-
RoC Profile: Butylated Hydroxyanisole; 15th RoC 2021 132KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/butylatedhydroxyanisole.pdf
Butylated Hydroxyanisole CAS No. 25013-16-5 Reasonably anticipated to be a human carcinogen First listed in the Sixth Annual Report on Carcinogens (1991) Also known as BHA or or ...
-
Abstract for TR-524 65KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr524
Organic acids with hydroxy groups on the second carbon from the carbonyl carbon are referred to as beta-hydroxy acids (BHA). Both AHA and BHA are used to treat various skin ...
-
RoC Profile: Diesel Exhaust Particulates; 15th RoC 2021 151KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/dieselexhaustparticulates.pdf
diesel exhaust (IARC 1989, Cohen and Higgins 1995, Bha- tia et al. 1998). Meta-analyses by Cohen and Higgins (1995) and Bha- tia et al. (1998) suggested an overall relative risk ...
-
TOX-70: Toxicity Studies of p-tert-Butylcatechol (CASRN 98-29... 2.8MB
https://ntp.niehs.nih.gov/go/tox070
... The analogs caffeic acid and butylated hydroxyanisole (BHA) were weak carcinogens in the rat forestomach epithelium; butylated hydroxytoluene (BHT) was not carcinogenic (Hirose et ...
-
TR-524: Glycolic Acid and Salicylic Acid (CASRNs 79-14-1 and... 2.8MB
https://ntp.niehs.nih.gov/go/tr524
... Organic acids with hydroxy groups on the second carbon from the carbonyl carbon are referred to as beta-hydroxy acids (BHA). Both AHA and BHA are used to treat various skin con- ...
-
15th RoC: Appendix F 165KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/appendix_f.pdf
... Be see Beryllium and Beryllium Compounds BHA see Butylated Hydroxyanisole B[j]F see ... 2-tert-butyl-4-hydroxyanisole (2-BHA) see Butylated Hydroxyanisole ...
-
Stokes: Current and Future Contributions of NICEATM and ICCVAM... 3.1MB
https://ntp.niehs.nih.gov/iccvam/meetings/7thwc/ms/reb4-stokes1.pdf
... ICCVAM and NICeAtM also have liaisons contributing to two JaCVAM-led validation studies: the in vivo/in vitro comet assay and the BHAS cell transformation assay. 4 Independent ...
-
Appendix G; 15th RoC 2021 69KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/appendix_g.pdf
... Chemotherapeutic Agents 23214-92-8 see Adriamycin 23246-96-0 see Riddelliine 25013-16-5 see Butylated Hydroxyanisole 25316-40-9 (doxorubicin hydrochloride) see Adriamycin ...
-
Background Document: Styrene oxide; BSC RoC, Jan. 20-21, 2000 267KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/roc10/bg_styrene_oxide_508.pdf
... Additional rats received diets containing 0%, 0.5%, 1%, or 2% butylated hydroxyanisole (BHA) as a positive control treatment. (BHA is a widely used food additive [antioxidant] and ...
-
TR-371: Toluene (CASRN108-88-3) in F344/N Rats and B6C3F1Mice... 15.6MB
https://ntp.niehs.nih.gov/go/tr371
... on BHA-induced forestomach carcinogene- sis, Ito exposed groups of 15 F344 rats to 2% ben- zoic acid in the diet for 52 weeks with and without 2% butylated hydroxyanisole (BHA) ...
-
Appendices A-G; 15th RoC 2021 433KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/appendices_508.pdf
... Be see Beryllium and Beryllium Compounds BHA see Butylated Hydroxyanisole B[j]F see ... 2-tert-butyl-4-hydroxyanisole (2-BHA) see Butylated Hydroxyanisole ...
-
TOX-27: Riddelliine (CASRN 23246-96-0) 3.4MB
https://ntp.niehs.nih.gov/go/tox027
... Presumably, the sulfhydryls bind the toxic metabolites of PAs and minimize the amount of toxicant available to cause tissue damage. Administration of antioxidants such as BHA or ...
