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TR-575: Acrylamide (CASRN 79-06-1) in F344/N Rats and B6C3F1... 3.9MB
https://ntp.niehs.nih.gov/go/tr575
acRylamide (cas No. 79-06-1) iN f344/N RaTs aNd B6c3f1 mice (feed aNd dRiNkiNg WaTeR sTudies) NTP TR 575 JULY 2012 NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES ...
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CERHR Monograph: Potential Human Reproductive and Developmental... 4.8MB
https://ntp.niehs.nih.gov/ntp/ohat/acrylamide/acrylamide_monograph.pdf
Effects of Acrylamide February 2005 NIH Publication No. 05 - 4472 iii Table of Contents Preface ...... v Introduction .... vi NTP Brief on Acrylamide ...
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RoC Profile: Acrylamide; 15th RoC 2021 154KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/acrylamide.pdf
Acrylamide CAS No. 79-06-1 Reasonably anticipated to be a human carcinogen First listed in the Sixth Annual Report on Carcinogens (1991) Also known as 2-propenamide H 2 C H C C NH ...
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Abstract for TR-575 74KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr575
Abstract for TR-575 Toxicology and Carcinogenesis Studies of Acrylamide in F344/N Rats and B6C3F1 Mice (Feed and Drinking Water Studies) CASRN: 79-06-1 Chemical Formula: C3H5NO ...
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Abstract for TER88048 56KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter88048
8abs Abstract for TER88048 Acrylamide Administered to Sprague Dawley (CD) Rats on Gestational Days 6 Through 20 CASRN: 79-06-1 Chemical Formula: C3H5NO Molecular Weight: 71.0785 ...
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Abstract for TER89049 56KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter89049
9abs Abstract for TER89049 Acrylamide Administered to Swiss CD-1 Mice on Gestational Days 6 Through 17 CASRN: 79-06-1 Chemical Formula: C3H5NO Molecular Weight: 71.079 Report Date: ...
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Abstract for RACB90022 58KB
https://ntp.niehs.nih.gov/publications/abstracts/repro/racb90022
2abs Abstract for RACB90022 Acrylamide: Reproductive Toxicity in CD-1 Swiss Mice CASRN: 79-06-1 Chemical Formula: C3H5NO Molecular Weight: 71.079 Report Date: January 1993 Abstract ...
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Abstract for RACB90016 56KB
https://ntp.niehs.nih.gov/publications/abstracts/repro/racb90016
Methylenebisacrylamide (MBA), a crosslinker and congener of acrylamide, was evaluated for ... MBA was tested as one of a series of acrylamide congeners with varying degrees of ...
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Abstract for TR-588 77KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr588
Glycidamide is a reactive electrophile that occurs primarily as a metabolite of acrylamide. Because acrylamide can be formed as a by-product during the cooking of starchy foods ...
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Target Organs and Levels of Evidence for TR-575 57KB
https://ntp.niehs.nih.gov/data/tr/500s/tr575levels
Target Organs and Levels of Evidence for TR-575 Toxicology and Carcinogenesis Studies of Acrylamide (CASRN 79-06-1) in F344/N Rats and B6C3F1 Mice (Feed and Drinking Water Studies) ...
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Abstract for RACB90017 60KB
https://ntp.niehs.nih.gov/publications/abstracts/repro/racb90017
N'(Hydroxymethyl)-acrylamide (HACR) was evaluated for reproductive toxicity, neurotoxicity, and dominant lethal effects using a modified Reproductive Assessment by Continuous ...
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Abstract for RACB90018 56KB
https://ntp.niehs.nih.gov/publications/abstracts/repro/racb90018
Methacrylamide (MACR), a congener of acrylamide, was tested for reproductive toxicity, neurotoxicity, and dominant lethal effects in Swiss CD-1 mice using the Continuous Breeding ...
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TR-588: Glycidamide (CASRN 5694-00-8) in F344/N Nctr Rats and... 3.5MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr588_508.pdf
... Table 42. Comparison of Mean Daily Acrylamide and Glycidamide Consumption in Male and ... Female F344/N Nctr Rats Administered Acrylamide or Glycidamide in Two-year Drinking ...
