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Butylated hydroxyanisole (BHA) M88172 21KB
https://ntp.niehs.nih.gov/go/ts-m88172
Butylated hydroxyanisole (BHA) M88172 CASRN: 25013-16-5 Formula: C11-H16-O2 Synonyms/Common Names BHA tert-Butyl-4-methoxyphenol Genetic Toxicology Micronucleus (A65600) Completed ...
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Nomination Summary for BHA (N20509) 19KB
https://ntp.niehs.nih.gov/go/nm-n20509
BHA (N20509) Nominated Substances: Butylated hydroxyanisole (BHA) Nomination Date: 12/05/2004 Nominator: Private Individual Rationale: BHA is a widely used preservative in pet ...
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RoC Profile: Butylated Hydroxyanisole; 15th RoC 2021 132KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/butylatedhydroxyanisole.pdf
Butylated Hydroxyanisole CAS No. 25013-16-5 Reasonably anticipated to be a human carcinogen First listed in the Sixth Annual Report on Carcinogens (1991) Also known as BHA or or ...
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Nomination Summary for Chemicals id by IARC as possible carcinogens... 30KB
https://ntp.niehs.nih.gov/go/nm-n87322
Nominated Substances: p-Aminoazobenzene, o-Aminoazotoluene, Auramine, Benzyl violet 4B, Butylated hydroxyanisole (BHA), beta-Butyrolactone, C.I. Solvent Red 80 (8CI), ...
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Abstract for TR-524 31KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr524/index.html
Organic acids with hydroxy groups on the second carbon from the carbonyl carbon are referred to as beta-hydroxy acids (BHA). Both AHA and BHA are used to treat various skin ...
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Nomination Summary for t-butylhydroquinone (N85325) 19KB
https://ntp.niehs.nih.gov/go/nm-n85325
Rationale: Potential for increased use because of questions about safety of phenolic antioxidants Butylated hydroxyanisole (BHA) and Butylated hydroxytoluene (BHT), available ...
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RoC Profile: Diesel Exhaust Particulates; 15th RoC 2021 151KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dieselexhaustparticulates.pdf
diesel exhaust (IARC 1989, Cohen and Higgins 1995, Bha- tia et al. 1998). Meta-analyses by Cohen and Higgins (1995) and Bha- tia et al. (1998) suggested an overall relative risk ...
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TOX-70: p-tert-Butylcatechol (CASRN 98-29-3) 4.6MB
https://ntp.niehs.nih.gov/go/tox070
... The analogs caffeic acid and butylated hydroxyanisole (BHA) were weak carcinogens in the rat forestomach epithelium; butylated hydroxytoluene (BHT) was not carcinogenic (Hirose et ...
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TR-524: Photocarcinogenesis Study of Glycolic Acid and Salicylic... 17.0MB
https://ntp.niehs.nih.gov/go/tr524
... Organic acids with hydroxy groups on the second carbon from the carbonyl carbon are referred to as beta-hydroxy acids (BHA). Both AHA and BHA are used to treat various skin con- ...
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15th RoC: Appendix F 174KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_f.pdf
... Be see Beryllium and Beryllium Compounds BHA see Butylated Hydroxyanisole B[j]F see ... 2-tert-butyl-4-hydroxyanisole (2-BHA) see Butylated Hydroxyanisole ...
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Substance Search 453KB
https://ntp.niehs.nih.gov/whatwestudy/testpgm/status/index.html
... tert-Butylamine n-Butyl-p-aminobenzoate Butyl anthranilate Butylated hydroxyanisole (BHA) Butylated hydroxytoluene N-Butylbenzenesulfonamide Butyl benzyl phthalate ...
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Stokes: Current and Future Contributions of NICEATM and ICCVAM... 3.1MB
https://ntp.niehs.nih.gov/iccvam/meetings/7thwc/ms/reb4-stokes1.pdf
... ICCVAM and NICeAtM also have liaisons contributing to two JaCVAM-led validation studies: the in vivo/in vitro comet assay and the BHAS cell transformation assay. 4 Independent ...
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Nomination Background: Ethoxyquin (CASRN: 91-53-2) 3.0MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/ethoxyquin_508.pdf
... During the second week, butylated hydroxy-anisole (BHA) was also added to the test diet, and food intake was measured . BHA-induced epithelial hyperplasia in the forestomach was ...
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Background Document: Styrene oxide; BSC RoC, Jan. 20-21, 2000 267KB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/bg_styrene_oxide_508.pdf
... Additional rats received diets containing 0%, 0.5%, 1%, or 2% butylated hydroxyanisole (BHA) as a positive control treatment. (BHA is a widely used food additive [antioxidant] and ...
