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Search suggestions for "ethylene oxide".

  1. CEBS Data Related to Ethylene oxide (75-21-8) https://cebs.niehs.nih.gov/cebs/test_article/75-21-8
  2. Report on Carcinogens Ethylene oxide https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/ethyleneoxide.pdf


182 results found for "ethylene oxide".

  1. TR-326: Ethylene Oxide (CASRN 75-21-8) in B6C3F1Mice (Inhalation... 6.5MB

    https://ntp.niehs.nih.gov/go/tr326

    6 TOXICOLOGY AND CARCINOGENESIS STUDIES O F ETHYLENE OXIDE (CAS NO. 75-21-8) IN B6C3F1 MIiCE (INHALATION STUDIES) U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service ...

  2. RoC Background Document: Ethylene Oxide; Dec. 2-3, 1998 4.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/other_background/ethyloxide_oneapp_508.pdf

    ETHYLENE OXIDE FINAL MARCH 1999 Prepared for the December 2-3, 1998, Meeting of the Report ... NTP Report on Carcinogens 1998 Background Document for Ethylene Oxide TABLE OF CONTENTS ...

  3. RoC Profile: Ethylene Oxide; 15th RoC 2021 126KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/ethyleneoxide.pdf

    CAS No. 75-21-8 Known to be a human carcinogen First listed in the Fourth Annual Report on Carcinogens (1985) Also known as oxirane, EtO Carcinogenicity Ethylene oxide is known to ...

  4. Abstract for TR-326 54KB

    https://ntp.niehs.nih.gov/publications/reports/tr/tr326

    Abstract for TR-326 Toxicology and Carcinogenesis Studies of Ethylene Oxide in B6C3F1 Mice (Inhalation Studies) CASRN: 75-21-8 Chemical Formula: C2H4O Molecular Weight: 44.05 ...

  5. Abstract for TER82078 54KB

    https://ntp.niehs.nih.gov/publications/abstracts/dev/ter82078

    8abs Abstract for TER82078 Teratologic Evaluation of Ethylene Oxide in New Zealand White Rabbits CASRN: 75-21-8 Chemical Formula: C2H4O Molecular Weight: 44.0526 Report Date: April ...

  6. Target Organs and Levels of Evidence for TR-326 50KB

    https://ntp.niehs.nih.gov/data/tr/300s/tr326levels

    Target Organs and Levels of Evidence for TR-326 Toxicology and Carcinogenesis Studies of Ethylene Oxide (CASRN 75-21-8) in B6C3F1 Mice (Inhalation Studies) Chemical (Study Title) ...

  7. Abstract for TR-80 55KB

    https://ntp.niehs.nih.gov/publications/reports/tr/tr080

    CASRN: 123-91-1 Chemical Formula: C4H8O2 Molecular Weight: 88.1052 Report Date: 1978 Full Report PDF Abstract 1,4-Dioxane, a dimer of ethylene oxide, is used extensively as an ...

  8. Abstract for TER84071 54KB

    https://ntp.niehs.nih.gov/publications/abstracts/dev/ter84071

    Ethylene Chlorohydrin (2-chloroethanol), a widely used industrial chemical and reaction product of the gaseous sterilant ethylene oxide, was evaluated for toxic and teratogenic ...

  9. Abstract for TER84070A, TER84070B, TER84070C, and TER84070D 54KB

    https://ntp.niehs.nih.gov/publications/abstracts/dev/ter84070

    Ethylene chlorohydrin (2-chloroethanol), a widely used industrial chemical and reaction product of the gaseous sterilant ethylene oxide, was evaluated for toxic and teratogenic ...

  10. Abstract for TR-275 54KB

    https://ntp.niehs.nih.gov/publications/reports/tr/tr275

    Toxicology and carcinogenesis studies of 2-chloroethanol (99% pure), an industrial chemical and an intermediate in the synthesis of ethylene oxide, were conducted by dermal ...

  11. TR-275: 2-Chloroethanol (Ethylene Chlorohydrin) (CASRN 107-07... 14.0MB

    https://ntp.niehs.nih.gov/go/tr275

    ... an intermediate in the synthesis of ethylene oxide, were conducted by dermal application ... of 2-Chloroethanol Toxicology of Ethylene Oxide Regulatory Status of 2-Chloroethanol ...

  12. Minutes: BSC TRRS; Aug. 19, 1986 686KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1986/aug/86aug19trrsmins_508.pdf

    1,2-Epoxybutane I n h a l a t i o n Ethylene Oxide I n h a l a t i o n Methyl Carbarnate ... Since two-year studies with l,3-butadiene and ethylene oxide were conducted i n the same ...

