-
TR-326: Ethylene Oxide (CASRN 75-21-8) in B6C3F1Mice (Inhalation... 6.5MB
https://ntp.niehs.nih.gov/go/tr326
6 TOXICOLOGY AND CARCINOGENESIS STUDIES O F ETHYLENE OXIDE (CAS NO. 75-21-8) IN B6C3F1 MIiCE (INHALATION STUDIES) U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service ...
-
RoC Background Document: Ethylene Oxide; Dec. 2-3, 1998 4.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/other_background/ethyloxide_oneapp_508.pdf
ETHYLENE OXIDE FINAL MARCH 1999 Prepared for the December 2-3, 1998, Meeting of the Report ... NTP Report on Carcinogens 1998 Background Document for Ethylene Oxide TABLE OF CONTENTS ...
-
RoC Profile: Ethylene Oxide; 15th RoC 2021 126KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/ethyleneoxide.pdf
CAS No. 75-21-8 Known to be a human carcinogen First listed in the Fourth Annual Report on Carcinogens (1985) Also known as oxirane, EtO Carcinogenicity Ethylene oxide is known to ...
-
Abstract for TR-326 54KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr326
Abstract for TR-326 Toxicology and Carcinogenesis Studies of Ethylene Oxide in B6C3F1 Mice (Inhalation Studies) CASRN: 75-21-8 Chemical Formula: C2H4O Molecular Weight: 44.05 ...
-
Abstract for TER82078 54KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter82078
8abs Abstract for TER82078 Teratologic Evaluation of Ethylene Oxide in New Zealand White Rabbits CASRN: 75-21-8 Chemical Formula: C2H4O Molecular Weight: 44.0526 Report Date: April ...
-
Target Organs and Levels of Evidence for TR-326 50KB
https://ntp.niehs.nih.gov/data/tr/300s/tr326levels
Target Organs and Levels of Evidence for TR-326 Toxicology and Carcinogenesis Studies of Ethylene Oxide (CASRN 75-21-8) in B6C3F1 Mice (Inhalation Studies) Chemical (Study Title) ...
-
Abstract for TR-80 55KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr080
CASRN: 123-91-1 Chemical Formula: C4H8O2 Molecular Weight: 88.1052 Report Date: 1978 Full Report PDF Abstract 1,4-Dioxane, a dimer of ethylene oxide, is used extensively as an ...
-
Abstract for TER84071 54KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter84071
Ethylene Chlorohydrin (2-chloroethanol), a widely used industrial chemical and reaction product of the gaseous sterilant ethylene oxide, was evaluated for toxic and teratogenic ...
-
Abstract for TER84070A, TER84070B, TER84070C, and TER84070D 54KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter84070
Ethylene chlorohydrin (2-chloroethanol), a widely used industrial chemical and reaction product of the gaseous sterilant ethylene oxide, was evaluated for toxic and teratogenic ...
-
Abstract for TR-275 54KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr275
Toxicology and carcinogenesis studies of 2-chloroethanol (99% pure), an industrial chemical and an intermediate in the synthesis of ethylene oxide, were conducted by dermal ...
-
TR-275: 2-Chloroethanol (Ethylene Chlorohydrin) (CASRN 107-07... 14.0MB
https://ntp.niehs.nih.gov/go/tr275
... an intermediate in the synthesis of ethylene oxide, were conducted by dermal application ... of 2-Chloroethanol Toxicology of Ethylene Oxide Regulatory Status of 2-Chloroethanol ...
-
Minutes: BSC TRRS; Aug. 19, 1986 686KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1986/aug/86aug19trrsmins_508.pdf
1,2-Epoxybutane I n h a l a t i o n Ethylene Oxide I n h a l a t i o n Methyl Carbarnate ... Since two-year studies with l,3-butadiene and ethylene oxide were conducted i n the same ...
-
TR-329: 1,2-Epoxybutane (CASRN 106-88-7) in F344/N Rats and B6C3F1Mice... 10.0MB
https://ntp.niehs.nih.gov/go/tr329
... oxide; 1,Zbutylene oxide; ethyl ethylene oxide; ethyl oxirane ABSTRACT ... Since 2- year studies with 1,3-butadiene and ethylene oxide were conducted in the same ...
