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93 results found for "acrylamide".
  1. TR-575: Acrylamide (CASRN 79-06-1) in F344/N Rats and B6C3F1... 9.9MB

    https://ntp.niehs.nih.gov/go/tr575

    NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ACRYLAMIDE (CAS No. 79-06-1) IN F344/N RATS AND B6C3F1 MICE (FEED AND DRINKING WATER STUDIES) NATIONAL ...

  2. CERHR Monograph: Potential Human Reproductive and Developmental... 4.8MB

    https://ntp.niehs.nih.gov/ntp/ohat/acrylamide/acrylamide_monograph.pdf

    Effects of Acrylamide February 2005 NIH Publication No. 05 - 4472 iii Table of Contents Preface ...... v Introduction .... vi NTP Brief on Acrylamide ...

  3. RoC Profile: Acrylamide; 15th RoC 2021 154KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/acrylamide.pdf

    Acrylamide CAS No. 79-06-1 Reasonably anticipated to be a human carcinogen First listed in the Sixth Annual Report on Carcinogens (1991) Also known as 2-propenamide H 2 C H C C NH ...

  4. Abstract for TR-575 80KB

    https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr575

    Abstract for TR-575 Toxicology and Carcinogenesis Studies of Acrylamide in F344/N Rats and B6C3F1 Mice (Feed and Drinking Water Studies) CASRN: 79-06-1 Chemical Formula: C3H5NO ...

  5. Abstract for TER88048 61KB

    https://ntp.niehs.nih.gov/publications/abstracts/dev/ter88048

    8abs Abstract for TER88048 Acrylamide Administered to Sprague Dawley (CD) Rats on Gestational Days 6 Through 20 CASRN: 79-06-1 Chemical Formula: C3H5NO Molecular Weight: 71.0785 ...

  6. Abstract for TER89049 62KB

    https://ntp.niehs.nih.gov/publications/abstracts/dev/ter89049

    9abs Abstract for TER89049 Acrylamide Administered to Swiss CD-1 Mice on Gestational Days 6 Through 17 CASRN: 79-06-1 Chemical Formula: C3H5NO Molecular Weight: 71.079 Report Date: ...

  7. Abstract for RACB90022 64KB

    https://ntp.niehs.nih.gov/publications/abstracts/repro/racb90022

    2abs Abstract for RACB90022 Acrylamide: Reproductive Toxicity in CD-1 Swiss Mice CASRN: 79-06-1 Chemical Formula: C3H5NO Molecular Weight: 71.079 Report Date: January 1993 Abstract ...

  8. Abstract for RACB90016 62KB

    https://ntp.niehs.nih.gov/publications/abstracts/repro/racb90016

    Methylenebisacrylamide (MBA), a crosslinker and congener of acrylamide, was evaluated for ... MBA was tested as one of a series of acrylamide congeners with varying degrees of ...

  9. Abstract for TR-588 84KB

    https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr588

    Glycidamide is a reactive electrophile that occurs primarily as a metabolite of acrylamide. Because acrylamide can be formed as a by-product during the cooking of starchy foods ...

  10. Target Organs and Levels of Evidence for TR-575 63KB

    https://ntp.niehs.nih.gov/data/tr/500s/tr575levels

    Target Organs and Levels of Evidence for TR-575 Toxicology and Carcinogenesis Studies of Acrylamide (CASRN 79-06-1) in F344/N Rats and B6C3F1 Mice (Feed and Drinking Water Studies) ...

  11. Abstract for RACB90017 66KB

    https://ntp.niehs.nih.gov/publications/abstracts/repro/racb90017

    N'(Hydroxymethyl)-acrylamide (HACR) was evaluated for reproductive toxicity, neurotoxicity, and dominant lethal effects using a modified Reproductive Assessment by Continuous ...

  12. Abstract for RACB90018 62KB

    https://ntp.niehs.nih.gov/publications/abstracts/repro/racb90018

    Methacrylamide (MACR), a congener of acrylamide, was tested for reproductive toxicity, neurotoxicity, and dominant lethal effects in Swiss CD-1 mice using the Continuous Breeding ...

  13. TR-588: Glycidamide (CASRN 5694-00-8) in F344/N Nctr Rats and... 3.6MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr588_508.pdf

    ... Table 42. Comparison of Mean Daily Acrylamide and Glycidamide Consumption in Male and ... Female F344/N Nctr Rats Administered Acrylamide or Glycidamide in Two-year Drinking ...

