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Final RoC Background Document for Formaldehyde 5.8MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2009/november/formaldehyde_bd_final.pdf
Formaldehyde January 22, 2010 U.S. Department of Health and Human Services Public Health ... This Page Intentionally Left Blank Formaldehyde: RoC Background Document 1/22/10 i ...
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Formaldehyde Expert Panel Report Part B - Recommendation for... 406KB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2009/november/fa_partb.pdf
B Formaldehyde Expert Panel Report Part B - Recommendation for Listing Status for Formaldehyde and Scientific Justification for the Recommendation The Report on Carcinogens (RoC) ...
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RoC Profile: Formaldehyde; 15th RoC 2021 298KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/formaldehyde.pdf
Formaldehyde CAS No. 50-00-0 Known to be a human carcinogen First listed in the Second Annual Report on Carcinogens (1981) H 2 C=O Carcinogenicity Formaldehyde is known to be a ...
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Formaldehyde Expert Panel Report Part A - Peer Review of the... 567KB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2009/november/fa_parta.pdf
A Formaldehyde Expert Panel Report Part A - Peer Review of the Draft Background Document on Formaldehyde The Report on Carcinogens (RoC) expert panel for formaldehyde exposures met ...
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RR-03: Absence of Formaldehyde-Induced Neoplasia in TRP53 Haploinsuffi... 1.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/results/pubs/rr/reports/rr03_508.pdf
foRmaldehyde-INduced NeoPlasIa IN TRP53 haPloINsuffIcIeNT mIce exPosed by INhalaTIoN NTP RR 3 AUGUST 2017 NTP Research Report on Absence of Formaldehyde-Induced Neoplasia in ...
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Agenda: Formaldehyde Expert Panel Meeting; RoC; Nov. 2-4, 2009 163KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/twelfth/2009/november/agenda_formaldehyde.pdf
Report on Carcinogens (RoC) Formaldehyde Expert Panel Meeting November 2 - 4, 2009 ... James Swenberg (UNC) / Independent Scientist . Dr. Robert Golden / Formaldehyde Council, ...
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Roster: Formaldehyde Expert Panel; RoC; Nov. 2-4, 2009 144KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/twelfth/2009/november/eproster_formaldehyde.pdf
Report on Carcinogens (RoC) Formaldehyde Expert Panel Roster November 2-4, 2009 Kenneth E. McMartin, Ph.D., Chair Department of Pharmacology Toxicology & Neuroscience Louisiana ...
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Minutes: BSC; June 21-22, 2010 364KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2010/june/minutes20100622.pdf
for the 12 th Report on Carcinogens: Formaldehyde ......FDA Food and Drug Administration FDH formaldehyde dehydrogenase FEMA Federal Emergency ...
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NTP Response to BSC Peer Review Comments on the Draft Substances... 324KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/twelfth/2011/response062110bsc2011.pdf
and Technical Issues 4 References 4 Formaldehyde 5 BSC Comments and NTP Responses: ... cobalt-tungsten carbide: powders and hard metals, formaldehyde, and glass wool fibers. ...
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Nomination Background: 1,2,3,4-Butanetetracarboxylic acid (CASRN... 604KB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/btca_508.pdf
because of the increased potential for its use as a substitute for formaldehyde in the permanent press treatment of cotton resulting from the lowering of the TLV for formaldehyde. ...
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RoC Background Document: Methyl tertiary-Butyl Ether; Dec. 2... 1.2MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/mtbe1_508.pdf
... Carcinogenicity and Genotoxicity Studies of Formaldehyde ......32 6.4.1 Carcinogenicity of Formaldehyde (IARC 1995) ......
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Abstract for TR-552 73KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr552
It is also a by-product in the industrial synthesis of butynediol from acetylene and formaldehyde with copper acetylide as catalyst. Propargyl alcohol is used as a reactant/...
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Japanese Minimum Requirements for Biological Products 2.0MB
https://ntp.niehs.nih.gov/iccvam/methods/biologics/vaccine/japan-minreqs.pdf
.........306 Test for Formaldehyde Content......Virus shall then be inactivated by the addition of formalin or other suitable methods. The ...
