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525 results found for "fluoride neurotoxicity".

  1. Comment: The Neurotoxicity of Fluoride: A Ringside View of the... 497KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may/presentations/07_connett_bsc_508.pdf

    The Neurotoxicity of Fluoride: A Ringside View of the Politics versus Science Paul Connett, PhD Former Director, Fluoride Action Network Testimony before the BSC May 4, 2023 ...

  2. Comment: Fluoride; Paul Connett; Fluoride Action Network; BSC... 2.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may/publiccomm/connett20230428_bsc_508.pdf

    Action Network (2000-2022) Paul Connett's statement for the BSC meeting May 4, 2023 A ringside view of the battle between science and politics over fluoride's neurotoxicity. ...

  3. Comment: The Finding's of the NTP's 6-year Fluoride Neurotoxicity... 2.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may/presentations/04_neurath_bsc_508.pdf

    The finding's of the NTP's 6-year fluoride neurotoxicity evaluation Chris Neurath Science Director American Environmental Health Studies Project May 4, 2023 1 What did the NTP ...

  4. Comment: Fluoride; Chris Neurath; American Environmental Health... 3.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may/publiccomm/neurath20230429_bsc_508.pdf

    The finding's of the NTP's 6-year fluoride neurotoxicity evaluation Chris Neurath Science Director American Environmental Health Studies Project May 4, 2023 1 What did the NTP ...

  5. Comment: Fluoride; Bill Osmunson; Washington Action for Safe... 1.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may/publiccomm/osmunson20230428_bsc_508.pdf

    I was one of those nominating fluoride to OHAT, NTP and passed on to the Board of Scientific Counselors, for review of Developmental Neurotoxicity, another nomination for ...

  6. Documents Provided to the NTP Board of Scientific Counselors... 55.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/fluoride/documents_provided_bsc_wg_031523.pdf

    ... P, Jain A, Joshi C, Sharma D. 2011. Effects of fluoride in drinking water on NADPH-diaphorase neurons in the forebrain of mice: A possible mechanism of fluoride neurotoxicity. ...

  7. Literature Search Results: Systematic Review of Fluoride Exposure... 743KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/fluoride/literature_results20200916_508.pdf

    ... Wang A. 2019. Roles of mitochondrial fission inhibition in developmental fluoride neurotoxicity: Mechanisms of action in vitro and associations with cognition in rats and children. ...

  8. Comment: Show me the Science; Jack Kall, International Academy... 945KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may/presentations/09_kall_bsc_508.pdf

    Jack Kall, DMD, FAGD, MIAOMT The IAOMT has been especially interested and very concerned about recently published studies regarding the neurotoxicity of fluoride. What are the key ...

  9. Fluoride Exposure: Neurodevelopment and Cognition 85KB

    https://ntp.niehs.nih.gov/research/assessments/noncancer/completed/fluoride

    ... It does not, and was not intended to, assess the benefits of fluoride. Back to Top Documents Documents for Fluoride: Potential Developmental Neurotoxicity Date Document Oct 07, ...

  10. Comment: National Toxicology Program Board of Scientific Counselors... 328KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may/publiccomm/kall20230428_bsc_508.pdf

    We have been especially interested and very concerned about recently published studies regarding the neurotoxicity of fluoride and therefore support the NTP's systematic review. We ...

  11. NTP Working Group Report: Draft State of the Science Monograph... 20.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may/wgrptbsc20230400.pdf

    ... The risk-of-bias criteria were developed by subject matter experts with backgrounds in epidemiology, neurotoxicity, fluoride, and public health to address these specifics as part ...

  12. NTP Board of Scientific Counselors Working Group Report on the... 9.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may16/bsc_wg_report_final_version_bsc_approved051623_508.pdf

    ... The risk-of-bias criteria were developed by subject matter experts with backgrounds in epidemiology, neurotoxicity, fluoride, and public health to address these specifics as part ...

  13. NTP Working Group Report: Draft State of the Science Monograph... 9.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may16/meeting_materials/wgrptbsc20230400_interimver_508.pdf

    ... The risk-of-bias criteria were developed by subject matter experts with backgrounds in epidemiology, neurotoxicity, fluoride, and public health to address these specifics as part ...

  14. NTP Board of Scientific Counselors Working Group Report on the... 9.4MB

    https://ntp.niehs.nih.gov/sites/default/files/2023-05/BSC_WG_Report_Final_Version_BSC_approved051623_508.pdf

    ... The risk-of-bias criteria were developed by subject matter experts with backgrounds in epidemiology, neurotoxicity, fluoride, and public health to address these specifics as part ...