  14. Minutes: TRPRP; Apr. 5, 2011 272KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2011/april/minutes20110405.pdf

    and Carcinogenesis Studies of Acrylamide in F344/N Rats and B6C3F1 Mice (NTP TR ... VI. Draft NTP Technical Report on the Toxicology and Carcinogenesis Studies of Acrylamide ...

  15. TR-352: N-Methylolacrylamide (CASRN 924-42-5) in F344/N Rats... 27.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr352.pdf

    ... N-Methylol- acrylamide induced both sister chromatid exchanges (SCEs) and chromosomal ... the draft Technical Report on N-methylol- acrylamide on October 3, 1988, are listed below. ...

  16. Abstract for TR-506 73KB

    https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr506

    elastomers, acrylonitrile-butadiene-styrene and styrene-acrylonitrile resins, nitrile rubbers, gas barrier resins, and chemical intermediates such as adiponitrile and acrylamide. ...

  17. Public Comment: 2022 SACATM Meeting 131KB

    https://ntp.niehs.nih.gov/ntp/about_ntp/sacatm/2022/cmts/sacatm_2022_metrics_twbl-comments_508.pdf

    ... never 100% complete, can contain residual neurotoxic acrylamide monomers. Toxic brain encephalopathy, caused by acrylamide monomer poisoning, has affected my daughter's quality ...

  18. Target Organs and Levels of Evidence for TR-588 64KB

    https://ntp.niehs.nih.gov/data/tr/500s/tr588levels

    Chemical CASRN (Study Title) Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory Glycidamide 5694-00-8 10/29/2013 Metabolite of acrylamide. Associated with ...

  19. 15th RoC: Appendix F 174KB

    https://ntp.niehs.nih.gov/ntp/roc/content/appendix_f.pdf

    carbon see Soots acrylic acid amide see Acrylamide actinolite see Asbestos actinon see ... 1,3-Propane Sultone 2-propenamide see Acrylamide 2-propenenitrile see Acrylonitrile ...

  20. Public Comment: 2022 SACATM Meeting 80KB

    https://ntp.niehs.nih.gov/ntp/about_ntp/sacatm/2022/cmts/sacatm_2022_validation_twbl-comments.pdf

    Experimentation with acrylamide has been occurring for decades as has its industrial use. ... demonstrated lower than assumed doses of acrylamide can impact learning and memory. ...

  21. White Coat Waste Project Report: Toxic Testing 1.4MB

    https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2018/wcw-neavs-rpt-2018pubforum-508.pdf

    ... Among the substances actively being evaluated by NTP is acrylamide, a by-product of ... feeding mice and rats massive doses of acrylamide, dosing their food and water, and ...

  22. Abstract for TER90008 65KB

    https://ntp.niehs.nih.gov/publications/abstracts/dev/ter90008

    The CD-1 mouse was selected as the test animal for this study based on evidence for acrylamide-induced toxicity in other strains/ stocks of mice in the literature, and to ...

  23. Developing an in vitro integrated organ model for pharmacokinetic... 3.3MB

    https://ntp.niehs.nih.gov/iccvam/meetings/commprac-2023/20230130-iccvam-cop-mckim-508.pdf

    ... that are naturally pres ent in food Acrylamide Metabolism Three Organ Model Intestine ... 100000 150000 200000 250000 20 40 60 80 Acrylamide - Intestine - HuDMOP Time (hr) ...

  24. Public Health Impact 1.5MB

    https://ntp.niehs.nih.gov/media/impact

    ... 5, New Section 25506 Exposures to Acrylamide in Cooked or Heat Processed Foods On ... 25505. The new section addresses acrylamide in food formed by cooking or heat ...

  25. Panel Actions: TRPRP; Apr. 5, 2011 66KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2011/april/actions20110405.pdf

    Acrylamide (TR 575) The Panel accepted unanimously the conclusions (6 yes, 0 no, 0 abstentions) as written, clear evidence of carcinogenic activity of acrylamide in male and female ...

  26. Minutes: BSC; Sept. 10-11, 2003 500KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2003/mins2003sept10_508.pdf

    ... for 2004 - one to discuss Fluoxetine (Prozac®) and the other to review acrylamide. ... 4. Environmental contaminants - acrylamide, glycidamide, 4-phenylcyclohexene, ...

