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1748 results found for "Polysorbate 80".

  1. TR-415: Polysorbate 80 (CASRN 9005-65-6) in F344/N Rats and B6C3F1Mice... 12.2MB

    https://ntp.niehs.nih.gov/go/tr415

    ... Toxicity and carcinogenicity studies were conducted by administering polysorbate 80 (which met all compendia1 specifications) in f e e d to groups of F3WN rats and B6C3Fl mice of ...

  2. Abstract for TR-415 61KB

    https://ntp.niehs.nih.gov/publications/reports/tr/tr415

    5abs Abstract for TR-415 Toxicology and Carcinogenesis Studies of Polysorbate 80 in F344/N Rats and B6C3F1 Mice (Feed Studies) CASRN: 9005-65-6 Chemical Formula: C64H124O26 ...

  3. Target Organs and Levels of Evidence for TR-415 56KB

    https://ntp.niehs.nih.gov/data/tr/400s/tr415levels

    Target Organs and Levels of Evidence for TR-415 Toxicology and Carcinogenesis Studies of Polysorbate 80 (CASRN 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies) Chemical ...

  4. TR-057: beta-TGdR (CASRN 789-61-7) 3.9MB

    https://ntp.niehs.nih.gov/go/tr057

    ... Groups of 35 rats of each sex were administered ß-TGdR in a buffered saline and polysorbate 80 vehicle at one of two doses, either 3.5 or 7 mg/kg body weight, three times per week ...

  5. TR-049: Acronycine (CASRN 7008-42-6) 5.4MB

    https://ntp.niehs.nih.gov/go/tr049

    ... Initially, groups of 35 rats of each sex were administered acronycine at one of two doses, either 7.5 or 15 mg/kg body weight, in a vehicle composed of 0.05% polysorbate 80 in ...

  6. Abstract for TR-49 62KB

    https://ntp.niehs.nih.gov/publications/reports/tr/tr049

    Initially, groups of 35 rats of each sex were administered acronycine at one of two doses, either 7.5 or 15 mg/kg body weight, in a vehicle composed of 0.05% polysorbate 80 in ...

  7. Abstract for TR-57 62KB

    https://ntp.niehs.nih.gov/publications/reports/tr/tr057

    Groups of 35 rats of each sex were administered b-TGdR in a buffered saline and polysorbate 80 vehicle at one of two doses, either 3.5 or 7 mg/kg body weight, three times per week ...

  8. Minutes: BSC TRRS; July 9, 1991 979KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1991/july/trrs9july1991mins_508.pdf

    l f o n i c Acid Ethylene Glycol H C Yellow 4 Mercuric Chloride p-Ni trophenol Polysorbate 80 1,2,3-Trichloropropane Short-Term T o x i c i t y Studies Black Newsprint I n k ...

  9. TR-059: Estradiol Mustard (CASRN 22966-79-6) 4.0MB

    https://ntp.niehs.nih.gov/go/tr059

    ... The vehicle used for the test chemical con- sisted of 0.05% polysorbate 80 in phosphate-buffered saline. The rats and mice were dosed three times per week for 52 weeks, then ...

  10. TR-060: Phenesterin (CASRN 3546-10-9) 4.1MB

    https://ntp.niehs.nih.gov/go/tr060

    ... The vehicle used was 0.05% polysorbate 80 in buffered saline. Controls consisted of groups of 10 rats of each sex which received the vehicle (vehicle control) and 10 rats of each ...

  11. TR-072: Phenoxybenzamine Hydrochloride (CASRN 63-92-3) 3.0MB

    https://ntp.niehs.nih.gov/go/tr072

    ... The vehicle used for most of the period of the bioassay was 6% propylene glycol in saline, although other vehicles, including 0.05% polysorbate 80 in saline, were used at the ...

  12. Abstract for TR-59 62KB

    https://ntp.niehs.nih.gov/publications/reports/tr/tr059

    The vehicle used for the test chemical consisted of 0.05% polysorbate 80 in phosphate-buffered saline. The rats and mice were dosed three times per week for 52 weeks, then observed ...

  13. Abstract for TR-60 62KB

    https://ntp.niehs.nih.gov/publications/reports/tr/tr060

    The vehicle used was 0.05% polysorbate 80 in buffered saline. Controls consisted of groups of 10 rats of each sex which received the vehicle (vehicle control) and 10 rats of each ...

  14. Abstract for TR-72 60KB

    https://ntp.niehs.nih.gov/publications/reports/tr/tr072

    The vehicle used for most of the period of the bioassay was 6% propylene glycol in saline, although other vehicles, including 0.05% polysorbate 80 in saline, were used at the ...

