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TR-575: Acrylamide (CASRN 79-06-1) in F344/N Rats and B6C3F1... 3.9MB
https://ntp.niehs.nih.gov/go/tr575
acRylamide (cas No. 79-06-1) iN f344/N RaTs aNd B6c3f1 mice (feed aNd dRiNkiNg WaTeR sTudies) NTP TR 575 JULY 2012 NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES ...
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CERHR Monograph: Potential Human Reproductive and Developmental... 4.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/acrylamide/acrylamide_monograph.pdf
Effects of Acrylamide February 2005 NIH Publication No. 05 - 4472 iii Table of Contents Preface ...... v Introduction .... vi NTP Brief on Acrylamide ...
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RoC Profile: Acrylamide; 15th RoC 2021 154KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/acrylamide.pdf
Acrylamide CAS No. 79-06-1 Reasonably anticipated to be a human carcinogen First listed in the Sixth Annual Report on Carcinogens (1991) Also known as 2-propenamide H 2 C H C C NH ...
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Abstract for TR-575 71KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr575
Abstract for TR-575 Toxicology and Carcinogenesis Studies of Acrylamide in F344/N Rats and B6C3F1 Mice (Feed and Drinking Water Studies) CASRN: 79-06-1 Chemical Formula: C3H5NO ...
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Abstract for TER88048 53KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter88048
8abs Abstract for TER88048 Acrylamide Administered to Sprague Dawley (CD) Rats on Gestational Days 6 Through 20 CASRN: 79-06-1 Chemical Formula: C3H5NO Molecular Weight: 71.0785 ...
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Abstract for TER89049 53KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter89049
9abs Abstract for TER89049 Acrylamide Administered to Swiss CD-1 Mice on Gestational Days 6 Through 17 CASRN: 79-06-1 Chemical Formula: C3H5NO Molecular Weight: 71.079 Report Date: ...
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Abstract for RACB90022 54KB
https://ntp.niehs.nih.gov/publications/abstracts/repro/racb90022
2abs Abstract for RACB90022 Acrylamide: Reproductive Toxicity in CD-1 Swiss Mice CASRN: 79-06-1 Chemical Formula: C3H5NO Molecular Weight: 71.079 Report Date: January 1993 Abstract ...
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Abstract for RACB90016 53KB
https://ntp.niehs.nih.gov/publications/abstracts/repro/racb90016
Methylenebisacrylamide (MBA), a crosslinker and congener of acrylamide, was evaluated for ... MBA was tested as one of a series of acrylamide congeners with varying degrees of ...
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Abstract for TR-588 74KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr588
Glycidamide is a reactive electrophile that occurs primarily as a metabolite of acrylamide. Because acrylamide can be formed as a by-product during the cooking of starchy foods ...
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Target Organs and Levels of Evidence for TR-575 54KB
https://ntp.niehs.nih.gov/data/tr/500s/tr575levels
Target Organs and Levels of Evidence for TR-575 Toxicology and Carcinogenesis Studies of Acrylamide (CASRN 79-06-1) in F344/N Rats and B6C3F1 Mice (Feed and Drinking Water Studies) ...
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Abstract for RACB90017 57KB
https://ntp.niehs.nih.gov/publications/abstracts/repro/racb90017
N'(Hydroxymethyl)-acrylamide (HACR) was evaluated for reproductive toxicity, neurotoxicity, and dominant lethal effects using a modified Reproductive Assessment by Continuous ...
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Abstract for RACB90018 53KB
https://ntp.niehs.nih.gov/publications/abstracts/repro/racb90018
Methacrylamide (MACR), a congener of acrylamide, was tested for reproductive toxicity, neurotoxicity, and dominant lethal effects in Swiss CD-1 mice using the Continuous Breeding ...
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TR-588: Glycidamide (CASRN 5694-00-8) in F344/N Nctr Rats and... 3.5MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr588_508.pdf
... Table 42. Comparison of Mean Daily Acrylamide and Glycidamide Consumption in Male and ... Female F344/N Nctr Rats Administered Acrylamide or Glycidamide in Two-year Drinking ...