  13. TR-329: 1,2-Epoxybutane (CASRN 106-88-7) in F344/N Rats and B6C3F1Mice... 10.0MB

    https://ntp.niehs.nih.gov/go/tr329

    ... oxide; 1,Zbutylene oxide; ethyl ethylene oxide; ethyl oxirane ABSTRACT ... Since 2- year studies with 1,3-butadiene and ethylene oxide were conducted in the same ...

  14. RoC Profile: Vinyl Halides (Selected); 15th RoC 2021 199KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/vinylhalides.pdf

    References IARC. 2008a. Vinyl bromide. In 1,3-Butadiene, Ethylene Oxide and Vinyl Halides ... Vinyl chloride. In 1,3-Butadiene, Ethylene Oxide and Vinyl Halides (Vinyl Fluoride, ...

  15. Abstract for TR-329 59KB

    https://ntp.niehs.nih.gov/publications/reports/tr/tr329

    CASRN: 106-88-7 Chemical Formula: C4H8O Molecular Weight: 72.1 Synonyms/Common Names: 1-Butene oxide; 1,2-butene oxide; butylene oxide; 1,2-butyleneoxide; ethyl ethylene oxide; ...

  16. Abstract for GMM-13 59KB

    https://ntp.niehs.nih.gov/publications/reports/gmm/gmm13

    3-hydroxy-1,2-epoxypropane; 3-hydroxyl-1,2-epoxypropane; hydroxymethyl ethylene oxide; 2-(hydroxymethyl)oxirane; 2-hydroxymethyloxiran; oxiranemethanol; ...

  17. Abstract for TR-477 64KB

    https://ntp.niehs.nih.gov/publications/reports/tr/tr477

    nominated 1-chloro-2-propanol for study because of potential for human exposure due to its residues in various foods that are fumigated with ethylene oxide or propylene oxide. ...

  18. Listed Substances; 15th RoC 2021 76KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/listed_substances_508.pdf

    Epstein-Barr Virus (see Viruses: Eight Listings) Erionite Estrogens, Steroidal Ethylene Oxide Formaldehyde Helicobacter pylori (Chronic Infection) Hepatitis B Virus (see ...

  19. CERHR Monograph: Potential Human Reproductive and Developmental... 4.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/egpg/ethylene/eg_monograph.pdf

    ... It can be produced by oxidation of ethyl- ene to ethylene oxide, followed by hydration; by ... Possible trace impurities of ethylene glycol in- clude formaldehyde, ethylene oxide, and ...

  20. TR-477: 1-Chloro-2-Propanol (Technical Grade) (CASRN 127-00-4... 9.9MB

    https://ntp.niehs.nih.gov/go/tr477

    ... its residues in various foods that are fumigated with ethylene oxide or propylene oxide. ... Prior to 1969, all propylene oxide and most ethylene oxide produced in the United States ...

  21. Research at CDRH to Evaluate Medical Device Safety Using Alternative... 3.0MB

    https://ntp.niehs.nih.gov/sites/default/files/2024-06/03_Rufer_ICCVAMForum2024_508_0.pdf

    ... approach for risk of changing from ethylene oxide to vaporized hydrogen peroxide ... device manufacturers to change from ethylene oxide (EtO) to vaporized hydrogen peroxide ...

  22. RoC Profile: 1,2-Dichloroethane; 15th RoC 2021 145KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/dichloroethane.pdf

    ethane and other chemicals (such as ethylene oxide or chlorohydrin) (IARC 1999). ... A cohort study of mortality and cancer incidence in ethylene oxide production workers. ...

  23. RoC Profile: Propylene Oxide; 15th RoC 2021 134KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/propyleneoxide.pdf

    to propylene oxide as well as to ethylene oxide, benzene, ethylene chloro hydrin, and ... L, Gustavsson A. 1986. Epidemiologic support for ethylene oxide as a cancer-causing agent. ...

  24. Appendix G; 15th RoC 2021 69KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/appendix_g.pdf

    ... Vinyl Halides (Selected) 75-07-0 see Acetaldehyde 75-09-2 see Dichloromethane 75-21-8 see Ethylene Oxide 75-27-4 see Bromodichloromethane 75-52-5 see Nitromethane 75-55-8 see ...

  25. RoC Profile: Styrene; 15th RoC 2021 252KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/styrene.pdf

    ... such as 1,3-buta diene and ethylene oxide (see the profiles for those substances). ... 1,3-butadiene, and ethylene oxide (NTP 2004a,b; see the profiles for those substances). ...

