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TR-326: Ethylene Oxide (CASRN 75-21-8) in B6C3F1Mice (Inhalation... 6.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr326.pdf
6 TOXICOLOGY AND CARCINOGENESIS STUDIES O F ETHYLENE OXIDE (CAS NO. 75-21-8) IN B6C3F1 MIiCE (INHALATION STUDIES) U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service ...
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RoC Background Document: Ethylene Oxide; Dec. 2-3, 1998 4.0MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/ethyloxide_oneapp_508.pdf
ETHYLENE OXIDE FINAL MARCH 1999 Prepared for the December 2-3, 1998, Meeting of the Report on Carcinogens Subcommittee of the NTP Board of Scientific Counselors Prepared by ...
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RoC Profile: Ethylene Oxide; 15th RoC 2021 133KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/ethyleneoxide.pdf
First listed in the Fourth Annual Report on Carcinogens (1985) Also known as oxirane, EtO Carcinogenicity Ethylene oxide is known to be a human carcinogen based on sufficient ...
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Abstract for TR-326 62KB
https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr326
6abs Abstract for TR-326 Toxicology and Carcinogenesis Studies of Ethylene Oxide in B6C3F1 Mice (Inhalation Studies) CASRN: 75-21-8 Chemical Formula: C2H4O Molecular Weight: 44.05 ...
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Abstract for TER82078 60KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter82078
8abs Abstract for TER82078 Teratologic Evaluation of Ethylene Oxide in New Zealand White Rabbits CASRN: 75-21-8 Chemical Formula: C2H4O Molecular Weight: 44.0526 Report Date: April ...
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Target Organs and Levels of Evidence for TR-326 57KB
https://ntp.niehs.nih.gov/data/tr/300s/tr326levels
Target Organs and Levels of Evidence for TR-326 Toxicology and Carcinogenesis Studies of Ethylene Oxide (CASRN 75-21-8) in B6C3F1 Mice (Inhalation Studies) Chemical (Study Title) ...
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Abstract for TR-80 63KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr080
CASRN: 123-91-1 Chemical Formula: C4H8O2 Molecular Weight: 88.1052 Report Date: 1978 Full Report PDF Abstract 1,4-Dioxane, a dimer of ethylene oxide, is used extensively as an ...
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Abstract for TER84070A, TER84070B, TER84070C, and TER84070D 61KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter84070
Ethylene chlorohydrin (2-chloroethanol), a widely used industrial chemical and reaction product of the gaseous sterilant ethylene oxide, was evaluated for toxic and teratogenic ...
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Abstract for TER84071 60KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter84071
Ethylene Chlorohydrin (2-chloroethanol), a widely used industrial chemical and reaction product of the gaseous sterilant ethylene oxide, was evaluated for toxic and teratogenic ...
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Abstract for TR-275 62KB
https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr275
Toxicology and carcinogenesis studies of 2-chloroethanol (99% pure), an industrial chemical and an intermediate in the synthesis of ethylene oxide, were conducted by dermal ...
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CERHR Monograph: Potential Human Reproductive and Developmental... 4.3MB
https://ntp.niehs.nih.gov/ntp/ohat/egpg/ethylene/eg_monograph.pdf
... EG can be manufactured by one of four meth- ods. It can be produced by oxidation of ethyl- ene to ethylene oxide, followed by hydration; by acetoxylation to form mixed mono- and ...
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TR-275: 2-Chloroethanol (Ethylene Chlorohydrin) (CASRN 107-07... 14.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr275.pdf
... (99% pure), an industrial chemical and an intermediate in the synthesis of ethylene oxide, were conducted by dermal application of 2-chloro- ethanol dissolved in 70% ...
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TR-329: 1,2-Epoxybutane (CASRN 106-88-7) in F344/N Rats and B6C3F1Mice... 10.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr329.pdf
... 1-butene oxide; 1,a-butene oxide; butylene oxide; 1,Zbutylene oxide; ethyl ethylene oxide; ethyl oxirane ABSTRACT l,&Epoxybutane was selected for study because it is a ...
