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TR-565: Milk Thistle Extract (CASRN 84604-20-6) in F344/N Rats... 3.6MB
https://ntp.niehs.nih.gov/go/tr565
NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF MILK THISTLE EXTRACT ... TOXICOLOGY AND CARCINOGENESIS STUDIES OF MILK THISTLE EXTRACT (CAS NO. 84604-20-6) IN ...
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Abstract for TR-565 63KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr565
Abstract for TR-565 Toxicology and Carcinogenesis Studies of Milk Thistle Extract in F344/... Mary thistle; mild thistle; milk ipecac; pig leaves; royal thistle; ...
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CERHR Monograph: Soy Infant Formula 122.6MB
https://ntp.niehs.nih.gov/go/soy_monograph
... Soy infant formula contains soy protein isolates and is fed to infants as a supplement to or replacement for human milk or cow milk. Soy protein isolates contains estrogenic ...
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Target Organs and Levels of Evidence for TR-565 51KB
https://ntp.niehs.nih.gov/data/tr/500s/tr565levels
of Milk Thistle Extract (CASRN 84604-20-6) in F344/N Rats and B6C3F1 Mice (Feed studies) Chemical (Study Title) CASRN Peer Review Date Route/Exposure Levels Study Laboratory Milk ...
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Monograph on Potential Human Reproductive and Developmental Effects... 2.4MB
https://ntp.niehs.nih.gov/go/fluoxetine_monograph
... Fluoxetine crosses the placenta and is found in breast milk. Thus, taking fluoxetine dur- ... Fluoxetine has also been detected in blood and milk of breastfeeding women and in the ...
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CERHR Monograph: Potential Human Reproductive and Developmental... 6.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/bisphenol/bisphenol.pdf
... Table.3:..Blood.and.breast.milk.biomonitoring.of.bisphenol.A.in.people.........Bisphenol.A.can.also.be.found.in. breast.milk.(5)..Short.-.term.exposure.can.occur. ...
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BSC_Evaluating NAMs (ICCVAM 2024 Public Forum) 4.5MB
https://ntp.niehs.nih.gov/sites/default/files/2024-06/15_Rider_ICCVAMPublicForum2024_508.pdf
Ginseng . Goldenseal . Gum guggul . Kava kava . Milk thistle . Senna . Usnea lichen ... Root and Rhizome Kratom Mitragyna speciosa (Korth.) Havil. Leaf Milk thistle Silybum ...
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Abstract for TOX-27 61KB
https://ntp.niehs.nih.gov/publications/reports/tox/tox027
Two-week and 13-week rodent toxicity studies of riddelliine were conducted because riddelliine can be a contaminant of foodstuffs, such as meat, grains, seeds, milk, herbal tea, ...
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NTP Monograph: Developmental Effects and Pregnancy Outcomes Associated... 23.8MB
https://ntp.niehs.nih.gov/go/mgraph02
... (e.g., evidence for placenta and breast milk transport, develop- mental toxicity in ... evidence of transfer to fetus or breast milk, and developmental toxicity in laboratory ...
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Abstract for TR-508 68KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr508
Cattle, horses, and sheep that ingest these plants succumb to their toxic effects. Riddelliine residues have been found in meat, milk, and honey, and the plants may contaminate ...
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Botanical Dietary Supplements 72KB
https://ntp.niehs.nih.gov/research/topics/botanical
biloba extract Ginseng Kava kava extract Milk thistle extract Echinacea purpurea extract ... TOX-99 Kava Kava Anxiety Completed TR-571 Milk Thistle Liver cirrhosis, chronic hepatitis, ...
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Abstract for TR-240 58KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr240
As an additive, it may be found in edible fats, oils, mayonnaise, shortening, baked goods, candy, dried meat, fresh pork sausage, and dried milk, and it is used in hair grooming ...
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Abstract for TR-554 66KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr554
and has been identified in honey, apple juice, citrus juices, beer, brandy, milk, breakfast cereal, baked foods, tomato products, and home cooking of sugar and carbohydrates. ...