  15. Comment: Fluoride; George R. Shepley and Raymond A. Cohlmia;... 537KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may/publiccomm/shepley-cohlmia20230428_bsc_508.pdf

    ... J Dent Research 2023;102(1):28-36. doi:10.1177/00220345221119431 Farmus L, Till C, Green R, et al. Critical windows of fluoride neurotoxicity in Canadian children. Environmental ...

  16. RR-01: Systematic Literature Review on the Effects of Fluoride... 7.1MB

    https://ntp.niehs.nih.gov/go/rr01

    ... China Preventive Medicine. 6:489-491.]* 33. Jain A, Mehta VK, Chittora R, Mahdi AA, Bhatnagar M. 2015. Melatonin ameliorates fluoride induced neurotoxicity in young rats: An In ...

  17. NTP Protocol: Systematic Review of Effects of Fluoride Exposure... 2.1MB

    https://ntp.niehs.nih.gov/ntp/ohat/fluoride/ntpprotocol_revised20200916_508.pdf

    ... J. Public Health 105(1): 72-76. Choi AL, Sun G, Zhang Y, Grandjean P. 2012. Developmental fluoride neurotoxicity: A systematic review and meta-analysis. Environ. Health Perspect. ...

  18. NTP Monograph: State of the Science Concerning Fluoride Exposure... 18.8MB

    https://ntp.niehs.nih.gov/go/mgraph08

    ... Farmus L, Till C, Green R, Hornung R, Martinez Mier EA, Ayotte P, Muckle G, Lanphear BP, Flora DB. 2021. Critical windows of fluoride neurotoxicity in Canadian children. ...

  19. Minutes: BSC; May 4 and 16, 2023 354KB

    https://ntp.niehs.nih.gov/sites/default/files/2023-09/minutesbsc20230504and16_508.pdf

    ... He discussed several studies funded by NIEHS and other federal agencies, which represented a major advancement in the scientific evidence of fluoride neurotoxicity. He noted that ...

  20. Protocol for Systematic Review of Effects of Fluoride Exposure... 2.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/fluoride/protocol_fluoridejune2017_508.pdf

    ... - PMC4265943 PMCR- 4262016/4265901/4265901 4265900 4265900. Choi AL, Sun G, Zhang Y, Grandjean P. 2012. Developmental fluoride neurotoxicity: a systematic review and meta-analysis. ...

  21. Protocol for Systematic Review of Effects of Fluoride Exposure... 1.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/fluoride/protocol_fluoridemay2019_508.pdf

    ... Am J Public Health 105: 3-4. Choi AL, Sun G, Zhang Y, Grandjean P. 2012. Developmental fluoride neurotoxicity: A systematic review and meta-analysis. Environ Health Perspect ...

  22. Comment: Scientific Integrity and a Fluoride Hazard to Public... 105KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may/publiccomm/hirzy20230427_bsc_508.pdf

    ... again attempting to quietly engage management, I along with other scientists visited EPA officials twice to report on research showing fluoride's developmental neurotoxicity. ...

  23. Comment: Testimony for NTP Board of Scientific Counselors; Rick... 166KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may/publiccomm/north20230427_bsc_508.pdf

    Philippe Grandjean, one of the world's leading experts on neurotoxicity, stated that, "Fluoride seems to fit in with lead, mercury, and other poisons that cause chemical brain ...

  24. Proposed NTP Evaluation on Fluoride Exposure and Potential for... 1012KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2015/december/meetingmaterial/fluoride_508.pdf

    ... Eur J Pharmacol 579(1-3):196-201. Choi AL, Sun GF, Zhang Y, Grandjean P. 2012. Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis. Environ Health Perspect ...

  25. Developmental Neurotoxicity Health Effects | National Institute... 397KB

    https://www.niehs.nih.gov/research/atniehs/dtt/strategic-plan/health/developmental

    ... disease Health Assessment and Translation Project on Parkinson's Disease Fluoride developmental neurotoxicity Systematic review to evaluate potential neurobehavioral effects from ...

  26. Comment: Fluoride; Bill Osmunson; Washington Action for Safe... 547KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may/publiccomm/osmunson20230510_bsc_508.pdf

    ... Al- most two decades ago, I wanted to see if there was any evidence linking fluoride to develop- mental neurotoxicity in the USA. I ranked the 50 USA states on their whole ...