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Minutes: TRPRP; Apr. 5, 2011 272KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2011/april/minutes20110405.pdf
and Carcinogenesis Studies of Acrylamide in F344/N Rats and B6C3F1 Mice (NTP TR ... VI. Draft NTP Technical Report on the Toxicology and Carcinogenesis Studies of Acrylamide ...
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TR-588: Glycidamide (CASRN 5694-00-8) in F344/N Nctr Rats and... 3.5MB
https://ntp.niehs.nih.gov/go/tr588
... Table 42. Comparison of Mean Daily Acrylamide and Glycidamide Consumption in Male and ... Female F344/N Nctr Rats Administered Acrylamide or Glycidamide in Two-year Drinking ...
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TR-352: N-Methylolacrylamide (CASRN 924-42-5) in F344/N Rats... 27.2MB
https://ntp.niehs.nih.gov/go/tr352
... N-Methylol- acrylamide induced both sister chromatid exchanges (SCEs) and chromosomal ... the draft Technical Report on N-methylol- acrylamide on October 3, 1988, are listed below. ...
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Abstract for TR-506 63KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr506
elastomers, acrylonitrile-butadiene-styrene and styrene-acrylonitrile resins, nitrile rubbers, gas barrier resins, and chemical intermediates such as adiponitrile and acrylamide. ...
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TR-588: Lay Summary; Glycidamide (CASRN 5694-00-8) 203KB
https://ntp.niehs.nih.gov/sites/default/files/2025-02/tr588_summary_508.pdf
generated during metabolism) of acrylamide, a chemical that is produced in the ... Although the toxicity of acrylamide in humans is well documented, the toxicity of ...
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Target Organs and Levels of Evidence for TR-588 55KB
https://ntp.niehs.nih.gov/data/tr/500s/tr588levels
Chemical CASRN (Study Title) Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory Glycidamide 5694-00-8 10/29/2013 Metabolite of acrylamide. Associated with ...
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Public Comment: 2022 SACATM Meeting 131KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/sacatm/2022/cmts/sacatm_2022_metrics_twbl-comments_508.pdf
... never 100% complete, can contain residual neurotoxic acrylamide monomers. Toxic brain encephalopathy, caused by acrylamide monomer poisoning, has affected my daughter's quality ...
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15th RoC: Appendix F 165KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/appendix_f.pdf
carbon see Soots acrylic acid amide see Acrylamide actinolite see Asbestos actinon see ... 1,3-Propane Sultone 2-propenamide see Acrylamide 2-propenenitrile see Acrylonitrile ...
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Public Comment: 2022 SACATM Meeting 80KB
https://ntp.niehs.nih.gov/ntp/about_ntp/sacatm/2022/cmts/sacatm_2022_validation_twbl-comments.pdf
Experimentation with acrylamide has been occurring for decades as has its industrial use. ... demonstrated lower than assumed doses of acrylamide can impact learning and memory. ...
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FAQs & Fact Sheets 61KB
https://ntp.niehs.nih.gov/media/faqs
2024 Nonneoplastic Lesion Atlas Pocket Card Mar 2019 NTP Archives Brochure Apr 2014 Acrylamide FAQ Jun 2024 Air Pollution and Your Health FAQ Apr 2025 Aloe Vera FAQ Aug 2021 ...
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Public Health Impact 1.9MB
https://ntp.niehs.nih.gov/media/impact
... 2024 OEHHA Safe Harbor Warnings for Acrylamide Exposure from Food The Office of ... option for businesses that cause significant exposures to acrylamide from food products. ...
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Developing an in vitro integrated organ model for pharmacokinetic... 3.3MB
https://ntp.niehs.nih.gov/iccvam/meetings/commprac-2023/20230130-iccvam-cop-mckim-508.pdf
... that are naturally pres ent in food Acrylamide Metabolism Three Organ Model Intestine ... 100000 150000 200000 250000 20 40 60 80 Acrylamide - Intestine - HuDMOP Time (hr) ...
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Abstract for TER90008 57KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter90008
The CD-1 mouse was selected as the test animal for this study based on evidence for acrylamide-induced toxicity in other strains/ stocks of mice in the literature, and to ...