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Appendix G; 15th RoC 2021 73KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_g.pdf
... Chemotherapeutic Agents 23214-92-8 see Adriamycin 23246-96-0 see Riddelliine 25013-16-5 see Butylated Hydroxyanisole 25316-40-9 (doxorubicin hydrochloride) see Adriamycin ...
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TR-371: Toluene (CASRN108-88-3) in F344/N Rats and B6C3F1Mice... 15.6MB
https://ntp.niehs.nih.gov/go/tr371
... on BHA-induced forestomach carcinogene- sis, Ito exposed groups of 15 F344 rats to 2% ben- zoic acid in the diet for 52 weeks with and without 2% butylated hydroxyanisole (BHA) ...
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TOX-27: Riddelliine (CASRN 23246-96-0) 3.4MB
https://ntp.niehs.nih.gov/go/tox027
... Presumably, the sulfhydryls bind the toxic metabolites of PAs and minimize the amount of toxicant available to cause tissue damage. Administration of antioxidants such as BHA or ...
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Appendices A-G; 15th RoC 2021 448KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendices_508.pdf
... Be see Beryllium and Beryllium Compounds BHA see Butylated Hydroxyanisole B[j]F see ... 2-tert-butyl-4-hydroxyanisole (2-BHA) see Butylated Hydroxyanisole ...
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DART-07: Prenatal Development Studies of 2-((1-(4-Phenoxyphenoxy... 1.6MB
https://ntp.niehs.nih.gov/go/dart07
... <10.0 1 Nitrite Nitrogen b,c (ppm) <0.61 1 BHA b,d (ppm) <1.0 1 BHT b,d (ppm) <1.0 1 ... BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming ...
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Nomination Background: p-tert-Butylcatechol 1.1MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/butylcatechol_508.pdf
... Finally, Hirose ti al. (1988) reported that analogs, caffeic acid and BHA were weak carcinogens in rat f orestomach epithelium; BHT was negative in this study. 16 Prepared for NCI ...
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Summary Minutes SACATM Meeting Sept. 16, 2014 271KB
https://ntp.niehs.nih.gov/ntp/about_ntp/sacatm/2014/september/minutes20140916_508.pdf
... He described the Cell Transformation Assay based on the Bhas 42 cell line, which is used to evaluate carcinogenicity, noting that it can be used to replace animal testing. He ...
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TOX-103: Select Ionic Liquids (1-Ethyl-3-Methylimidazolium Chloride... 4.7MB
https://ntp.niehs.nih.gov/go/tox103
... b 10 1 Nitrite Nitrogen (ppm) a,b <0.61 1 BHA (ppm) a,c <1.00 1 BHT (ppm) a,c <1.00 1 ... BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming ...
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TR-459: t-Butylhydroquinone (CASRN 1948-33-0) in F344 Rats and... 25.3MB
https://ntp.niehs.nih.gov/go/tr459
... lesions in the forestomach of rats by 3-tert-butyl-4-hydroxyanisole (BHA). Food Chem. ... Mutagenicity of 3-tert- butyl-4-hydroxyanisole (BHA) and its metabolites in short-term ...
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RR-11: The Chemical and Physical Characterization of Recycled... 3.0MB
https://ntp.niehs.nih.gov/go/rr11
... (Sigma-Aldrich, Milwaukee, WI) 25013-16-5 2/8/2016 500 mg 99.9 White Crystals ... 204.27 Butylated Hydroxyanisole 25013-16-5 180.25 Butylated Hydroxytoluene ...
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TOX-102: Trans-resveratrol Administered by Gavage for Two Weeks... 2.6MB
https://ntp.niehs.nih.gov/go/tox102
... 14.2 1 Nitrite Nitrogen (ppm) a,b <0.61 1 BHA (ppm) a,c <1.0 1 BHT (ppm) a,c <1.0 1 ... BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming ...
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NIEHS/DTT Toxicity Specifications: Chapter 6. Laboratory Animal... 423KB
https://ntp.niehs.nih.gov/ntp/test_info/toxspecs/chapter6_laboratory_animal_medicine_toxicology_508.pdf
... Sulfate 0.03 PCBs (ppm) 0.20 Miscellaneous (Maximum Limits, ppm) Nitrate 20 Nitrite 5 BHA 10 BHT 5 Bacterial Plate Count Total (CFU/g) 1,000 Coliform (MPN/g) 10 E. Coli (MPN/g) ...
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TR-600: Di-n-butyl Phthalate Administered in Feed to Sprague... 3.4MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr600_508.pdf
... 2 Nitrite Nitrogen (ppm) a,b <0.61 - 2 BHA (ppm) a,c <1.0 - 2 BHT (ppm) a,c <1.0 - 2 ... BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming ...
