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213 results found for "Trichloroethylene (TCE)".

  1. RoC Background Document: Trichloroethylene (TCE); Oct. 30-31... 3.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/other_background/trichl_tce1997_2apps_508.pdf

    ... D-1 v NTP Report on Carcinogens 1997 Background Document for Trichloroethylene NTP Report on Carcinogens Listing For Trichloroethylene Carcinogenicity Trichloroethylene (TCE) is ...

  2. Abstract for TR-243 59KB

    https://ntp.niehs.nih.gov/publications/reports/tr/tr243

    Trichloroethylene (TCE) is an industrial solvent used for vapor degreasing and cold cleaning of fabricated metal parts. TCE has also been used as a carrier solvent for the active ...

  3. RoC Monograph: Trichloroethylene; January 2015 4.6MB

    https://ntp.niehs.nih.gov/go/rocmgraph05

    .........1 Figure 1-1. Oxidative Metabolism of Trichloroethylene (TCE) ......11 Figure 1-2. ...

  4. RoC Profile: Trichloroethylene; 15th RoC 2021 237KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/trichloroethylene.pdf

    First listed in the Ninth Report on Carcinogens (2000) Also known as 1,1,2-trichloroethene or TCE H C C Cl Cl Cl Carcinogenicity Trichloroethylene is known to be a human carcinogen ...

  5. Abstract for TR-2 58KB

    https://ntp.niehs.nih.gov/publications/reports/tr/tr002

    CASRN: 79-01-6 Chemical Formula: C2HCl3 Molecular Weight: 131.40 Synonyms/Common Names: trichloroethene; acetylene trichloride; ethinyl trichloride; 1,1,2-trichloroethylene, TCE ...

  6. Abstract for RoC MGRAPH-05 55KB

    https://ntp.niehs.nih.gov/publications/roc/rocmgraph05

    CASRN: 79-01-6 Chemical Formula: C2HCl3 Molecular Weight: 131.4 Synonyms/Common Names: TCE; TRI; 1,1,2-trichloroethylene; trichloroethene; ethylene trichloride; acetylene ...

  7. Abstract for RACB84113 56KB

    https://ntp.niehs.nih.gov/publications/abstracts/repro/racb84113

    Trichloroethylene (TCE), a common industrial solvent and dry cleaning agent, was tested for its effects on reproduction and fertility in Swiss CD-1 mice using the RACB protocol. ...

  8. Abstract for RACB84112 56KB

    https://ntp.niehs.nih.gov/publications/abstracts/repro/racb84112

    Trichloroethylene (TCE), a common industrial solvent and dry cleaning agent, was tested for its effects on reproduction and fertility in Fisher 344 rats using the RACB protocol. ...

  9. RoC Concept: Trichloroethylene 729KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/thirteenth/concepts/tce_revised_concdocroc12-31-13_508.pdf

    RoC Concept: Trichloroethylene (August 2012) 1 Project Leader: Ruth Lunn, DrPH, Office of the RoC (ORoC), DNTP, NIEHS 1. Rationale Trichloroethylene (TCE) is a volatile chlorinated ...

  10. TR-243: Trichloroethylene (Without Epichlorohydrin) (CASRN 79... 7.8MB

    https://ntp.niehs.nih.gov/go/tr243

    ... C2HC13 Mol. Wt. 131.40 ABSTRACT Carcinogenesis studies of epichlorohydrin-free trichloroethylene (TCE) were conducted by administering the test chemical in corn oil by gavage to ...

  11. TR-002: Trichloroethylene (CASRN 79-01-6) 19.9MB

    https://ntp.niehs.nih.gov/go/tr002

    ... SUMMARY Trichloroethylene (TCE), a halogenated chemical, has been tested for carcinogenicity in the National Cancer Institute's Carcinogenesis Bioassay Program. Trichloroethylene ...

  12. Protocol: Methods for preparing the RoC Monograph: TCE 1.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/thirteenth/protocols/tce_final20140625_508.pdf

    ... Substance-specific search terms 3 Epidemiologic search terms Cancer search terms ((trichloroethylene) OR TCE) OR trichloroethene) OR "acetylene trichloride") OR "ethylene ...

  13. Protocol: Methods for preparing the draft RoC Monograph: TCE 1.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/thirteenth/protocols/tce_protocol12-31-13_508.pdf

    ... search terms 3 Epidemiologic search terms Cancer search terms ((trichloroethylene) OR TCE) OR trichloroethene) OR "acetylene trichloride") OR "ethylene trichloride")) OR ...

