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235 results found for "ethylene oxide".

  1. TR-326: Ethylene Oxide (CASRN 75-21-8) in B6C3F1Mice (Inhalation... 6.6MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr326.pdf

    PROGRAM Technical Report Series No. 326 TOXICOLOGY AND CARCINOGENESIS STUDIES O F ETHYLENE OXIDE (CAS NO. 75-21-8) IN B6C3F1 MIiCE (INHALATION STUDIES) U.S. DEPARTMENT OF HEALTH ...

  2. RoC Background Document: Ethylene Oxide; Dec. 2-3, 1998 3.5MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/ethyloxide_oneapp_508.pdf

    ETHYLENE OXIDE FINAL MARCH 1999 Prepared for the December 2-3, 1998, Meeting of the Report ... NTP Report on Carcinogens 1998 Background Document for Ethylene Oxide TABLE OF CONTENTS ...

  3. RoC Profile: Ethylene Oxide 387KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/ethyleneoxide.pdf

    CAS No. 75-21-8 Known to be a human carcinogen First listed in the Fourth Annual Report on Carcinogens (1985) H 2 C H 2 C O Carcinogenicity Ethylene oxide is known to be a human ...

  4. Ethylene oxide 10020-A 25KB

    https://ntp.niehs.nih.gov/testing/status/agents/ts-10020-a.html

    Ethylene oxide 10020-A CASRN: 75-21-8 Formula: C2-H4-O Synonyms/Common Names Oxirane (9CI) Short-Term Toxicity 14-Day (Inhalation) (C50088) Completed Mice: B6C3F1 13-Week ...

  5. Ethylene oxide: Target Organs and Levels of Evidence for TR-326 20KB

    https://ntp.niehs.nih.gov/data/tr/300s/tr326levels/index.html

    8 Ethylene oxide: Target Organs and Levels of Evidence for TR-326 Toxicology and Carcinogenesis Studies of Ethylene Oxide (CASRN 75-21-8) in B6C3F1 Mice (Inhalation Studies) ...

  6. Nomination Summary for Ethylene oxide (N83321) 19KB

    https://ntp.niehs.nih.gov/testing/noms/search/summary/nm-n83321.html

    Ethylene oxide (N83321) Nominated Substances: Ethylene oxide Nomination Date: 05/00/1983 Nominator: NIEHS, EPA Rationale: Gene toxicity class study of alkyl epoxides NTP ...

  7. Nomination Summary for Ethylene oxide (N79383) 19KB

    https://ntp.niehs.nih.gov/testing/noms/search/summary/nm-n79383.html

    Ethylene oxide (N79383) Nominated Substances: Ethylene oxide Nomination Date: 01/00/1979 Nominator: NCI, NIOSH, OSHA Rationale: Very high production, concern as to worker exposure ...

  8. Nomination Summary for Ethylene oxide (N83321) 19KB

    https://ntp.niehs.nih.gov/getinvolved/nominate/summary/nm-n83321.html

    Ethylene oxide (N83321) Nominated Substances: Ethylene oxide Nomination Date: 05/00/1983 Nominator: NIEHS, EPA Rationale: Gene toxicity class study of alkyl epoxides NTP ...

  9. Nomination Summary for Ethylene oxide (N79383) 19KB

    https://ntp.niehs.nih.gov/getinvolved/nominate/summary/nm-n79383.html

    Ethylene oxide (N79383) Nominated Substances: Ethylene oxide Nomination Date: 01/00/1979 Nominator: NCI, NIOSH, OSHA Rationale: Very high production, concern as to worker exposure ...

  10. Abstract for TER82078: Ethylene oxide (CASRN 75-21-8) 22KB

    https://ntp.niehs.nih.gov/publications/abstracts/dev/ter82078/ter82078.html

    8abs Abstract for TER82078 Teratologic Evaluation of Ethylene Oxide in New Zealand White Rabbits CASRN: 75-21-8 Chemical Formula: C2H4O Molecular Weight: 44.0526 Report Date: April ...

  11. Abstract for TR-326: Ethylene Oxide (CASRN 75-21-8) 22KB

    https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr326/index.html

    Abstract for TR-326 Toxicology and Carcinogenesis Studies of Ethylene Oxide in B6C3F1 Mice (Inhalation Studies) CASRN: 75-21-8 Chemical Formula: C2H4O Molecular Weight: 44.05 ...

  12. TR-275: 2-Chloroethanol (Ethylene Chlorohydrin) (CASRN 107-07... 14.0MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr275.pdf

    ... an intermediate in the synthesis of ethylene oxide, were conducted by dermal application ... of 2-Chloroethanol Toxicology of Ethylene Oxide Regulatory Status of 2-Chloroethanol ...