-
DART-07: Prenatal Development Studies of 2-((1-(4-Phenoxyphenoxy... 1.6MB
https://ntp.niehs.nih.gov/go/dart07
... <10.0 1 Nitrite Nitrogen b,c (ppm) <0.61 1 BHA b,d (ppm) <1.0 1 BHT b,d (ppm) <1.0 1 ... BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming ...
-
TOX-103: Select Ionic Liquids (1-Ethyl-3-Methylimidazolium Chloride... 4.7MB
https://ntp.niehs.nih.gov/go/tox103
... b 10 1 Nitrite Nitrogen (ppm) a,b <0.61 1 BHA (ppm) a,c <1.00 1 BHT (ppm) a,c <1.00 1 ... BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming ...
-
TOX-102: Trans-resveratrol Administered by Gavage for Two Weeks... 2.6MB
https://ntp.niehs.nih.gov/go/tox102
... 14.2 1 Nitrite Nitrogen (ppm) a,b <0.61 1 BHA (ppm) a,c <1.0 1 BHT (ppm) a,c <1.0 1 ... BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming ...
-
TR-459: t-Butylhydroquinone (CASRN 1948-33-0) in F344 Rats and... 25.3MB
https://ntp.niehs.nih.gov/go/tr459
... lesions in the forestomach of rats by 3-tert-butyl-4-hydroxyanisole (BHA). Food Chem. ... Mutagenicity of 3-tert- butyl-4-hydroxyanisole (BHA) and its metabolites in short-term ...
-
TR-603: Black Cohosh Root Extract (CASRN 84776-26-1) Administered... 3.1MB
https://ntp.niehs.nih.gov/sites/default/files/2023-12/tr603_508.pdf
... 4 Nitrite Nitrogen (ppm) a,b <0.61 - 4 BHA (ppm) a,c <1.0 - 4 BHT (ppm) a,c <1.0 - 4 ... BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming ...
-
NTP RR-11: The Chemical and Physical Characterization of Recycled... 2.1MB
https://ntp.niehs.nih.gov/go/rr11
... (Sigma-Aldrich, Milwaukee, WI) 25013-16-5 2/8/2016 500 mg 99.9 White Crystals ... 204.27 Butylated Hydroxyanisole 25013-16-5 180.25 Butylated Hydroxytoluene ...
-
NIEHS/DTT Toxicity Specifications: Chapter 6. Laboratory Animal... 554KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/test_info/toxspecs/chapter6_laboratory_animal_medicine_toxicology_508.pdf
... Sulfate 0.03 PCBs (ppm) 0.20 Miscellaneous (Maximum Limits, ppm) Nitrate 20 Nitrite 5 BHA 10 BHT 5 Bacterial Plate Count Total (CFU/g) 1,000 Coliform (MPN/g) 10 E. Coli (MPN/g) ...
-
TOX-98: Acetoin (CASRN 513-86-0) and 2,3-Pentanedione (CASRN... 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox098_508.pdf
... 8 Nitrite Nitrogen (ppm) a,b <0.61 - 8 BHA (ppm) a,c <1.0 - 8 BHT (ppm) a,c <1.0 - 8 ... BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming ...
-
TR-600: Di-n-butyl Phthalate Administered in Feed to Sprague... 3.4MB
https://ntp.niehs.nih.gov/go/tr600
... 2 Nitrite Nitrogen (ppm) a,b <0.61 - 2 BHA (ppm) a,c <1.0 - 2 BHT (ppm) a,c <1.0 - 2 ... BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming ...
-
TOX-106: Sodium Metavanadate (CASRN 13718-26-8) and Vanadyl Sulfate... 2.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox106_508.pdf
... 3 Nitrite Nitrogen (ppm) a,b <0.61 - 3 BHA (ppm) a,c <1.0 - 3 BHT (ppm) a,c <1.0 - 3 ... BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming ...
-
Draft RoC Monograph for ortho-Toluidine: Literature Search Strategy... 1.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/thirteenth/litsearchstrategy/otol_literaturesearch20130815_508.pdf
... YM, Yamazaki S, Umeda M, Tanaka N. 2010. A Bhas 42 cell transformation assay on 98 chemicals: The characteristics and performance for the prediction of chemical carcinogenicity. ...