  27. TR-506: Acrylonitrile (CASRN 107-13-1) in B6C3F1 Mice (Gavage... 2.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr506.pdf

    ... gas barrier resins, and chemical intermediates such as adiponitrile and acrylamide. ... dehydration of ethylene cyanohydrin or acrylamide by phosphorus pentoxide (Brazdil, 1999). ...

  28. Appendix G; 15th RoC 2021 73KB

    https://ntp.niehs.nih.gov/ntp/roc/content/appendix_g.pdf

    ... see Lead and Lead Compounds 78-79-5 see Isoprene 79-01-6 see Trichloroethylene 79-06-1 see Acrylamide 79-43-6 (dichloroacetic acid) see Haloacetic Acids Found as Water Disinfection ...

  29. RoC Profile: Acrylonitrile; 15th RoC 2021 145KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/acrylonitrile.pdf

    ... resins, 17% for acrylic fibers, 11% for acrylamide, 3% for nitrile elastomers, and 9% for ... Bergmark E. 1997. Hemoglobin adducts of acrylamide and acrylonitrile in laboratory ...

  30. Spinal cord - Demyelination - Nonneoplastic Lesion Atlas 291KB

    https://ntp.niehs.nih.gov/atlas/nnl/nervous-system/spinal-cord/Demyelination

    injury and loss, such that axonopathy and demyelination often coexist as a result of axonal injury from classic axonopathic compounds such as organophosphate agents and acrylamide. ...

  31. NTP at the SOT; March 6, 2005 308KB

    https://ntp.niehs.nih.gov/ntp/meetings/2005/ntpsot2_508.pdf

    484 Symposium/Presentation R03 Ghanayem, Burhan Role of CYP2E1 in the Oxidation of Acrylamide (AA) to Glycidamide (GA) and Formation of DNA and Hemoglobin Adducts 361 R01 Gohlke, ...

  32. Spinal Cord - Demyelination 310KB

    https://ntp.niehs.nih.gov/sites/default/files/nnl/nervous/spinal_cord/demyelin/spinal_cord-demyelination_508.pdf

    injury and loss, such that axonopathy and demyelination often coexist as a result of axonal injury from classic axonopathic compounds such as organophosphate agents and acrylamide. ...

  33. NTP Technical Reports Index 1.5MB

    https://ntp.niehs.nih.gov/data/tr

    ... Evidence NE No Evidence NE No Evidence SE Some Evidence TR-575 04/05/11 Acrylamide 79-06-1 P Clear Evidence P Clear Evidence P Clear Evidence P Clear Evidence TR-574 02/08/...

  34. Listed Substances; 15th RoC 2021 76KB

    https://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf

    ... Reasonably Anticipated To Be Human Carcinogens Acetaldehyde 2-Acetylaminofluorene Acrylamide Acrylonitrile Adriamycin 2-Aminoanthraquinone o-Aminoazotoluene ...

  35. Monographs 73KB

    https://ntp.niehs.nih.gov/publications/monographs

    ... All NTP-CERHR Monographs Substance/Topic Year Acrylamide 2005 Amphetamines 2005 Bisphenol A 2008 1-Bromopropane 2003 2-Bromopropane 2003 Ethylene Glycol 2004 Fluoxetine 2004 ...

  36. Minutes: BSC; June 29, 2004 883KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2004/june/20040629_508.pdf

    ... expert panel reviews of fluoxetine (March 2-5, 2004) and acrylamide (May 17-19, 2004). Dr. ... The expert panel that evaluated acrylamide concluded that there is negligible concern for ...

  37. Comment: Meat-related exposures; Robert Turesky, University of... 4.6MB

    https://ntp.niehs.nih.gov/ntp/roc/nominations/2016/publiccomm/turesky20161005.pdf

    ... furan, acrylamide, among other chemicals that may be harmful to human health. ... genotoxicants in the diet, such as acrylamide, which are present at higher levels ...

  38. Minutes: SACATM; Mar. 10-11, 2004 961KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/sacatm/archives/2004/minutes20040311_508be.pdf

    ... The CERHR has produced nine monographs and just completed its evaluation of fluoxetine (Prozac). In May, CERHR will evaluate acrylamide as a potential reproductive and ...