  26. RoC Background Document: 1,3-Butadiene; Oct. 30-31, 1997 9.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/other_background/butadiene_508.pdf

    ... similar to the mutational spectrum of ethylene oxide, an alkylating agent that was ... product and where neither benzene nor ethylene oxide was present Duration: 39 yr (workers ...

  27. Public Health Impact 1.9MB

    https://ntp.niehs.nih.gov/media/impact

    ... for Ethylene Oxide The Office of Environmental Health Hazard Assessment (OEHHA) is proposing to update the Proposition 65 No Significant Risk Level (NSRL) for ethylene oxide by ...

  28. RoC Profile: 1,3-Butadiene; 15th RoC 2021 162KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/butadiene.pdf

    ... The mutational spectra for 1,3-butadiene and its epox- ide metabolites at the hprt locus in mouse lymphocytes are similar to the mutational spectrum for ethylene oxide, an ...

  29. 1-Bromopropane: Preliminary Literature Search Strategy and List... 639KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/thirteenth/litsearchstrategy/1-bp-litsearch&references5oct2012_508.pdf

    ... in combination with ethylene oxide or propylene oxide in human fibroblasts. ... M. 1996. In vivo dosimetry of ethylene oxide and propylene oxide in the cynomolgus monkey. ...

  30. 15th Report on Carcinogens 91KB

    https://ntp.niehs.nih.gov/research/assessments/cancer/roc

    ... Dimethylcarbamoyl Chloride 1,1-Dimethylhydrazine Dimethyl Sulfate Dimethylvinyl Chloride 1,4-Dioxane Disperse Blue E Epichlorohydrin Erionite Estrogens, Steroidal Ethylene Oxide ...

  31. TR-413: Ethylene Glycol (CASRN 107-21-1) in B6C3F1Mice (Feed... 11.1MB

    https://ntp.niehs.nih.gov/go/tr413

    ... on a large-scale basis primarily by hydration o f ethylene oxide (Kirk- Othmer, 1982). ... Disposition kinetics of ethylene oxide, ethylene glycol, and 2-chlorethanol in the dog. J. ...

  32. TR-484: Toxicology and Carcinogenesis Studies of 2-Butoxyethanol... 4.7MB

    https://ntp.niehs.nih.gov/go/tr484

    ... PRODUCTION, USE, AND HUMAN EXPOSURE 2-Butoxyethanol is produced by reacting ethylene oxide ... Additionally, the ethylene oxide content was measured with system B. Impurities in the ...

  33. TR-415: Polysorbate 80 (CASRN 9005-65-6) in F344/N Rats and B6C3F1Mice... 12.2MB

    https://ntp.niehs.nih.gov/go/tr415

    ... It is produced by' reacting sorbitol and its anhydrides with ethylene oxide followed by esterification o f the reaction product with oleic acid. The reaction with ethylene oxide is ...

  34. RoC Background Document for Diethanolamine; March 22, 2002 1.1MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/deapub_no_appendices_508.pdf

    ... DEA usually is produced by reaction of ethylene oxide with ammonia in a 2:1 molar ratio. ... DEA usually is produced by reaction of ethylene oxide with ammonia in a 2:1 molar ratio. ...

  35. TR-267: Propylene Oxide (CASRN 75-56-9) in F344/N Rats and B6C3F1Mice... 7.5MB

    https://ntp.niehs.nih.gov/go/tr267

    ... vapors ap- pear to be about one-third as toxic as ethylene oxide (Hine et al., 1981). ... Ethylene oxide produced weakly positive results in the same study (NIOSH, 1983). Tumors of ...

  36. Completed RoC Evaluations 116KB

    https://ntp.niehs.nih.gov/research/assessments/cancer/completed/roc

    ... Request Archived Materials Ethyl Acrylate Delisted Background Document Appendix A Request Archived Materials Ethylene Oxide Known to be a human carcinogen Background Document ...

  37. Handbook on Methods for Conducting Cancer Hazard Evaluations... 5.2MB

    https://ntp.niehs.nih.gov/sites/default/files/2025-05/handbook_roc_508.pdf

    .........165 Box 7-2. Ethylene Oxide Example......Box 7-3. Ethylene Oxide Example Known to be a human carcinogen Limited evidence from ...

  38. GMM-13: Genetically Modified Model Report on Glycidol (Gavage... 905KB

    https://ntp.niehs.nih.gov/go/gmm13

    ...roxyl-1,2-epoxypropane; hydroxymethyl ethylene oxide; 2-(hydroxymethyl)oxirane; ...roxyl-1,2-epoxypropane; hydroxymethyl ethylene oxide; 2-(hydroxymethyl)oxirane; ...