  13. Regulatory Actions for Year 1984 36KB

    https://ntp.niehs.nih.gov/media/impact/1980s/1984/index.html

    Type: Final Rule October 10, 1984 49 FR 39810 71-55-6 1984 OSHA Ethylene Oxide OSHA final ... Type: Other June 22, 1984 49 FR 25734 75-21-8 1984 EPA Dichloromethane EPA proposed rule ...

  14. Abstract for TR-080: 1,4-Dioxane (CASRN 123-91-1) 23KB

    https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr080/index.html

    CASRN: 123-91-1 Chemical Formula: C4H8O2 Molecular Weight: 88.1052 Report Date: 1978 FULL REPORT PDF Abstract 1,4-Dioxane, a dimer of ethylene oxide, is used extensively as an ...

  15. Minutes: BSC TRRS; Aug. 19, 1986 669KB

    https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/trrs/1986/aug/86aug19trrsmins_508.pdf

    1,2-Epoxybutane I n h a l a t i o n Ethylene Oxide I n h a l a t i o n Methyl Carbarnate ... Since two-year studies with l,3-butadiene and ethylene oxide were conducted i n the same ...

  16. RoC Profile: Vinyl Halides 298KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/vinylhalides.pdf

    References IARC. 2008a. Vinyl bromide. In 1,3-Butadiene, Ethylene Oxide and Vinyl Halides ... Vinyl chloride. In 1,3-Butadiene, Ethylene Oxide and Vinyl Halides (Vinyl Fluoride, ...

  17. TR-329: 1,2-Epoxybutane (CASRN 106-88-7) in F344/N Rats and B6C3F1Mice... 10.0MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr329.pdf

    ... oxide; 1,Zbutylene oxide; ethyl ethylene oxide; ethyl oxirane ABSTRACT ... Since 2- year studies with 1,3-butadiene and ethylene oxide were conducted in the same ...

  18. Abstract for TR-329: 1,2-Epoxybutane (CASRN 106-88-7) 27KB

    https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr329/index.html

    CASRN: 106-88-7 Chemical Formula: C4H8O Molecular Weight: 72.1 Synonyms/Common Names: 1-butene oxide; 1,2-butene oxide; butylene oxide; 1,2-butyleneoxide;ethyl ethylene oxide; ...

  19. Abstract for TR-275: 2-Chloroethanol (Ethylene Chlorohydrin)... 22KB

    https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr275/index.html

    Toxicology and carcinogenesis studies of 2-chloroethanol (99% pure), an industrial chemical and an intermediate in the synthesis of ethylene oxide, were conducted by dermal ...

  20. Abstract for GMM-13: Glycidol (CASRN 556-52-5) 27KB

    https://ntp.niehs.nih.gov/publications/reports/gmm/gmm13/index.html

    3-hydroxy-1,2-epoxypropane; 3-hydroxyl-1,2-epoxypropane; hydroxymethyl ethylene oxide; 2-(hydroxymethyl)oxirane; 2-hydroxymethyloxiran; oxiranemethanol; ...

  21. Abstract for IMM20303 - Diethanolamine (CASRN 111-42-2) 37KB

    https://ntp.niehs.nih.gov/publications/abstracts/imm/imm20303/imm20303.html

    Diethanolamine is a viscous, colorless liquid which is formed by ammonolysis of ethylene oxide. Diethanolamine has found extensive use in pharmaceutical ointments and skin ...

  22. Abstract for IMM90005 - Triethanolamine (CASRN 102-71-6) 23KB

    https://ntp.niehs.nih.gov/publications/abstracts/imm/imm90005/index.html

    Introduction Triethanolamine, produced along with mono- and diethanolamine by ammonolysis of ethylene oxide, is used in many cosmetics, fatty acid soaps, household detergents and ...

  23. Abstract for IMM98011 - Diethanolamine (CASRN 111-42-2) 37KB

    https://ntp.niehs.nih.gov/publications/abstracts/imm/imm98011/index.html

    Diethanolamine is a viscous, colorless liquid which is formed by ammonolysis of ethylene oxide. Diethanolamine is extensively used in pharmaceutical ointments and skin cleaners. It ...

  24. Abstract for TR-477: 1-Chloro-2-propanol (TechnicalGrade) (CASRN... 32KB

    https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr477/index.html

    nominated 1-chloro-2-propanol for study because of potential for human exposure due to its residues in various foods that are fumigated with ethylene oxide or propylene oxide. ...