-
TR-604: Triclosan (CASRN 3380-34-5) Administered Dermally to... 1.2MB
https://ntp.niehs.nih.gov/sites/default/files/2024-05/tr604_508.pdf
... (ppm) b 0.395 ± 0.245 0.12-0.63 13 BHA (ppm) c 1.412 ± 1.064 1.0-4.76 13 BHT ... BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming ...
-
TR-550: Toxicology and Carcinogenesis Studies of Cresols (CASRN... 2.4MB
https://ntp.niehs.nih.gov/go/tr550
... For example, butylated
hydroxyanisole (BHA), non-DNA reactive and a skin irritant, produces a low incidence of carcinoma in the forestomach of rodents, presumably as a result of ...
-
DART-01: Prenatal Development Studies of Tris(chloropropyl) Phosphate... 911KB
https://ntp.niehs.nih.gov/go/dart01
... - 1 Nitrite Nitrogen (ppm) c <0.61 - 1 BHA (ppm) d <1.0 - 1 BHT (ppm) d <1.0 - 1 ... II <0.01 - 1 Endosulfane Sulfate <0.03 - 1 BHA = butylated hydroxyanisole; BHT = butylated ...
-
DART-02: Prenatal Development Studies of 4-Methylcyclohexanemethanol... 1.1MB
https://ntp.niehs.nih.gov/go/dart02
... 10 1 Nitrite Nitrogen c (ppm) <0.61 1 BHA d (ppm) 2.37 1 BHT d (ppm) <1.0 1 Aerobic ... II <0.01 1 Endosulfane Sulfate <0.03 1 BHA = butylated hydroxyanisole; BHT = butylated ...
-
DART-04: Prenatal Development Studies of Dimethylaminoethanol... 1006KB
https://ntp.niehs.nih.gov/go/dart04
... 2 Nitrite Nitrogen (ppm) c <0.61 - 2 BHA (ppm) d <1.0 - 2 BHT (ppm) d <1.0 - 2 ... II <0.01 - 2 Endosulfan Sulfate <0.03 - 2 BHA = butylated hydroxyanisole; BHT = butylated ...
-
TOX-9: Cresols (CASRNs 95-48-7, 108-39-4, 106-44-5) 6.1MB
https://ntp.niehs.nih.gov/go/tox009
... antioxidant 3-tert-butyl-4-hydroxyanisole (BHA) induces mild hyperplasia and ... Earlier studies by Ito et al (1983) demonstrated that 2 % dietary BHA is carcinogenic in ...
-
NTP Technical Report on the Toxicity Study of (CASRN 67892-26... 426KB
https://ntp.niehs.nih.gov/go/tox107abs
... 11.5 1 Nitrite nitrogen (ppm)a,b <0.12 1 BHA (ppm)a,c <1.0 1 BHT (ppm)a,c <1.0 1 Aerobic ... 11.5 1 Nitrite nitrogen (ppm)a,b <0.12 1 BHA (ppm)a,c <1.0 1 BHT (ppm)a,c <1.0 1 Aerobic ...
-
DART-02: Prenatal Development Studies of 4-Methylcyclohexanemethanol... 1.1MB
https://ntp.niehs.nih.gov/ntp/htdocs/dart/dart02_508.pdf
... 10 1 Nitrite Nitrogen c (ppm) <0.61 1 BHA d (ppm) 2.37 1 BHT d (ppm) <1.0 1 Aerobic ... II <0.01 1 Endosulfane Sulfate <0.03 1 BHA = butylated hydroxyanisole; BHT = butylated ...
-
TOX-107: Toxicity Study of Stachybotrys chartarum (CASRN 67892... 2.9MB
https://ntp.niehs.nih.gov/sites/default/files/2024-09/tox107_508.pdf
... 11.5 1 Nitrite Nitrogen (ppm) a,b <0.12 1 BHA (ppm) a,c <1.0 1 BHT (ppm) a,c <1.0 1 ... BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming ...
