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TR-575: Acrylamide (CASRN 79-06-1) in F344/N Rats and B6C3F1... 9.9MB
https://ntp.niehs.nih.gov/go/tr575
ACRYLAMIDE (CAS No. 79-06-1) IN F344/N RATS AND B6C3F1 MICE (FEED AND DRINKING WATER STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 Research Triangle Park, NC 27709 July 2012 ...
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CERHR Monograph: Potential Human Reproductive and Developmental... 4.8MB
https://ntp.niehs.nih.gov/ntp/ohat/acrylamide/acrylamide_monograph.pdf
Effects of Acrylamide February 2005 NIH Publication No. 05 - 4472 iii Table of Contents Preface ...... v Introduction .... vi NTP Brief on Acrylamide ...
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RoC Profile: Acrylamide; 15th RoC 2021 154KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/acrylamide.pdf
Acrylamide CAS No. 79-06-1 Reasonably anticipated to be a human carcinogen First listed in the Sixth Annual Report on Carcinogens (1991) Also known as 2-propenamide H 2 C H C C NH ...
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Abstract for TR-575 79KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr575
Abstract for TR-575 Toxicology and Carcinogenesis Studies of Acrylamide in F344/N Rats and B6C3F1 Mice (Feed and Drinking Water Studies) CASRN: 79-06-1 Chemical Formula: C3H5NO ...
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Abstract for TER88048 59KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter88048
8abs Abstract for TER88048 Acrylamide Administered to Sprague Dawley (CD) Rats on Gestational Days 6 Through 20 CASRN: 79-06-1 Chemical Formula: C3H5NO Molecular Weight: 71.0785 ...
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Abstract for TER89049 60KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter89049
9abs Abstract for TER89049 Acrylamide Administered to Swiss CD-1 Mice on Gestational Days 6 Through 17 CASRN: 79-06-1 Chemical Formula: C3H5NO Molecular Weight: 71.079 Report Date: ...
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Abstract for RACB90022 62KB
https://ntp.niehs.nih.gov/publications/abstracts/repro/racb90022
2abs Abstract for RACB90022 Acrylamide: Reproductive Toxicity in CD-1 Swiss Mice CASRN: 79-06-1 Chemical Formula: C3H5NO Molecular Weight: 71.079 Report Date: January 1993 Abstract ...
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Abstract for RACB90016 61KB
https://ntp.niehs.nih.gov/publications/abstracts/repro/racb90016
Methylenebisacrylamide (MBA), a crosslinker and congener of acrylamide, was evaluated for ... MBA was tested as one of a series of acrylamide congeners with varying degrees of ...
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Abstract for TR-588 82KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr588
Glycidamide is a reactive electrophile that occurs primarily as a metabolite of acrylamide. Because acrylamide can be formed as a by-product during the cooking of starchy foods ...
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Target Organs and Levels of Evidence for TR-575 62KB
https://ntp.niehs.nih.gov/data/tr/500s/tr575levels
Target Organs and Levels of Evidence for TR-575 Toxicology and Carcinogenesis Studies of Acrylamide (CASRN 79-06-1) in F344/N Rats and B6C3F1 Mice (Feed and Drinking Water Studies) ...
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Abstract for RACB90017 65KB
https://ntp.niehs.nih.gov/publications/abstracts/repro/racb90017
N'(Hydroxymethyl)-acrylamide (HACR) was evaluated for reproductive toxicity, neurotoxicity, and dominant lethal effects using a modified Reproductive Assessment by Continuous ...
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Abstract for RACB90018 61KB
https://ntp.niehs.nih.gov/publications/abstracts/repro/racb90018
Methacrylamide (MACR), a congener of acrylamide, was tested for reproductive toxicity, neurotoxicity, and dominant lethal effects in Swiss CD-1 mice using the Continuous Breeding ...
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TR-588: Glycidamide (CASRN 5694-00-8) in F344/N Nctr Rats and... 3.6MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr588_508.pdf
... Table 42. Comparison of Mean Daily Acrylamide and Glycidamide Consumption in Male and ... Female F344/N Nctr Rats Administered Acrylamide or Glycidamide in Two-year Drinking ...