  14. Nomination Background: Dichloroacetic acid (CASRN: 79-43-6) 6.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/chem_background/exsumpdf/dcaa_508.pdf

    ... In an Italian study, 141 blood donors were analyzed for plasma and urinary levels of TCA and trichloroethanol (TCEH) from exposure to different levels of trichloroethylene (TCE) ...

  15. RoC Review of Trichloroethylene (TCE) 70KB

    https://ntp.niehs.nih.gov/research/assessments/cancer/completed/tce

    1176 RoC Review of Trichloroethylene (TCE) Large blue drums of trichloroethylene Substance Overview CASRN: 79-01-6 Status: RoC: Known to be a human carcinogen Profile: ...

  16. Agenda: ORoC Public Webinar Human Cancer Studies on Exposure... 427KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/thirteenth/webinars/2014/tce_agenda20140317_508.pdf

    Logistics Presentations: Human Cancer Studies on Trichloroethylene (TCE) Each presentation will be followed by a short question and answer period specific for the presentation. ...

  17. 15th RoC: Acronyms 49KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/acronyms_508.pdf

    ... T thymine TCBQ tetrachlorobenzoquinone TCDD tetrachlorodibenzo-p-dioxin TCE trichloroethylene TCHQ tetrachlorohydroquinone TCLP toxicity characteristic leaching procedure ...

  18. Actions: RoC Peer Review; Aug. 12, 2014 41KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2014/august/actions20140812_508.pdf

    Actions from Peer Review of the Draft Report on Carcinogens (RoC) Monograph for Trichloroethylene (TCE) August 12, 2014 The NTP Monograph Peer-Review Panel ("the Panel") was ...

  19. Acronyms & Abbreviations 75KB

    https://ntp.niehs.nih.gov/support/acronyms

    ... Supplement T Thymine Tumor TCBQ Tetra-chloro-benzo-quinone TCDD Tetra-chloro-dibenzo-p-dioxin TCE Trichloroethylene TCHQ Tetra-chloro-hydro-quinone TCLP Toxicity characteristic ...

  20. Handbook on Methods for Conducting Cancer Hazard Evaluations... 5.2MB

    https://ntp.niehs.nih.gov/sites/default/files/2025-05/handbook_roc_508.pdf

    ... Increased estrogen levels associated with night shift work . Hormone-receptor positive tumors Sources: NTP (2021a; 2021h). TCE = trichloroethylene; GSH = glutathione conjugation; ...

  21. Agenda: Peer Review of Draft RoC Monograph: Trichloroethylene... 64KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2014/august/agenda20140812_508.pdf

    Peer Review of Draft Report on Carcinogens (RoC) Monograph on Trichloroethylene (TCE) Agenda August 12, 2014 National Institute of Environmental Health Sciences (NIEHS) Rodbell ...

  22. 15th RoC: Appendix F 165KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/appendix_f.pdf

    ... TCDD see 2,3,7,8-Tetrachlorodibenzo-p-dioxin 2,3,7,8-TCDD see 2,3,7,8-Tetrachlorodibenzo-p-dioxin TCE see Trichloroethylene TDI see Toluene Diisocyanates TEPA see Thiotepa TFE see ...

  23. Appendices A-G; 15th RoC 2021 433KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/appendices_508.pdf

    ... TCDD see 2,3,7,8-Tetrachlorodibenzo-p-dioxin 2,3,7,8-TCDD see 2,3,7,8-Tetrachlorodibenzo-p-dioxin TCE see Trichloroethylene TDI see Toluene Diisocyanates TEPA see Thiotepa TFE see ...

  24. TR-273: Trichloroethylene (CASRN 79-01-6) in Four Strains of... 16.9MB

    https://ntp.niehs.nih.gov/go/tr273

    ... R.; Guengerich, F. (1982) Oxidation of TCE by liver microsomal cytochrome p-450: Evidence for chlorine migration in a transition state not involving trichloroethylene oxide. ...

  25. Public Health Impact 1.9MB

    https://ntp.niehs.nih.gov/media/impact

    ... Type: Notice; request for public comment January 11, 2017 82 FR 3518 7775-09-9 631-64-1 5589-96-8 71133-14-7 7681-49-4 2017 EPA Trichloroethylene (TCE); Regulation of Use in Vapor ...