-
DART-03: Prenatal Development Studies of Vinpocetine (CASRN 42971... 1.2MB
https://ntp.niehs.nih.gov/go/dart03
... c 9.65 1 Nitrite Nitrogen (ppm) c <0.61 1 BHA (ppm) d <1.0 1 BHT (ppm) d <1.0 1 Aerobic ... II <0.01 1 Endosulfane sulfate <0.03 1 BHA = butylated hydroxyanisole; BHT = butylated ...
-
TOX-77: Hexachlorobenzene (CASRN 118-74-1) Administered by Gavage... 2.2MB
https://ntp.niehs.nih.gov/go/tox077
... 1 Nitrite Nitrogen (ppm) a,b <0.61 - 1 BHA (ppm) a,c <1.0 - 1 BHT (ppm) a,c <1.0 - 1 ... BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming ...
-
TOX-101: Trimethylsilyldiazomethane (CASRN 18107-18-1) Administered... 6.7MB
https://ntp.niehs.nih.gov/go/tox101
... 2 Nitrite Nitrogen (ppm) a,b <0.61 - 2 BHA (ppm) a,c <1.00 - 2 BHT (ppm) a,c <1.00 - 2 ... a <0.01 - 2 Endosulfan Sulfate a <0.03 - 2 BHA = butylated hydroxyanisole; BHT = butylated ...
-
TR-602: Isomeric Mixture of Tris(chloropropyl) Phosphate Administered... 8.0MB
https://ntp.niehs.nih.gov/sites/default/files/2023-06/tr602_508.pdf
... 4 Nitrite Nitrogen (ppm) a,b <0.61 - 4 BHA (ppm) a,c <1.0 - 4 BHT (ppm) a,c <1.0 - 4 ... BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming ...
-
TR-599: Sodium Tungstate Dihydrate in Sprague Dawley (Hsd:Sprague... 4.2MB
https://ntp.niehs.nih.gov/go/tr599
... 2 Nitrite Nitrogen (ppm) a,b <0.61 - 2 BHA (ppm) a,c <1.0 - 2 BHT (ppm) a,c <1.0 - 2 ... BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming ...
-
TR-601: Di(2-ethylhexyl) Phthalate Administered in Feed to Sprague... 4.5MB
https://ntp.niehs.nih.gov/go/tr601
... 2 Nitrite Nitrogen (ppm) a,b <0.61 - 2 BHA (ppm) a,c <1.0 - 2 BHT (ppm) a,c <1.0 - 2 ... BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming ...
-
IMM-01: Dermal Hypersensitivity and Irritancy Studies of 4-Methylcyclo... 969KB
https://ntp.niehs.nih.gov/go/imm001
... 3 Nitrate Nitrogen (ppm) c 11.51 ± 2.18 10.0-14.0 3 Nitrite Nitrogen (ppm) c 0.61 - 3 BHA (ppm) d 1.41 ± 0.72 1.0-2.24 3 BHT (ppm) d <1.0 - 3 Aerobic Plate Count (CFU/g) <10 - 3 ...
-
ICCVAM Biennial Progress Report 2008-2009 11.8MB
https://ntp.niehs.nih.gov/iccvam/docs/annrpt/biennialrpt2010-508r.pdf
... Carcinogen Testing . Validation study of the Bhas 42 cell transformation assay to screen chemicals for carcinogenic potential - NICEATM and ICCVAM have liaison members to the ...
-
DART-06: Modified One-Generation Study of 2-Ethylhexyl p-Methoxycinnam... 5.2MB
https://ntp.niehs.nih.gov/go/dart06
... 5 Nitrite Nitrogen (ppm) a,b <1.0 - 5 BHA (ppm) a,c <1.0 - 5 BHT (ppm) a,c <1.0 - 5 ... BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming ...
-
TOX-89: Toxicity Studies of 5-Amino-o-cresol (CASRN 2835-95-2... 2.5MB
https://ntp.niehs.nih.gov/go/tox089
... (ppm) c 14.6 ± 6.6 5.09-23.7 5 Nitrite nitrogen (ppm) c 1.34 ± 1.34 0.30-3.04 5 BHA (ppm) d <1.0 - 5 BHT (ppm) d <1.0 - 5 Aerobic plate count (CFU/g) 10 ± 0.0 10 5 ...