  27. Response to Comments: NASEM Peer Review of Draft NTP Monograph... 258KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/nasem/response202009.pdf

    ... to represent any NTP determination or policy. 6 References Choi AL, Sun G, Zhang Y, Grandjean P. 2012. Developmental fluoride neurotoxicity: A systematic review and meta-analysis. ...

  28. Response to Comments: NASEM Review of the Revised NTP Monograph... 456KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/nasem/response202204.pdf

    ... J. Public Health 105(1):3-4. Choi, A.L., Sun G., Zhang Y., Grandjean P. 2012. Developmental fluoride neurotoxicity: A systematic review and meta-analysis. Environ. Health. ...

  29. All Past Events 217KB

    https://ntp.niehs.nih.gov/events/past

    ... NTP Board of Scientific Counselors (BSC) and BSC Working Group Fluoride: Assessment for Developmental Neurotoxicity web page on NTP website Public Comments Name, Affiliation, ...

  30. NTP BSC Working Group Report on the Draft State of the Science... 1.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may/presentations/ntp_bsc_wg_report_presentation_508.pdf

    the Draft Meta-Analysis Manuscript on Fluoride David L. Eaton, PhD, DABT, FATS BSC ... Center for Early Life Exposures and Neurotoxicity Gillings School of Global Public ...

  31. Public Comments from PETA (2023 ICCVAM Public Forum) 652KB

    https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2023/pubcmts/peta20230511_508.pdf

    ... to demonstrate the availability of fluoride in over-the-counter dentifrice formulations. ... Reprod Toxicol. 2018;81:259-271. 10. Tsuji R, Crofton KM. Developmental neurotoxicity ...

  32. Developmental Neurotoxicity Screening Assay Chemical List | National... 418KB

    https://www.niehs.nih.gov/research/atniehs/dtt/strategic-plan/health/developmental/chemical-list

    ... Cannabinoid 58-08-2 DTXSID0020232 Caffeine Drug 7681-49-4 DTXSID2020630 Sodium fluoride Drug 134678-17-4 DTXSID7023194 Lamivudine Drug 58-55-9 DTXSID5021336 Theophylline ...

  33. Response to Request for Data and Information on Zebrafish Embryo... 1.6MB

    https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-26605/kanungo-508.pdf

    ... an additional 0.1 mM DTT and 1 mM phenylmethylsulfonyl fluoride (protease inhibitor)]. ... showing ketamine as an inducer of neurotoxicity in zebrafish embryos (Kanungo et al., ...

  34. Public Comment on 81 FR 42718: C. Elegans Models for Developmental... 2.0MB

    https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/hunt-81fr42718.pdf

    ... moderately to slightly toxic (sodium fluoride - LD50 = 52 mg/kg; caffeine - LD 50 = ... elegans as a model of organophosphate-induced mammalian neurotoxicity. Toxicol. Appl. ...

  35. RoC Background Document for Lead and Lead Compounds - May 8,... 3.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/roc11/lead-public_508.pdf

    ......... 158 6.2.1 Neurotoxicity ......green 15; pure lemon chrome l3gs Lead fluoride 7783-46-2 lead difluoride, lead(2+) ...

  36. Minutes: BSC; Dec. 8, 2021 3.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2021/december/minutesbsc20211208_508.pdf

    ... He gave the example of the fluoride report that Dr. Berridge discussed during his ... Innovation Programs (Carcinogenesis, Cardiovascular [CV], Developmental Neurotoxicity). ...

  37. TR-563: Pulegone (CASRN 89-82-7) in F344/N Rats and B6C3F1 Mice... 6.4MB

    https://ntp.niehs.nih.gov/go/tr563

    ... Toxi- cology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N ... Xenobiotica 22, 1157-1164. Olsen, P., and Thorup, I. (1984). Neurotoxicity in rats dosed ...

  38. Report: International Workshop on In Vitro Methods for Assessing... 25.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf

    ... 167.2 0.72 232.26 0.7 106 14 Sodium I fluoride 7681-49-4 77.68 1.85 180.1 4.29 NA NA ... Veronesi, H. Vijverberg, E. Walum, and C. Williams. 1994. In vitro Neurotoxicity Testing. ...

  39. Public Health Impact 1.9MB

    https://ntp.niehs.nih.gov/media/impact

    ... reproductive toxicity, neurotoxicity, and mutagenic effects in the dominant lethal assay. ... National Toxicology Program (NTP). Testing status of vinylidene fluoride 10180-D, CASRN ...