  15. GMM-14: Genetically Modified Model Report on 3'-Azido-3'-Deoxythymidin... 3.2MB

    https://ntp.niehs.nih.gov/go/gmm14

    ... doses of 75/37.5 mg/kg AZT/3TC or the vehicle control mixture of 0.1% polysorbate 80 and 0.2% methylcellulose, the hearts of PND 28 pups treated with AZT/3TC showed ...

  16. Clitoral gland - Inflammation - Nonneoplastic Lesion Atlas 287KB

    https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-female/clitoral-gland/Inflammation

    ... National Toxicology Program. 1992. NTP TR-415. Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP, ...

  17. Eye, Vitreous - Fibrosis - Nonneoplastic Lesion Atlas 293KB

    https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/eye/Vitreous-Fibrosis

    ... National Toxicology Program. 1992. NTP TR-415. Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP, ...

  18. Eye, Iris - Synechia - Nonneoplastic Lesion Atlas 291KB

    https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/eye/Iris-Synechia

    ... National Toxicology Program. 1992. NTP TR-415. Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP, ...

  19. Clitoral Gland - Infiltration Cellular 420KB

    https://ntp.niehs.nih.gov/sites/default/files/nnl/female_reproductive/clitoral_gland/inflamm/clitoral-gland-inflammation-pdf-508.pdf

    ... National Toxicology Program. 1992. NTP TR-415. Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F 1 Mice (Feed Studies). ...

  20. Eye, Iris - Synechia 410KB

    https://ntp.niehs.nih.gov/sites/default/files/nnl/special_senses/eye/irsyn/eye-iris-synechia_508.pdf

    ... National Toxicology Program. 1992. NTP TR-415. Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F 1 Mice (Feed Studies). ...

  21. Eye, Vitreous - Fibrosis 529KB

    https://ntp.niehs.nih.gov/sites/default/files/nnl/special_senses/eye/vtfibr/eye-vitreous-fibrosis_508.pdf

    ... NTP, Research Triangle Park, NC. Abstract: http://ntp.niehs.nih.gov/go/7694 National Toxicology Program. 1992. NTP TR-415. Toxicology and Carcinogenesis Studies of Polysorbate 80 ...

  22. TR-372: 3,3'-Dimethoxybenzidine Dihydrochloride (CASRN 20325... 12.7MB

    https://ntp.niehs.nih.gov/go/tr372

    ... The ve- hicle was a proprietary mixture composed of so- dium chloride, sodium carboxymethylcellulose, polysorbate 80, and benzyl alcohol in water. The animals were exposed for 52 ...

  23. GMM-16: Genetically Modified Model Report on Study of Mixtures... 5.4MB

    https://ntp.niehs.nih.gov/go/gmm16

    ... doses of 75/37.5 mg/kg AZT/3TC or the vehicle control mixture of 0.1% polysorbate 80 and 0.2% methylcellulose, the hearts of PND 28 pups treated with AZT/3TC showed ...

  24. TR-128: 3,3'-Dimethoxybenzidine-4,4'-diisocyanate (CASRN 91-93... 3.6MB

    https://ntp.niehs.nih.gov/go/tr128

    ... weeks of the bioassay.) * Steroid suspending vehicle = 9 gm NaCl, 5 gm carboxymethylcellulose, ~4 ml polysorbate 80, and 9 ml benzyl alcohol q.s. to 1 liter with distilled water. ...

  25. TR-522: Transplacental AZT (CASRN 30516-87-1) in Swiss (CD-1... 2.1MB

    https://ntp.niehs.nih.gov/go/tr522

    ... doses of 75/37.5 mg/kg AZT/3TC or the vehicle control mixture of 0.1% polysorbate 80 and 0.2% methylcellulose, the hearts of PND 28 pups treated with AZT/3TC showed ...

  26. NTP Technical Reports Index 1.5MB

    https://ntp.niehs.nih.gov/data/tr

    ... Evidence P Clear Evidence P Clear Evidence SE Some Evidence TR-415 07/10/91 Polysorbate 80 (Glycol) 9005-65-6 EE Equivocal Evidence NE No Evidence NE No Evidence NE No Evidence ...

  27. RoC Profile: Cyclosporin A; 15th RoC 2021 128KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/cyclosporina.pdf

    ... preparations contain 33% alcohol and a castor-oil vehicle; and topi- cal preparations may contain glycerin, castor oil, polysorbate 80, car- bomer 1342, and sodium hydroxide. ...