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Panel Actions: TRPRP; Apr. 5, 2011 66KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2011/april/actions20110405.pdf
Acrylamide (TR 575) The Panel accepted unanimously the conclusions (6 yes, 0 no, 0 abstentions) as written, clear evidence of carcinogenic activity of acrylamide in male and female ...
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TR-506: Acrylonitrile (CASRN 107-13-1) in B6C3F1 Mice (Gavage... 2.9MB
https://ntp.niehs.nih.gov/go/tr506
... gas barrier resins, and chemical intermediates such as adiponitrile and acrylamide. ... dehydration of ethylene cyanohydrin or acrylamide by phosphorus pentoxide (Brazdil, 1999). ...
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Study Abstracts 368KB
https://ntp.niehs.nih.gov/publications/abstracts
... (CASRN: 109-99-9) in Mice and Rats 1988 Developmental TER88048 Acrylamide Teratologic Evaluation of Acrylamide (CASRN: 791-06-1) Administered to Sprague Dawley (CD) Rats on ...
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NTP at the SOT; March 6, 2005 308KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/meetings/2005/ntpsot2_508.pdf
484 Symposium/Presentation R03 Ghanayem, Burhan Role of CYP2E1 in the Oxidation of Acrylamide (AA) to Glycidamide (GA) and Formation of DNA and Hemoglobin Adducts 361 R01 Gohlke, ...
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Appendix G; 15th RoC 2021 69KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/appendix_g.pdf
... see Lead and Lead Compounds 78-79-5 see Isoprene 79-01-6 see Trichloroethylene 79-06-1 see Acrylamide 79-43-6 (dichloroacetic acid) see Haloacetic Acids Found as Water Disinfection ...
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RoC Profile: Acrylonitrile; 15th RoC 2021 145KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/acrylonitrile.pdf
... resins, 17% for acrylic fibers, 11% for acrylamide, 3% for nitrile elastomers, and 9% for ... Bergmark E. 1997. Hemoglobin adducts of acrylamide and acrylonitrile in laboratory ...
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Spinal cord - Demyelination - Nonneoplastic Lesion Atlas 278KB
https://ntp.niehs.nih.gov/atlas/nnl/nervous-system/spinal-cord/Demyelination
injury and loss, such that axonopathy and demyelination often coexist as a result of axonal injury from classic axonopathic compounds such as organophosphate agents and acrylamide. ...
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Spinal Cord - Demyelination 325KB
https://ntp.niehs.nih.gov/sites/default/files/2025-03/spinal_cord-demyelination_508.pdf
injury and loss, such that axonopathy and demyelination often coexist as a result of axonal injury from classic axonopathic compounds such as organophosphate agents and acrylamide. ...
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Developmental (Teratology) Abstracts 215KB
https://ntp.niehs.nih.gov/publications/abstracts/dev
... (CASRN: 109-99-9) in Mice and Rats 1988 Developmental TER88048 Acrylamide Teratologic Evaluation of Acrylamide (CASRN: 791-06-1) Administered to Sprague Dawley (CD) Rats on ...
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15th Report on Carcinogens 91KB
https://ntp.niehs.nih.gov/research/assessments/cancer/roc
... A Acetaldehyde 2-Acetylaminofluorene Acrylamide Acrylonitrile Adriamycin Aflatoxins Alcoholic Beverage Consumption 2-Aminoanthraquinone o-Aminoazotoluene 4-Aminobiphenyl ...
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Monographs 63KB
https://ntp.niehs.nih.gov/publications/monographs
... All NTP-CERHR Monographs Substance/Topic Year Acrylamide 2005 Amphetamines 2005 Bisphenol A 2008 1-Bromopropane 2003 2-Bromopropane 2003 Ethylene Glycol 2004 Fluoxetine 2004 ...