  25. Abstract for TER84071: Ethylene Chlorohydrin (CASRN 107-07-3... 22KB

    https://ntp.niehs.nih.gov/publications/abstracts/dev/ter84071/ter84071.html

    Ethylene Chlorohydrin (2-chloroethanol), a widely used industrial chemical and reaction product of the gaseous sterilant ethylene oxide, was evaluated for toxic and teratogenic ...

  26. NTP Dose Range-Finding Study for Immunological Evaluation of... 21KB

    https://ntp.niehs.nih.gov/publications/abstracts/imm/imm20004/imm20004.html

    Diethanolamine is a viscous, colorless liquid which is formed by ammonolysis of ethylene oxide. Diethanolamine is extensively used in pharmaceutical ointments and skin cleaners. It ...

  27. Abstract for TER84070A, TER84070B, TER84070C, and TER84070D:... 22KB

    https://ntp.niehs.nih.gov/publications/abstracts/dev/ter84070a/ter84070a.html

    Ethylene chlorohydrin (2-chloroethanol), a widely used industrial chemical and reaction product of the gaseous sterilant ethylene oxide, was evaluated for toxic and teratogenic ...

  28. Nomination Background: Phenothiazine (CASRN: 92-84-2) 381KB

    https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/phenothiazine_508.pdf

    organic ester lubricating oils, ethylene oxide polymers, tetrahydrofuran polymers, ... (tetrahydrofuran [THF] polymers and ethylene oxide polymers) to prevent thermal ...

  29. Presentation: Non-Hodgkin Lymphoma: Human Cancer and Mechanistic... 635KB

    https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2014/august/presentations/7-tce-peer-review-nhlaug12b_508-compliant.pdf

    Risk factors: - Occupational (limited evidence): benzene, ethylene oxide, 2,3,7,8- TCDD, polychlorinated biphenyls, phenoxy herbicides, styrene, ionizing radiation, possibly ...

  30. RoC Listed Substances 99KB

    https://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf

    Epstein-Barr Virus (see Viruses: Eight Listings) Erionite Estrogens, Steroidal Ethylene Oxide Formaldehyde Hepatitis B Virus (see Viruses: Eight Listings) Hepatitis C Virus ...

  31. Cancer Driver Mutations in Experimental Rodents and Prediction... 136KB

    https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2019/june/meeting_materials/3parsons_bsc_508.pdf

    tissues after relatively short exposures (1 - 4 weeks) to model mutagenic carcinogens (azoxymethane, aristolochic acid, benzo[a]pyrene, ethylene oxide, or simulated solar light). ...

  32. RoC Profile: Styrene 247KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/styrene.pdf

    ... such as 1,3-buta diene and ethylene oxide (see the profiles for those substances). ... 1,3-butadiene, and ethylene oxide (NTP 2004a,b; see the profiles for those substances). ...

  33. Human Breast Cancer Studies; Pam Schwingl; ROCPRP; Oct. 5, 2018 2.1MB

    https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/october/presentations/05schwingl_rocprp_508.pdf

    ... Population- specific co- exposures Cosmic radiation (transmeridian) Ethylene oxide ... Population- specific co- exposures Cosmic radiation (transmeridian) Ethylene oxide ...

  34. CERHR Monograph: Potential Human Reproductive and Developmental... 4.4MB

    https://ntp.niehs.nih.gov/ntp/ohat/egpg/ethylene/eg_monograph.pdf

    ... It can be produced by oxidation of ethyl- ene to ethylene oxide, followed by hydration; by ... Possible trace impurities of ethylene glycol in- clude formaldehyde, ethylene oxide, and ...

  35. Index of 14th Report on Carcinogens 39KB

    https://ntp.niehs.nih.gov/ntp/roc/content/rocindex.xlsx

    Halides [Selected]) RAHC 75-07-0 Acetaldehyde RAHC 75-09-2 Dichloromethane RAHC 75-21-8 Ethylene Oxide Known 75-27-4 Bromodichloromethane RAHC 75-52-5 Nitromethane RAHC 75-55-8 ...

  36. RoC Profile: Dichloroethane 268KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dichloroethane.pdf

    ethane and other chemicals (such as ethylene oxide or chlorohydrin) (IARC 1999). ... A cohort study of mortality and cancer incidence in ethylene oxide production workers. ...

  37. RoC Profile: Propylene Oxide 136KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/propyleneoxide.pdf

    to propylene oxide as well as to ethylene oxide, benzene, ethylene chloro hydrin, and ... L, Gustavsson A. 1986. Epidemiologic support for ethylene oxide as a cancer-causing agent. ...

  38. Regulatory Actions for Year 1989 34KB

    https://ntp.niehs.nih.gov/media/impact/1980s/1989/index.html

    2-ethoxyethanol, ethylene oxide, 2-nitropropane, perchloroethylene, and saccharin. ... Type: Final Rule August 14, 1989 54 FR 33418 75-21-8 110-80-5 79-46-9 123-91-1 81-07-2 ...