-
TOX-99: A Gum Guggul Extract Formulation Administered by Gavage... 1.0MB
https://ntp.niehs.nih.gov/go/tox099
... 5 Nitrate Nitrogen (ppm) c 22.54 ± 12.0 10.0-35.9 5 Nitrite Nitrogen (ppm) c 0.61 - 5 BHA (ppm) d <1.0 - 5 BHT (ppm) d <1.0 - 5 Aerobic Plate Count (CFU/g) <10.0 - 5 Coliform ...
-
TR-294: Chlorinated Trisodium Phosphate (CASRN 56802-99-4) in... 6.5MB
https://ntp.niehs.nih.gov/go/tr294
... Selenium (ppm) Aflatoxins (ppb) (b,c) Nitrate nitrogen (ppm) (d,e) Nitrite nitrogen (ppm) (d,e) BHA (ppm) (f,g) BHT (ppm) (0 Aerobic plate count (CFUlg) (h) Coliform (MPN/g) (ij) ...
-
TR-381: d-Carvone (CASRN 2244-16-8) in B6C3F1Mice (Gavage Studies... 6.3MB
https://ntp.niehs.nih.gov/go/tr381
... (ppm) (b) 9.03 k 4.76 0.10-22.0 Nitrite nitrogen (ppm) (b) 1.66 f 1.76 0.10-7.10 BHA (ppm) (c) 4.08 f 4.76 2.00-17.0 BHT (ppm) (c) 2.68 f 2.55 1.00-12.0 Aerobic plate count ...
-
TOX-99: A Gum Guggul Extract Formulation Administered by Gavage... 1.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox99_508.pdf
... 5 Nitrate Nitrogen (ppm) c 22.54 ± 12.0 10.0-35.9 5 Nitrite Nitrogen (ppm) c 0.61 - 5 BHA (ppm) d <1.0 - 5 BHT (ppm) d <1.0 - 5 Aerobic Plate Count (CFU/g) <10.0 - 5 Coliform ...
-
Specifications for the Conduct of Toxicity Studies by the Division... 8.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/test_info/toxspecs/dtt_specs_compiled_508.pdf
... Sulfate 0.03 PCBs (ppm) 0.20 Miscellaneous (Maximum Limits, ppm) Nitrate 20 Nitrite 5 BHA 10 BHT 5 Bacterial Plate Count Total (CFU/g) 1,000 Coliform (MPN/g) 10 E. Coli (MPN/g) ...
-
RoC Monograph: ortho-Toluidine; July 2014 2.4MB
https://ntp.niehs.nih.gov/go/rocmgraph04
... Lim YM, Yamazaki S, Umeda M et al. 2010. A Bhas 42 cell transformation assay on 98 ... - + 330 150 Matthews et al. (1985) Mouse Bhas 42 b initiation assay promotion assay - + ...
-
TOX-80: Sodium Thioglycolate (CASRN 367-51-1) Administered Dermally... 3.5MB
https://ntp.niehs.nih.gov/go/tox080
... (ppb) <5.00 1 Nitrate nitrogen (ppm) c 18.8 1 Nitrite nitrogen (ppm) c <0.61 1 BHA (ppm) d <1.0 1 BHT (ppm) d <1.0 1 Aerobic plate count (CFU/g) 50 1 Coliform (MPN/g) 3.0 ...
-
TOX-85: Toxicity Study of Tetrabromobisphenol A-bis(2,3-dibromopropyl... 2.7MB
https://ntp.niehs.nih.gov/go/tox085
... (ppm) c 21.3 ± 3.08 16.8-23.7 4 Nitrite nitrogen (ppm) c 2.50 ± 1.56 0.30-3.86 4 BHA (ppm) d <1.0 - 4 BHT (ppm) d <1.0 - 4 Aerobic plate count (CFU/g) 10 ± 0.0 10 4 ...