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TR-568: Photocarcinogenesis Studies of Retinoic Acid and Retinyl... 11.9MB
https://ntp.niehs.nih.gov/go/tr568
PhoTococaRciNogeNesis sTudy of ReTiNoic acid aNd ReTiNyl PalmiTaTe [cas Nos. 302-79-4 (all-TRaNs-ReTiNoic ... alter the process of photocarcinogenesis in SKH-1 hairless mice ...
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Abstract for TR-568 74KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr568
8abs Abstract for TR-568 Photocarcinogenesis Study of Retinoic Acid and Retinyl Palmitate in SKH-1 Mice (Simulated Solar Light and Topical Application Study) Substances: ...
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Technical Reports 858KB
https://ntp.niehs.nih.gov/publications/reports/tr
... (19.01 MB) Photococarcinogenesis Study of Retinoic Acid and Retinyl Palmitate (All-trans-retinoic acid ... TR-553 PDF (6.77 MB) Photocarcinogenesis Study of Aloe Vera [CASRN ...
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Study Reports 1.0MB
https://ntp.niehs.nih.gov/publications/reports
... (19.01 MB) Photococarcinogenesis Study of Retinoic Acid and Retinyl Palmitate (All-trans-retinoic acid ... TR-553 PDF (6.77 MB) Photocarcinogenesis Study of Aloe Vera [CASRN ...
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Toxicology/Carcinogenicity 1.1MB
https://ntp.niehs.nih.gov/research/apptoxres/cartox
... (19.01 MB) Photococarcinogenesis Study of Retinoic Acid and Retinyl Palmitate (All-trans-retinoic acid ... TR-553 PDF (6.77 MB) Photocarcinogenesis Study of Aloe Vera [CASRN ...
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TR-524: Glycolic Acid and Salicylic Acid (CASRNs 79-14-1 and... 2.8MB
https://ntp.niehs.nih.gov/go/tr524
NTP TECHNICAL REPORT ON THE PHOTOCARCINOGENESIS STUDY OF GLYCOLIC ACID AND SALICYLIC ACID (CAS ... Vitamins A 22,000,000 IU Vitamin A palmitate or acetate D 3 3,800,000 IU ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
... TR-568 01/26/11 Retinoic Acid and Retinyl Palmitate 302-79-4 and 79-81-2 TR-567 11/19/... 09/27/05 Salicylic Acid (Photocarcinogenesis Study) 69-72-7 NT Chemical Not Tested in ...
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TR-529: 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) (CASRN 35065... 4.0MB
https://ntp.niehs.nih.gov/go/tr529
... exposure to polychlorinated biphenyls: Lessons from the Inuit Cohort Study. Environ. ... Effect of dietary retinyl palmitate on the promotion of altered hepatic foci by ...
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TR-530: Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB... 8.2MB
https://ntp.niehs.nih.gov/go/tr530
... exposure to polychlorinated biphenyls: Lessons from the Inuit Cohort Study. Environ. ... Effect of dietary retinyl palmitate on the promotion of altered hepatic foci by ...
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TR-536: Toxicology and Carcinogenesis Studies of bis(2-Chloroethoxy... 5.4MB
https://ntp.niehs.nih.gov/go/tr536
... did not alter the photocarcinogenesis of simulated solar ... study in SKH-1 hairless mice (NTP, 2007). ... IU Stabilized vitamin A palmitate or acetate D 1,000 IU ...
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GMM-15: Genetically Modified Model Report on Senna (Feed Studies... 4.0MB
https://ntp.niehs.nih.gov/go/gmm15
... Photocarcinogenesis Study of Aloe Vera (CAS No. 481-82-1) in SKH1 Mice (Simulated Solar Light ... A 4,000 IU Stabilized vitamin A palmitate or acetate D 1,000 IU D-activated ...
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TR-553: Aloe Vera [CASRN 481-72-1 (Aloe-emodin)] in SKH-1 Mice... 2.9MB
https://ntp.niehs.nih.gov/go/tr553
... The purpose of this 1-year photococarcinogenesis study was ... the process of photocarcinogenesis in SKH-1 hairless ... Vitamins A U 22,000,000 I Vitamin A palmitate or acetate D 3 ...
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TR-565: Milk Thistle Extract (CASRN 84604-20-6) in F344/N Rats... 3.6MB
https://ntp.niehs.nih.gov/go/tr565
... The silymarin used in this study contained 55% silybinin as ... and Agarwal, 2005), photocarcinogenesis in SKH-1 hairless ... IU Stabilized vitamin A palmitate or acetate D 1,000 IU ...