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RoC Profile: Propylene Oxide; 15th RoC 2021 196KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/propyleneoxide.pdf
In a cohort study of 602 workers poten- tially exposed to propylene oxide as well as to ethylene oxide, benzene, ethylene chloro hydrin, and other chemicals, no significant ...
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Minutes: BSC TRRS; Aug. 19, 1986 686KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1986/aug/86aug19trrsmins_508.pdf
Technical Report CAS No. - Route Page Number Bromodichloromethane Gavage Dimethyl Methylphosphonate Gavage 1,2-Epoxybutane I n h a l a t i o n Ethylene Oxide I n h a l a t i o n ...
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Abstract for TR-329 67KB
https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr329
CASRN: 106-88-7 Chemical Formula: C4H8O Molecular Weight: 72.1 Synonyms/Common Names: 1-Butene oxide; 1,2-butene oxide; butylene oxide; 1,2-butyleneoxide; ethyl ethylene oxide; ...
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TR-413: Ethylene Glycol (CASRN 107-21-1) in B6C3F1Mice (Feed... 11.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr413.pdf
... PRODUCTION AND USE Ethylene glycol is manufactured on a large-scale basis primarily by hydration o f ethylene oxide (Kirk- Othmer, 1982). Domestic U.S. production o f ethylene ...
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RoC Profile: Vinyl Halides (Selected); 15th RoC 2021 199KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/vinylhalides.pdf
... Agency for Research on Cancer. pp. 445-457. IARC. 2008b. Vinyl chloride. In 1,3-Butadiene, Ethylene Oxide and Vinyl Halides (Vinyl Fluoride, Vinyl Chloride and Vinyl Bromide). ...
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TR-477: 1-Chloro-2-Propanol (Technical Grade) (CASRN 127-00-4... 9.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr477.pdf
... nominated 1-chloro-2-propanol for study because of potential for human exposure due to its residues in various foods that are fumigated with ethylene oxide or propylene oxide. ...
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RoC Profile: 1,2-Dichloroethane; 15th RoC 2021 145KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dichloroethane.pdf
studies and one nested case- control study of chemical workers with exposure to 1,2-dichloro- ethane and other chemicals (such as ethylene oxide or chlorohydrin) (IARC 1999). ...
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TR-267: Propylene Oxide (CASRN 75-56-9) in F344/N Rats and B6C3F1Mice... 7.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr267.pdf
... Ethylene oxide produced weakly positive results in the same study (NIOSH, 1983). Tumors of the forestomach, mainly squamous cell carcinomas, occurred in 4% and 40% of female ...
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Abstract for TR-477 72KB
https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr477
nominated 1-chloro-2-propanol for study because of potential for human exposure due to its residues in various foods that are fumigated with ethylene oxide or propylene oxide. ...
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Listed Substances; 15th RoC 2021 76KB
https://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf
Epstein-Barr Virus (see Viruses: Eight Listings) Erionite Estrogens, Steroidal Ethylene Oxide Formaldehyde Helicobacter pylori (Chronic Infection) Hepatitis B Virus (see ...
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RoC Profile: Styrene; 15th RoC 2021 252KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/styrene.pdf
... different co- horts; a similar pattern has been observed for other epoxide-forming substances, such as 1,3-buta diene and ethylene oxide (see the profiles for those substances). ...
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Abstract for GMM-13 67KB
https://ntp.niehs.nih.gov/publications/reports/gmm/gmm13
3-hydroxy-1,2-epoxypropane; 3-hydroxyl-1,2-epoxypropane; hydroxymethyl ethylene oxide; 2-(hydroxymethyl)oxirane; 2-hydroxymethyloxiran; oxiranemethanol; ...
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RoC Background Document: 1,3-Butadiene; Oct. 30-31, 1997 9.0MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/butadiene_508.pdf
... The mutational spectra for 1 ,3-butadiene and its epoxide metabolites at the hprt locus in mouse lymphocytes are similar to the mutational spectrum of ethylene oxide, an alkylating ...