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Comment: Antimony Trioxide (Attachment); Caroline Braibant, Geert... 9.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/nominations/2016/publiccomm/braibant_attach2.pdf
... 258 9.0.4.3. Exposure via mother´s milk ......specified Main ADME results: secretion in milk: Secretion of Sb in milk was small, 0.008 ...
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NTP-CERHR Monograph: Potential Human Reproductive and Developmental... 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/dehp/dehp-monograph.pdf
... DEHP. metabolites. can. cross.the.placenta.and.enter.breast.milk,.fetuses. and. nursing. ... uid,.saliva,.breast.milk (4-7) 5-OH-MEHP Oxidized.monoester.metabolite. . ...
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Background Document: RoC: Riddelliine; 2010 1.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/twelfth/2010/finalbds/riddelliine_final_508.pdf
... studies of cows fed Senecio plants have demonstrated that PAs can be transmitted in milk. ... PA residues have been found in grains, milk, eggs, and honey, and the plants may ...
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Historical Controls: Pathology Tables by Feed for Mice 100KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/historical_controls/ntp2000_2009/mice_feed_path_hist09.pdf
052000804 03/25/03 729 50 (1) 45(712) 49.8 Milk thistle extract Female Southern Research ... 052000804 03/25/03 732 50 (5) 40(714) 51.0 Milk thistle extract Version: May2009 ...
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Historical Controls: Pathology Tables by Oral/Feed for Fischer... 101KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/historical_controls/ntp2000_2009/rats_feed_path_hist09.pdf
03/04/03 729 50 (3) 36(704) 452.1 Milk thistle extract Female Southern Research ... 03/04/03 732 50 (5) 38(693) 328.4 Milk thistle extract Version: May2009 ...
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RoC Background Document: Danthron; Nov. 18-19, 1996 1.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/other_background/danthron1_508.pdf
... 15 6.1.2 Transfer ofDanthron in Human Milk ...... 15 ... induction of labor; and there is strong evidence of milk transfer of danthron in humans. ...
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TR-539: Multigenerational Reproductive Toxicology Study of Genistein... 5.6MB
https://ntp.niehs.nih.gov/go/tr539
... through their mothers' milk, and during their lifetimes through feed containing genistein. ... early neonatal period when the pups were receiving exposures exclu- sively from the milk. ...
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Historical Controls: Chemicals by Species/Route/Vehicle for Fischer... 206KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/historical_controls/ntp2000_2009/2009_byroute.pdf
Feed Cresols (No Males) Mice Oral Feed Milk thistle extract Mice Oral Feed ... Feed Cresols (No Females) Rats Oral Feed Milk thistle extract Rats Oral Feed ...
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Historical Controls: Pathology Tables by Oral/Feed for B6C3F1... 153KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/historical_controls/ntp2000_2010/oralfeedmice2010mar.pdf
052000804 03/25/03 729 50(1) 45(712) 49.8 Milk thistle extract Female Southern Research ... 052000804 03/25/03 732 50(5) 40(714) 51.0 Milk thistle extract NOTE: The text on page 2 ...
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Historical Controls: Pathology Tables by Oral/Feed for Fischer... 154KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/historical_controls/ntp2000_2010/oralfeedrats2010mar.pdf
052000803 03/04/03 729 50(3) 36(704) 452.1 Milk thistle extract Female Southern Research ... 052000803 03/04/03 732 50(5) 38(693) 328.4 Milk thistle extract NOTE: The text on page 2 ...
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RoC Review of Human Immunodeficiency Virus Type 1 (HIV-1) 72KB
https://ntp.niehs.nih.gov/research/assessments/cancer/completed/hiv1
Spread from unprotected sexual activity (oral, anal, or vaginal) and sharing of needles by injection. It can also be transmitted from mother to child through breast milk and during ...
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Historical Controls: Pathology Tables by Oral/Feed for B6C3F1... 158KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/historical_controls/ntp2000_2011/miceoralfeed.pdf
052000804 03/25/03 729 50(1) 45(712) 49.8 Milk thistle extract Female Southern Research ... 052000804 03/25/03 732 50(5) 40(714) 51.0 Milk thistle extract NOTE: The text on page 2 ...
