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TR-311: Tetrachloroethylene (Perchloroethylene) (CASRN 127-18... 13.6MB
https://ntp.niehs.nih.gov/go/tr311
PROGRAM Technical Report Series No. 311 X J """''V TOXICOLOGY AND CARCINOGENESIS STUDIES OF TETRACHLOROETHYLENE (PERCHLOROETHYLENE) (CAS NO. 127-18-4) IN F344/N RATS AND B6C3Fi ...
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TR-013: Tetrachloroethylene (CASRN 127-18-4) 3.7MB
https://ntp.niehs.nih.gov/go/tr013
Series No. 13 1 9 7 7 BIOASSAY OF TETRACHLOROETHYLENE FOR POSSIBLE CARCINOGENICITY CAS ... 77-813 REPORT ON THE BIOASSAY OF TETRACHLOROETHYLENE FOR POSSIBLE CARCINOGENICITY ...
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RoC Profile: Tetrachloroethylene; 15th RoC 2021 151KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/tetrachloroethylene.pdf
Tetrachloroethylene CAS No. 127-18-4 Reasonably anticipated to be a human carcinogen First listed in the Fifth Annual Report on Carcinogens (1989) Also known as perchloroethylene ...
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Tetrachloroethylene: Target Organs and Levels of Evidence for... 53KB
https://ntp.niehs.nih.gov/data/tr/000s/tr013levels
5 Tetrachloroethylene: Target Organs and Levels of Evidence for TR-013 Bioassay of Tetrachloroethylene for Possible Carcinogenicity (CASRN 127-18-4) Chemical (Study Title) CASRN ...
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Abstract for TR-311 61KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr311
Toxicology and Carcinogenesis Studies of Tetrachloroethylene (Perchloroethylene) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) CASRN: 127-18-4 Chemical Formula: C2Cl4 Molecular ...
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Tetrachloroethylene 52KB
https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr260
0abs Tetrachloroethylene Abstract A technical report number was assigned to the chronic ... Tetrachloroethylene was previously tested in Osborne-Mendel rats and B6C3F1 mice by gavage ...
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Abstract for TR-13 59KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr013
3abs Abstract for TR-13 Bioassay of Tetrachloroethylene for Possible Carcinogenicity CASRN: 127-18-4 Chemical Formula: C2Cl4 Molecular Weight: 165.83 Synonyms/Common Names: ...
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Target Organs and Levels of Evidence for TR-311 54KB
https://ntp.niehs.nih.gov/data/tr/300s/tr311levels
Target Organs and Levels of Evidence for TR-311 Toxicology and Carcinogenesis Studies of Tetrachloroethylene (Perchloroethylene) (CASRN 127-18-4) in F344/N Rats and B6C3F1 Mice ...
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RoC Background Document: Tetrafluoroethylene; March 1999 4.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/other_background/tetrafluoroethylene1.pdf
......... 13 6.4.2 Tetrachloroethylene ......(DCVC), chlorotrifluoroethylene, tetrachloroethylene, and hexachloro-1 ,3-butadiene are ...
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Abstract for TR-263 59KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr263
Abstract 1,2-Dichloropropane is a chemical intermediate widely used in the production of tetrachloroethylene and carbon tetrachloride. It is an oil and fat solvent in certain ...
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RoC Background Document: Trichloroethylene (TCE); Oct. 30-31... 3.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/other_background/trichl_tce1997_2apps_508.pdf
......... 35 6.3.2.3 Tetrachloroethylene ......1-dichloroethylene ), and 1,1 ,2,2-tetrachloroethylene (perchloroethylene ). 6.3.2.1 Vinyl ...
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Abstract for TR-3 59KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr003
In 1959, Browning reported that 1,1,2-trichloroethane was replacing the more toxic industrial solvents: trichloroethylene, tetrachloroethylene, and carbon tetrachloride. The ...
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Abstract for TR-232 61KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr232
is a solvent that was used primarily as an intermediate in the manufacture of tetrachloroethylene.) Doses were administered for 103 weeks for rats and 41-103 weeks for mice. ...
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TOX-35: Chemical Mixture of 25 Groundwater Contaminants 11.5MB
https://ntp.niehs.nih.gov/go/tox035
... .8 Phenol 3 .27 0 .87 2 .9 8 .7 29 Tetrachloroethylene 9 .68 0 .102 0 .34 1 .02 3 .4 ... 108-95-2 3 .27 0 .87 2 .9 8 .7 29 Tetrachloroethylene 127-18-4 9 .68 0 .102 0 .34 1 .02 3 ...