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Draft TR-600: Di-n-butyl Phthalate (CASRN 84-74-2) Administered... 2.0MB
https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2021/april/tr600_508.pdf
... 2 Nitrite Nitrogen (ppm) a,b <0.61 - 2 BHA (ppm) a,c <1.0 - 2 BHT (ppm) a,c <1.0 - 2 ... BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming ...
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TOX-106: Sodium Metavanadate (CASRN 13718-26-8) and Vanadyl Sulfate... 2.7MB
https://ntp.niehs.nih.gov/go/tox106
... 3 Nitrite Nitrogen (ppm) a,b <0.61 - 3 BHA (ppm) a,c <1.0 - 3 BHT (ppm) a,c <1.0 - 3 ... BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming ...
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Draft RoC Monograph for ortho-Toluidine: Literature Search Strategy... 1.1MB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/litsearchstrategy/otol_literaturesearch20130815_508.pdf
... YM, Yamazaki S, Umeda M, Tanaka N. 2010. A Bhas 42 cell transformation assay on 98 chemicals: The characteristics and performance for the prediction of chemical carcinogenicity. ...
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TR-550: Cresols (CASRN 1319-77-3) in Male F344/N Rats and Female... 3.2MB
https://ntp.niehs.nih.gov/go/tr550
... For example, butylated
hydroxyanisole (BHA), non-DNA reactive and a skin irritant, produces a low incidence of carcinoma in the forestomach of rodents, presumably as a result of ...
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DART-01: Prenatal Development Studies of Tris(chloropropyl) Phosphate... 937KB
https://ntp.niehs.nih.gov/ntp/htdocs/dart/dart01_508.pdf
... - 1 Nitrite Nitrogen (ppm) c <0.61 - 1 BHA (ppm) d <1.0 - 1 BHT (ppm) d <1.0 - 1 ... II <0.01 - 1 Endosulfane Sulfate <0.03 - 1 BHA = butylated hydroxyanisole; BHT = butylated ...
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DART-04: Prenatal Development Studies of Dimethylaminoethanol... 1006KB
https://ntp.niehs.nih.gov/ntp/htdocs/dart/dart04_508.pdf
... 2 Nitrite Nitrogen (ppm) c <0.61 - 2 BHA (ppm) d <1.0 - 2 BHT (ppm) d <1.0 - 2 ... II <0.01 - 2 Endosulfan Sulfate <0.03 - 2 BHA = butylated hydroxyanisole; BHT = butylated ...
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TOX-9: Cresols (CASRNs 95-48-7, 108-39-4, 106-44-5) 6.1MB
https://ntp.niehs.nih.gov/go/tox009
... antioxidant 3-tert-butyl-4-hydroxyanisole (BHA) induces mild hyperplasia and ... Earlier studies by Ito et al (1983) demonstrated that 2 % dietary BHA is carcinogenic in ...
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Nomination Background: Butyl Paraben (CASRN: 94-26-8) 1.1MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/butylparaben_508.pdf
... However, parabens were lumped together with butylated hydroxyanisole (BHA), phytoestrogens, and synthetic steroids. Of the occupations listed with possible exposure to parabens, ...
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DART-02: Prenatal Development Studies of 4-Methylcyclohexanemethanol... 1.1MB
https://ntp.niehs.nih.gov/ntp/htdocs/dart/dart02_508.pdf
... 10 1 Nitrite Nitrogen c (ppm) <0.61 1 BHA d (ppm) 2.37 1 BHT d (ppm) <1.0 1 Aerobic ... II <0.01 1 Endosulfane Sulfate <0.03 1 BHA = butylated hydroxyanisole; BHT = butylated ...
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DART-02: Prenatal Development Studies of 4-Methylcyclohexanemethanol... 1.1MB
https://ntp.niehs.nih.gov/go/dart02
... 10 1 Nitrite Nitrogen c (ppm) <0.61 1 BHA d (ppm) 2.37 1 BHT d (ppm) <1.0 1 Aerobic ... II <0.01 1 Endosulfane Sulfate <0.03 1 BHA = butylated hydroxyanisole; BHT = butylated ...
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TOX-77: Hexachlorobenzene (CASRN 118-74-1) Administered by Gavage... 2.2MB
https://ntp.niehs.nih.gov/go/tox077
... 1 Nitrite Nitrogen (ppm) a,b <0.61 - 1 BHA (ppm) a,c <1.0 - 1 BHT (ppm) a,c <1.0 - 1 ... BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming ...