-
RoC Profile: Vinyl Halides (Selected); 15th RoC 2021 199KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/vinylhalides.pdf
References IARC. 2008a. Vinyl bromide. In 1,3-Butadiene, Ethylene Oxide and Vinyl Halides ... Vinyl chloride. In 1,3-Butadiene, Ethylene Oxide and Vinyl Halides (Vinyl Fluoride, ...
-
Abstract for TR-329 59KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr329
CASRN: 106-88-7 Chemical Formula: C4H8O Molecular Weight: 72.1 Synonyms/Common Names: 1-Butene oxide; 1,2-butene oxide; butylene oxide; 1,2-butyleneoxide; ethyl ethylene oxide; ...
-
Abstract for GMM-13 59KB
https://ntp.niehs.nih.gov/publications/reports/gmm/gmm13
3-hydroxy-1,2-epoxypropane; 3-hydroxyl-1,2-epoxypropane; hydroxymethyl ethylene oxide; 2-(hydroxymethyl)oxirane; 2-hydroxymethyloxiran; oxiranemethanol; ...
-
Abstract for TR-477 64KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr477
nominated 1-chloro-2-propanol for study because of potential for human exposure due to its residues in various foods that are fumigated with ethylene oxide or propylene oxide. ...
-
Listed Substances; 15th RoC 2021 76KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/listed_substances_508.pdf
Epstein-Barr Virus (see Viruses: Eight Listings) Erionite Estrogens, Steroidal Ethylene Oxide Formaldehyde Helicobacter pylori (Chronic Infection) Hepatitis B Virus (see ...
-
CERHR Monograph: Potential Human Reproductive and Developmental... 4.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/egpg/ethylene/eg_monograph.pdf
... It can be produced by oxidation of ethyl- ene to ethylene oxide, followed by hydration; by ... Possible trace impurities of ethylene glycol in- clude formaldehyde, ethylene oxide, and ...
-
TR-477: 1-Chloro-2-Propanol (Technical Grade) (CASRN 127-00-4... 9.9MB
https://ntp.niehs.nih.gov/go/tr477
... its residues in various foods that are fumigated with ethylene oxide or propylene oxide. ... Prior to 1969, all propylene oxide and most ethylene oxide produced in the United States ...
-
Research at CDRH to Evaluate Medical Device Safety Using Alternative... 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/2024-06/03_Rufer_ICCVAMForum2024_508_0.pdf
... approach for risk of changing from ethylene oxide to vaporized hydrogen peroxide ... device manufacturers to change from ethylene oxide (EtO) to vaporized hydrogen peroxide ...
-
RoC Profile: 1,2-Dichloroethane; 15th RoC 2021 145KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/dichloroethane.pdf
ethane and other chemicals (such as ethylene oxide or chlorohydrin) (IARC 1999). ... A cohort study of mortality and cancer incidence in ethylene oxide production workers. ...
-
RoC Profile: Propylene Oxide; 15th RoC 2021 134KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/propyleneoxide.pdf
to propylene oxide as well as to ethylene oxide, benzene, ethylene chloro hydrin, and ... L, Gustavsson A. 1986. Epidemiologic support for ethylene oxide as a cancer-causing agent. ...
-
Appendix G; 15th RoC 2021 69KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/appendix_g.pdf
... Vinyl Halides (Selected) 75-07-0 see Acetaldehyde 75-09-2 see Dichloromethane 75-21-8 see Ethylene Oxide 75-27-4 see Bromodichloromethane 75-52-5 see Nitromethane 75-55-8 see ...
-
RoC Profile: Styrene; 15th RoC 2021 252KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/styrene.pdf
... such as 1,3-buta diene and ethylene oxide (see the profiles for those substances). ... 1,3-butadiene, and ethylene oxide (NTP 2004a,b; see the profiles for those substances). ...
-
RoC Background Document: 1,3-Butadiene; Oct. 30-31, 1997 9.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/other_background/butadiene_508.pdf
... similar to the mutational spectrum of ethylene oxide, an alkylating agent that was ... product and where neither benzene nor ethylene oxide was present Duration: 39 yr (workers ...