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Historical Controls: Pathology Tables by Oral/Feed for Fischer... 155KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/historical_controls/ntp2000_2011/ratsoralfeed.pdf
052000803 03/04/03 729 50(3) 36(704) 452.1 Milk thistle extract Female Southern Research ... 052000803 03/04/03 732 50(5) 38(693) 328.4 Milk thistle extract NOTE: The text on page 2 ...
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RoC Review of Epstein-Barr Virus (EBV) 72KB
https://ntp.niehs.nih.gov/research/assessments/cancer/completed/ebv
It may also be transmitted from contact with blood (blood transfusion and organ transplants), genital fluids, and breast milk. Back to Top Documents Documents for Epstein-Barr ...
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Abstract for T0166 59KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/t0166
Three randomly selected dams per dose group were also selected for milk collection and milk samples were analyzed for HCBD content. All dams were euthanized and livers and kidneys ...
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RoC Profile: Acetaldehyde; 15th RoC 2021 176KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/acetaldehyde.pdf
... It is an important component of food flavorings and is added to milk products, baked ... Acetaldehyde has also been detected in breast milk. Consumers may be exposed to ...
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RoC References: Antimony and Other Antimony Compounds; Aug. 17... 599KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/references/antimonyreferences_508.pdf
... determination of trace toxic elements in milk based on combining Fe3O4 nanoparticles ... of arsenic and antimony in milk hydride generation atomic fluorescence spectrometry. ...
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Food Antigen Transport Across the Intestinal Epithelium: Outcomes... 5.1MB
https://ntp.niehs.nih.gov/sites/default/files/2023-12/Wb3_02_Hogan_GutModels2023_508.pdf
Noah et al., JACI 2020 Food Allergens passage across the intestinal epithelial layer via Goblet cell antigen passages Food allergen DAPI Peanut Milk Egg Milk MUC2 DAPI Miller, ...
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TR-545: Toxicology and Carcinogenesis Study of Genistein (CASRN... 2.8MB
https://ntp.niehs.nih.gov/go/tr545
... toxi- cology study, indicated minimal transfer of genistein to pups via the dams' milk. ... Milk from the dams contained 0.14 µM total genistein, but the pup stomach contents ...
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Toxicology/Carcinogenicity 1.1MB
https://ntp.niehs.nih.gov/research/apptoxres/cartox
pregnancy in utero via the placenta as well as the lactation period via the mother's milk. ... Toxicology and Carcinogenesis Studies of Milk Thistle Extract (CASRN 84604-20-6) in ...
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RoC Monograph: Antimony Trioxide; October 2018 2.6MB
https://ntp.niehs.nih.gov/go/rocmgraph13
... Exposure Levels from Food, Breast Milk, and Drinking Water Based on Data Measured ... No U.S. data on total antimony concentrations in breast milk were found, but ...
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Historical Controls: Chemicals by Sex/Species/Route/Vehicle for... 14KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/historical_controls/ntp2000_2010/histcont_2010_studies.pdf
Mice B6C3F1 Male and Female Oral Feed Milk thistle extract Mice B6C3F1 Male and ... Rats F 344/N Male and Female Oral Feed Milk thistle extract Rats F 344/N Male and ...
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Historical Controls: Chemicals by Sex/Species/Route/Vehicle for... 83KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/historical_controls/ntp2000_2011/histcont_2011_studies.pdf
Mice B6C3F1 Male and Female Oral Feed Milk thistle extract Mice B6C3F1 Male and ... Rats F 344/N Male and Female Oral Feed Milk thistle extract Rats F 344/N Male and ...
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TOX-27: Riddelliine (CASRN 23246-96-0) 3.4MB
https://ntp.niehs.nih.gov/go/tox027
... be a contaminant of foodstuffs, such as meat, grains, seeds, milk, herbal tea, and honey. ... Chan replied that the USFDA was concerned about the contamination of meat, milk, honey, ...
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TR-573: Styrene-acrylonitrile trimer in F344/N Rats (Perinatal... 2.8MB
https://ntp.niehs.nih.gov/go/tr573
... during nursing through their mothers' milk, and through their lifetimes through feed. ... Gravid F-344 rats were dosed at 200 mg/kg, and blood, placenta, fetus, and milk samples ...