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TR-588: Glycidamide (CASRN 5694-00-8) in F344/N Nctr Rats and... 3.5MB
https://ntp.niehs.nih.gov/go/tr588
... Table 42. Comparison of Mean Daily Acrylamide and Glycidamide Consumption in Male and ... Female F344/N Nctr Rats Administered Acrylamide or Glycidamide in Two-year Drinking ...
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Minutes: TRPRP; Apr. 5, 2011 272KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2011/april/minutes20110405.pdf
and Carcinogenesis Studies of Acrylamide in F344/N Rats and B6C3F1 Mice (NTP TR ... VI. Draft NTP Technical Report on the Toxicology and Carcinogenesis Studies of Acrylamide ...
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TR-352: N-Methylolacrylamide (CASRN 924-42-5) in F344/N Rats... 27.2MB
https://ntp.niehs.nih.gov/go/tr352
... N-Methylol- acrylamide induced both sister chromatid exchanges (SCEs) and chromosomal ... the draft Technical Report on N-methylol- acrylamide on October 3, 1988, are listed below. ...
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Abstract for TR-506 66KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr506
elastomers, acrylonitrile-butadiene-styrene and styrene-acrylonitrile resins, nitrile rubbers, gas barrier resins, and chemical intermediates such as adiponitrile and acrylamide. ...
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Public Health Impact 1.4MB
https://ntp.niehs.nih.gov/media/impact
... 2024 OEHHA Safe Harbor Warnings for Acrylamide Exposure from Food The Office of ... option for businesses that cause significant exposures to acrylamide from food products. ...
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Public Comment: 2022 SACATM Meeting 131KB
https://ntp.niehs.nih.gov/ntp/about_ntp/sacatm/2022/cmts/sacatm_2022_metrics_twbl-comments_508.pdf
... never 100% complete, can contain residual neurotoxic acrylamide monomers. Toxic brain encephalopathy, caused by acrylamide monomer poisoning, has affected my daughter's quality ...
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Target Organs and Levels of Evidence for TR-588 58KB
https://ntp.niehs.nih.gov/data/tr/500s/tr588levels
Chemical CASRN (Study Title) Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory Glycidamide 5694-00-8 10/29/2013 Metabolite of acrylamide. Associated with ...
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15th RoC: Appendix F 165KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_f.pdf
carbon see Soots acrylic acid amide see Acrylamide actinolite see Asbestos actinon see ... 1,3-Propane Sultone 2-propenamide see Acrylamide 2-propenenitrile see Acrylonitrile ...
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Public Comment: 2022 SACATM Meeting 80KB
https://ntp.niehs.nih.gov/ntp/about_ntp/sacatm/2022/cmts/sacatm_2022_validation_twbl-comments.pdf
Experimentation with acrylamide has been occurring for decades as has its industrial use. ... demonstrated lower than assumed doses of acrylamide can impact learning and memory. ...
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Abstract for TER90008 60KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter90008
The CD-1 mouse was selected as the test animal for this study based on evidence for acrylamide-induced toxicity in other strains/ stocks of mice in the literature, and to ...
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Developing an in vitro integrated organ model for pharmacokinetic... 3.3MB
https://ntp.niehs.nih.gov/iccvam/meetings/commprac-2023/20230130-iccvam-cop-mckim-508.pdf
... that are naturally pres ent in food Acrylamide Metabolism Three Organ Model Intestine ... 100000 150000 200000 250000 20 40 60 80 Acrylamide - Intestine - HuDMOP Time (hr) ...
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Panel Actions: TRPRP; Apr. 5, 2011 66KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2011/april/actions20110405.pdf
Acrylamide (TR 575) The Panel accepted unanimously the conclusions (6 yes, 0 no, 0 abstentions) as written, clear evidence of carcinogenic activity of acrylamide in male and female ...
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Minutes: BSC; Sept. 10-11, 2003 500KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2003/mins2003sept10_508.pdf
... for 2004 - one to discuss Fluoxetine (Prozac®) and the other to review acrylamide. ... 4. Environmental contaminants - acrylamide, glycidamide, 4-phenylcyclohexene, ...