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TR-232 Carcinogenesis Studies of Pentachloroethane (CASRN 76... 7.3MB
https://ntp.niehs.nih.gov/go/tr232
... manufacture of tetrachloroethylene (Kirk- Othmer, 1979). With the development of alter- n a t e m a n u f a c t u r i n g p r o c e s s e s f o r tetrachloroethylene, the annual ...
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Combining NAM Data and IVIVE for Evaluating Potential Inhalation... 17KB
https://ntp.niehs.nih.gov/iccvam/meetings/sot23/chang-sot2023-abstract_508.pdf
In this study, we selected 20 volatile organic compounds (e.g., styrene, tetrachloroethylene, 2-butoxyethanol) with abundant pharmacokinetic data and published minimal risk levels ...
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RoC Profile: Hexachloroethane; 15th RoC 2021 145KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/hexachloroethane.pdf
oils, and very soluble in diethyl ether and tetrachloroethylene (Akron 2009, HSDB 2009). ... It may be used in-house or recycled in feedstock to produce tetrachloroethylene or carbon ...
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Nomination Background: Dichloroacetic acid (CASRN: 79-43-6) 6.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/chem_background/exsumpdf/dcaa_508.pdf
... of trichloroethylene and tetrachloroethylene which have been identified as ... of trichloroethylene (TCE) and tetrachloroethylene (PER) in drinking water or in the air . ...
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TR-237 Carcinogenesis Studies of 1,1,1,2-Tetrachloroethane (CASRN... 6.4MB
https://ntp.niehs.nih.gov/go/tr237
... a chemical intermediate in the production of trichloroethyl- ene and tetrachloroethylene. ... solutions: acetone (0.05%), tetrachloroethylene (0.04%), tri- chloroethylene ...
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RoC Concept:1-Bromopropane 268KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/thirteenth/concepts/1-bp_concdocroc8-30-12_508.pdf
... such as trichloroethylene, tetrachloroethylene (perc, primarily used in the dry ... 759-769. RoC Concept: 1-Bromopropane (August 2012) 7 18. IARC. 1995. Tetrachloroethylene. ...
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1-Bromopropane: Preliminary Literature Search Strategy and List... 639KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/thirteenth/litsearchstrategy/1-bp-litsearch&references5oct2012_508.pdf
... Formal searches were not conducted for epidemiologic studies of dry cleaners because these workers would have most likely been exposed to other solvents such as tetrachloroethylene...
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TR-361: Hexachloroethane (CASRN 67-72-1) in F344/N Rats (Gavage... 7.2MB
https://ntp.niehs.nih.gov/go/tr361
... Production Chlorination of tetrachloroethylene in the pres- ence of ferric chloride a t ... Photochemical chlorination of tetrachloroethylene under pressure and below 60"C is a ...
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TR-450: Tetrafluoroethylene (CASRN 116-14-3) in F344 Rats and... 21.3MB
https://ntp.niehs.nih.gov/go/tr450
... neo- plasms from the current study with those from the NTP study of tetrachloroethylene. ... The conjugates of hexachlorobutadiene, trichloroethylene, and tetrachloroethylene were ...
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Presentation: Cobalt and Certain Cobalt Compounds Human Cancer... 479KB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2015/july/presentations/humancancerstudies_508.pdf
... esophageal cancer risk factors - Occupational: rubber production industry, tetrachloroethylene exposure, and dry cleaning. - Non-occupational: x- and gamma-radiation, alcohol, ...
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TOX-49: Toxicity Studies of 1,1,2,2-Tetrachloroethane (CASRN... 1.2MB
https://ntp.niehs.nih.gov/go/tox049
... of trichloroethylene, tetrachloroethylene, and 1,2-dichloroethylene (Archer, 1979). ... Minor metabolites were tri- and tetrachloroethylene in expired air. B6C3F 1 mice ...
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Combining NAM Data and IVIVE for Evaluating Potential Inhalation... 595KB
https://ntp.niehs.nih.gov/iccvam/meetings/sot23/sot2023-chang-poster.pdf
... Chemical Lowest ACC (µM) In Vitro Assay Target Ratio: EAD-plasma vs. LOAEL Ratio: EAD-lung vs. LOAEL In Vivo Toxicity Endpoint Tetrachloroethylene 29 Regulation of gene expression ...