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GMM-03: Genetically Modified Model Report on Trimethylolpropane... 7.3MB
https://ntp.niehs.nih.gov/go/gmm03
... R.W. (1998). Photocarcinogenesis and susceptibility ... MICE IN THE 6-MONTH DERMAL STUDY OF TRIMETHYLOLPROPANE ... IU Stabilized vitamin A palmitate or acetate D 1,000 IU ...
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GMM-04: Genetically Modified Model Report on Pentaerythritol... 5.3MB
https://ntp.niehs.nih.gov/go/gmm04
... R.W. (1998). Photocarcinogenesis and susceptibility ... MICE IN THE 6-MONTH DERMAL STUDY OF PENTAERYTHRITOL ... IU Stabilized vitamin A palmitate or acetate D 1,000 IU ...
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TR-359: 8-Methoxypsoralen (CASRN 298-81-7) in F344/N Rats (Gavage... 7.8MB
https://ntp.niehs.nih.gov/go/tr359
... Stabilized vitamin A palmitate or acetate D-activated ... A chronic study of 8-MOPand uv radiation is currently in ... Photocarcinogenesis: A n over- view. J. Invest. Demaiol. ...
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Target Organs and Levels of Evidence for TR-524 51KB
https://ntp.niehs.nih.gov/data/tr/500s/tr524levels
9369 Target Organs and Levels of Evidence for TR-524 Photocarcinogenesis Study of Glycolic Acid and Salicylic Acid (CASRNs 79-14-1 and 69-72-7) in SKH-1 Mice (Simulated Solar Light ...
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Abstract for TR-524 65KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr524
4abs Abstract for TR-524 Photocarcinogenesis Study of Glycolic Acid and Salicylic Acid in SKH-1 Mice (Simulated Solar Light and Topical Application Study) Substances: Glycolic acid ...
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Abstract for TR-553 66KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr553
3abs Abstract for TR-553 Photocarcinogenesis Study of Aloe Vera in SKH-1 Mice (Simulated Solar Light and Topical Application Study) CASRN: 481-72-1 Chemical Formula: C15H10O5 ...
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Public Health Impact 1.9MB
https://ntp.niehs.nih.gov/media/impact
... NTP Information Cited National Toxicology Program (NTP). 2007. NTP technical report on the photocarcinogenesis study of glycolic acid and salicylic acid (CASRN 79-14-1 and 69-72-7) ...
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TR-044 In Vitro Carcinogenesis: Guide to the Literature, Recent... 18.9MB
https://ntp.niehs.nih.gov/go/tr044
... Likewise, 12.5 yg/ml retinyl acetate in the medium prevents keratinization and increases ... these cells valuable for the study of proliferation control as well as carcinogenesis. ...
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RoC Background Document: Ultraviolet (UV) Radiation, Broad Spectrum... 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/roc10/uv_no_appendices_508.pdf
... Cancer Res 42(7):2796-803. 69. Forbes P.D. (1985). UV-A and photocarcinogenesis. Photochem ... Long-term follow-up of skin cancer in the PUVA-48 cooperative study. Arch Dermatol ...
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TR-436: t-Butyl Alcohol (CASRN 75-65-0) in F344/N Rats and B6C3F1Mice... 16.5MB
https://ntp.niehs.nih.gov/go/tr436
... accompanied by an early increase in palmitate uptake into triacylglycerols and a ... In a study of five butyl alcohols (method not given), t-butyl alcohol was found t o have ...
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TOX-53: t-Butyl Alcohol 3.6MB
https://ntp.niehs.nih.gov/go/tox053
... accompanied by an early increase in palmitate uptake into triacylglycerols and a ... In a study of five butyl alcohols (method not given), t-butyl alcohol was found to have ...
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RoC Background Document: Solar Radiation & Exposure to Sunlamps... 3.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/other_background/solar_rad_sunlamps_2apps_508.pdf
... S. Kanjilal. 1996. Oncogenes and tumor suppressor genes in photocarcinogenesis. Photochem. ... or sunbeds: An EORTC multicenter case- control study in Belgium, France and Germany. Int. ...
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TR-598: Perfluorooctanoic Acid (CASRN 335-67-1) Administered... 5.5MB
https://ntp.niehs.nih.gov/go/tr598
... Table B-2. Vitamins and Minerals Added to NTP-2000 Rat Ration a Study 1 Study 2 Amount Source Amount Source Vitamins A 4,000 IU Stabilized vitamin A palmitate or acetate 4,000 IU ...