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Abstract for TOX-78 68KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox078
Triethylamine is used primarily as a catalyst to cure the resin systems incorporated into sand cores for foundry molds. It is also used as a curing catalyst in phenol-formaldehyde ...
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Response to Expert Panels' Peer-Review Comments on Background... 354KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/twelfth/2011/responseexpertpanelreport2011.pdf
Peer-Review Comments 9 References 10 Formaldehyde 11 Expert Panel Meeting 11 NTP ... Expert Panels' Peer-Review Comments Formaldehyde 11 Formaldehyde Expert Panel Meeting ...
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RoC Background Document: Wood Dust; Dec. 13-14, 2000 1.2MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/wd_no_appendices_508.pdf
... dust rather than other concurrent exposure(s) such as formaldehyde or wood preservatives. ... the incidence of tumors induced by formaldehyde in female Sprague-Dawley rats, ...
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Presentation: Characteristics of Enzymatic and Binding Activities... 971KB
https://ntp.niehs.nih.gov/iccvam/meetings/histwksp-2012/present/oh-508.pdf
I) according to formaldehyde (at final concentration 0.26%), glutaraldehyde (at final concentration 0.05%), mixture of glutaraldehyde (0.05%) and formaldehyde (0.26%) § Methods ...
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Public Comment: General Issues; Richard Becker; RoC; Jan. 19... 85KB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2012/publiccomm/becker20120228.pdf
of Sciences (NAS) of the 12 th ROC's evaluation of formaldehyde and styrene is completed. ... peer review of the 12 th RoC determinations related to formaldehyde and styrene. ...
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Nomination Background: bis(2-Chloroethoxy)methane (CASRN: 111... 531KB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/bis(2-chloroethoxy)methane_508.pdf
of ethylene chlorohydrin (a possible impurity) and formaldehyde under acid catalysis. ... Bis(β-chloroethyl)formal Formaldehyde bis(β-chloroethyl) acetal ...
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bis(2-Chloroethoxy)methane M980065 38KB
https://ntp.niehs.nih.gov/go/ts-m980065
Synonyms/Common Names CEM Dichloroethyl formal Ethane, 1,1'-(methylenebis(oxy))bis(2-chloro- Formaldehyde bis(2-chloroethyl) acetal Short-Term Toxicity 2 weeks (Topical ...
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TR-490: Glutaraldehyde (CASRN 111-30-8) in F344/N Rats and B6C3F1Mice... 10.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr490.pdf
... Bus commented that the section comparing delivered doses of glutaraldehyde to formaldehyde ... anterior portion of the nose, whereas formaldehyde is deposited deeper in the respiratory ...
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CERHR Monograph: Potential Human Reproductive and Developmental... 5.0MB
https://ntp.niehs.nih.gov/ntp/ohat/methanol/methanol_monograph.pdf
... in the production of chemicals such as formaldehyde, methyl tertiary butyl ether (MTBE), ... In primates, including humans, methanol is converted to formaldehyde by the enzyme alco - ...
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TR-472: Isobutyraldehyde (CASRN 78-84-2) in F344/N Rats and B6C3F1Mice... 11.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr472.pdf
... its structural relationship to formaldehyde (a nasal carcinogen in rats), and the ... Formaldehyde (a structurally related chemical) was administered by inhalation 6 hours per ...
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Abstract for TR-536 69KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr536
ethane; ethane, 1,1-[methylenebis(oxy)]bis(2-chloro)-; formaldehyde bis(2-chloroethyl) acetal; formaldehyde bis(beta;-chloroethyl) acetal; methane, bis(2-chloroethoxy)-; ...
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Public Comment: Draft OHAT Approach; Dr. Lorenz Rhomberg and... 609KB
https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/publiccomm/rhomberg20130611_508.pdf
The NRC Committee that reviewed US EPA's formaldehyde risk assessment made important ... The formaldehyde review Committee set out a so-called "roadmap" for reform that called for ...