  28. Monograph on Potential Human Reproductive and Developmental Effects... 2.4MB

    https://ntp.niehs.nih.gov/go/fluoxetine_monograph

    ... In addition to the above ingredients, the 10 mg tablet contains FD&C Blue No. 1 aluminum lake and polysorbate 80. The oral solution contains fluoxetine HCl equivalent to 20 mg ...

  29. TR-405: C.I. Acid Red 114 (CASRN 6459-94-5) in F344/N Rats (Drinking... 12.7MB

    https://ntp.niehs.nih.gov/go/tr405

    ... The vehicle was a proprietary mixture composed o f sodium chloride, sodium carboxymethylcellulose, polysorbate 80, and benzyl alcohol in water. The animals were exposed for 52 ...

  30. CERHR Update on the Reproductive and Developmental Toxicity of... 4.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/dehp/dehp-monograph.pdf

    ... A.1.m.segment.of.PVC.tubing.was.used.to.measure.DEHP.release.into.polysorbate.80.solutions. (64)..Physiological.saline.and.distilled.water.solutions.of.polysorbate.80.resulted.in.g...

  31. TR-390: 3,3'-Dimethylbenzidine Dihydrochloride (CASRN 612-82... 12.3MB

    https://ntp.niehs.nih.gov/go/tr390

    ... The vehicle was a propri- etary mixture composed o f NaCl, carboxymethyl- cellulose, polysorbate 80, and benzyl alcohol in water. Animals received these dose formulations for 52 ...

  32. TR-452: 2,2-Bis(Bromomethyl)-1,3-Propanediol (FR-1138) (CASRN... 31.1MB

    https://ntp.niehs.nih.gov/go/tr452

    ... 0/50 o-Nitroanisole 1/50 0/50 3/50 0/50 p-Nitrobenzoie Acid 0/50 0/50 3/50 0.50 Polysorbate 80 0/50 0/50 2/50 0/50 Rhodamine 6G 0/50 0/50 1/50 0/50 Roxarsone 0/50 0/50 4/50 0/50 ...

  33. Study Reports 1.0MB

    https://ntp.niehs.nih.gov/publications/reports

    ... Technical Report TR-415 PDF (12.19 MB) Toxicology and Carcinogenesis Studies of Polysorbate 80 (CASRN 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1992 Technical Report ...

  34. Toxicology/Carcinogenicity 1.1MB

    https://ntp.niehs.nih.gov/whatwestudy/testpgm/cartox

    ... Carcinogenicity TR-415 PDF (12.19 MB) Toxicology and Carcinogenesis Studies of Polysorbate 80 (CASRN 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1992 Long-Term ...

  35. Technical Reports 862KB

    https://ntp.niehs.nih.gov/publications/reports/tr

    ... Technical Report TR-415 PDF (12.19 MB) Toxicology and Carcinogenesis Studies of Polysorbate 80 (CASRN 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1992 Technical Report ...

  36. TR-463: D&C Yellow No. 11 (CASRN 8003-22-3) in F344 Rats (Feed... 12.5MB

    https://ntp.niehs.nih.gov/go/tr463

    ... 0/50 0/50 0/50 o-Nitroanisole 0/50 0/50 0/50 p-Nitrobenzoic Acid 2/49 3/49 4/49 Polysorbate 80 2/50 0/50 2/50 Overall Historical Incidence Total 30/1,301 (2.3%) 9/1,301 (0.7%) 37/...

  37. RoC Background Document: Dyes Metabolized to 3,3'-Dimethoxybenzidine... 2.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/roc10/dmob_no_appendices_508.pdf

    ... A proprietary mixture composed of sodium chloride, sodium carboxymethylcellulose polysorbate 80, and benzyl alcohol in water was used as a vehicle in this study. No controls were ...

  38. TR-407: C.I. Pigment Red 3 (CASRN 2425-85-6) in F344/N Rats and... 15.9MB

    https://ntp.niehs.nih.gov/go/tr407

    ... Study Benign H b t o r i d Incidene at Southern Research Institute C.I.PigmentRed 3 Nitrofurantoin o-Nitroanisole Polysorbate 80 Rhodamine 6 G Roxamne Total Standard deviation ...

  39. TR-416: o-Nitroanisole (CASRN 91-23-6) in F344 Rats and B6C3F1... 24.5MB

    https://ntp.niehs.nih.gov/go/tr416

    ... at Southern Research Institute C.I. Pigment Red 3 Nitrofuratoin o-Nitroanisole Polysorbate80 Rhodamine 6G Roxarsone Overall Historical Incidence Total Standard deviation Range a ...