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Public Health Impact 1.5MB
https://ntp.niehs.nih.gov/media/impact
... Type: Final Rule April 21, 2023 Proposition 65 71-55-6 129-73-7 2023 OEHHA Updated No Significant Risk Level for Ethylene Oxide The Office of Environmental Health Hazard Assessment ...
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TR-484: 2-Butoxyethanol (CASRN 111-76-2) in F344/N Rats and B6C3F1Mice... 11.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr484.pdf
... PRODUCTION, USE, AND HUMAN EXPOSURE 2-Butoxyethanol is produced by reacting ethylene oxide with butyl alcohol. It may also be produced by reacting ethylene chlorohydrin or ethylene ...
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TOX-26: Ethylene Glycol Ethers 2-Methoxyethanol, 2-Ethoxyethanol... 8.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox026.pdf
... Chemical and physical properties for the three compounds are listed in Table 1. The three glycol alkyl ethers are produced by reaction of ethylene oxide with their respective ...
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Background: Dimethylethanolamine (DMAE) [108-01-0] and Selected... 1.3MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dmae_update_110002_508.pdf
... a list of chemicals produced at levels greater than 1,000 tonnes (2,205,000 lbs) per year. DMAE is synthesized from equimolar amounts of ethylene oxide and dimethylamine. ...
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Human Breast Cancer Studies; Pam Schwingl; ROCPRP; Oct. 5, 2018 2.4MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/october/presentations/05schwingl_rocprp_508.pdf
... Occupational co-exposures Population- specific co- exposures Cosmic radiation (transmeridian) Ethylene oxide Radiation Potential confounders: Weak or population specific ...
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Appendix G; 15th RoC 2021 73KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_g.pdf
... (Selected) 75-07-0 see Acetaldehyde 75-09-2 see Dichloromethane 75-21-8 see Ethylene Oxide 75-27-4 see Bromodichloromethane 75-52-5 see Nitromethane 75-55-8 see ...
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1-Bromopropane: Preliminary Literature Search Strategy and List... 639KB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/litsearchstrategy/1-bp-litsearch&references5oct2012_508.pdf
... Authors affiliated with NIOSH, OH.) 12. Chovanec M, Cedervall B, Kolman A. 2001. DNA damage induced by gamma-radiation in combination with ethylene oxide or propylene oxide in ...
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Background Document: Styrene oxide; BSC RoC, Jan. 20-21, 2000 267KB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/bg_styrene_oxide_508.pdf
... Further, the observed protection against genotoxicity was specific for SO, as ethylene oxide-induced DNA damage was not affected by the presence of 92hmEH-V79. The metabolic ...
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RoC Profile: 1,3-Butadiene; 15th RoC 2021 162KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/butadiene.pdf
... The mutational spectra for 1,3-butadiene and its epox- ide metabolites at the hprt locus in mouse lymphocytes are similar to the mutational spectrum for ethylene oxide, an ...
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TR-415: Polysorbate 80 (CASRN 9005-65-6) in F344/N Rats and B6C3F1Mice... 12.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr415.pdf
... It is produced by' reacting sorbitol and its anhydrides with ethylene oxide followed by esterification o f the reaction product with oleic acid. The reaction with ethylene oxide is ...
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TR-506: Acrylonitrile (CASRN 107-13-1) in B6C3F1Mice (Gavage... 7.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr506.pdf
... These data provided direct evidence that cyanide formation from acrylonitrile is preceded by its metabolism to 2-cyano- ethylene oxide exclusively via CYP2E1. Significant ...
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GMM-13: Genetically Modified Model Report on Glycidol (Gavage... 905KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/gmm_rpts/gmm13_508.pdf
... 3-hydroxy-1,2-epoxypropane; 3-hydroxyl-1,2-epoxypropane; hydroxymethyl ethylene oxide; 2-(hydroxymethyl)oxirane; 2-hydroxymethyloxiran; oxiranemethanol; ...