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Appendix G; 15th RoC 2021 73KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_g.pdf
number of the major chemicals or metals that are highlighted in the profile. 50-00-0 see Formaldehyde 50-18-0 see Cyclophosphamide 50-28-2 (estradiol-17β) see Estrogens, ...
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Background Document: RoC: Glass Wool Fibers; 2010 3.7MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/glasswoolbd20100408_508.pdf
... exposures, including asbestos, formaldehyde, and silica, in the nested case- ... (95% CI = 0.55 to 3.42, P = 0.50). (Formaldehyde exposure was also independently ...
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TOX-59: Chloral Hydrate (CASRN 302-17-0) 10.8MB
https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox059.pdf
... forming malondialdehyde, formaldehyde, acetaldehyde, acetone, and propionaldehyde. ... were fixed in 10% neutral buffered formalin, trimmed, embedded in paraffin, ...
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TOX-19: Formic Acid (CASRN 64-18-6) 1.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox019.pdf
... of its structural relationship with formaldehyde and because inhalation is an important ... and as a by-product in the manufacture of acetaldehyde and formaldehyde (Wagner, 1980). ...
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TOX-25: Glutaraldehyde (CASRN 111-30-8) 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox025.pdf
... the toxic effects of glutaraldehyde and formaldehyde be included in the discussion. Dr. ... glutaraldehyde and formaldehyde, a known nasal carcinogen in rats (Kerns et al., 1983). ...
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NTP Archives 62KB
https://ntp.niehs.nih.gov/data/archives
Available materials include: 7.5 million histological slides 4.6 million paraffin embedded tissue blocks 242,000 bags of formalin preserved tissues 74,000 frozen specimens Study ...
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Nomination Background: beta-Picoline (CASRN: 108-99-6) 443KB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/picoline_508.pdf
It is produced from the vapor-phase reaction of acetaldehyde and ammonia with formaldehyde ... of acetaldehyde and ammonia with formaldehyde and/or methanol in the presence of a ...
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Abstract for TR-430 72KB
https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr430
C.I. Direct Blue 218 is a copper chelated dye used for cellulose, acetate, nylon, silk, wool, tissue, papers, and textile goods with a urea-formaldehyde finish. C.I. Direct Blue ...
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Immunotoxicity Study Pathology Specifications; Oct. 7, 2016 678KB
https://ntp.niehs.nih.gov/ntp/htdocs/levels/finalntpitoxspecs_508.pdf
... The tissues shall be stored in formalin and sent to the pathology contract laboratory with ... shall be weighed and transferred to a container filled with 10% neutral buffered formalin. ...
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Abstract for TR-472 71KB
https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr472
variety of aldehydes, its structural relationship to formaldehyde (a nasal carcinogen in rats), and the lack of toxicity and carcinogenicity studies on isobutyraldehyde in animals. ...
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Listed Substances; 15th RoC 2021 76KB
https://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf
Virus (see Viruses: Eight Listings) Erionite Estrogens, Steroidal Ethylene Oxide Formaldehyde Helicobacter pylori (Chronic Infection) Hepatitis B Virus (see Viruses: Eight ...
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RoC Profile: Wood Dust; 15th RoC 2021 313KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/wooddust.pdf
to other substances, such as formaldehyde or wood preservatives (IARC 1995, NTP 2000). ... or experimental animals), including formaldehyde or sidestream cigarette smoke in rats ...
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2017 Annual Report (PDF) 6.1MB
https://ntp.niehs.nih.gov/annualreport/2017/2017annualreportdownloadpdf.pdf
... Report Title Research Report Number Absence of Formaldehyde-Induced Neoplasia in Trp53 ... NTP Information Cited Final Rule: Formaldehyde Emission Standards for Composite Wood ...