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Listed Substances; 15th RoC 2021 76KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/listed_substances_508.pdf
... Reasonably Anticipated To Be Human Carcinogens Acetaldehyde 2-Acetylaminofluorene Acrylamide Acrylonitrile Adriamycin 2-Aminoanthraquinone o-Aminoazotoluene ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
... Evidence NE No Evidence NE No Evidence SE Some Evidence TR-575 04/05/11 Acrylamide 79-06-1 P Clear Evidence P Clear Evidence P Clear Evidence P Clear Evidence TR-574 02/08/...
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Developmental Neurotoxicity Screening Assay Chemical List | National... 428KB
https://www.niehs.nih.gov/research/atniehs/dtt/strategic-plan/health/developmental/chemical-list
... Mixture* 115-09-3 DTXSID5020813 Methyl mercuric (II) chloride Mixture* 79-06-1 DTXSID5020027 Acrylamide Mixture* NOCAS_ 1354859 DTXSID101354859 Dieldrin + BDE-47 (2:1 molarity ...
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Minutes: TR Panel; Oct. 29, 2013 234KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2013/october/minutes20131029_508.pdf
... He provided background information on acrylamide, of which glycidamide is a metabolite. ... and compare the long-term effects of acrylamide and glycidamide in male and female ...
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Technical Reports 857KB
https://ntp.niehs.nih.gov/publications/reports/tr
... Report TR-575 PDF (9.97 MB) Toxicology and Carcinogenesis Studies of Acrylamide (CASRN 79-06-1) in F344/N Rats and B6C3F1 Mice (Feed and Drinking Water Studies) 2012 ...
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Presentation: The EURL ECVAM Toxicokinetics Report and EURL ECVAM... 2.5MB
https://ntp.niehs.nih.gov/iccvam/meetings/ivive-wksp-2016/wksp-ppts/0-2-paini-508.pdf
... 81812 1 acetaminophen 103902 2 1 acetylsalicylic acid 50782 1 1 3 acrolein 107028 acrylamide 79061 4 amiodarone 1951253 2 1 amitriptyline 50486 1 2 amphetamine 300629 1 1 1 ...
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Reproductive Abstracts 195KB
https://ntp.niehs.nih.gov/publications/abstracts/repro
... Formamide (CASRN: 68-12-2) in CD-1 Swiss Mice 1992 Reproductive RACB90022 Acrylamide Acrylamide (CASRN: 79-06-1): Reproductive Toxicity in CD-1 Swiss Mice 1993 Reproductive ...
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Minutes: BSC; Dec. 9-10, 2009 394KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2009/december/minutes20091210.pdf
... The next TRRS meeting, reviewing acrylamide, retinyl palmitate/retinoic acid phototoxicity, AIDS therapeutics, kava kava extract, alpha-beta thujone, methyl trans- styryl ketone, ...
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Appendices A-G; 15th RoC 2021 433KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/appendices_508.pdf
... carbon see Soots acrylic acid amide see Acrylamide actinolite see Asbestos actinon see ... 1,3-Propane Sultone 2-propenamide see Acrylamide 2-propenenitrile see Acrylonitrile ...
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Study Reports 1.0MB
https://ntp.niehs.nih.gov/publications/reports
... Report TR-575 PDF (9.97 MB) Toxicology and Carcinogenesis Studies of Acrylamide (CASRN 79-06-1) in F344/N Rats and B6C3F1 Mice (Feed and Drinking Water Studies) 2012 ...
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Minutes: BSC; April 13, 2011 257KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2011/april/minutesbsc20110413.pdf
... Bucher also mentioned the draft TRs peer review meeting that took place April 5, 2011, which reviewed reports on senna, acrylamide, Aloe vera, and combinations of AIDS ...
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Minutes; BSC; Dec. 15, 2011 258KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2011/december/minutesbsc20111215.pdf
... Four draft TRs were reviewed at the meeting: senna, a nondecolorized whole leaf extract of Aloe barbadensis Miller (Aloe vera), acrylamide, and combinations of AIDS therapeutics ...
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State of the DNTP FY 2021; BSC; Dec. 8, 2021 2.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2021/december/presentations/state_of_dntp_bsc_presentation_508.pdf
... People are exposed to substantially more acrylamide from tobacco smoke than from food. Does Brown Rice Really Have Arsenic in It? ...according to the U.S. National Toxicology ...