  39. TR-477: 1-Chloro-2-Propanol (Technical Grade) (CASRN 127-00-4... 10.0MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr477.pdf

    ... its residues in various foods that are fumigated with ethylene oxide or propylene oxide. ... Prior to 1969, all propylene oxide and most ethylene oxide produced in the United States ...

  40. RoC Appendix G 109KB

    https://ntp.niehs.nih.gov/ntp/roc/content/appendix_g.pdf

    Vinyl Halides (Selected) 75-07-0 see Acetaldehyde 75-09-2 see Dichloromethane 75-21-8 see Ethylene Oxide 75-27-4 see Bromodichloromethane 75-52-5 see Nitromethane 75-55-8 see ...

  41. Nomination Background: n-Butyl Glycidyl Ether (CASRN: 2426-08... 448KB

    https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/butyl_glycidyl_ether_508.pdf

    ... epoxy moiety have been shown to be carcinogens (e.g., ethylene oxide and diepoxybutane). ... been shown to be carcinogens (e.g., ethylene oxide and diepoxybutane). 2.0 Introduction ...

  42. RoC Background Document: 1,3-Butadiene; Oct. 30-31, 1997 7.7MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/butadiene_508.pdf

    ... similar to the mutational spectrum of ethylene oxide, an alkylating agent that was ... product and where neither benzene nor ethylene oxide was present Duration: 39 yr (workers ...

  43. Presentation: TR-581 Cobalt Metal; Mamta Behl; TR Panel; Oct... 362KB

    https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2013/october/presentations/06pandiri_tr581mutationdata_508.pdf

    (83%; 20/24) - Cumene (87%; 45/52) - Cobalt sulfate heptahydrate (35%; 9/26) - Ethylene oxide (100%; 23/23) Sills et al., 1995; Sills et al., 1999; Hong et al., 2007; Hong et ...

  44. Regulatory Actions for Year 1994 41KB

    https://ntp.niehs.nih.gov/media/impact/1990s/1994/index.html

    ... NTP Information Cited NTP toxicology and carcinogenesis study of ethylene oxide (TR-326) is cited as one of the studies used for conclusions that ethylene oxide induces cancer in ...

  45. Nomination Background: Dimethylethanolamine (CASRN: 108-01-0... 687KB

    https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dimethylethanolamine_508.pdf

    ... DMAE is synthesized from equimolar amounts of ethylene oxide and dimethylamine. The amino ... synthesized from equimolar amounts of ethylene oxide and dimethylamine (Budavari, 2001). ...

  46. Background: Dimethylethanolamine (DMAE) [108-01-0] and Selected... 672KB

    https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dmae_update_110002_508.pdf

    ... DMAE is synthesized from equimolar amounts of ethylene oxide and dimethylamine. The amino ... synthesized from equimolar amounts of ethylene oxide and dimethylamine (Budavari, 2001). ...

  47. Regulatory Actions for Year 2006 48KB

    https://ntp.niehs.nih.gov/media/impact/2000s/2006/index.html

    ... 71 FR 28924 2006 EPA Ethylene Oxide Emissions Standards for Sterilization Facilities This action finalizes our decision not to revise the Ethylene Oxide Emission Standards for ...

  48. Aristolochic Acid Related Exposures Expert Panel Report Part... 58KB

    https://ntp.niehs.nih.gov/ntp/roc/twelfth/2008/expertpanelmtgs/aapanelreportpartb_508.pdf

    ... Dimethylcarbamoyl Chloride 1,1-Dimethylhydrazine Dimethyl Sulfate Dimethylvinyl Chloride 1,4-Dioxane Disperse Blue E Epichlorohydrin Erionite Estrogens, Steroidal Ethylene Oxide ...

  49. RoC Profile: Butadiene 275KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/butadiene.pdf

    ... The mutational spectra for 1,3-butadiene and its epox- ide metabolites at the hprt locus in mouse lymphocytes are similar to the mutational spectrum for ethylene oxide, an ...

  50. Aristolochic Acid/Riddelliine Related Exposures Expert Panel... 58KB

    https://ntp.niehs.nih.gov/ntp/roc/twelfth/2008/expertpanelmtgs/aapanelreportparta_508.pdf

    ... Dimethylcarbamoyl Chloride 1,1-Dimethylhydrazine Dimethyl Sulfate Dimethylvinyl Chloride 1,4-Dioxane Disperse Blue E Epichlorohydrin Erionite Estrogens, Steroidal Ethylene Oxide ...

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