-
Public Health Impact 1.9MB
https://ntp.niehs.nih.gov/media/impact
... for Ethylene Oxide The Office of Environmental Health Hazard Assessment (OEHHA) is proposing to update the Proposition 65 No Significant Risk Level (NSRL) for ethylene oxide by ...
-
RoC Profile: 1,3-Butadiene; 15th RoC 2021 162KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/butadiene.pdf
... The mutational spectra for 1,3-butadiene and its epox- ide metabolites at the hprt locus in mouse lymphocytes are similar to the mutational spectrum for ethylene oxide, an ...
-
1-Bromopropane: Preliminary Literature Search Strategy and List... 639KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/thirteenth/litsearchstrategy/1-bp-litsearch&references5oct2012_508.pdf
... in combination with ethylene oxide or propylene oxide in human fibroblasts. ... M. 1996. In vivo dosimetry of ethylene oxide and propylene oxide in the cynomolgus monkey. ...
-
15th Report on Carcinogens 91KB
https://ntp.niehs.nih.gov/research/assessments/cancer/roc
... Dimethylcarbamoyl Chloride 1,1-Dimethylhydrazine Dimethyl Sulfate Dimethylvinyl Chloride 1,4-Dioxane Disperse Blue E Epichlorohydrin Erionite Estrogens, Steroidal Ethylene Oxide ...
-
TR-413: Ethylene Glycol (CASRN 107-21-1) in B6C3F1Mice (Feed... 11.1MB
https://ntp.niehs.nih.gov/go/tr413
... on a large-scale basis primarily by hydration o f ethylene oxide (Kirk- Othmer, 1982). ... Disposition kinetics of ethylene oxide, ethylene glycol, and 2-chlorethanol in the dog. J. ...
-
TR-484: Toxicology and Carcinogenesis Studies of 2-Butoxyethanol... 4.7MB
https://ntp.niehs.nih.gov/go/tr484
... PRODUCTION, USE, AND HUMAN EXPOSURE 2-Butoxyethanol is produced by reacting ethylene
oxide ... Additionally, the ethylene oxide content was measured with system B. Impurities in the ...
-
TR-415: Polysorbate 80 (CASRN 9005-65-6) in F344/N Rats and B6C3F1Mice... 12.2MB
https://ntp.niehs.nih.gov/go/tr415
... It is produced by' reacting sorbitol and its anhydrides with ethylene oxide followed by esterification o f the reaction product with oleic acid. The reaction with ethylene oxide is ...
-
RoC Background Document for Diethanolamine; March 22, 2002 1.1MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/deapub_no_appendices_508.pdf
... DEA usually is produced by reaction of ethylene oxide with ammonia in a 2:1 molar ratio. ... DEA usually is produced by reaction of ethylene oxide with ammonia in a 2:1 molar ratio. ...
-
TR-267: Propylene Oxide (CASRN 75-56-9) in F344/N Rats and B6C3F1Mice... 7.5MB
https://ntp.niehs.nih.gov/go/tr267
... vapors ap- pear to be about one-third as toxic as ethylene
oxide (Hine et al., 1981). ... Ethylene oxide produced weakly positive results in the same study (NIOSH, 1983). Tumors of ...
-
Completed RoC Evaluations 116KB
https://ntp.niehs.nih.gov/research/assessments/cancer/completed/roc
... Request Archived Materials Ethyl Acrylate Delisted Background Document Appendix A Request Archived Materials Ethylene Oxide Known to be a human carcinogen Background Document ...
-
Handbook on Methods for Conducting Cancer Hazard Evaluations... 5.2MB
https://ntp.niehs.nih.gov/sites/default/files/2025-05/handbook_roc_508.pdf
.........165 Box 7-2. Ethylene Oxide Example......Box 7-3. Ethylene Oxide Example Known to be a human carcinogen Limited evidence from ...
-
GMM-13: Genetically Modified Model Report on Glycidol (Gavage... 905KB
https://ntp.niehs.nih.gov/go/gmm13
...roxyl-1,2-epoxypropane; hydroxymethyl ethylene oxide; 2-(hydroxymethyl)oxirane; ...roxyl-1,2-epoxypropane; hydroxymethyl ethylene oxide; 2-(hydroxymethyl)oxirane; ...