  26. TOX-45: Renal Selected Halogenated Ethanes 1.2MB

    https://ntp.niehs.nih.gov/go/tox045

    ... (mmol/kg) 0.62 1.24 MALE Part A 1,1,2,2-TCE 1,1,1,2-TCE PCE 0.40 ± 0.10 0.067 ± 0.018 ... , perchloroethylene, and trichloroethylene indicated that pentachloroethane was ...

  27. TOX-49: Toxicity Studies of 1,1,2,2-Tetrachloroethane (CASRN... 1.2MB

    https://ntp.niehs.nih.gov/go/tox049

    ... sym-tetrachloroethane; TCE; 1,1,2,2-TCE; tetrachloroethane Trade ... was the production of trichloroethylene, tetrachloroethylene, and ...

  28. Response to Comments: NASEM Review of the Revised NTP Monograph... 456KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/nasem/response202204.pdf

    ... an Occupational Exposure Limit for TCE. She received an MS in environmental ... the EPA Science Advisory Board on trichloroethylene and Libby amphibole asbestos, and ...

  29. TOX-59: Chloral Hydrate (CASRN 302-17-0) 10.8MB

    https://ntp.niehs.nih.gov/go/tox059

    ... The pharmacokinetics and macromolecular interactions of trichloroethylene in mice and ... (µM) max AUC (µmol C C hour) Chloral TCA TCE TCE Chloral TCA TCE TCE hydrate glucuronide ...

  30. TOX-41: Toxicity Studies of 1,1,1-Trichloroethane (CASRN 71-55... 1.3MB

    https://ntp.niehs.nih.gov/go/tox041

    ... trichloromethane; "-trichloroethane; 1,1,1-TCE 1,1,1-Trichloroethane is a widely used ... Embryo and fetotoxicity of inhaled trichloroethylene, perchloroethylene, ...

  31. Documents Provided to the NTP Board of Scientific Counselors... 55.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/fluoride/documents_provided_bsc_wg_031523.pdf

    ... an Occupational Exposure Limit for TCE. She received an MS in environmental ... the EPA Science Advisory Board on trichloroethylene and Libby amphibole asbestos, and ...

  32. TR-429: Diethylphthalate (CASRN 84-66-2) in F344/N Rats and B6C3F1Mice... 12.5MB

    https://ntp.niehs.nih.gov/go/tr429

    ... 42t TABLE DS Summary of the Incide1;tce of Non.neoplastic Lesions in Female Mice in the t. ... CHEMICAL 2,3, 7 ,8-Tetrachlorodibenzop-dioxin (Dermal) 273 Trichloroethylene (Four Rat ...

  33. Abstract for TR-273 59KB

    https://ntp.niehs.nih.gov/publications/reports/tr/tr273

    Toxicology and Carcinogenesis Studies of Trichloroethylene in Four Strains of Rats (ACI, August, Marshall, Osborne-Mendel) (Gavage Studies) CASRN: 79-01-6 Chemical Formula: C2HCl3 ...

  34. Trichloroethylene: Target Organs and Levels of Evidence for TR... 51KB

    https://ntp.niehs.nih.gov/data/tr/000s/tr002levels

    2 Trichloroethylene: Target Organs and Levels of Evidence for TR-002 Carcinogenesis Bioassay of Trichloroethylene (CASRN 79-01-6) Chemical (Study Title) CASRN Peer Review Date ...

  35. Target Organs and Levels of Evidence for TR-273 52KB

    https://ntp.niehs.nih.gov/data/tr/200s/tr273levels

    Target Organs and Levels of Evidence for TR-273 Toxicology and Carcinogenesis Studies of Trichloroethylene (CASRN 79-01-6) in Four Strains of Rats (ACI, August, Marshall, ...

  36. Target Organs and Levels of Evidence for TR-243 51KB

    https://ntp.niehs.nih.gov/data/tr/200s/tr243levels

    Target Organs and Levels of Evidence for TR-243 Carcinogenesis Studies of Trichloroethylene (Without Epichlorohydrin) (CASRN 79-01-6) in F344/N Rats and B6C3F1 Mice (Gavage ...

  37. Abstract for TOX-49 60KB

    https://ntp.niehs.nih.gov/publications/reports/tox/tox049

    Acetylene tetrachloride; 1,1-dichloro-2,2-dichloroethane; sym-tetrachloroethane; TCE; 1,1,2,2-TCE; tetrachloroethane Report Date: March 2004 Full Report PDF Abstract ...

  38. NTP Response to Peer Review report: RoC Peer Review; Aug. 12... 226KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2014/august/ntpresponsereporttceoct23_508.pdf

    Report on Carcinogens Monograph on Trichloroethylene Public Meeting August 12, 2014 ......... 1 Trichloroethylene Peer-Review Panel ...