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RoC Profile: Hexachlorobenzene; 15th RoC 2021 155KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/hexachlorobenzene.pdf
... blood and breast milk of pregnant and lactating women, and in the placenta and cord blood. ... Breast-milk concentrations of hexachlorobenzene were elevated in populations of women who ...
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CERHR Monograph: Amphetamines 4.1MB
https://ntp.niehs.nih.gov/go/amphetamine_monograph
... to. the. fetus. and. are. found. in.breast.milk..Thus,.taking.amphetamines.dur- ... reporting. amphetamine.levels.in.breast.milk.or.premature.infants,.studies.examining.sp...
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OPFR Prioritization using the Developmental Neurotoxicity In... 140KB
https://ntp.niehs.nih.gov/sites/default/files/2024-01/Oyetade-SOT_2024_abstract-508.pdf
... We also added exposure data from new sources that sampled breast milk, urine, house dust, ... through breast milk for BDE-47, TPHP, TDCIPP, and EHDP, suggesting a human risk concern. ...
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Background Document for Selected Heterocyclic Amines: PhIP, MeIQ... 3.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/roc11/hcaspub_508.pdf
... HCAs and their metabolites also have been detected in fetuses and in the milk of lactating ... Table 4-8. Effects of transplacental and transbreast milk exposure on PhIP-induced mammary ...
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Applying In vitro Approaches to Understand Complex Mixtures in... 5.3MB
https://ntp.niehs.nih.gov/iccvam/meetings/commprac-2021/20210126-iccvam-cop-rider-508.pdf
... Green tea extract . Gum guggul extract . Kava kava extract . Milk thistle extract . Senna ... Green tea No No No No Kava Kava Equivocal No Clear Clear Milk thistle No No No No Senna ...
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CERHR Monograph: Potential Human Reproductive and Developmental... 4.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/acrylamide/acrylamide_monograph.pdf
... wheels) 20 - 267 Infant formulas (soy or milk-based) ND - <10 French fries (fast food or ... cheese, sauces) <10 - 1184 Dairy foods (milk, cheese, ice cream, milk shake, pudding, ...
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RoC Profile: Safrole; 15th RoC 2021 130KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/safrole.pdf
The incidence of liver tumors (adenoma and carcinoma) was increased in male mice exposed during infancy via milk and in adult female mice adminis- tered safrole in the diet ...
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TOX-8: D&C Yellow No. 11 (CASRN 8003-22-3) 2.1MB
https://ntp.niehs.nih.gov/go/tox008
... After exposure to D&C Yellow No. 11 for 4 weeks through the milk and to feed containing ... a decreased level of lactation or reduced milk/feed palatabil- ity) During the lactation ...
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Historical Controls: Pathology Tables for All Routes/Vehicles... 309KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2010/2010-03-22-hist-ratsallroutes.pdf
... 052000803 03/04/03 729 50(3) 36(704) 452.1 Milk thistle extract Battelle Columbus ... 052000803 03/04/03 732 50(5) 38(693) 328.4 Milk thistle extract Battelle Columbus ...
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RoC Profile: Aflatoxins; 15th RoC 2021 135KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/aflatoxins.pdf
... Meat, eggs, milk, and other edible products from animals that consume aflatoxin-contam- ... Nursing infants may be exposed to aflatoxins in breast milk (Zarba et al. 1992). ...
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TR-554: 5-(Hydroxymethyl)-2-furfural (CASRN 67-47-0) in F344... 4.4MB
https://ntp.niehs.nih.gov/go/tr554
... apple juice, citrus juices, beer, brandy, milk, breakfast cereal, baked foods, tomato ... apple juice, citrus juices, beer, brandy, milk, breakfast cereal baked foods, tomato ...
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Historical Controls: All Route and Vehicles for Rats; Studies... 162KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/historical_controls/ntp2000_2008/r_hcrtp_allrte_20081100.pdf
... 03/04/03 729 50 (3) 36(704) 452.1 Milk thistle extract Battelle Columbus ... 03/04/03 732 50 (5) 38(693) 328.4 Milk thistle extract Battelle Columbus ...