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RoC Profile: Hexachlorobenzene; 15th RoC 2021 155KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/hexachlorobenzene.pdf
... by-product of production of other chlori- nated solvents and pesticides such as tetrachloroethylene, trichlo- roethylene, carbon tetrachloride, vinyl chloride, atrazine, propazine, ...
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Appendix G; 15th RoC 2021 69KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/appendix_g.pdf
... 126-72-7 see Tris(2,3-dibromopropyl) Phosphate 126-99-8 see Chloroprene 127-18-4 see Tetrachloroethylene 131-52-2 (pentachlorophenol, sodium salt) see Pentachlorophenol and ...
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RoC Monograph: Trichloroethylene; January 2015 4.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/monographs/finaltce_508.pdf
... unclear and indistinguishable from tetrachloroethylene, or other petroleum-derived ... to indirectly characterize exposure to trichloroethylene (and tetrachloroethylene). ...
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TR-003: 1,1,1-Trichloroethane (CASRN 71-55-6) 1.0MB
https://ntp.niehs.nih.gov/go/tr003
... industrial solvents: trichloroethylene, tetrachloroethylene, and carbon tetrachloride. ... Chloroform, Trichloroethylene, Tetrachloroethylene, Ion Exchange Resins. 31 APPENDIX ...
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TR-027: 1,1,2,2-Tetrachloroethane (CASRN 79-34-5) 3.0MB
https://ntp.niehs.nih.gov/go/tr027
... of trichloroethylene and tetrachloroethylene (National Institute for ... 1,1,2- trichloroethane (79-00-5), tetrachloroethylene (127-18-4), hexachloro- ethane ...
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TR-273: Trichloroethylene (CASRN 79-01-6) in Four Strains of... 16.9MB
https://ntp.niehs.nih.gov/go/tr273
... ethylene, tetrachloroethylene, carbon tetrachloride, chloroform, and methyl chloride. ... chloroethane, NCI, 1978c;tetrachloroethylene, NCI, 1977;pentachloroethane, NTP, ...
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Application of In Vitro to In Vivo Extrapolation (IVIVE) to Inform... 2.9MB
https://ntp.niehs.nih.gov/iccvam/meetings/sot22/poster/mumtaz-sot2022.pdf
... 1 0.2 - 277.5 chlordecone 0.01 1 0.4 - 67.2 chlorfenvinphos 0.002 2 0.1 - 70.3 tetrachloroethylene* 0.008 2.4 3.9 dichlorvos 0.004 4 0.7 beta-hexachlorocyclohexane 0.05 5 0.3 - ...
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Listed Substances; 15th RoC 2021 76KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/listed_substances_508.pdf
... (see Nitrosourea Chemotherapeutic Agents) Styrene Styrene-7,8-oxide Sulfallate Tetrachloroethylene Tetrafluoroethylene Tetranitromethane Thioacetamide 4,4'-Thiodianiline Thiourea ...
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TR-102: 3-Sulfolene (CASRN 77-79-2) 3.6MB
https://ntp.niehs.nih.gov/go/tr102
... Untreated control rats were housed in a room with other rats intubated with 1,1,2-trichloroethane (79-00-5) and tetrachloroethylene (127-18-4). All mice used in the 3-sulfolene ...
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TR-110: Iodoform (CASRN 75-47-8) 3.1MB
https://ntp.niehs.nih.gov/go/tr110
... The untreated control rats were housed with other rats intubated with 1,1,2-trichloroethane (79-00-5) and tetrachloroethylene (127-18-4). All mice utilized in the iodoform ...
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Abstract for TOX-35 69KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox035
... 3.75 11.25 37.5 Nickel 0.5 0.204 0.68 2.04 6.8 Phenol 3.27 0.87 2.9 8.7 29 Tetrachloroethylene 9.68 0.102 0.34 1.02 3.4 Toluene 5.18 0.21 0.7 2.1 7 1,1,1-Trichloroethane 1.25 ...
