.nih.gov/sites/default/files/2024-10/3-3_Shafer_SACATM2024_508.pdf
... Differentiation (Neurite Outgrowth) Nicotine, Pb, MeHg Schizophrenia (reduced axons and dendrites) Synaptogenesis Triethyltin, Pb, permethrin, PCBs IQ/learning decrements ...
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Minutes: BSC; June 29, 2004 883KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2004/june/20040629_508.pdf
... at NIEHS where further studies on polychlorinated biphenyls (PCBs) will be presented. ... involving polychlorinated biphenyls (PCBs), which are dioxin-like compounds, and ...