  40. TR-508: Riddelliine (CASRN 23246-96-0) in F344/N Rats and B6C3F1... 3.1MB

    https://ntp.niehs.nih.gov/go/tr508

    ... Physicochemical and metabolic basis for the differing neurotoxicity of the pyrrolizidine ... Trihydrate 445 Sodium Azide 389 Sodium Fluoride 393 Sodium Nitrite 495 Sodium ...

  41. TR-435: 4,4'-Thiobis(6-t-butyl-m-cresol) (CASRN 96-69-5) in F344... 16.3MB

    https://ntp.niehs.nih.gov/go/tr435

    ... No standard error calculated. 265 Neurotoxicity Evaluations TABLE H6 Gastrocnemius ... Water and Chloraminated Water 393 Sodium Fluoride 394 Acetaminophen 395 Probenecid 396 ...

  42. TR-495: Sodium Nitrite (CASRN 7632-00-0) in F344/N Rats and B6C3F1... 2.4MB

    https://ntp.niehs.nih.gov/go/tr495

    ... NEUROTOXICITY After a single subcutaneous dose of 55 mg sodium nitrite/kg body weight, ... Battelle Columbus Laboratories b Sodium fluoride 0/80 1/80 1/80 Overall Historical ...

  43. GMM-09: Genetically Modified Model Report on Dicyclohexylcarbodiimide... 1.1MB

    https://ntp.niehs.nih.gov/go/gmm09

    ... AC activity and activity stimu- lated by sodium fluoride or guanyl-5N-imidodiphosphate. ...yclohexylcarbodiimide, similar dose-related clinical signs of neurotoxicity were reported. ...

  44. TR-391: Tris(2-chloroethyl) Phosphate (CASRN 115-96-8) in F344... 11.0MB

    https://ntp.niehs.nih.gov/go/tr391

    ... Dr. Matthews stated that there had been neurotoxicity studies done including some brain ... 8-Methoxypsoralen 393 386 Sodium Fluoride Tetranitromethane 361 Hexachloroethane ...

  45. TR-385: Methyl Bromide (CASRN 74-83-9) in B6C3F1Mice (Inhalation... 7.3MB

    https://ntp.niehs.nih.gov/go/tr385

    ... Clinical signs indicative of neurotoxicity, includingtremors,abnormal posture, tachypnea, ... Tris(2-chloroethyl) Phosphate Sodium Fluoride Probenecid 362 363 364 365 ...

  46. TR-433: Tricresyl Phosphate (CASRN 1330-78-5) in F344/N Rats... 24.1MB

    https://ntp.niehs.nih.gov/go/tr433

    ... Dr. Ryan inquired as to why extensive neurotoxicity testing was reported in an appendix ... Chloraminated Water 393 Sodium Fluoride 394 Acetaminophen 395 Probenecid 396 ...

  47. TR-502: Chloral Hydrate (CASRN 302-17-0) in B6C3F1 Mice (Gavage... 1.9MB

    https://ntp.niehs.nih.gov/go/tr502

    ... Evidence suggests neurotoxicity may result from chronic exposure of humans to ... Trihydrate 445 Sodium Azide 389 Sodium Fluoride 393 Sodium Nitrite 495 Sodium ...

  48. Peer Review Evaluation Report: Oral Up-and-down Procedure (NIH... 2.1MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/udpproc/udpfin01/vol_2.pdf

    ... Neurotoxicity ...... 81-7 When compared with controls, treated ... kits. 173.162 Gallium. 173.163 Hydrogen fluoride. 173.164 Mercury (metallic and articles ...

  49. TR-403: Resorcinol (CASRN 108-46-3) in F344 Rats and B6C3F1Mice... 15.0MB

    https://ntp.niehs.nih.gov/go/tr403

    ... Indications of neurotoxicity resulting from resorcinol administration have been reported ... Water 359 8-Methoxypaoralen 393 Sodium Fluoride 360 N,N-Dimethylaniline 395 Probenecid ...

  50. TR-519: Stoddard Solvent IIC (CASRN 64742-88-7) in F344/N Rats... 2.0MB

    https://ntp.niehs.nih.gov/go/tr519

    ... Comparison of local neurotoxicity of three white spirit formulations by percutaneous ... Trihydrate 445 Sodium Azide 389 Sodium Fluoride 393 Sodium Nitrite 495 Sodium ...

 
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