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Protocol: Evidence Map of Inflammation-Based Atherosclerosis... 643KB
https://ntp.niehs.nih.gov/sites/default/files/2023-07/protocol_atherosclerosis_supplementaljuly2023_508.pdf
... tetrachlorodibenzodioxin[tiab] OR tetrachloroethylene[tiab] OR Tin[tiab] OR tobacco- ... OR tetrachlorodibenzodioxin OR tetrachloroethylene OR Tin OR toluene OR toxicant* OR ...
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Public Health Impact 1.4MB
https://ntp.niehs.nih.gov/media/impact
... Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/tetrachloroethylene.pdf NTP (National ... carcinogenesis studies of tetrachloroethylene (perchloroethylene) ...
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Minutes: BSC TRRS; Aug. 14, 1985 792KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1985/aug/85aug14trrsmins_508.pdf
... Tetrachloroethylene (Perchloroethylene) . D r . J. Mennear, NTP Chemical Manager, introduced the toxicology and carcinogenesis studies o f tetrachloroethylene by reviewing the ...
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TR-074: 1,1,2-Trichloroethane (CASRN 79-00-5) 3.2MB
https://ntp.niehs.nih.gov/go/tr074
... The rats dosed with 1,1,2-trichloroethane and their untreated * controls were housed in the same room with rats intubated with tetrachloroethylene (127-18-4). Vehicle control rats ...
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TR-055: 1,2-Dichloroethane (CASRN 107-06-2) 3.7MB
https://ntp.niehs.nih.gov/go/tr055
... Untreated control rats were housed in a different room along with other rats intubated with 1,1,2-trichloroethane (79-00-5), and tetrachloroethylene (127-
18-4). All mice used in ...
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TOX-4: 1,2-Dichloroethane (Ethylene Dichloride) (CASRN 107-06... 4.0MB
https://ntp.niehs.nih.gov/go/tox004
... chlorine with ethylene in the presence of 1,2-di- ethane, trichloroethylene, tetrachloroethylene, bromoethane or a metal chloride catalyst or by vinylidine chloride, and ...
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TR-066: 1,1-Dichloroethane (CASRN 75-34-3) 3.3MB
https://ntp.niehs.nih.gov/go/tr066
... (79-00-5) and tetra- chloroethylene (127-18-4). 1,1-Dichloroethane-treated and control ... 1,2-dibromoethane (106-93-4), tetrachloroethylene (127-18-4), iodoform (75-47-8), ...
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Appendices A-G; 15th RoC 2021 433KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/appendices_508.pdf
... pentachlorobiphenyl see Polychlorinated Biphenyls perc see Tetrachloroethylene perchloroethylene see Tetrachloroethylene National Toxicology Program, Department of Health and Human ...
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TR-000: Chloroform (CASRN 67-66-3) 2.1MB
https://ntp.niehs.nih.gov/go/tr000chloroform
... 1,1,2-trichloroethane, tetrachloroethylene, hexachloroethane, carbon disulfide, trichlorofluoromethane, carbon tetrachloride, ethylene dibromide and dibromochloropropane. ...
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TR-028: Dibromochloropropane (CASRN 96-12-8) 3.2MB
https://ntp.niehs.nih.gov/go/tr028
... tetrachloride (56-23-5), chloroform (67-66-3), chloropicirin (76-06-2), tetrachloroethylene (127-18-4), methylchloroform (71-55-6), hexachloroethane (67-72-1), 1,1-dichloro- ethane ...
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TR-068: Hexachloroethane (CASRN 67-72-1) 3.4MB
https://ntp.niehs.nih.gov/go/tr068
... (75-47-8), methylchloroform (71-55-6), 1,1,2-trichloroethane (79-00-5), tetrachloroethylene (127-18-4), 1,1,2,2-tetrachloroethane (79-34-5), carbon disulfide (75-15-0), ...
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TR-073: Allyl Chloride (CASRN 107-05-1) 3.5MB
https://ntp.niehs.nih.gov/go/tr073
... (79-01-6); carbon tetrachloride (56-23-5); 1,1,2-trichloroethane (79-00-5); hexachloro- ethane (67-72-1) carbon disulfide (75-15-0); and tetrachloroethylene (127-18-4). ...
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BSC Meeting: Draft RoC Concept: Di- and Tri- Haloacetic Acids... 240KB
https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2016/april/haa_508.pdf
... Dichloroacetic acid. In Trichloroethylene, Tetrachloroethylene, and Some Other Chlorinated ... Trichloroacetic acid. In Trichloroethylene, Tetrachloroethylene, and Some Other ...