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Minutes: TRPRP; Apr. 5, 2011 272KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2011/april/minutes20110405.pdf
and Carcinogenesis Studies of Acrylamide in F344/N Rats and B6C3F1 Mice (NTP TR ... VI. Draft NTP Technical Report on the Toxicology and Carcinogenesis Studies of Acrylamide ...
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TR-352: N-Methylolacrylamide (CASRN 924-42-5) in F344/N Rats... 27.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr352.pdf
... N-Methylol- acrylamide induced both sister chromatid exchanges (SCEs) and chromosomal ... the draft Technical Report on N-methylol- acrylamide on October 3, 1988, are listed below. ...
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Abstract for TR-506 71KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr506
elastomers, acrylonitrile-butadiene-styrene and styrene-acrylonitrile resins, nitrile rubbers, gas barrier resins, and chemical intermediates such as adiponitrile and acrylamide. ...
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Public Comment: 2022 SACATM Meeting 131KB
https://ntp.niehs.nih.gov/ntp/about_ntp/sacatm/2022/cmts/sacatm_2022_metrics_twbl-comments_508.pdf
... never 100% complete, can contain residual neurotoxic acrylamide monomers. Toxic brain encephalopathy, caused by acrylamide monomer poisoning, has affected my daughter's quality ...
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Target Organs and Levels of Evidence for TR-588 63KB
https://ntp.niehs.nih.gov/data/tr/500s/tr588levels
Chemical CASRN (Study Title) Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory Glycidamide 5694-00-8 10/29/2013 Metabolite of acrylamide. Associated with ...
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15th RoC: Appendix F 174KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_f.pdf
carbon see Soots acrylic acid amide see Acrylamide actinolite see Asbestos actinon see ... 1,3-Propane Sultone 2-propenamide see Acrylamide 2-propenenitrile see Acrylonitrile ...
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Public Comment: 2022 SACATM Meeting 80KB
https://ntp.niehs.nih.gov/ntp/about_ntp/sacatm/2022/cmts/sacatm_2022_validation_twbl-comments.pdf
Experimentation with acrylamide has been occurring for decades as has its industrial use. ... demonstrated lower than assumed doses of acrylamide can impact learning and memory. ...
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White Coat Waste Project Report: Toxic Testing 1.4MB
https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2018/wcw-neavs-rpt-2018pubforum-508.pdf
... Among the substances actively being evaluated by NTP is acrylamide, a by-product of ... feeding mice and rats massive doses of acrylamide, dosing their food and water, and ...
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Abstract for TER90008 64KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter90008
The CD-1 mouse was selected as the test animal for this study based on evidence for acrylamide-induced toxicity in other strains/ stocks of mice in the literature, and to ...
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Developing an in vitro integrated organ model for pharmacokinetic... 3.3MB
https://ntp.niehs.nih.gov/iccvam/meetings/commprac-2023/20230130-iccvam-cop-mckim-508.pdf
... that are naturally pres ent in food Acrylamide Metabolism Three Organ Model Intestine ... 100000 150000 200000 250000 20 40 60 80 Acrylamide - Intestine - HuDMOP Time (hr) ...
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Public Health Impact 1.5MB
https://ntp.niehs.nih.gov/media/impact
... 5, New Section 25506 Exposures to Acrylamide in Cooked or Heat Processed Foods On ... 25505. The new section addresses acrylamide in food formed by cooking or heat ...
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Panel Actions: TRPRP; Apr. 5, 2011 66KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2011/april/actions20110405.pdf
Acrylamide (TR 575) The Panel accepted unanimously the conclusions (6 yes, 0 no, 0 abstentions) as written, clear evidence of carcinogenic activity of acrylamide in male and female ...
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Minutes: BSC; Sept. 10-11, 2003 500KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2003/mins2003sept10_508.pdf
... for 2004 - one to discuss Fluoxetine (Prozac®) and the other to review acrylamide. ... 4. Environmental contaminants - acrylamide, glycidamide, 4-phenylcyclohexene, ...