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TR-506: Acrylonitrile (CASRN 107-13-1) in B6C3F1 Mice (Gavage... 2.9MB
https://ntp.niehs.nih.gov/go/tr506
... gas barrier resins, and chemical intermediates such as adiponitrile and acrylamide. ... dehydration of ethylene cyanohydrin or acrylamide by phosphorus pentoxide (Brazdil, 1999). ...
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Appendix G; 15th RoC 2021 69KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_g.pdf
... see Lead and Lead Compounds 78-79-5 see Isoprene 79-01-6 see Trichloroethylene 79-06-1 see Acrylamide 79-43-6 (dichloroacetic acid) see Haloacetic Acids Found as Water Disinfection ...
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RoC Profile: Acrylonitrile; 15th RoC 2021 145KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/acrylonitrile.pdf
... resins, 17% for acrylic fibers, 11% for acrylamide, 3% for nitrile elastomers, and 9% for ... Bergmark E. 1997. Hemoglobin adducts of acrylamide and acrylonitrile in laboratory ...
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Spinal cord - Demyelination - Nonneoplastic Lesion Atlas 282KB
https://ntp.niehs.nih.gov/atlas/nnl/nervous-system/spinal-cord/Demyelination
injury and loss, such that axonopathy and demyelination often coexist as a result of axonal injury from classic axonopathic compounds such as organophosphate agents and acrylamide. ...
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Spinal Cord - Demyelination 310KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/nervous/spinal_cord/demyelin/spinal_cord-demyelination_508.pdf
injury and loss, such that axonopathy and demyelination often coexist as a result of axonal injury from classic axonopathic compounds such as organophosphate agents and acrylamide. ...
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NTP at the SOT; March 6, 2005 308KB
https://ntp.niehs.nih.gov/ntp/meetings/2005/ntpsot2_508.pdf
484 Symposium/Presentation R03 Ghanayem, Burhan Role of CYP2E1 in the Oxidation of Acrylamide (AA) to Glycidamide (GA) and Formation of DNA and Hemoglobin Adducts 361 R01 Gohlke, ...
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Listed Substances; 15th RoC 2021 76KB
https://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf
... Reasonably Anticipated To Be Human Carcinogens Acetaldehyde 2-Acetylaminofluorene Acrylamide Acrylonitrile Adriamycin 2-Aminoanthraquinone o-Aminoazotoluene ...
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Monographs 66KB
https://ntp.niehs.nih.gov/publications/monographs
... All NTP-CERHR Monographs Substance/Topic Year Acrylamide 2005 Amphetamines 2005 Bisphenol A 2008 1-Bromopropane 2003 2-Bromopropane 2003 Ethylene Glycol 2004 Fluoxetine 2004 ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
... Evidence NE No Evidence NE No Evidence SE Some Evidence TR-575 04/05/11 Acrylamide 79-06-1 P Clear Evidence P Clear Evidence P Clear Evidence P Clear Evidence TR-574 02/08/...
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Minutes: BSC; June 29, 2004 883KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2004/june/20040629_508.pdf
... expert panel reviews of fluoxetine (March 2-5, 2004) and acrylamide (May 17-19, 2004). Dr. ... The expert panel that evaluated acrylamide concluded that there is negligible concern for ...
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National Institute of Environmental Health Sciences: Developmental... 521KB
https://www.niehs.nih.gov/research/atniehs/dtt/strategic-plan/health/developmental/chemical-list
... Mixture* 115-09-3 DTXSID5020813 Methyl mercuric (II) chloride Mixture* 79-06-1 DTXSID5020027 Acrylamide Mixture* NOCAS_ 1354859 DTXSID101354859 Dieldrin + BDE-47 (2:1 molarity ...
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Minutes: SACATM; Mar. 10-11, 2004 961KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/sacatm/archives/2004/minutes20040311_508be.pdf
... The CERHR has produced nine monographs and just completed its evaluation of fluoxetine (Prozac). In May, CERHR will evaluate acrylamide as a potential reproductive and ...