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TOX-101: Trimethylsilyldiazomethane (CASRN 18107-18-1) Administered... 6.7MB
https://ntp.niehs.nih.gov/go/tox101
... 2 Nitrite Nitrogen (ppm) a,b <0.61 - 2 BHA (ppm) a,c <1.00 - 2 BHT (ppm) a,c <1.00 - 2 ... a <0.01 - 2 Endosulfan Sulfate a <0.03 - 2 BHA = butylated hydroxyanisole; BHT = butylated ...
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Minutes: SACATM; June 17, 2011 343KB
https://ntp.niehs.nih.gov/ntp/about_ntp/sacatm/2011/june/minutes20110617.pdf
... or international peer review, e.g., the Bhas cell transformation assay and the LabCyte ... transformation assay in a BHAS42 cell line for the assessment of carcinogenic potential. ...
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Draft TR-599: Sodium Tungstate Dihydrate (CASRN 10213-10-2) in... 3.4MB
https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2021/april/tr599_508.pdf
... 2 Nitrite Nitrogen (ppm) a,b <0.61 - 2 BHA (ppm) a,c <1.0 - 2 BHT (ppm) a,c <1.0 - 2 ... BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming ...
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Draft TR-601: Di(2-ethylhexyl) Phthalate (CASRN 117-81-7) Administered... 3.6MB
https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2021/april/tr601_508.pdf
... 2 Nitrite Nitrogen (ppm) a,b <0.61 - 2 BHA (ppm) a,c <1.0 - 2 BHT (ppm) a,c <1.0 - 2 ... BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming ...
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DART-03: Prenatal Development Studies of Vinpocetine (CASRN 42971... 1.2MB
https://ntp.niehs.nih.gov/ntp/htdocs/dart/dart03_508.pdf
... c 9.65 1 Nitrite Nitrogen (ppm) c <0.61 1 BHA (ppm) d <1.0 1 BHT (ppm) d <1.0 1 Aerobic ... II <0.01 1 Endosulfane sulfate <0.03 1 BHA = butylated hydroxyanisole; BHT = butylated ...
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TR-599: Sodium Tungstate Dihydrate in Sprague Dawley (Hsd:Sprague... 4.2MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr599_508.pdf
... 2 Nitrite Nitrogen (ppm) a,b <0.61 - 2 BHA (ppm) a,c <1.0 - 2 BHT (ppm) a,c <1.0 - 2 ... BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming ...
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TR-601: Di(2-ethylhexyl) Phthalate Administered in Feed to Sprague... 4.5MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr601_508.pdf
... 2 Nitrite Nitrogen (ppm) a,b <0.61 - 2 BHA (ppm) a,c <1.0 - 2 BHT (ppm) a,c <1.0 - 2 ... BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming ...
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Nomination Background: 3,4-Dihydroxycinnamic acid (CASRN: 331... 2.4MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/chlorogenicacid_508.pdf
... 1997. Carcinogenicity of antioxidants BHA, caffeic acid, sesamol, 4-methoxyphenol and ... 1997. Carcinogenicity of antioxidants BHA, caffeic acid, sesamol, 4-methoxyphenol and ...
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IMM-01: Dermal Hypersensitivity and Irritancy Studies of 4-Methylcyclo... 969KB
https://ntp.niehs.nih.gov/go/imm001
... 3 Nitrate Nitrogen (ppm) c 11.51 ± 2.18 10.0-14.0 3 Nitrite Nitrogen (ppm) c 0.61 - 3 BHA (ppm) d 1.41 ± 0.72 1.0-2.24 3 BHT (ppm) d <1.0 - 3 Aerobic Plate Count (CFU/g) <10 - 3 ...
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ICCVAM Biennial Progress Report 2008-2009 11.8MB
https://ntp.niehs.nih.gov/iccvam/docs/annrpt/biennialrpt2010-508r.pdf
... Carcinogen Testing . Validation study of the Bhas 42 cell transformation assay to screen chemicals for carcinogenic potential - NICEATM and ICCVAM have liaison members to the ...
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Draft DART-06: Modified One-Generation Study of 2-Ethylhexyl... 2.7MB
https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2021/october/dart06_508.pdf
... 5 Nitrite Nitrogen (ppm) a,b <1.0 - 5 BHA (ppm) a,c <1.0 - 5 BHT (ppm) a,c <1.0 - 5 ... BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming ...
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DART-06: Modified One-Generation Study of 2-Ethylhexyl p-Methoxycinnam... 5.2MB
https://ntp.niehs.nih.gov/ntp/htdocs/dart/dart06_508.pdf
... 5 Nitrite Nitrogen (ppm) a,b <1.0 - 5 BHA (ppm) a,c <1.0 - 5 BHT (ppm) a,c <1.0 - 5 ... BHA = butylated hydroxyanisole; BHT = butylated hydroxytoluene; CFU = colony-forming ...