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TR-506: Acrylonitrile (CASRN 107-13-1) in B6C3F1Mice (Gavage... 7.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr506.pdf
... gas barrier resins, and chemical intermediates such as adiponitrile and acrylamide. ... dehydration of ethylene cyanohydrin or acrylamide by phosphorus pentoxide (Brazdil, 1999). ...
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Appendix G; 15th RoC 2021 73KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_g.pdf
... see Lead and Lead Compounds 78-79-5 see Isoprene 79-01-6 see Trichloroethylene 79-06-1 see Acrylamide 79-43-6 (dichloroacetic acid) see Haloacetic Acids Found as Water Disinfection ...
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RoC Profile: Acrylonitrile; 15th RoC 2021 145KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/acrylonitrile.pdf
... resins, 17% for acrylic fibers, 11% for acrylamide, 3% for nitrile elastomers, and 9% for ... Bergmark E. 1997. Hemoglobin adducts of acrylamide and acrylonitrile in laboratory ...
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Spinal cord - Demyelination - Nonneoplastic Lesion Atlas 290KB
https://ntp.niehs.nih.gov/atlas/nnl/nervous-system/spinal-cord/Demyelination
injury and loss, such that axonopathy and demyelination often coexist as a result of axonal injury from classic axonopathic compounds such as organophosphate agents and acrylamide. ...
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NTP at the SOT; March 6, 2005 308KB
https://ntp.niehs.nih.gov/ntp/meetings/2005/ntpsot2_508.pdf
484 Symposium/Presentation R03 Ghanayem, Burhan Role of CYP2E1 in the Oxidation of Acrylamide (AA) to Glycidamide (GA) and Formation of DNA and Hemoglobin Adducts 361 R01 Gohlke, ...
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Spinal Cord - Demyelination 310KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/nervous/spinal_cord/demyelin/spinal_cord-demyelination_508.pdf
injury and loss, such that axonopathy and demyelination often coexist as a result of axonal injury from classic axonopathic compounds such as organophosphate agents and acrylamide. ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
... Evidence NE No Evidence NE No Evidence SE Some Evidence TR-575 04/05/11 Acrylamide 79-06-1 P Clear Evidence P Clear Evidence P Clear Evidence P Clear Evidence TR-574 02/08/...
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Listed Substances; 15th RoC 2021 76KB
https://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf
... Reasonably Anticipated To Be Human Carcinogens Acetaldehyde 2-Acetylaminofluorene Acrylamide Acrylonitrile Adriamycin 2-Aminoanthraquinone o-Aminoazotoluene ...
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Monographs 71KB
https://ntp.niehs.nih.gov/publications/monographs
... All NTP-CERHR Monographs Substance/Topic Year Acrylamide 2005 Amphetamines 2005 Bisphenol A 2008 1-Bromopropane 2003 2-Bromopropane 2003 Ethylene Glycol 2004 Fluoxetine 2004 ...
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Comment: Meat-related exposures; Robert Turesky, University of... 4.6MB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2016/publiccomm/turesky20161005.pdf
... furan, acrylamide, among other chemicals that may be harmful to human health. ... genotoxicants in the diet, such as acrylamide, which are present at higher levels ...
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Minutes: BSC; June 29, 2004 883KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2004/june/20040629_508.pdf
... expert panel reviews of fluoxetine (March 2-5, 2004) and acrylamide (May 17-19, 2004). Dr. ... The expert panel that evaluated acrylamide concluded that there is negligible concern for ...
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Minutes: SACATM; Mar. 10-11, 2004 961KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/sacatm/archives/2004/minutes20040311_508be.pdf
... The CERHR has produced nine monographs and just completed its evaluation of fluoxetine (Prozac). In May, CERHR will evaluate acrylamide as a potential reproductive and ...
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Minutes: TR Panel; Oct. 29, 2013 234KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2013/october/minutes20131029_508.pdf
... He provided background information on acrylamide, of which glycidamide is a metabolite. ... and compare the long-term effects of acrylamide and glycidamide in male and female ...