  39. TR-374: Glycidol (CASRN 556-52-5) In F344/N Rats and B6C3F1Mice... 11.9MB

    https://ntp.niehs.nih.gov/go/tr374

    ... In inhalation studies, ethylene oxide induced neoplasms of the lung and harderian gland in ... In long-term inhalation studies conducted with F344 rats, exposure to ethylene oxide a t ...

  40. RoC Profile: 1,4-Dioxane; 15th RoC 2021 154KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/dioxane.pdf

    ... Properties 1,4-Dioxane (a dimer of ethylene oxide) is a cyclic ether that exists at room ... of reactions based on condensing ethylene oxide or ethyl- ene glycol during ...

  41. TR-506: Acrylonitrile (CASRN 107-13-1) in B6C3F1 Mice (Gavage... 2.9MB

    https://ntp.niehs.nih.gov/go/tr506

    ... by its metabolism to 2-cyano- ethylene oxide exclusively via CYP2E1. Significant ... with 1,3-butadiene, vinyl chloride, ben- zene, or ethylene oxide (Melnick and Huff, 1993). ...

  42. Minutes: BSC; Oct. 28, 1983 699KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1983/minutesbsc19831028_508.pdf

    ... He expressed concern that other inhalation studies with chemicals as potent as ethylene oxide and 1,2-epoxybutane were conducted in the same chamber room. and hoped this could be ...

  43. TR-080: 1,4-Dioxane (CASRN 123-91-1) 3.3MB

    https://ntp.niehs.nih.gov/go/tr080

    ... 17 , 26 . 27 xi I. INTRODUCTION 1,4-Dioxane (CAS 123-91-1; NCI C03689), a dimer of ethylene oxide, hereinafter called dioxane, is used extensively as an industrial solvent for ...

  44. RoC Profile: Acrylonitrile; 15th RoC 2021 145KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/acrylonitrile.pdf

    ... Fennell TR, MacNeela JP, Morris RW, Watson M, Thompson CL, Bell DA. 2000. Hemoglobin adducts from acrylonitrile and ethylene oxide in cigarette smokers: Effects of glutathione ...

  45. NTP Response to BSC Peer Review Comments on the Draft Substances... 339KB

    https://ntp.niehs.nih.gov/ntp/roc/twelfth/2011/response022409bsc2011.pdf

    ... epoxides related to styrene, such as ethylene oxide and butadiene, which have presumably ... and ethylene oxide) that are metabolized through similar metabolic pathways. ...

  46. TOX-26: Ethylene Glycol Ethers 2-Methoxyethanol, 2-Ethoxyethanol... 8.2MB

    https://ntp.niehs.nih.gov/go/tox026

    ... The three glycol alkyl ethers are produced by reaction of ethylene oxide with their respective alcohols or by direct alkylation of ethylene oxide with agents like dimethyl, ...

  47. TOX-20: Diethanolamine (CASRN 111-42-2) 2.5MB

    https://ntp.niehs.nih.gov/go/tox020

    ... Along with monoethanolamine and triethanolamine, DEA is produced by ammonolysis of ethylene oxide, then separated by distillation (Mullins, 1978). In 1989, 202 million pounds (92 x ...

  48. TR-288: 1,3-Butadiene (CASRN 106-99-0) in B6C3F1Mice (Inhalation... 5.4MB

    https://ntp.niehs.nih.gov/go/tr288

    ... such as ethylene oxide and 1,Z-epoxybutane were conducted in the same chamber room. ... Test in Same Room Propylene Propylene Ethylene Oxide 1,2- E poxy b utane CHEMISTRY Lot No. ...

  49. TR-272: Propylene (CASRN 115-07-1) in F344/N Rats and B6C3F1Mice... 8.1MB

    https://ntp.niehs.nih.gov/go/tr272

    ... In the case of ethylene, conversion to the epoxide form, ethylene oxide, has been ... The epoxi- dated forms of both ethylene (i.e., ethylene oxide) and propylene (i.e. ...

  50. RoC Background Document: Vinyl Bromide; Jan. 20-21, 2000 220KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/roc10/vb_no_appendices_508.pdf

    ... Hydroquinone methyl ether (0.02%, used as stabilizer), ethylene oxide (0.03%), acetylene (0.0007%), and aldehydes and ketones (0.008%) were present in the VB used. The animals in ...

 
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