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RoC Background Document for Diethanolamine; March 22, 2002 1.1MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/deapub_no_appendices_508.pdf
... Production. DEA usually is produced by reaction of ethylene oxide with ammonia in a 2:1 molar ratio. Estimated annual production of DEA in the United States in 1995 was 106 ...
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Completed RoC Evaluations 119KB
https://ntp.niehs.nih.gov/whatwestudy/assessments/cancer/completed/roc
... Ethyl Acrylate Delisted Background Document Appendix A Request Archived Materials Ethylene Oxide Known to be a human carcinogen Background Document Appendix A Request Archived ...
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RoC Background Document: Vinyl Bromide; Jan. 20-21, 2000 220KB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/vb_no_appendices_508.pdf
... Hydroquinone methyl ether (0.02%, used as stabilizer), ethylene oxide (0.03%), acetylene (0.0007%), and aldehydes and ketones (0.008%) were present in the VB used. The animals in ...
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TR-518: Triethanolamine (CASRN 102-71-6) in B6C3F1Mice (Dermal... 5.0MB
https://ntp.niehs.nih.gov/go/tr518
... PRODUCTION, USE, AND HUMAN EXPOSURE Ethanolamines are produced on an industrial scale by aminating ethylene oxide with excess ammonia. Triethanolamine is separated from the mixture ...
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TR-272: Propylene (CASRN 115-07-1) in F344/N Rats and B6C3F1Mice... 8.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr272.pdf
... halation study, F344 rats exposed to ethylene oxide a t 100 ppm developed mononuclear cell leukemia, peritoneal mesotheliomas, and mixed cell brain gliomas (Lynch et al., 1984). ...
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NTP Response to BSC Peer Review Comments on the Draft Substances... 339KB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2011/response022409bsc2011.pdf
... found with other epoxides or substances metabolized to epoxides related to styrene, such as ethylene oxide and butadiene, which have presumably similar modes of action as styrene. ...
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Poster: Building a Comprehensive Search of Epigenetic Studies... 1.3MB
https://ntp.niehs.nih.gov/ntp/results/pubs/posters/garner_sot20220327.pdf
... splicing" OR "intron retention") NOT widely associated with epigenetic changes Ethylene oxide 2-Naphthlamine Cyclophosphamide Results; 1. For each epigenetic carcinogen, < 20 to ...
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15th RoC: Appendix F 174KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_f.pdf
... Owens-Corning glass wool see Certain Glass Wool Fibers (Inhalable) 1,2-oxathiolane, 2,2-dioxide see 1,3-Propane Sultone 2-oxetanone see β-Propiolactone oxirane see Ethylene Oxide ...
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Minutes: BSC; Feb. 24, 2009 209KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2009/february/minutes022409.pdf
... pattern is seen in the types of lymphohematopoeitic tumors found with other epoxides related to styrene, such as ethylene oxide and butadiene that have similar modes of action. ...
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TR-374: Glycidol (CASRN 556-52-5) In F344/N Rats and B6C3F1Mice... 11.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr374.pdf
... In inhalation studies, ethylene oxide induced neoplasms of the lung and harderian gland in both male and fe- male mice (NTP, 1987). Glycidol and certain representative glycidyl e t ...
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RoC Profile: 1,4-Dioxane; 15th RoC 2021 156KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dioxane.pdf
... Properties 1,4-Dioxane (a dimer of ethylene oxide) is a cyclic ether that exists at room temperature as a colorless liquid with a faint, pleasant ethe- real odor. It is miscible ...
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TR-288: 1,3-Butadiene (CASRN 106-99-0) in B6C3F1Mice (Inhalation... 5.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr288.pdf
... [see p. 961 and expressed concern that other in- halation studies with potent chemicals such as ethylene oxide and 1,Z-epoxybutane were conducted in the same chamber room. Dr. ...