  40. TR-442: p-Nitrobenzoic Acid (CASRN 62-23-7) in F344/N Rats and... 15.9MB

    https://ntp.niehs.nih.gov/go/tr442

    ... C.I. Pigment Red 3 0/50 0/50 0/50 1/50 0/50 1/50 o-Nitroanisole 0/49 0/49 0/49 Polysorbate 80 0/50 1/50 1/50 Rhodamine 6G 0150 0/50 0/50 Roxarsone 1/50 1/50 2/50 Total 1B99 (0.3%) ...

  41. TR-503: Chloral Hydrate (Ad Libitum and Dietary Controlled) ... 1.4MB

    https://ntp.niehs.nih.gov/go/tr503

    ...o-2,2N-stilbenedisulfonic Acid, Disodium Salt Feed 413 Ethylene Glycol Feed 415 Polysorbate 80 Feed 428 Manganese (II) Sulfate Monohydrate Feed Studies with Single Housing 362 ...

  42. Japanese Minimum Requirements for Biological Products 2.0MB

    https://ntp.niehs.nih.gov/iccvam/methods/biologics/vaccine/japan-minreqs.pdf

    ... be reconstituted in accordance with the description on the label, and then diluted 2×10 6 times using Sauton's liquid medium containing 0.025% polysorbate 80 as the test solution. ...

  43. TR-413: Ethylene Glycol (CASRN 107-21-1) in B6C3F1Mice (Feed... 11.1MB

    https://ntp.niehs.nih.gov/go/tr413

    ... 0/54 0/54 0/54 Nitrofurantoin 2/50 0150 2/50 o-Nitroanisole 9/50 1/50 lOl50 Polysorbate 80 0149 0/49 0/49 Rhodamine 6G 7/50 0150 7/50 Roxarsone 1/50 0/50 1/50 Total 211353 ...

  44. ICCVAM Background Review Document (Vol 2): In Vitro Cytotoxicity... 61.6MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/brd_tmer/brdvol2_nov2006.pdf

    ... 100- 110 g male oral suspended in 0.25% carboxymethylcellulose with 0.2% polysorbate 80; doses in geometrical progression observed for 7 days post-treatment; rats presented ...

  45. Independent Peer Review Evaluation of the Murine Local Lymph... 13.1MB

    https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna/llnarep.pdf

    ... chloride 36727-29- 4 acylating agent + + Ashby et al. (1995) Tween 80// Polysorbate 80// Polyoxyethylenesorbitan oleate 9005-65-6 polyoxyethylene sorbitan ester polyol ...

  46. TR-417: p-Nitrophenol (CASRN 100-02-7) in Swiss Webster Mice... 7.4MB

    https://ntp.niehs.nih.gov/go/tr417

    ...-2,2'-Stilknedisulfonic Acid 370 Benzofuran 413 Ethylene Glycol 371 Toluene 415 Polysorbate 80 312 3,3'-Dimethoxyknzidine Dihydrochloride 419 HC Hellow4 373 Succinic Anhydride ...

  47. TR-511: Dipropylene Glycol (CASRN 25265-71-8) in F344/N Rats... 3.0MB

    https://ntp.niehs.nih.gov/go/tr511

    ... FF-1) (Gavage) 244 Polybrominated Biphenyl Mixture (Firemaster FF-1) (Feed) 398 Polysorbate 80 (Glycol) 415 Polyvinyl Alcohol 474 Primidone 476 Probenecid 395 Promethazine ...

  48. TR-385: Methyl Bromide (CASRN 74-83-9) in B6C3F1Mice (Inhalation... 7.3MB

    https://ntp.niehs.nih.gov/go/tr385

    ... 396 399 405 415 Monochloroacetic Acid Titanocene Dichloride C.I. Acid Red 114 Polysorbate 80 These NTP Technical Reports are available for sale from the National Technical ...

  49. TR-433: Tricresyl Phosphate (CASRN 1330-78-5) in F344/N Rats... 24.1MB

    https://ntp.niehs.nih.gov/go/tr433

    ...mino-2,2-stilbenedisulfonic Acid 413 Ethylene Glycol 414 Pentachloroanisole 415 Polysorbate 80 416 o-Nitroanisole 417 p-Nitrophenol 418 p-Nitroaniline 419 HC Yellow 4 420 ...

  50. TR-414: Pentachloroanisole (CASRN 1825-21-4) in F344 Rats and... 15.1MB

    https://ntp.niehs.nih.gov/go/tr414

    ...Z,2'-Stilbenedisulfonic Acid 370 Benzofuran 413 Ethylene Glycol 371 Toluene 415 Polysorbate 80 372 3,3'-Dimethoxybenzidine Dihydruchloride 419 H C Hellow 4 373 Succinic Anhydride ...

 
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