  39. Abstract for TOX-41 57KB

    https://ntp.niehs.nih.gov/publications/reports/tox/tox041

    CASRN: 71-55-6 Chemical Formula: C2H3Cl3 Molecular Weight: 133.40 Synonyms/Common Names: Chloroethene; methylchloroform; methyl trichloromethane; alpha-trichloroethane; 1,1,1-TCE ...

  40. Abstract for TOX-59 61KB

    https://ntp.niehs.nih.gov/publications/reports/tox/tox059

    One of its metabolites, trichloroacetic acid, has demonstrated hepatocarcinogenic activity in mice. Trichloroethylene and perchloroethylene, both of which are metabolized to ...

  41. Abstract for TR-3 56KB

    https://ntp.niehs.nih.gov/publications/reports/tr/tr003

    In 1959, Browning reported that 1,1,2-trichloroethane was replacing the more toxic industrial solvents: trichloroethylene, tetrachloroethylene, and carbon tetrachloride. The ...

  42. Abstract for TR-237 58KB

    https://ntp.niehs.nih.gov/publications/reports/tr/tr237

    50 female B6C3F1 mice at doses of 250 or 500 mg/kg. (1,1,1,2-tetrachloroethane is used as a chemical intermediate in the production of trichloroethylene and tetrachloroethylene). ...

  43. TR-503: Chloral Hydrate (Ad Libitum and Dietary Controlled) ... 1.4MB

    https://ntp.niehs.nih.gov/go/tr503

    ... Trichloroethylene is oxidized to chloral hydrate by cytochrome P450 (Miller and ... et al., 1990, 1993). However, trichloroethylene appears to be a suicide substrate ...

  44. TOX-35: Chemical Mixture of 25 Groundwater Contaminants 11.5MB

    https://ntp.niehs.nih.gov/go/tox035

    ... 1 .25 0 .06 0 .2 0 .6 2 Trichloroethylene 3 .82 0 .195 0 .65 1 .95 6 .5 ... 71-55-6 1 .25 0 .06 0 .2 0 .6 2 Trichloroethylene 79-01-6 3 .82 0 .195 0 .65 1 .95 6 ...

  45. TR-000: Technical Grade Chlordecone (Kepone) (CASRN 143-50-0... 994KB

    https://ntp.niehs.nih.gov/go/tr000kepone

    ... HIGH DOSE 5(11*) 2(4*) 1 1 1(2*) 1(2*) 1 1(2*) 1 1(2*) 1(2*) 20 TABLE IV. Number of M-tce with Tumors by Anatomic Site (Chiordecone) (Percentages by System and by Organ Are Based ...

  46. TR-232 Carcinogenesis Studies of Pentachloroethane (CASRN 76... 7.3MB

    https://ntp.niehs.nih.gov/go/tr232

    ... is metabolized to trichloroethylene, which was positive for carcinogenicity in a n earlier bioassay. In that study, trichloroethylene was contaminated with ...

  47. TR-502: Chloral Hydrate (CASRN 302-17-0) in B6C3F1 Mice (Gavage... 1.9MB

    https://ntp.niehs.nih.gov/go/tr502

    ... Irreversible binding of 14 C-labelled trichloroethylene to mice liver constituents in vivo ... Tumorigenicity of chloral hydrate (CH), trichloroacetic acid (TCA), trichloroethanol (TCE)...

  48. Monographs 64KB

    https://ntp.niehs.nih.gov/publications/monographs

    RoC 2018 Cobalt and Cobalt Compounds That Release Cobalt Ions In Vivo Monograph (Abstract) RoC 2016 Epstein-Barr Virus (EBV) Monograph (Abstract) RoC 2016 Trichloroethylene (TCE) ...

  49. Abstract for TR-55 56KB

    https://ntp.niehs.nih.gov/publications/reports/tr/tr055

    synthesis of the chlorinated solvents 1,1,1-trichloroethane, trichloroethylene, and perchloroethylene and as a constituent of rubber cements and acrylic-type adhesive formulations. ...

  50. Agenda: BSC; June 21-22, 2012 77KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2012/june/agenda20120622_508.pdf

    Eastmond 2:00 - Cumene . Public Comments . BSC Discussion Dr. Jahnke Dr. Eastmond 2:45 BREAK 3:15 - Trichloroethylene . Public Comments . BSC Discussion Dr. Lunn Dr. Eastmond 4:00 ...

 
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