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Minutes: BSC; Nov. 30-Dec. 1, 2010 984KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2010/novdec/minutes20101201.pdf
... Drug Administration FF fresh frozen FFPE formalin-fixed, paraffin-embedded FN false ... more than 230,000 bags of formalin-fixed tissues, and more than 50,000 frozen specimens. ...
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Usefulness and Limitations of the LLNA for Potency Categorization... 25.3MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-pot/tmer.pdf
... molecular weight less than 200; (4) formaldehyde and products containing ≥1%; and (5) ... pig data are 4-phenylenediamine and formaldehyde, two of the five substances that meet ...
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Agenda: BSC; June 21-22, 2010 84KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2010/june/agenda20100621.pdf
Report on Carcinogens - Formaldehyde . Public Comments . BSC Discussion Dr. Lunn Dr. Novak 10:30 BREAK 11:00 - Formaldehyde (continued) 11:45 Report of the NTP Associate Director . ...
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TR-552: Propargyl Alcohol (CASRN 107-19-7) in F344/N Rats and... 3.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr552.pdf
... synthesis of butynediol from acetylene and formaldehyde with copper acetylide as catalyst. ... synthesis of butynediol from acetylene and formaldehyde with copper acetylide as catalyst. ...
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Public Comment: 2-Butoxyethanol; Seth Barna; RoC; Sept. 20, 2013 256KB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2013/publiccomm/barna20131017_508.pdf
Risks to Humans; Volume 88: Formaldehyde, 2- Butoxyethanol and 1-tert-Butoxy-2-propanol. ... of the ongoing NAS review of formaldehyde and styrene, and the NAS ...
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RoC Background Document: Tobacco Smoking; Dec. 2-3, 1998 3.5MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/environmentalts_noapps_508.pdf
... Ethene Propene 1,3-Butadiene Isoprene Formaldehyde 1.2 mg 1.3 mg 0.4 mg 3.1 mg 1500 µg ... Prominent among them are the respiratory irritants: ammonia, formaldehyde, and sulfur ...
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Nomination Background: Indole-3-carbinol (CASRN: 700-06-1) 238KB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/indolecarbinol_508.pdf
I3C has been synthesized from indole and formaldehyde by the use of cyclodextrins as ... 7. Preparation of 3-(hydroxymethyl)indole from indole and formaldehyde. Supramol. ...
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Presentation: International Collaborative Study on Validation... 891KB
https://ntp.niehs.nih.gov/iccvam/meetings/histwksp-2012/present/xing-508.pdf
with glutaraldehyde and formaldehyde, in combination with diphtheria and tetanus. ... pertussis vaccine detoxified with formaldehyde in combination with diphtheria and ...
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ICCVAM Test Method Evaluation Report: LLNA BrdU-ELISA 35.6MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-elisa/tmer.pdf
... Amines 0.11 (26.4) 0.285 (14.7) Formaldehyde Disinfectant; Manufacturing Aldehydes ... 2.60, 4.10, 5.10, 5.10, 5.40, 8.90 Formaldehyde (3, 1) ACE 1.97, 4.40, 16.60 4.00 ...
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RoC Background Document for Nitromethane; March 25, 2002 1.2MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/nmpub_no_appendices_508.pdf
... Although nitromethane may be metabolized to formaldehyde by rat liver microsomes in vitro, ...hydroxymethyl)nitromethane reaction of formaldehyde and nitromethane (3:1 molar ratio) via ...
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Protocol for a Systematic Review of Traffic-Related Air Pollution... 1.3MB
https://ntp.niehs.nih.gov/ntp/ohat/airpollchildhealth/protocol_20160616_508.pdf
... toxics as key: benzene, 1,3-butadiene, formaldehyde, acetaldehyde, acrolein, polycyclic ... Formaldehyde or other volatile organic compounds relevant to vehicle exhaust Comparators . ...
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Minutes: BSC TRRS; Dec. 11, 1996 1.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1996/dec/trrs11dec1996mins_508.pdf
... Hailey reported there were problems with using PCR, one being that none of the PCR based assays had proven reliable for use with formalin fixed tissues and only formalin fixed ...