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TR-591: TRIM VX in Wistar Han [Crl:WI (Han)] Rats and B6C3F1... 7.4MB
https://ntp.niehs.nih.gov/go/tr591
... of the bulk test material was observed over the course of the study (Table H-3). ... glycol monobutyl ether 1.02 1.11 Methyl palmitate 1.18 1.20 Methyl oleate 5.65 5.81 Methyl ...
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RoC Profile: Ultraviolet-Radiation-Related Exposures; 15th RoC... 169KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/ultravioletradiationrelatedexposures.pdf
... exposure to ultraviolet radiation: results of a case-control study in Ontario, Canada. ... Brash DE. 1999. Ultraviolet radiation induced signature mutations in photocarcinogenesis. ...
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GMM-10: Genetically Modified Model Report on Diispropylcarbodiimide... 380KB
https://ntp.niehs.nih.gov/go/gmm10
... J.E., and Tennant, R.W. (1998). Photocarcinogenesis and susceptibility to UV radiation ... HEMIZYGOUS MICE IN THE 20-WEEK DERMAL STUDY OF DIISOPROPYLCARBODIIMIDE TABLE A1 ...
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GMM-02: Genetically Modified Model Report on Acesulfame Potassium... 2.2MB
https://ntp.niehs.nih.gov/go/gmm02
... J.E., and Tennant, R.W. (1998). Photocarcinogenesis and susceptibility to UV radiation ... Tg.AC HEMIZYGOUS MICE IN THE 9-MONTH FEED STUDY OF ACESULFAME POTASSIUM TABLE A1 Summary ...
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GMM-01: Genetically Modified Model Report on Aspartame (Feed... 1.2MB
https://ntp.niehs.nih.gov/go/gmm01
... J.E., and Tennant, R.W. (1998). Photocarcinogenesis and susceptibility to UV radiation ... Tg.AC HEMIZYGOUS MICE IN THE 9-MONTH FEED STUDY OF ASPARTAME TABLE A1 Summary of the ...
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GMM-05: Genetically Modified Model Report on Bromodichloromethane... 1.6MB
https://ntp.niehs.nih.gov/go/gmm05
... J.E., and Tennant, R.W. (1998). Photocarcinogenesis and susceptibility to UV radiation ... Case-control study of colon cancer and drinking water trihalomethanes in Wisconsin. ...
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GMM-09: Genetically Modified Model Report on Dicyclohexylcarbodiimide... 1.1MB
https://ntp.niehs.nih.gov/go/gmm09
... J.E., and Tennant, R.W. (1998). Photocarcinogenesis and susceptibility to UV radiation ... IN F344/N RATS IN THE 13-WEEK DERMAL STUDY OF DICYCLOHEXYLCARBODIIMIDE TABLE A1 TABLE ...
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GMM-07: Genetically Modified Model Report on Allyl Bromide (Dermal... 1.2MB
https://ntp.niehs.nih.gov/go/gmm07
... J.E., and Tennant, R.W. (1998). Photocarcinogenesis and susceptibility to UV radiation ... SUMMARY OF LESIONS IN FVB/N MICE IN THE 40-WEEK GAVAGE STUDY OF ALLYL BROMIDE tABLe A1 ...
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GMM-11: Genetically Modified Model Report on Dichloroacetic Acid... 1.2MB
https://ntp.niehs.nih.gov/go/gmm11
... J.E., and Tennant, R.W. (1998). Photocarcinogenesis and susceptibility to UV radiation ... Hemizygous Mice in the 26-Week Dermal Study of Dichloroacetic Acid . . . . . . . . . . ...
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TOX-21: 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) 21.5MB
https://ntp.niehs.nih.gov/go/tox021
... J., and Barbier, A. (1982) Experimental study of the protection index of sunscreen ... and Klingman, A.M. (1980) Sunscreens prevent ultraviolet photocarcinogenesis. J. Am. Acad. ...
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TR-002: Trichloroethylene (CASRN 79-01-6) 19.9MB
https://ntp.niehs.nih.gov/go/tr002
... oil Brewer's dried yeast Vitamin A palmitate Irradiated dried yeast (source of ... Zinc oxide 66 Basal Feed Analysis A study of apparent pesticide residues in basal ...
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GMM-06: Genetically Modified Model Report on Sodium Bromate ... 1.1MB
https://ntp.niehs.nih.gov/go/gmm06
... J.E., and Tennant, R.W. (1998). Photocarcinogenesis and susceptibility to UV radiation ... Hemizygous Mice in the 26-Week Dermal Study of Sodium Bromate . . . . . . . . . . . . ...