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Technical Reports 903KB
https://ntp.niehs.nih.gov/publications/reports/tr
... Report TR-575 PDF (9.97 MB) Toxicology and Carcinogenesis Studies of Acrylamide (CASRN 79-06-1) in F344/N Rats and B6C3F1 Mice (Feed and Drinking Water Studies) 2012 ...
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Presentation: The EURL ECVAM Toxicokinetics Report and EURL ECVAM... 2.5MB
https://ntp.niehs.nih.gov/iccvam/meetings/ivive-wksp-2016/wksp-ppts/0-2-paini-508.pdf
... 81812 1 acetaminophen 103902 2 1 acetylsalicylic acid 50782 1 1 3 acrolein 107028 acrylamide 79061 4 amiodarone 1951253 2 1 amitriptyline 50486 1 2 amphetamine 300629 1 1 1 ...
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Reproductive Abstracts 202KB
https://ntp.niehs.nih.gov/publications/abstracts/repro
... Formamide (CASRN: 68-12-2) in CD-1 Swiss Mice 1992 Reproductive RACB90022 Acrylamide Acrylamide (CASRN: 79-06-1): Reproductive Toxicity in CD-1 Swiss Mice 1993 Reproductive ...
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Minutes: BSC; Aug. 18, 2005 1.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2005/august/bscmins2005aug18_508.pdf
... The expert panel reports for amphetamine and methylphenidate and the NTP-CERHR monographs for fluoxetine and acrylamide are on the CERHR website. CERHR sponsored a symposium, "Gene ...
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Appendices A-G; 15th RoC 2021 448KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendices_508.pdf
... carbon see Soots acrylic acid amide see Acrylamide actinolite see Asbestos actinon see ... 1,3-Propane Sultone 2-propenamide see Acrylamide 2-propenenitrile see Acrylonitrile ...
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Study Abstracts 375KB
https://ntp.niehs.nih.gov/publications/abstracts
... Formamide (CASRN: 68-12-2) in CD-1 Swiss Mice 1992 Reproductive RACB90022 Acrylamide Acrylamide (CASRN: 79-06-1): Reproductive Toxicity in CD-1 Swiss Mice 1993 Reproductive ...
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Minutes: BSC; Dec. 9-10, 2009 394KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2009/december/minutes20091210.pdf
... The next TRRS meeting, reviewing acrylamide, retinyl palmitate/retinoic acid phototoxicity, AIDS therapeutics, kava kava extract, alpha-beta thujone, methyl trans- styryl ketone, ...
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State of the DNTP FY 2021; BSC; Dec. 8, 2021 2.7MB
https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2021/december/presentations/state_of_dntp_bsc_presentation_508.pdf
... People are exposed to substantially more acrylamide from tobacco smoke than from food. Does Brown Rice Really Have Arsenic in It? ...according to the U.S. National Toxicology ...
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Minutes: BSC; April 13, 2011 257KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2011/april/minutesbsc20110413.pdf
... Bucher also mentioned the draft TRs peer review meeting that took place April 5, 2011, which reviewed reports on senna, acrylamide, Aloe vera, and combinations of AIDS ...
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Presentation: Developing Reverse Toxicokinetic Models to Correlate... 2.5MB
https://ntp.niehs.nih.gov/iccvam/meetings/commprac-2015/wambaugh-508.pdf
... NA 0.641 0.348 0.364 0.309 4.328 0.338 0.542 0.485 0.208 NA 0.37 0.711 0.169 NA NA Acrylamide NA NA 0.331 NA 0.913 0.268 4.639 0.298 0.162 0.126 0.22 0.206 NA 0.096 0.885 3.132 ...
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Minutes; BSC; Dec. 15, 2011 258KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2011/december/minutesbsc20111215.pdf
... Four draft TRs were reviewed at the meeting: senna, a nondecolorized whole leaf extract of Aloe barbadensis Miller (Aloe vera), acrylamide, and combinations of AIDS therapeutics ...