  39. Minutes: TR Panel; Oct. 29, 2013 234KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2013/october/minutes20131029_508.pdf

    ... He provided background information on acrylamide, of which glycidamide is a metabolite. ... and compare the long-term effects of acrylamide and glycidamide in male and female ...

  40. Presentation: The EURL ECVAM Toxicokinetics Report and EURL ECVAM... 2.5MB

    https://ntp.niehs.nih.gov/iccvam/meetings/ivive-wksp-2016/wksp-ppts/0-2-paini-508.pdf

    ... 81812 1 acetaminophen 103902 2 1 acetylsalicylic acid 50782 1 1 3 acrolein 107028 acrylamide 79061 4 amiodarone 1951253 2 1 amitriptyline 50486 1 2 amphetamine 300629 1 1 1 ...

  41. Reproductive Abstracts 204KB

    https://ntp.niehs.nih.gov/publications/abstracts/repro

    ... Formamide (CASRN: 68-12-2) in CD-1 Swiss Mice 1992 Reproductive RACB90022 Acrylamide Acrylamide (CASRN: 79-06-1): Reproductive Toxicity in CD-1 Swiss Mice 1993 Reproductive ...

  42. Technical Reports 907KB

    https://ntp.niehs.nih.gov/publications/reports/tr

    ... Report TR-575 PDF (9.97 MB) Toxicology and Carcinogenesis Studies of Acrylamide (CASRN 79-06-1) in F344/N Rats and B6C3F1 Mice (Feed and Drinking Water Studies) 2012 ...

  43. Minutes: BSC; Aug. 18, 2005 1.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2005/august/bscmins2005aug18_508.pdf

    ... The expert panel reports for amphetamine and methylphenidate and the NTP-CERHR monographs for fluoxetine and acrylamide are on the CERHR website. CERHR sponsored a symposium, "Gene ...

  44. Appendices A-G; 15th RoC 2021 448KB

    https://ntp.niehs.nih.gov/ntp/roc/content/appendices_508.pdf

    ... carbon see Soots acrylic acid amide see Acrylamide actinolite see Asbestos actinon see ... 1,3-Propane Sultone 2-propenamide see Acrylamide 2-propenenitrile see Acrylonitrile ...

  45. Study Abstracts 377KB

    https://ntp.niehs.nih.gov/publications/abstracts

    ... Formamide (CASRN: 68-12-2) in CD-1 Swiss Mice 1992 Reproductive RACB90022 Acrylamide Acrylamide (CASRN: 79-06-1): Reproductive Toxicity in CD-1 Swiss Mice 1993 Reproductive ...

  46. Minutes: BSC; Dec. 9-10, 2009 394KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2009/december/minutes20091210.pdf

    ... The next TRRS meeting, reviewing acrylamide, retinyl palmitate/retinoic acid phototoxicity, AIDS therapeutics, kava kava extract, alpha-beta thujone, methyl trans- styryl ketone, ...

  47. State of the DNTP FY 2021; BSC; Dec. 8, 2021 2.7MB

    https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2021/december/presentations/state_of_dntp_bsc_presentation_508.pdf

    ... People are exposed to substantially more acrylamide from tobacco smoke than from food. Does Brown Rice Really Have Arsenic in It? ...according to the U.S. National Toxicology ...

  48. Minutes: BSC; April 13, 2011 257KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2011/april/minutesbsc20110413.pdf

    ... Bucher also mentioned the draft TRs peer review meeting that took place April 5, 2011, which reviewed reports on senna, acrylamide, Aloe vera, and combinations of AIDS ...

  49. Presentation: Developing Reverse Toxicokinetic Models to Correlate... 2.5MB

    https://ntp.niehs.nih.gov/iccvam/meetings/commprac-2015/wambaugh-508.pdf

    ... NA 0.641 0.348 0.364 0.309 4.328 0.338 0.542 0.485 0.208 NA 0.37 0.711 0.169 NA NA Acrylamide NA NA 0.331 NA 0.913 0.268 4.639 0.298 0.162 0.126 0.22 0.206 NA 0.096 0.885 3.132 ...

  50. Minutes; BSC; Dec. 15, 2011 258KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2011/december/minutesbsc20111215.pdf

    ... Four draft TRs were reviewed at the meeting: senna, a nondecolorized whole leaf extract of Aloe barbadensis Miller (Aloe vera), acrylamide, and combinations of AIDS therapeutics ...

 
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