-
TR-374: Glycidol (CASRN 556-52-5) In F344/N Rats and B6C3F1Mice... 11.9MB
https://ntp.niehs.nih.gov/go/tr374
... In inhalation studies, ethylene oxide induced neoplasms of the lung and harderian gland in ... In long-term inhalation studies conducted with F344 rats, exposure to ethylene
oxide a t ...
-
RoC Profile: 1,4-Dioxane; 15th RoC 2021 154KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/dioxane.pdf
... Properties 1,4-Dioxane (a dimer of ethylene oxide) is a cyclic ether that exists at room ... of reactions based on condensing ethylene oxide or ethyl- ene glycol during ...
-
TR-506: Acrylonitrile (CASRN 107-13-1) in B6C3F1 Mice (Gavage... 2.9MB
https://ntp.niehs.nih.gov/go/tr506
... by its metabolism to 2-cyano- ethylene oxide exclusively via CYP2E1. Significant ... with 1,3-butadiene, vinyl chloride, ben- zene, or ethylene oxide (Melnick and Huff, 1993). ...
-
Minutes: BSC; Oct. 28, 1983 699KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1983/minutesbsc19831028_508.pdf
... He expressed concern that other inhalation studies with chemicals as potent as ethylene oxide and 1,2-epoxybutane were conducted in the same chamber room. and hoped this could be ...
-
TR-080: 1,4-Dioxane (CASRN 123-91-1) 3.3MB
https://ntp.niehs.nih.gov/go/tr080
... 17 , 26 . 27 xi I. INTRODUCTION 1,4-Dioxane (CAS 123-91-1; NCI C03689), a dimer of ethylene
oxide, hereinafter called dioxane, is used extensively as an industrial solvent for ...
-
RoC Profile: Acrylonitrile; 15th RoC 2021 145KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/acrylonitrile.pdf
... Fennell TR, MacNeela JP, Morris RW, Watson M, Thompson CL, Bell DA. 2000. Hemoglobin adducts from acrylonitrile and ethylene oxide in cigarette smokers: Effects of glutathione ...
-
NTP Response to BSC Peer Review Comments on the Draft Substances... 339KB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2011/response022409bsc2011.pdf
... epoxides related to styrene, such as ethylene oxide and butadiene, which have presumably ... and ethylene oxide) that are metabolized through similar metabolic pathways. ...
-
TOX-26: Ethylene Glycol Ethers 2-Methoxyethanol, 2-Ethoxyethanol... 8.2MB
https://ntp.niehs.nih.gov/go/tox026
... The three glycol alkyl ethers are produced by reaction of ethylene oxide with their respective alcohols or by direct alkylation of ethylene oxide with agents like dimethyl, ...
-
TOX-20: Diethanolamine (CASRN 111-42-2) 2.5MB
https://ntp.niehs.nih.gov/go/tox020
... Along with monoethanolamine and triethanolamine, DEA is produced by ammonolysis of ethylene
oxide, then separated by distillation (Mullins, 1978). In 1989, 202 million pounds (92 x ...
-
TR-288: 1,3-Butadiene (CASRN 106-99-0) in B6C3F1Mice (Inhalation... 5.4MB
https://ntp.niehs.nih.gov/go/tr288
... such as ethylene oxide and 1,Z-epoxybutane were conducted in the same chamber room. ... Test in Same Room Propylene Propylene Ethylene Oxide 1,2- E poxy b utane CHEMISTRY Lot No. ...
-
TR-272: Propylene (CASRN 115-07-1) in F344/N Rats and B6C3F1Mice... 8.1MB
https://ntp.niehs.nih.gov/go/tr272
... In the case of ethylene, conversion to the epoxide form, ethylene oxide, has been ... The epoxi- dated forms of both ethylene (i.e., ethylene
oxide) and propylene (i.e. ...
-
RoC Background Document: Vinyl Bromide; Jan. 20-21, 2000 220KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/roc10/vb_no_appendices_508.pdf
... Hydroquinone methyl ether (0.02%, used as stabilizer), ethylene
oxide (0.03%), acetylene (0.0007%), and aldehydes and ketones (0.008%) were present in the VB used. The animals in ...