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Minutes: TR Panel; Oct. 29, 2013 234KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2013/october/minutes20131029_508.pdf
... He provided background information on acrylamide, of which glycidamide is a metabolite. ... and compare the long-term effects of acrylamide and glycidamide in male and female ...
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Presentation: The EURL ECVAM Toxicokinetics Report and EURL ECVAM... 2.5MB
https://ntp.niehs.nih.gov/iccvam/meetings/ivive-wksp-2016/wksp-ppts/0-2-paini-508.pdf
... 81812 1 acetaminophen 103902 2 1 acetylsalicylic acid 50782 1 1 3 acrolein 107028 acrylamide 79061 4 amiodarone 1951253 2 1 amitriptyline 50486 1 2 amphetamine 300629 1 1 1 ...
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Reproductive Abstracts 199KB
https://ntp.niehs.nih.gov/publications/abstracts/repro
... Formamide (CASRN: 68-12-2) in CD-1 Swiss Mice 1992 Reproductive RACB90022 Acrylamide Acrylamide (CASRN: 79-06-1): Reproductive Toxicity in CD-1 Swiss Mice 1993 Reproductive ...
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Minutes: BSC; Aug. 18, 2005 1.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2005/august/bscmins2005aug18_508.pdf
... The expert panel reports for amphetamine and methylphenidate and the NTP-CERHR monographs for fluoxetine and acrylamide are on the CERHR website. CERHR sponsored a symposium, "Gene ...
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Appendices A-G; 15th RoC 2021 433KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendices_508.pdf
... carbon see Soots acrylic acid amide see Acrylamide actinolite see Asbestos actinon see ... 1,3-Propane Sultone 2-propenamide see Acrylamide 2-propenenitrile see Acrylonitrile ...
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Study Abstracts 372KB
https://ntp.niehs.nih.gov/publications/abstracts
... Formamide (CASRN: 68-12-2) in CD-1 Swiss Mice 1992 Reproductive RACB90022 Acrylamide Acrylamide (CASRN: 79-06-1): Reproductive Toxicity in CD-1 Swiss Mice 1993 Reproductive ...
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Minutes: BSC; Dec. 9-10, 2009 394KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2009/december/minutes20091210.pdf
... The next TRRS meeting, reviewing acrylamide, retinyl palmitate/retinoic acid phototoxicity, AIDS therapeutics, kava kava extract, alpha-beta thujone, methyl trans- styryl ketone, ...
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State of the DNTP FY 2021; BSC; Dec. 8, 2021 2.7MB
https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2021/december/presentations/state_of_dntp_bsc_presentation_508.pdf
... People are exposed to substantially more acrylamide from tobacco smoke than from food. Does Brown Rice Really Have Arsenic in It? ...according to the U.S. National Toxicology ...
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Study Reports 1.1MB
https://ntp.niehs.nih.gov/publications/reports
... Report TR-575 PDF (9.97 MB) Toxicology and Carcinogenesis Studies of Acrylamide (CASRN 79-06-1) in F344/N Rats and B6C3F1 Mice (Feed and Drinking Water Studies) 2012 ...
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Minutes: BSC; April 13, 2011 257KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2011/april/minutesbsc20110413.pdf
... Bucher also mentioned the draft TRs peer review meeting that took place April 5, 2011, which reviewed reports on senna, acrylamide, Aloe vera, and combinations of AIDS ...
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Minutes; BSC; Dec. 15, 2011 258KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2011/december/minutesbsc20111215.pdf
... Four draft TRs were reviewed at the meeting: senna, a nondecolorized whole leaf extract of Aloe barbadensis Miller (Aloe vera), acrylamide, and combinations of AIDS therapeutics ...
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Guidance Document on Using In Vitro Data to Estimate In Vivo... 6.5MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/guidance0801/iv_guide.pdf
... 13235-36-4 0.95 0.50 Ascorbic acid 50-81-7 0.49 0.81 Phenol 108-95-2 0.35 0.74 Acrylamide 79-06-1 0.29 0.19 Copper (II) sulfate 7758-98-7 0.10 0.05 Sodium lauryl sulfate 151-21-3 ...