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ICCVAM Evaluation of In Vitro Test Methods for Assessing Dermal... 3.1MB
https://ntp.niehs.nih.gov/iccvam/docs/dermal_docs/cwgfinal02/cwgfinal.pdf
... number of trials conducted in the validation study minus the non-qualified (NQ) results. ... propionate NORG NC NC NC N/A 27 Methyl palmitate NORG NC NC NC N/A 44 Benzyl acetone NORG ...
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DART-07: Prenatal Development Studies of 2-((1-(4-Phenoxyphenoxy... 1.6MB
https://ntp.niehs.nih.gov/go/dart07
... B-2 B.1. Prenatal Developmental Toxicity Study in Rats Table B-1. Ingredients of NIH-07 ... A 6,062 IU Stabilized vitamin A palmitate or acetate D 5,070 IU D-activated animal ...
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Background Review Document: In Vitro Test Methods for Assessing... 2.4MB
https://ntp.niehs.nih.gov/iccvam/docs/dermal_docs/epis_brd0801.pdf
... number of trials conducted in the validation study minus the non-qualified (NQ) results. ... propionate NORG NC NC NC N/A 27 Methyl palmitate NORG NC NC NC N/A 44 Benzyl acetone NORG ...
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RoC Background Document: Chloramphenicol; Dec. 13-14, 2000 751KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/roc10/chl_no_appendices_508.pdf
... capsules, and chloramphenicol palmitate oral suspension. 21 CFR 522-PART ... However, only one analytic epidemiologic study was available: a case-control study of ...
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RoC Profile: Chloramphenicol; 15th RoC 2021 142KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/chloramphenicol.pdf
... Chloramphenicol in ophthalmic, topical dosage, tablet, capsule, palmitate oral suspension, ... The Aplastic Anemia Study Group. Blood 89(11): 4034-4039. National Toxicology Program, ...
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TR-001: Guidelines for Carcinogen Bioassay in Small Rodents 3.2MB
https://ntp.niehs.nih.gov/go/tr001
... The Technical Report provides a full documentation on the bioassay study of a particular ... Source Stabilized vitamin A palmitate Menadione sodium Choline chloride Calcium ...
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TR-586: CIMSTAR 3800 in F344/NTac Rats and B6C3F1/N Mice and... 2.8MB
https://ntp.niehs.nih.gov/go/tr586
... Quantitation of the mineral oils using GC/FID indicated 0.20% methyl palmitate, 0.78% ... laboratory and the study laboratory at least every 6 months during the 2-year studies. ...
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DART-01: Prenatal Development Studies of Tris(chloropropyl) Phosphate... 911KB
https://ntp.niehs.nih.gov/go/dart01
... target concentration but determined to not affect the quality or integrity of the study. ... A 6,062 IU Stabilized vitamin A palmitate or acetate D 5,070 IU D-activated animal ...
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DART-02: Prenatal Development Studies of 4-Methylcyclohexanemethanol... 1.1MB
https://ntp.niehs.nih.gov/go/dart02
... Prenatal Developmental Toxicity Gavage Study of 4-Methylcyclohexanemethanol Date ... A 5,500,000 IU Stabilized vitamin A palmitate or acetate D 4,600,000 IU D-activated ...
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DART-02: Prenatal Development Studies of 4-Methylcyclohexanemethanol... 1.1MB
https://ntp.niehs.nih.gov/ntp/htdocs/dart/dart02_508.pdf
... Prenatal Developmental Toxicity Gavage Study of 4-Methylcyclohexanemethanol Date ... A 5,500,000 IU Stabilized vitamin A palmitate or acetate D 4,600,000 IU D-activated ...
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DART-03: Prenatal Development Studies of Vinpocetine (CASRN 42971... 1.2MB
https://ntp.niehs.nih.gov/go/dart03
... Rabbits in the Dose Range-finding Gavage Study of Vinpocetine Date Prepared Date Analyzed ... A 6,062 IU Stabilized vitamin A palmitate or acetate D 5,070 IU D-activated animal ...
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DART-04: Prenatal Development Studies of Dimethylaminoethanol... 1006KB
https://ntp.niehs.nih.gov/go/dart04
... Prenatal Developmental Toxicity Gavage Study of Dimethylaminoethanol Bitartrate Date ... A 5,500,000 IU Stabilized vitamin A palmitate or acetate D 3 4,600,000 IU D-activated ...